THE PROTECTIVE EFFECTS OF MOLYBDENUM (Mo)AND ZINC(Zn) ON MYOCARDIAL NECROSIS IN KESHAN DISEASE-E XPERIMENTAL STUDIES OF Mo AND Zn:THE CONTENTS OF PLASMA cGMP AND SERUM Mg++ Ca++ FOLLOWING ANOXIC MYOCARDIAL INJURY
T-AOC level in liver was also much higher (p<0.05); MDA level in serum and liver in SI group were much lower than thosein DC group(p<0.05); although XOD level of serum and liver in SI group were lower than DC group.
④The serum creatinine, urea nitrogen and quantities of 24-hour urine albumin of the model and PDTC groups were higher than the control group (P < 0.01, 0.05), but all the indexes of the PDTC group were lower than the model group (P < 0.01).
RESULTS: Serum OC, ALP, BALP, TRAP and HYP levels in OVX group were significantly higher than that in sham group. As regard to the time of peak level arrived, the sequence of changes was as follows: TRAP/HYP→OC→ALP/BALP.
Relationship between Serum Paraoxonase 1 Activities, Gene L55M Polymorphism and the Angiographic Characteristics of Coronary Arteries in Chinese Patients with Coronary Heart Disease Complicated with Hyperglycemia.
Sequential studies on the potassium metabolism in a group of normal malesubjects receiving Gossypol acetate for 2 years were made. The findingswere as follows: (1) The mean serum potassium levels tended to declinein the course of medication, and the tendency became more obvious withthe passage of time. (2) Intracellular potassium concentrations of RBCwere also decreased definitely after the contraceptive regime being startedhalf a year and thereafter. (3) Urinary excretion of potassium tended toincrease...
Sequential studies on the potassium metabolism in a group of normal malesubjects receiving Gossypol acetate for 2 years were made. The findingswere as follows: (1) The mean serum potassium levels tended to declinein the course of medication, and the tendency became more obvious withthe passage of time. (2) Intracellular potassium concentrations of RBCwere also decreased definitely after the contraceptive regime being startedhalf a year and thereafter. (3) Urinary excretion of potassium tended toincrease concomitantly. (4) Serum magnesium levels were markedly depr-essed in part of the receivers after 6 to 8 months of application ofGossypol actate, but the mean levels of serum magnesium restored topremedication level when the medication program extended to 1-2 years. The observation that during the administration of Gossypol acetateboth intracelluar and extracellular potassium concentrations tended to dec-line indicated that there was a total body potassium depletion. The con-comitant increase of urinary potassium out-put showed that the loss wasthrough the kidneys. The depressive effect of Gossypol on the renal tu-bular reabsorption of potassium has been documented previously. However,one must take into consideration of the fact that Gossypol can causemuscular leakage of potassium into the blood stream, causing a secondaryincrease of urinary out-put of potassium, but under such a conditionthere should not be any total body depletoins as they were shown by ourpatients. It has been revealed that the effect of Gossypol on muscles couldbe augmented by low intake of potassium. On account of the potentialdanger of developing a severe hypokaliemia during the prolonged courseof Gossypol administration, the authors feel that potassium supplementsseem mandatory.
Quantitative determinations of serum β-lipoprotein,cholesterol and trigly-ceride and agarose-gel electrophoresis have been made on normal subjects andpatients with coronary heart disease(CHD),myocardium infarction(MI)andhypertension,totalling 247 cases.According mainly to the data of agarose elec-trophoretograms,the 247 subjects could be classified into seven different types,namely,types Ⅱ_1,Ⅱ_2,Ⅱ_3,Ⅱ_4,Ⅲ,Ⅳ,and Ⅴ.The distribution of these 247 casesin each type was different,being the highest in type Ⅱ(88...
Quantitative determinations of serum β-lipoprotein,cholesterol and trigly-ceride and agarose-gel electrophoresis have been made on normal subjects andpatients with coronary heart disease(CHD),myocardium infarction(MI)andhypertension,totalling 247 cases.According mainly to the data of agarose elec-trophoretograms,the 247 subjects could be classified into seven different types,namely,types Ⅱ_1,Ⅱ_2,Ⅱ_3,Ⅱ_4,Ⅲ,Ⅳ,and Ⅴ.The distribution of these 247 casesin each type was different,being the highest in type Ⅱ(88 cases)and the lowestin type Ⅴ(2 cases).The order of the overall distribution was as follows:TypesⅡ_4,>Ⅱ_3>Ⅳ>Ⅱ_1vⅡ_2>Ⅲ>Ⅴ.Among the 247 subjects examined,there were 118 cases of hyper-β-lipopro-teinemia.Their distribution in each type was similar to the above results,beingalso highest in type Ⅱ_4(44 cases),and lowest in type Ⅴ(2 cases).The overalldistribution was that Ⅱ4>Ⅳ>Ⅱ_3>Ⅱ_1>Ⅲ>Ⅲ>Ⅴ.Amongthe 118 cases of hyper-β-lipoproteinemia studied,there were 67 casesof CHD,34 cases of hypertension and 20 cases of MI.The distribution of CHDin different phenotypes of hyper-β-lipoproteinemia of types Ⅱ_4,Ⅳ and Ⅱ_3 wasabout the same,being 22,20 and 18 cases respectively,that in types Ⅱ_1 and Ⅱ_2was much lower,being 4 and 3 cases respectively,and there was none in types Ⅲand Ⅴ.MI also occurred quite frequently in types Ⅳ,Ⅱ_4 and Ⅱ_3 but none intypes Ⅲ and Ⅴ.Furthermore,it was found that both CHD and hypertension were moreclosely related with hyper-β-lipoproteinemia than with hypercholesterolemia andtriglyceridemia.All above results imply that an early discovery and diagnosis of hyper-lipo-proteinemia would be of value to the prevention and treatment of CHD and MI.
Calf thymosin fration 5 (THF 5), prepared by modified Goldstein method, was given to 7 patients with acute acquired immunodeficiency diseases, including 1 fulminant Japanese B encephalitis associated with respiratory failure: 1 fulminant infectious hepatitis associated with hepatic coma; 1 chronic active hepatitis associated with peritonitis; 1 systemic lupus erythematosus associated with herpes zoster: 1 severe heat-exhaustion associated with deep coma, bacteriemia, and decubitus ulcer: 1 chronic granulocytic...
Calf thymosin fration 5 (THF 5), prepared by modified Goldstein method, was given to 7 patients with acute acquired immunodeficiency diseases, including 1 fulminant Japanese B encephalitis associated with respiratory failure: 1 fulminant infectious hepatitis associated with hepatic coma; 1 chronic active hepatitis associated with peritonitis; 1 systemic lupus erythematosus associated with herpes zoster: 1 severe heat-exhaustion associated with deep coma, bacteriemia, and decubitus ulcer: 1 chronic granulocytic leukemia associated with fungal pneumonia: and 1 acute lymphocytic leukemia associated with pseudomonas aerogenosa infection.The molecular weight of THF 5 is less than 15000. Electrophoretic analysis revealed no bovine serum albumin. Further studies on this substance which is promising in treating immunodeficiency diseases are necessary before it can be recommended in clinical practice.
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