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Sequential studies on the potassium metabolism in a group of normal malesubjects receiving Gossypol acetate for 2 years were made. The findingswere as follows: (1) The mean serum potassium levels tended to declinein the course of medication, and the tendency became more obvious withthe passage of time. (2) Intracellular potassium concentrations of RBCwere also decreased definitely after the contraceptive regime being startedhalf a year and thereafter. (3) Urinary excretion of potassium tended toincrease... Sequential studies on the potassium metabolism in a group of normal malesubjects receiving Gossypol acetate for 2 years were made. The findingswere as follows: (1) The mean serum potassium levels tended to declinein the course of medication, and the tendency became more obvious withthe passage of time. (2) Intracellular potassium concentrations of RBCwere also decreased definitely after the contraceptive regime being startedhalf a year and thereafter. (3) Urinary excretion of potassium tended toincrease concomitantly. (4) Serum magnesium levels were markedly depr-essed in part of the receivers after 6 to 8 months of application ofGossypol actate, but the mean levels of serum magnesium restored topremedication level when the medication program extended to 1-2 years. The observation that during the administration of Gossypol acetateboth intracelluar and extracellular potassium concentrations tended to dec-line indicated that there was a total body potassium depletion. The con-comitant increase of urinary potassium out-put showed that the loss wasthrough the kidneys. The depressive effect of Gossypol on the renal tu-bular reabsorption of potassium has been documented previously. However,one must take into consideration of the fact that Gossypol can causemuscular leakage of potassium into the blood stream, causing a secondaryincrease of urinary out-put of potassium, but under such a conditionthere should not be any total body depletoins as they were shown by ourpatients. It has been revealed that the effect of Gossypol on muscles couldbe augmented by low intake of potassium. On account of the potentialdanger of developing a severe hypokaliemia during the prolonged courseof Gossypol administration, the authors feel that potassium supplementsseem mandatory. 本文报导对一批口服男性节育药醋酸棉酚正常成年男性对象进行了钾代谢的观察,发现服药后,血清钾均值下降,而尿钾则有增多。为了避免发生低钾血症,作者认为在服用棉酚过程中,特别是服药半年以上者,适当补充钾盐,甚属必要。 Quantitative determinations of serum β-lipoprotein,cholesterol and trigly-ceride and agarose-gel electrophoresis have been made on normal subjects andpatients with coronary heart disease(CHD),myocardium infarction(MI)andhypertension,totalling 247 cases.According mainly to the data of agarose elec-trophoretograms,the 247 subjects could be classified into seven different types,namely,types Ⅱ_1,Ⅱ_2,Ⅱ_3,Ⅱ_4,Ⅲ,Ⅳ,and Ⅴ.The distribution of these 247 casesin each type was different,being the highest in type Ⅱ(88... Quantitative determinations of serum β-lipoprotein,cholesterol and trigly-ceride and agarose-gel electrophoresis have been made on normal subjects andpatients with coronary heart disease(CHD),myocardium infarction(MI)andhypertension,totalling 247 cases.According mainly to the data of agarose elec-trophoretograms,the 247 subjects could be classified into seven different types,namely,types Ⅱ_1,Ⅱ_2,Ⅱ_3,Ⅱ_4,Ⅲ,Ⅳ,and Ⅴ.The distribution of these 247 casesin each type was different,being the highest in type Ⅱ(88 cases)and the lowestin type Ⅴ(2 cases).The order of the overall distribution was as follows:TypesⅡ_4,>Ⅱ_3>Ⅳ>Ⅱ_1vⅡ_2>Ⅲ>Ⅴ.Among the 247 subjects examined,there were 118 cases of hyper-β-lipopro-teinemia.Their distribution in each type was similar to the above results,beingalso highest in type Ⅱ_4(44 cases),and lowest in type Ⅴ(2 cases).The overalldistribution was that Ⅱ4>Ⅳ>Ⅱ_3>Ⅱ_1>Ⅲ>Ⅲ>Ⅴ.Amongthe 118 cases of hyper-β-lipoproteinemia studied,there were 67 casesof CHD,34 cases of hypertension and 20 cases of MI.The distribution of CHDin different phenotypes of hyper-β-lipoproteinemia of types Ⅱ_4,Ⅳ and Ⅱ_3 wasabout the same,being 22,20 and 18 cases respectively,that in types Ⅱ_1 and Ⅱ_2was much lower,being 4 and 3 cases respectively,and there was none in types Ⅲand Ⅴ.MI also occurred quite frequently in types Ⅳ,Ⅱ_4 and Ⅱ_3 but none intypes Ⅲ and Ⅴ.Furthermore,it was found that both CHD and hypertension were moreclosely related with hyper-β-lipoproteinemia than with hypercholesterolemia andtriglyceridemia.All above results imply that an early discovery and diagnosis of hyper-lipo-proteinemia would be of value to the prevention and treatment of CHD and MI. 本文对正常、冠心病及心肌梗塞病人共247例的血清进行了琼脂糖电泳和胆固醇、甘油三酯及β脂蛋白的含量测定。主要根据βLP 电泳图象的类型,必要时参考血清脂质含量将247例被检人员分为Ⅱ-1、Ⅱ_2、Ⅱ_3、Ⅱ_4、Ⅲ、Ⅳ、Ⅴ七种不同的类型。按其在每种类型中分布多少排列次序如下:Ⅱ_4>Ⅱ_3>Ⅳ>Ⅱ-1>Ⅱ_2>Ⅲ>Ⅴ。以Ⅱ_4最多,88例,Ⅴ型最少,仅2例。247例中118例有高脂蛋白血症。他们在各型中的分布情况亦以Ⅱ_4型为最多,Ⅴ型最少。排列次序与上述情况类似;为Ⅱ_4>Ⅳ>Ⅱ_3>Ⅱ_2>Ⅱ-1>Ⅱ>Ⅴ型。118例高脂蛋白血症者中67例有冠心病,34例有高血压,20人有 MI。冠心病的分 布以Ⅱ_4,Ⅳ及Ⅱ_3型较多,Ⅱ_1型中最少,Ⅲ、Ⅴ型中无,但以本型计则发病率以Ⅱ_2、Ⅱ_1和Ⅱ_3较多,Ⅱ_4及Ⅳ型中较少,MI 多集中于Ⅳ、Ⅱ_4及Ⅱ_3型中。说明Ⅱ及Ⅳ型与冠心病的关系较为密切。此外,还观察了104例冠心病和42例高血压在各型中的分布,发现二者均较集中地分布于Ⅱ_4Ⅳ及Ⅱ_3型中。比较了它们在高 Tg、高 Ch 及高脂蛋白血症中的发生率。发现冠心病和高血压与高脂蛋白血症的关系比高 Ch 及高 T... 本文对正常、冠心病及心肌梗塞病人共247例的血清进行了琼脂糖电泳和胆固醇、甘油三酯及β脂蛋白的含量测定。主要根据βLP 电泳图象的类型,必要时参考血清脂质含量将247例被检人员分为Ⅱ-1、Ⅱ_2、Ⅱ_3、Ⅱ_4、Ⅲ、Ⅳ、Ⅴ七种不同的类型。按其在每种类型中分布多少排列次序如下:Ⅱ_4>Ⅱ_3>Ⅳ>Ⅱ-1>Ⅱ_2>Ⅲ>Ⅴ。以Ⅱ_4最多,88例,Ⅴ型最少,仅2例。247例中118例有高脂蛋白血症。他们在各型中的分布情况亦以Ⅱ_4型为最多,Ⅴ型最少。排列次序与上述情况类似;为Ⅱ_4>Ⅳ>Ⅱ_3>Ⅱ_2>Ⅱ-1>Ⅱ>Ⅴ型。118例高脂蛋白血症者中67例有冠心病,34例有高血压,20人有 MI。冠心病的分 布以Ⅱ_4,Ⅳ及Ⅱ_3型较多,Ⅱ_1型中最少,Ⅲ、Ⅴ型中无,但以本型计则发病率以Ⅱ_2、Ⅱ_1和Ⅱ_3较多,Ⅱ_4及Ⅳ型中较少,MI 多集中于Ⅳ、Ⅱ_4及Ⅱ_3型中。说明Ⅱ及Ⅳ型与冠心病的关系较为密切。此外,还观察了104例冠心病和42例高血压在各型中的分布,发现二者均较集中地分布于Ⅱ_4Ⅳ及Ⅱ_3型中。比较了它们在高 Tg、高 Ch 及高脂蛋白血症中的发生率。发现冠心病和高血压与高脂蛋白血症的关系比高 Ch 及高 Tg 血症更为密切。以上结果均说明Ⅱ、Ⅳ型与冠心病、高血压有密切关系,因此对该二型高脂蛋白血症的早期发现和治疗对冠心病的防治看重要意义? Calf thymosin fration 5 (THF 5), prepared by modified Goldstein method, was given to 7 patients with acute acquired immunodeficiency diseases, including 1 fulminant Japanese B encephalitis associated with respiratory failure: 1 fulminant infectious hepatitis associated with hepatic coma; 1 chronic active hepatitis associated with peritonitis; 1 systemic lupus erythematosus associated with herpes zoster: 1 severe heat-exhaustion associated with deep coma, bacteriemia, and decubitus ulcer: 1 chronic granulocytic... Calf thymosin fration 5 (THF 5), prepared by modified Goldstein method, was given to 7 patients with acute acquired immunodeficiency diseases, including 1 fulminant Japanese B encephalitis associated with respiratory failure: 1 fulminant infectious hepatitis associated with hepatic coma; 1 chronic active hepatitis associated with peritonitis; 1 systemic lupus erythematosus associated with herpes zoster: 1 severe heat-exhaustion associated with deep coma, bacteriemia, and decubitus ulcer: 1 chronic granulocytic leukemia associated with fungal pneumonia: and 1 acute lymphocytic leukemia associated with pseudomonas aerogenosa infection.The molecular weight of THF 5 is less than 15000. Electrophoretic analysis revealed no bovine serum albumin. Further studies on this substance which is promising in treating immunodeficiency diseases are necessary before it can be recommended in clinical practice. 本组7例急性T细胞免疫功能缺陷病人,经用小牛FHF_(?)后,临床症状及实验室检查初步说明,该制品具有一定的改善患者细胞免疫功能状态和抗病毒、霉菌感染的作用。本文所采用的小牛THF_(?)是在Goldstein氏的提取方法基础上进行了改进,分子量在15,000以下,免疫电泳分析显示没有牛血清白蛋白的大分子物质,脐带血玫瑰花结测定存在活性。由于本组病例尚少,还有待进一步探讨。
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