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maleate
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  马来酸
    Perhexiline maleate in the treatment of 50 patients with ventricular extrasystole
    马来酸哌克昔林治疗室性早搏50例
短句来源
    HPLC DETERMINATION OF TIMOLOL MALEATE EYE DROPS
    马来酸噻吗洛尔滴眼液的HPLC测定
短句来源
    Simultaneous Assay for Hydrochlorothizide and Enalapril Maleate in Compound Enalapril Tablets by HPLC
    HPLC同时测定复方依那普利片中马来酸依那普利和氢氯噻嗪的含量
短句来源
    The results showed that the linear ranges of chlorphenamine maleate were 10~120 μg/mL (r=0.999 9, n=6).
    马来酸氯苯那敏浓度在2.5~75μg/mL范围内呈良好的线性关系,(r=0.9999,n=6)。
短句来源
    OBJECTIVE To evaluate the bioequivalence of enalapril maleate tablet of tested preparation and reference preparation in healthy volunteers.
    目的用HPLC-MS测定健康受试者口服马来酸依那普利制剂后的血药浓度,估算受试制剂和参比制剂的药动学参数,评价两种制剂的生物等效性和相对生物利用度。
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  马来酸盐
    Effect of dizocilpine maleate on discriminative properties of methamphetamine in rats
    地佐环平马来酸盐对大鼠甲基苯丙胺辨别效应的影响(英文)
短句来源
    Gallanilide [N-(β-diethylaminoethyl)-N-(O-methylphenyl)-3', 4', 5'-trime-thyloxycarboxylamide maleate (603)] is a new synthetic compound with antiarrhy-thmio action.
    棓酰苯胺即N-(β-二乙氨基乙基)-N-邻甲苯基-3′、4′、5′-三甲氧基苯甲酰胺马来酸盐(代号603),是我系合成的具有抗心律失常作用的一种新型化合物。
短句来源
    but pretreatment with dizocilpine maleate (0.025, 0.05 mg/kg) did not block discrimination behavior of MA in antagonistic test.
    但是地佐环平马来酸盐(0.025,0.05mg/kg,sc)均没有替代作用。
短句来源
    All of the rats had no substitution after injection of dizocilpine maleate (0.025, 0.05 mg/kg).
    而地佐环平马来酸盐(0.025,0.05mg/kg,sc)均没有拮抗甲基苯丙胺的辨别效应的作用。
短句来源
    Studies on the absorption kinetics of rosiglitazone maleate in rats' intestine
    罗格列酮马来酸盐大鼠在体肠吸收动力学的研究
短句来源
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  “maleate”译为未确定词的双语例句
    SYNTHESIS OF N-ETHYLPERHEXILINE MALEATE AND PERHEXILINE MALEATE
    N-乙基沛心达及沛心达的合成
短句来源
    STUDIES ON CONTENT UNIFORMITY OF CHLORPHENAMINE MALEATE TABLETS
    扑尔敏片含量均匀度的实验研究
短句来源
    SPECTROPHOTOMETRIC DETERMINATION OF TIMOLOL MALEATE TABLETS
    噻吗洛尔片的分光光度测定法
短句来源
    Content determination of chlorphenie maleate and caffeine in Jingang canmao tablet by high
    高效液相色谱法测定金刚感冒片中咖啡因和扑尔敏的含量
短句来源
    Flow Injection with On-line Filtration-UV Spectrophotometriy Determination of Dissolution of Chlorpheniramine Maleate Tablets
    流动注射在线过滤紫外分光光度法测定扑尔敏片溶出度
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  maleate
The uptake of 99mTc-AA was evaluated when administrated alone (group I), with chlorpheniramine maleate (CPR) (group II), with phenylpropanolamine hydrochloride (PPA) (group III), and with acetaminophen (APAP) (group IV).
      
xylosoxidanstransformed the maleate (30.0 g/l) entirely in 96 h during batch cultivation and only 15.0 g/l of the maleate in continuous cultivation at a flow rate of 0.03 h-1.
      
Diethyl maleate and GSH ester increase the activity of glutathione metabolizing enzymes under certain conditions.
      
Fumarate but not maleate competitively inhibited succinate transport into the S.
      
Voltammetric Determination of Timolol Maleate: A β-Adrenergic Blocking Agent
      
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A new compound N-ethylperhexiline maleate (Ⅱ) is isolated duringthe synthesis of perhexiline maleate (I), which has been known as an effective drug in the treatment of coronary atherosclerosis. Studies of its m. s., IR. and element analysis prove that it has the structure as indicated by (Ⅱ). (Ⅱ) was also prepared by alkylation of the free base of perhexiline maleate. Its pharmocologic test is shown to be more effective than ( I ) when it is used as an anti-arrhythmic agent.The new route of...

A new compound N-ethylperhexiline maleate (Ⅱ) is isolated duringthe synthesis of perhexiline maleate (I), which has been known as an effective drug in the treatment of coronary atherosclerosis. Studies of its m. s., IR. and element analysis prove that it has the structure as indicated by (Ⅱ). (Ⅱ) was also prepared by alkylation of the free base of perhexiline maleate. Its pharmocologic test is shown to be more effective than ( I ) when it is used as an anti-arrhythmic agent.The new route of synthesis is by condensing of benzophenone with 2-methylpyridine in the presence of sodamide giving 1,1-diphenyl-2- (2-pyri-dyl) ethanol (Ⅲ), which is dehydrated to yield 1 ,1-diphenyl-2-(2-pyridyl) ethene (Ⅳ), followed by complete hydrogenation in ethanol and then treated with maleic acid to form perhexiline maleate ( I ) and N-ethylperhexiline maleate (Ⅱ). The yields of (I) and (II) are 43% and 11% repectively.

沛心达是近年来很受重视的一个新型的防治冠心病的有效药物。我们在研究新的合成方法,由1,1-苯基-2-(2-吡啶基)乙烯进行催化氢化制备沛心达时,发现伴有N-乙基沛心达生成。经质谱、红外光谱和元素分析等试验证明了它的结构为1,1-二环己基-2-(2-N-乙基哌啶基)乙烷马来酸盐。由沛心达游离碱进行N-乙基化,也取得了相同的结果。并由药理试验表明,N-乙基沛心达有希望成为一个更好的心血管药物。

A liquid ohromatograph Model KYS (Shanghai, China) fitted with a reversed-phase Nuoleosil C18 particle size 5 μm column and equipped with a 254 nm UV detector was used. The mobile phase used is a mixture of OH3 OH:H2O:OH3OOOH (1,000: 6:0.9) and the flow rate is 1.5ml/min. N-(α-diethyl-aminoethyl)-3, 4, 5,-trimeth-oxy-benzotoluidine acid maleate was used as an internal standard. The retention times for amiodarone and internal standard are 3'30" and 1'63" respectively. The detection limit of amiodarone is...

A liquid ohromatograph Model KYS (Shanghai, China) fitted with a reversed-phase Nuoleosil C18 particle size 5 μm column and equipped with a 254 nm UV detector was used. The mobile phase used is a mixture of OH3 OH:H2O:OH3OOOH (1,000: 6:0.9) and the flow rate is 1.5ml/min. N-(α-diethyl-aminoethyl)-3, 4, 5,-trimeth-oxy-benzotoluidine acid maleate was used as an internal standard. The retention times for amiodarone and internal standard are 3'30" and 1'63" respectively. The detection limit of amiodarone is 0.01 μg or 0.5 μg/ml plasma. The within-day recovery and 0V were 98.68±6.31% and 6.38% (2.5±g/ml, n=4), and those of between-days were 98.01 ± 3.19 % and 3.25 % (1 ±g/ml, n=4) respectively.Three healthy volunteers and four rabbits were given amiodarone intravenously with a dose of 150 mg and 30 mg/kg respectively. Its plasma concentrations were determined by the above HPLC method. The plasma level-time curves belong to the two-compartment open body model. The pharmaco-kinetio parameters of amiodarone were determined.

我们研究和建立了用高效液相色谱仪反相色谱测定血浆中乙胺碘呋酮的方法,在氯仿溶剂中检出限为10ng,血浆中最低有效测定浓度为0.5μg/ml,平均回收率为98.35%,一日内回收率为98.68%,四日内回收率为98.0l%。乙胺碘呋酮的药物动力学过程属二室模型,其参数为:正常人静注150mg后的平均生物半衰期t_(1/2)(β)为13.75小时;家兔静注30mg/kg后的t_(1/2)(β)为7.17小时。

Gallanilide [N-(β-diethylaminoethyl)-N-(O-methylphenyl)-3', 4', 5'-trime-thyloxycarboxylamide maleate (603)] is a new synthetic compound with antiarrhy-thmio action. The change of electrically induced ventricular fibrillation threshold (EIVFT) is chosen as a graded quantitative pharmacological response in anesthetized rabbits for the study of pharmacodynamics of 603. The observed pharmacological data are converted, via the use of a dose-effect curve, to values corresponding to the relative drug levels...

Gallanilide [N-(β-diethylaminoethyl)-N-(O-methylphenyl)-3', 4', 5'-trime-thyloxycarboxylamide maleate (603)] is a new synthetic compound with antiarrhy-thmio action. The change of electrically induced ventricular fibrillation threshold (EIVFT) is chosen as a graded quantitative pharmacological response in anesthetized rabbits for the study of pharmacodynamics of 603. The observed pharmacological data are converted, via the use of a dose-effect curve, to values corresponding to the relative drug levels at the site of action. From kinetics of reversible pharmacological effect, we used Hill equation. It was found that the equation could determine the time course of an observed pharmacological effect (E). This equation can be written as:where E stands for the change EIVFT at the concentration (or dose) C, Emax is the maximum intensity of the pharmacological response when c-. Other calculated parameter values are as follows: fall rate of pharmacological effect R=0.1089min-1, drug elimination rate constant K =0.06498min-1, biological half life t1/2=12.6min.

棓酰苯胺即N-(β-二乙氨基乙基)-N-邻甲苯基-3′、4′、5′-三甲氧基苯甲酰胺马来酸盐(代号603),是我系合成的具有抗心律失常作用的一种新型化合物。为研究603的药效动力学,我们选用电刺激家兔心脏产生室颤阈的变化,作为分级定量的药理效应指标。把静脉注射603后观察到的药理效应强度,通过剂量-效应曲线转换成相应的作用部位的药物水平。根据可逆性药理作用的动力学,应用Hill方程决定了所观察药理作用的经时过程表达式:E=E_(max)C~(3.3011)/(1/0.2898)+C~(3.3011 计算得各种参数值如下:药理作用强度的下降速率R=0.1089min~(-1),药物消除速率常数K=0.05498min~(-1),生物半衰期t_(1/2)=12.6min。

 
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