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lung     
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    Chronic Obstructive Pulmonary Disease and Lung Cancer
    慢性阻塞性疾病与癌—α_1-抗胰蛋白酶与癌的遗传易感性关系的研究
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    Study on Gene Expression Patterns of Low-differentiated Human Lung Adenocarcinoma at Stage Ⅰ and Clinical Significance of Expression Status of Cyclin D1, MMP-2 and pRb
    Ⅰ期低分化腺癌基因表达谱及Cyclin D1、MMP-2和pRb表达的临床意义
短句来源
    Series Investigation of the Relationship between Microsatellite DNA Variations and Lung Squamous Cell Carcinoma Occurrence
    微卫星DNA改变与鳞癌发生关系的系列研究
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    Specific Inhibition of Expression of Lung Resistance-Related Protein Gene in K562 Cells by Short Interfering RNA
    短干涉RNA特异性抑制K562细胞耐药相关蛋白基因表达的研究
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    Experimental Therapeutic and Relative Clinical Studies of Gene Transfer of Endostatin Combined with Ionizing Radiation on Lung Adenocarcinoma
    内皮抑素基因转移联合电离辐射对腺癌的实验性治疗及相关临床研究
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  肺部
    Study on Rabbit Lung Transplanted Tumor Treated by Hiu
    高强度超声治疗兔肺部移植性肿瘤的实验研究
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    THE DIFFERENTIAL DIAGNOSIS OF PULMONARY CANCER AND TUBERCULOMA IN THE SOLITARY SPHERICAL FOCUS OF LUNG (An Analysis of 65 Cases)
    肺部孤立性球形病灶中肺癌与结核瘤的鉴别诊断(附65例临床分析)
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    Hamartoma of the Lung.Report of 9 Cases
    肺部错构瘤(附9例报告)
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    The diagnosis of inflammatory pseudotumor and scleroangloma of the lung
    肺部炎性假瘤和硬化性血管瘤的诊断问题
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    Clinical Analysis on 13 Cases of Inflammatory Pseudotumor in Lung
    肺部炎性假瘤13例临床分析
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  肺组织
    Study of the relation between mesothelioma and fiber types in lung tissues
    间皮瘤患者肺组织中纤维类型及形态的研究
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    Quantitative Study on DNA-adduct in Normal Lung Tissues of Smoking and Non-smoking Lung Cancer Patlents
    吸烟与非吸烟肺癌病人正常肺组织中DNA加合物定量研究
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    The influence of some factors on DNA adduct levels in human lung tissue
    人肺组织 DNA 加合物含量的某些影响因素分析
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    Methods Surgical specimens from 71 patients with NSCLC and 30 cases of normal lung specimens were measured for expression of Survivin、mutant p53 gene and Bcl-2 protein by streptavidinperoxdase immunohistochemical technique.
    方法用链霉菌生物素蛋白-过氧化物酶免疫组织化学法(SP法)检测71例手术切除的非小细胞肺癌(NSCLC)组织和30例正常肺组织中Survivin、突变型P53、Bcl-2蛋白的表达;
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    But there was non-expression of survivin and mutant P53(P<0.001) and 3.33% of Bcl-2 protein in 30 normal lung specimens(P<0.005).
    30例正常肺组织中无Survivin、突变型P53蛋白表达(P<0.001),Bcl-2蛋白表达率为3.33%(P<0.005);
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  肺癌
    Early detection of central lung cancer:preliminary study with low-dose spiral CT
    低剂量螺旋CT早期检出中央型肺癌的初步研究
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    Value of ~(18)FDG-PET in the diagnosis of lung cancer and expression and clinical significance of glucose transporter 1 in lung cancer
    18FDG-PET在肺癌诊断中的价值和GLUT1在肺癌细胞中的表达及其临床意义的相关研究
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    Image Processing and Simulating Experimental Study for Interventional Treatment on Lung Cancer
    肺癌介入治疗的图象处理和模拟实验研究
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    Role of Cell Adhesion Molecules and Gap Junctional Intercellular Communication in the Invasion and Metastasis of Lung Cancer and Study of Drugs Regulation
    粘附分子和细胞间隙连接通讯在肺癌侵袭和转移中的作用及药物的调控研究
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    p16 Methylation of Lung Cancer and Its Clinical Significance for the Early Diagnosis of Lung Cancer
    肺癌p16基因甲基化改变及对肺癌早期诊断的价值
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      lung
    EGFR is over-expressed in numerous tumors including, those derived from the brain, lung, bladder, head and neck.
          
    Compounds 4-21 were evaluated for cytotoxic activity against a panel NCI-H460 (lung), MCF7 (breast) and SF-268 (CNS) cancer cell lines.
          
    All newly synthesized compounds were evaluated for their antiproliferative activities against human lung tumor cell lines (A 549).
          
    In this study, we further isolated pluripotent stem cells from human fetal heart, liver, muscle, lung, derma, kidney, and fat and then analyzed the characteristics and function of these stem cells.
          
    Impact of siRNA targeting pirh2 on proliferation and cell cycle control of the lung adenocarcinoma cell line A549
          
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    Leukemic cells in L615 rapidly proliferate following subcutaneous inoculation, invade the blood vessels at the inoculated site, and disseminate by way of the blood stream to the entire body. The dissemination, is very rapid. As early as 3 hours after subcutaneous inoculation, leukemic cells are already present in the spleen. In various internal organs, leukemic infiltrations are chiefly around the blood vessels. This is obviously an important feature of generalized reticular-cell leukemia.Our studies showed...

    Leukemic cells in L615 rapidly proliferate following subcutaneous inoculation, invade the blood vessels at the inoculated site, and disseminate by way of the blood stream to the entire body. The dissemination, is very rapid. As early as 3 hours after subcutaneous inoculation, leukemic cells are already present in the spleen. In various internal organs, leukemic infiltrations are chiefly around the blood vessels. This is obviously an important feature of generalized reticular-cell leukemia.Our studies showed that in the early stage of transplantation, the thymic lymphocytes were proliferative, but later, when extensive leukemic infiltrations took place, there appeared atrophy and thinning of the organ, concomitantly with massive destruction of the lymphocytes.The immediate cause of the death of the transplanted animals might be due to the extensive thrombosis of the blood-vessels by leukemic cells, cellular debris and fibrinoid material seen in the lungs at the terminal stage.

    L615白血细胞于局部接种后迅速增殖,同时侵入局部血管进入血行,向全身播散。其播散的速度非常迅速,局部接种后3小时已有白血细胞停留于脾脏。各脏器白血细胞浸润的形式也都具有以血管为中心的特点。 615系小鼠在接种L615白血细胞后,最初胸腺皮质淋巴细胞增生活跃,随后萎缩变薄,晚期当白血细胞大量侵入胸腺时,整个皮质淋巴细胞出现广泛破坏现象。 L615白血病小鼠的死亡原因主要是肺血管内广泛出现的由白血细胞、核碎片及纤维素组成的瘤栓形成。

    Transfer factor (TP) is a dialysable (ultrafilterable) extract of sensitised leukocytes. It transfers cellular immunity from a skin test positive donor to a skin test negative recipient. Currently TF is recognized as one of the most potent immunological reagents. In this paper the detailed method for preparation of transfer factor from normal blood bank donors has been described and some physico-chemical and biological properties of the TF preparations have been examined. The production of TF is briefly as follows:...

    Transfer factor (TP) is a dialysable (ultrafilterable) extract of sensitised leukocytes. It transfers cellular immunity from a skin test positive donor to a skin test negative recipient. Currently TF is recognized as one of the most potent immunological reagents. In this paper the detailed method for preparation of transfer factor from normal blood bank donors has been described and some physico-chemical and biological properties of the TF preparations have been examined. The production of TF is briefly as follows: After separation of the plasma (for plasma products), the buffy coats are harvested and pooled. The contaiminating red blood cells are disrupted by tris buffered or isotonic NH_4Cl solution. The pooled leukocytes having been washed iwice with cold normal saline are then alternately frozen and thawed ten times with dry ice in acetone and a 37℃ water bath. The cell lysate is placed in dialysis tubing and dialysed in the cold for 36~48 hours against running pyrogenfree deionized water. The dialysate is lyophilized. The yellowish white powder is saved and redissolved in the desired volume of pyrogen-free deionized water, and passed through a Seitz filter (EKS). 2ml of the sterile TF solution (equivalent to the dialysate of 4×10~8 leukocytes) are placed in each ampoule. The final product is stored at -20℃.The TF preparation is protein-free as determined by protein precipitating reagents. It contains ca. 148μg of peptides and 14μg of ribose per mg of dry powder. The ultraviolet absorption curve gives a peak at 250~251nm. Adenine, guanine and uracil are present in the paper chromatogram of the TF acid hydrolysate. Silica- gel thin layer chromatography reveals four spots stained with ninhydrin. Sephadex G-25 filtration gives reproducibly a characteristic elution pattern yielding 3 main peaks and several small peaks with many of the eluted peaks beyond the total volume of the column. The results of animal experiments show that the TF preparations are non-toxic, non-anaphylactic and non-antigenic.So far over 160 patients (variously afflicted with herpes zoster, chronic hepatitis B, systemic lupus erythematosus, primary carcinoma of the liver, carcinoma of the lung and leukemia) have been treated with the TF preparations. The results will be published elsewhere.

    转移因子是致敏白细胞中的可透析物质,能将一个有免疫能力的人的某些细胞免疫力转移给无免疫力的人。所以供给转移因子可能是一种有效的免疫治疗措施。本文详细介绍综合利用血源制备正常人转移因子的方法,并分析其某些理化性质和生物学性质。收集分离血浆后的白细胞层,用三羟甲基氨基甲烷缓冲的或等渗的氯化铵溶液破坏其中污染的红细胞,白细胞经生理盐水洗涤后进行10次冻融,白细胞匀浆对流动去离子水透析,透析液冷冻干燥、除菌分装。每安瓿2毫升转移因子注射液相当4×10~8个白细胞的透析物,保存于-20℃备用。本制剂蛋白质定性检查阴性;每毫克干粉约含多肽148微克、核糖14微克;在250~251毫微米有吸收高峰;转移因子酸水解液硷基纸层析有三种硷基;硅胶薄板层析呈四个茚三酮显色点;葡聚糖G-25凝胶过滤呈可重复的特征性洗脱图谱,具有3个主要峰及若干个小峰,主要洗脱部分在V_t之后。动物实验表明此制剂无毒性、无过敏性和抗原性。本制剂已用于临床治疗带状疱疹、系统性红斑狼疮、慢性乙型肝炎、原发性肝癌、肺癌及白血病等一百六十余例,结果将另文发表。

    The chemical composition and the enzymatic activities of normal and silicotic alveolar macrophages were compared in order to investigate the changes occurring after the introduction of quartz into the lung. As shown from the SDS-PAGE results, the protein composition of the silicotic alveolar macrophages was different from the normal in three places. Two protein lines showed increased intensity and one protein line was absent from the gel of the silica containing cells.The lecithin and lysolecithin contents...

    The chemical composition and the enzymatic activities of normal and silicotic alveolar macrophages were compared in order to investigate the changes occurring after the introduction of quartz into the lung. As shown from the SDS-PAGE results, the protein composition of the silicotic alveolar macrophages was different from the normal in three places. Two protein lines showed increased intensity and one protein line was absent from the gel of the silica containing cells.The lecithin and lysolecithin contents were both increased in the silicotic macrophages. The presence of an increased amount of lysolecithin may indicate that the cells were destroyed by the quartz.The acid phosphatase actvity and the oxygen consumption of the silica containing cells were both lower than normal cells.After treatment of the silicotic rats with PVNO, the composition and the enzymatic activities of the macrophages were all returned to the normal level. This shows that PVNO protects the alveolar macrophages from destruction by the quartz particles. Other drugs tested also showed some protective effect on the cells.

    文中比较了正常大鼠与矽肺大鼠肺泡巨噬细胞中蛋白质与磷脂的组成,以及酸性磷酸酶活性与耗氧量的差别。根据SDS-PAG电泳的结果看到矽肺大鼠肺泡巨噬细胞的蛋白质区带比正常者多两条,但缺少了一条分子量较小的区带。矽肺大鼠肺泡巨噬细胞中含有大量卵磷脂,说明石英能引起肺表面活性物增多。同时,溶血卵磷脂也比正常者明显地增多,酸性磷酸酶活性与耗氧量均比正常者低,这些都说明石英改变了细胞的组成,破坏了细胞的功能。用克矽平(PVNO)治疗过的大鼠肺泡巨噬细胞的化学组成及酶活性都与正常者近似,证明此药能保护巨噬细胞防止被石英破坏。津_5、山梨醇铝等药物对细胞也表现有不同程度的保护作用。

     
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