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    Rapid Activation of MAPKs by Glucocorticoids in Primary Cultured Rat Hippocampal Cells
    糖皮质激素对原代培养的海马细胞中丝裂原激活蛋白激酶的快速激活作用
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    Studies on the Invasion Mechanism of Virulence mce1a Gene of Mycobacterium Tuberculosis and the Rapid Classification and Detection of Microbial 16S rDNAs
    结核分枝杆菌毒力基因mce1a侵袭性机制研究及微生物16S rDNAs快速分类鉴定
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    Presynaptic Cdc42 Signaling-mediated Rapid Maturation of Silent Synapses
    Cdc42信号介导的突触前快速成熟机制研究
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    RAPID PROPAGATION OF POPULUS DAVIDIANA ×. P.BOLLEANA LOUCNE HYBRID BY TISSUE CULTURE
    用组织培养方法快速繁殖山新杨(Populus davidiana×P. bolleana Loucne)的初步研究
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    APPLICATION OF THIOKINASE IN THE RAPID DETERMINATION OF COENZYME A PURITY
    硫激酶在快速测定辅酶A中的应用
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    A Simple Rapid Method of Purification of Mitochondrial DNA with PEG6000
    聚乙二醇6000沉淀法提纯线粒体DNA
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    A Simple and Rapid Method for the Preparation of EMBL4 DNA
    一个实用的制备EMBL_4 DNA的方法
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    ESTABLISHED A CAPTURE ELISA FOR DETECTING POLIO IgA ANTIBODY USING FOR RAPID DIAGNOSIS OF POLIOVIRUS INFECTION
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    Exogenous Acetylcholine plays the Nerve Transmitter in Rapid Tendril Coiling of Luffa cylindrica
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    Rapid Detection of Proviral DNA of Bovine Leukaemia Virus Using Nested PCR
    Nested PCR在检测牛白血病病毒前病毒中的应用
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The use of time-frequency methods (phase space methods) allows the use of rough symbols of ultra-rapid growth in place of smooth symbols in the standard classes.
      
The pharmaceutical sciences are advancing rapidly in the post-genomic era of the 21st century with the completion of the human genome, as well as those of many other organisms including bacteria and parasites, and the rapid advances in proteomics.
      
The α-isomer exhibited rapid and significantly higher peak plasma concentrations in all the species post intramuscular administrations, while β-isomer showed prolonged plasma levels.
      
This suggests that the rapid initial reduction in percent parasitemia may be due to α- isomer and the activity is maintained by the β- isomer.
      
Flavonoid antioxidants act as scavengers of free radicals by rapid donation of a hydrogen atom.
      
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The present investigation was undertaken to observe the renal response to the distention of the urinary bladder and to elucidate the mechanism by which the effect takes place. The results obtained in our experiments may be summarized as follows: (1)In the acute experiment the distention of the urinary bladder by introducing warm saline (about 37℃)through a cannula inserted in the neck of the bladder was,as a rule,accompanied by reflex oliguria or anuria. (2)Such a reflex was found to have two distinct phases:one...

The present investigation was undertaken to observe the renal response to the distention of the urinary bladder and to elucidate the mechanism by which the effect takes place. The results obtained in our experiments may be summarized as follows: (1)In the acute experiment the distention of the urinary bladder by introducing warm saline (about 37℃)through a cannula inserted in the neck of the bladder was,as a rule,accompanied by reflex oliguria or anuria. (2)Such a reflex was found to have two distinct phases:one of them appears at the beginning of the bladder distention and persists as long as the distention lasts,whereas the other occurs 8—10 minutes later and con- tinues over a period of 30—60 minutes. (3)The first or rapid phase is neurogenic in nature since it disappears completely after renal denervation,while the second or delayed phase is believed to be neurohumoral,being practically absent after hypophysectomy.

本实验是在狗的急性实验中观察膀胱加压对肾脏泌尿影响的机制,结果表明:(一)膀胱加压可反射地抑制肾脏泌尿,抑制持续的时间一般为30—60分钟。(二)肾脏泌尿的抑制可分为二个时相——快相和慢相,前者出现在膀胱加压期间,乃是交感性内脏神经的兴奋,改变了肾脏血液动力学的结果,后者出现较迟,而与脑垂体分泌体液因素有关。(三)关于我们实验中脑垂体激素反射性分泌的传入径路问题,在文中作了简单的分析。

The present study aims to observe (1) sex influence of the host on the development of male and female worms and (2) the effect of the normally developed and copulated males and females on the development of the unpaired worms. For this purpose, mice of different sexes were infected with either male or female cercariae and were killed at definite intervals after infection. The size of worms collected was measured and the condition of the development of sex organs was also observed. Another group of mice was infected...

The present study aims to observe (1) sex influence of the host on the development of male and female worms and (2) the effect of the normally developed and copulated males and females on the development of the unpaired worms. For this purpose, mice of different sexes were infected with either male or female cercariae and were killed at definite intervals after infection. The size of worms collected was measured and the condition of the development of sex organs was also observed. Another group of mice was infected with more female cercariae and less male cercariae while a third group, vice versa. Similar observations were made at definite intervals as in the first group.It was found that the sex difference in the host bore definite influence on males in the portal circulation, but this was not so evident on females. The development of the unisexual males in the male host was more rapid than in the female host. Female worms in the female host were only slightly bigger than in the male host.Mature males and females in copula did not hasten the normal development of the unpaired males which were only slightly larger than those in unisexual infection, but definitely smaller than those in copula. On the contrary, worms in copula seemed to exert an inhibitory action on the unpaired females which were definitely smaller than the females in unisexual infection.The copulation of male and female worms was permanent in character. It did not seem that male schisrosomes would change their partners. One male could only hasten the development and matura:ion of only one female.

1.单性感染之雌性日本血吸虫平均不超过5.35±0.07毫米,只为复性感染中成熟雌虫长度之1/3左右,且其生殖器官始终呈童雏状态。单性感染之雄虫能发育成熟,贮精囊内也有活动精子,但其大小与成熟合抱之雄虫平均相差3.05毫米左右。 2.宿主性别之不同对于血液中的雄性血吸虫有比较显著的影晌。在雄性宿主体内单性雄虫比雌性宿主体内之单性雄虫发育快。宿主性别之不同对于单性雌虫之影响则不甚明显,雌性宿主体内发育之雌虫仅略大于在雄性宿主体内之单性雌虫。 3.血液中合抱成熟之雌虫及雄虫的分泌物质不能促使未合抱之雄虫发育正常。未合抱之雄虫似略大于单性感染之雄虫,但是显著小于合抱雄虫。 4.合抱成熟之雌虫及雄虫的分泌物质对于未合抱之雌虫完全没有促使发育的作用。相反地,有一定的抑制作用而使未合抱之雌虫显著地小于单性感染之雌虫,二者之生殖器官皆停留于雏形状态。 5.复性感染中每对雌雄成虫之抱合是永久性的。每一条雄虫只能促使一条雌虫发育成熟而不再转换抱合其余未成熟之雌虫。 6.鉴于雌雄合抱对于日本血吸虫正常发育的必要性,故就生物进化之观点讨论了日本血吸虫雌雄异体的原始性。

A series of 9 compounds of the bis-tolyloxyalkane-bis-quaternary salts were synthesized by Kyi and Huang. Their actions on the nerve-muscle preparation of them. tibialis anticus and the superior cervical ganglion of the cat were investigated. All these compounds possessed neuromusular blocking action, among them AMBA-1 (1, 1-bis-p-tolyloxy-methane bis-trimethyl ammonium dibromide) was the most active with a potency twice that of d-tubocurarine. The mechanisms of their neuromuscular blocking actions were different....

A series of 9 compounds of the bis-tolyloxyalkane-bis-quaternary salts were synthesized by Kyi and Huang. Their actions on the nerve-muscle preparation of them. tibialis anticus and the superior cervical ganglion of the cat were investigated. All these compounds possessed neuromusular blocking action, among them AMBA-1 (1, 1-bis-p-tolyloxy-methane bis-trimethyl ammonium dibromide) was the most active with a potency twice that of d-tubocurarine. The mechanisms of their neuromuscular blocking actions were different. Compounds with trimethyl ammonium methyl groups at para- and meta-positions resembled decamethonium in antagonim to curare, lack of antagonism by prostigmine and persistence of tetanie contraction in spite of the reduction of twitch height; and those with trimethyl ammonium methyl groups at ortho-position resembled d-tubocurarine in potentiation of d-tubocurarine paralysis, antagonism by prostigmine, and rapid decay of tetanic contraction. AMBA-1, 2, 3, 4, 5, possessed feeble ganglion-blocking action at doses higher than those for blocking neuromuscular transmission, but AMBA-11, 21, 22, 23, were not active. Anticholinesterase actions of these compounds were tested manometrically and compared with physostigmine and prostigmine at the equimolar concentration (3×10~(-6) M). AMBA-4 was the most active (40% inhibition), but weaker than physostigmine and prostigmine.

(一)9个双甲苯氧烷季銨盐都具有神經肌肉阻断作用,其中AMBA-1作用最强,約为d-筒箭毒鹼的两倍。在作用机制上,三甲氨甲基附着于苯环对位或間位的化合物AMBA-1,2,3,4,5,11屬于去極化类型,而三甲氨甲基附着于苯环的邻位的化合物AMBA-21,22,23則屬于竞爭性抑制类型。 (二)这几个化合物对神經节的作用很弱。 (三)在抗胆鹼酯酶作用上,这些化合物都有一定的作用,其中以AMBA-4最强,在3×10~(-6)M濃度时抑制酶活力40%。 (四)这9个化合物主要作用点在横紋肌上,其中以AMBA-22比較符合理想的横紋肌松弛藥的要求,因此正在进一步地研究以确定其是否有实际应用的价值。

 
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