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retinoic acid receptor
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  retinoic acid receptor
Our previous data indicated that the combination of ligands for peroxisome proliferator-activated receptor γ (PPARγ) and retinoic acid receptor (RAR) induces apoptosis of breast cancer cells in vitro and in a murine model.
      
Using monoclonal antibodies for retinoic acid receptor alpha (RARα), we found nuclear staining in melanomas and lung carcinomas metastatic to brain and only rarely in gliomas.
      
Paucity of Retinoic Acid Receptor Alpha (RARα) Nuclear Immunostaining in Gliomas and Inability of Retinoic Acid to Influence Neu
      
CNS-1 was immunoreactive for glial fibrillary acidic protein, S100 protein, vimentin, neural cell adhesion molecule, retinoic acid receptor α, intercellular adhesion molecule, and neuron specific enolase.
      
RA was previously shown to down-regulate the steady state levels of retinoic acid receptor α (RARα) and retinoid X receptor α (RXRα) in primary brown adipocytes differentiated in culture.
      
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Retinoids mediate their actions via retinoic acid receptors(RARs) and retinoid X receptors(RXRs).Each of class of these nuclear retinoid receptor is further subdivided into three species namelyα,βandγ.Recently studies demonstrated that estrogen receptor(ER)-positive human breast cancer(HBC) cell lines are sensitive and ER-negative cell lines are resistant to growth inhibitory effects of retinoic acid(RA).In this study,we found that only RARαmRNA levels was strongly correlated...

Retinoids mediate their actions via retinoic acid receptors(RARs) and retinoid X receptors(RXRs).Each of class of these nuclear retinoid receptor is further subdivided into three species namelyα,βandγ.Recently studies demonstrated that estrogen receptor(ER)-positive human breast cancer(HBC) cell lines are sensitive and ER-negative cell lines are resistant to growth inhibitory effects of retinoic acid(RA).In this study,we found that only RARαmRNA levels was strongly correlated with ER-status.To further investigate the major role of RARαin retinoid-mediated inhibition of growth,we transfected RARαcDNA into two RA-resistant ER-negative HBC cell lines.Analysis of different clonal populations of RARαtransfectants from each cell line revealed growth inhibition by retinoids.Our results demonstrated that RARαplays a major role in mediating retinoids inhibition of growth in HBC cells and adequate levels of RARαare required for such an effect.

RETINOICACIDNUCLEARRECEPTORα(RARα)PLAYSAMAJORROLEINRETINOID-MEDIATEDINHIBITIONOFGROWTHINHUMANBREASTCARCINOMACELLS¥ShaoZhimin;...

Objective: To study the distribution of retinoic acid receptors (RARs) in variouns body tissues and some biologiccharacteristics of RARα in acute promyelocytic leukemia APL. Me:cells were investigated by the technique of radioligand-binding assay. Rsults:The results showed that retinoic acid-binding activity in tissues as stomach、kidney,brain,colon,lung and blood cells was quite different,more in The brain,colon and spleen. In APL cells,an There existed PMLRAR αof which the affinity of PML-RARα...

Objective: To study the distribution of retinoic acid receptors (RARs) in variouns body tissues and some biologiccharacteristics of RARα in acute promyelocytic leukemia APL. Me:cells were investigated by the technique of radioligand-binding assay. Rsults:The results showed that retinoic acid-binding activity in tissues as stomach、kidney,brain,colon,lung and blood cells was quite different,more in The brain,colon and spleen. In APL cells,an There existed PMLRAR αof which the affinity of PML-RARα to ATRA was lower than that of RARα (9.5±0. 5llnM vs 3. 3±0. 25nM)and the RARα in Sephadex G-100 chromatograph was normal. Conclusions:The discrepancy in distribution of receptorsreflects the difference in the ability of modulating the biologic behaviors of those tissues and the difference in the proportion of sabtypes of retinoic acid reescptors. The PML-RARα may be the molecular basis of ATRA induction therapy andbeing one of the factors in its pathogenesis.

研究人不同组织中维甲酸受体(RAR)的分布及早幼粒白血病(APL)细胞中RAR的一些生物学特性。方法:使用受体放射配体结合分析的方法。结果:在所研究的肝、脾、胃、结肠、肾、脑、肺等组织和白细胞中,组织间RAR的含量差异较大,其中以脑、脾、结肠组织中的含量较高。在APL细胞中除正常RARa外,尚存在融合受体(PML-RARα),该受体与全反式维甲酸(ATRA)的亲和力较RARα为低(9.5±0.51nM/3.3±0.25nM)。结论:这种分布差异反映了这些组织接受维甲酸调控能力的差异,及维甲酸受体不同亚型之间的比例不同。PML-RARα的存在可能是ATRA作用的分子基础,也可能是APL发病的环节之一。

Retinoid exerts its effect through two types of retinoid receptors, the retinoic acid receptors(RARs) and retinoid X receptors(RXRs). In this study, we investigated the relationship between apoptosis and growth inhibition induced by RAR and RXR selective retinoids in breast cancer cell lines, using fluorescent microscopy,TdTassay and MTT assay. In addition, RARα gene was stable transfected into RARα negative breast cancer cell line, MB 231 cells, apoptosis was induced. A synergistic growth...

Retinoid exerts its effect through two types of retinoid receptors, the retinoic acid receptors(RARs) and retinoid X receptors(RXRs). In this study, we investigated the relationship between apoptosis and growth inhibition induced by RAR and RXR selective retinoids in breast cancer cell lines, using fluorescent microscopy,TdTassay and MTT assay. In addition, RARα gene was stable transfected into RARα negative breast cancer cell line, MB 231 cells, apoptosis was induced. A synergistic growth inhibitory effect and apoptosis were observed on combining RAR and RXR selective retinoids. Our results demonstrate that retinoids can induce apoptosis in breast cancer cell lines, and contribute to growth inhibition of breast cancer cells.These may represent an important anti tumor mechanism of retinoic acid.

以不同的受体选择性视黄素处理乳腺癌细胞,通过荧光显微术、TdT测定和细胞生长测定,分析视黄素诱导的癌细胞凋亡及其对癌细胞生长抑制的相互关系;将受体RARα基因转染乳腺癌MB-231细胞,发现受体转染与细胞凋亡诱导有关;RAR和RXR受体选择性视黄素联合使用,对诱导癌细胞凋亡和抑制癌细胞生长具有加强作用.结果证实,视黄素能够诱导乳腺癌细胞的细胞凋亡,并与抑制癌细胞的恶性生长相一致,这可能是视黄素抗癌作用的机制之一.

 
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