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retinoic acid receptor
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  retinoic acid receptor
Our previous data indicated that the combination of ligands for peroxisome proliferator-activated receptor γ (PPARγ) and retinoic acid receptor (RAR) induces apoptosis of breast cancer cells in vitro and in a murine model.
      
Using monoclonal antibodies for retinoic acid receptor alpha (RARα), we found nuclear staining in melanomas and lung carcinomas metastatic to brain and only rarely in gliomas.
      
Paucity of Retinoic Acid Receptor Alpha (RARα) Nuclear Immunostaining in Gliomas and Inability of Retinoic Acid to Influence Neu
      
CNS-1 was immunoreactive for glial fibrillary acidic protein, S100 protein, vimentin, neural cell adhesion molecule, retinoic acid receptor α, intercellular adhesion molecule, and neuron specific enolase.
      
RA was previously shown to down-regulate the steady state levels of retinoic acid receptor α (RARα) and retinoid X receptor α (RXRα) in primary brown adipocytes differentiated in culture.
      
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Objective:To investigate the regulatory effect of nuclear receptors including peroxisome proliferator activated receptorγ (PPARγ) and α(PPARα),retinoic acid receptor(RAR),retinoid X receptor (RXR),vitamin D receptor (VDR),thyroxin receptor (TR) and glucocorticoid receptor (GR) agonist on aromatase activity in human ovarian granulosa and breast cancer MCF 7 cells.Methods:The human ovarian granulosa and breast cancer MCF 7 cells were treated with various nuclear receptor...

Objective:To investigate the regulatory effect of nuclear receptors including peroxisome proliferator activated receptorγ (PPARγ) and α(PPARα),retinoic acid receptor(RAR),retinoid X receptor (RXR),vitamin D receptor (VDR),thyroxin receptor (TR) and glucocorticoid receptor (GR) agonist on aromatase activity in human ovarian granulosa and breast cancer MCF 7 cells.Methods:The human ovarian granulosa and breast cancer MCF 7 cells were treated with various nuclear receptor agonist mentioned above for 2 d and then aromatase activity was determined by measuring the H 2O release upon the conversion of [1β 3H] and rostenedion to estrone (E 1).Results:(1) PPARγ or RXR agonist alone decreased aromatase activity in cultured granulosa cells,while combined treatment with both agonist caused a much greater reduction in aromatase activity and associated with comparable changes in the P450arom mRNA levels based on RT PCR;(2) Combined treatment with both RXR agonist and RAR agonist increased aromatase activity and P450arom mRNA level in MCF 7 cells.Conclusion:aromatase activity is regulated by different nuclear receptor agonist in human ovarian granulosa and breast cancer MCF 7 cells.

目的 :探讨各种核受体包括过氧化酶体增生物激活受体 γ(PPARγ)和 α(PPARα)、维甲酸受体 (RAR)、维甲类 X受体 (RXR)、维生素 D受体 (VDR)、甲状腺素受体 (TR)和糖皮质激素受体 (GR)的激动剂对人卵巢颗粒细胞和乳腺癌 MCF- 7细胞芳香化酶活性的调节作用。 方法 :测定人卵巢颗粒细胞和 MCF- 7细胞在上述各种核受体激动剂处理前后芳香化酶活性的变化和细胞色素 P4 5 0芳香化酶 (P4 5 0 arom) m RNA的表达水平。结果 :(1) PPARγ和 RXR激动剂均能显著抑制人卵巢颗粒细胞芳香化酶活性 ,两者结合使用抑制作用更进一步增强 ,并且伴有 P4 5 0 arom m RNA水平下降 ;(2 ) RAR和 RXR激动剂合用能显著刺激乳腺癌 MCF- 7细胞芳香化酶活性 ,并使 P4 5 0 arom m RNA表达水平升高。 结论 :人卵巢颗粒细胞和乳腺癌MCF- 7细胞芳香化酶活性受不同的核受体激动剂调节

 
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