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   retinoic acid receptor 在 皮肤病与性病 分类中 的翻译结果: 查询用时:0.175秒
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retinoic acid receptor
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  retinoic acid receptor
Our previous data indicated that the combination of ligands for peroxisome proliferator-activated receptor γ (PPARγ) and retinoic acid receptor (RAR) induces apoptosis of breast cancer cells in vitro and in a murine model.
      
Using monoclonal antibodies for retinoic acid receptor alpha (RARα), we found nuclear staining in melanomas and lung carcinomas metastatic to brain and only rarely in gliomas.
      
Paucity of Retinoic Acid Receptor Alpha (RARα) Nuclear Immunostaining in Gliomas and Inability of Retinoic Acid to Influence Neu
      
CNS-1 was immunoreactive for glial fibrillary acidic protein, S100 protein, vimentin, neural cell adhesion molecule, retinoic acid receptor α, intercellular adhesion molecule, and neuron specific enolase.
      
RA was previously shown to down-regulate the steady state levels of retinoic acid receptor α (RARα) and retinoid X receptor α (RXRα) in primary brown adipocytes differentiated in culture.
      
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Objective To analyze nucleotid sequence of the intron near the exon of retinoic acid receptor in patients with psoriasis vulgaris,to investigate the mechanism for reasonablely explaining the low expression in the basal cell of the patients with psoriasis vulgaris.Methods The karyotes of patients with psoriasis vulgaris whose reactivity to retinoic acid were different were selected and the DNA was extracted, then amplify with polymerase chain reaction and examine the sequence of exons of retinoic...

Objective To analyze nucleotid sequence of the intron near the exon of retinoic acid receptor in patients with psoriasis vulgaris,to investigate the mechanism for reasonablely explaining the low expression in the basal cell of the patients with psoriasis vulgaris.Methods The karyotes of patients with psoriasis vulgaris whose reactivity to retinoic acid were different were selected and the DNA was extracted, then amplify with polymerase chain reaction and examine the sequence of exons of retinoic acid receptor α(RARα).Results When compared to the reported neucletid sequence of RAR α,there was difference at 17th base pair on the intron 7,indicating change of T→G and base pairs of 18th and 55th were absent.But no difference of intron was found between these selected patients with psoriasis vulgaris.Conclusion Mutations in intron 7 of retinoic acid receptor of the patients with psoriasis vulgaris occurred.Because the function of intron 7 is not known well so far,its accurate function for expression of retinoic acid receptor is not certain.But it can be deduced from the results that intron probably correlate with the expression of retinoic acid receptor.

目的 分析银屑病患者维甲酸受体外显子附近的内含子碱基序列 ,寻找寻常性银屑病患者基底细胞维甲酸受体低表达的原因。方法 选取对维甲酸有不同反应性的寻常性银屑病患者有核细胞 ,提取其DNA ,通过聚合酶链反应扩增维甲酸受体α(RARα)的外显子序列 ,对扩增产物进行序列分析。结果 与已报告的维甲酸受体碱基序列相比 ,第七内含子第 17位碱基存在差异 ,出现T→G改变 ,而第 18位和第 5 5位出现碱基T的缺失 ,但选取的寻常性银屑病患者间未发现彼此间内显子碱基序列存在差异。结论 寻常性银屑病患者维甲酸受体α第七内含子碱基序列发生突变 ,由于目前对第七内含子的功能知之甚少 ,还不能确定其在维甲酸受体表达中具体的作用 ,但从目前对内含子的研究结果推测其可能与维甲酸受体的表达有关。

Objective To analyze nucleotide sequence of the g ene of retinoic acid receptor of patients with psoriasis vulgaris (PV). Methods The karyotes of PV patients were selected, and the DNA of the genome was extracted, then amplified with polymerase chain reaction to exami ne the sequence of its exon. Results Difference was found i n 93 rd nucleotide, indicating change of C→G. However, no difference in t he nucleotide sequence of these exons was detected in all these selected PV pati ents who had different...

Objective To analyze nucleotide sequence of the g ene of retinoic acid receptor of patients with psoriasis vulgaris (PV). Methods The karyotes of PV patients were selected, and the DNA of the genome was extracted, then amplified with polymerase chain reaction to exami ne the sequence of its exon. Results Difference was found i n 93 rd nucleotide, indicating change of C→G. However, no difference in t he nucleotide sequence of these exons was detected in all these selected PV pati ents who had different reactions to retinoic acid. Conclusion Mutation occurs in the exon 6 of retinoic acid receptor α for patien ts with PV. The function of the mutation in the nucleotide sequence for the diff erent reactions to retinoic acid is not certain.

目的 分析寻常型银屑病患者维甲酸受体α基因序列。方法 选取对维甲酸有不同反应性的寻常型银屑病患者有核细胞 ,提取其基因组DNA ,通过聚合酶链反应扩增维甲酸受体α的第 6外显子序列 ,并对扩增产物进行序列测定。结果 第 6外显子第 93位碱基存在差异 ,出现C→G的改变。但从我们选取的对维甲酸反应性不同的寻常型银屑病患者中 ,未发现彼此间外显子碱基序列存在差异。结论 银屑病患者维甲酸受体α第 6外显子碱基序列发生突变 ,但目前还不能确定突变点在维甲酸反应性差异中的作用

Objective To explore the level of expression of retinoic acid receptor mRNA in peripheral blood mononuclear cell(PBMC)of patients with psoriasis vulgaris.Methods The level of retinoic acid receptor mRNA in PMBC of 20 patients with psoriasis vulgaris was investigated by RT-PCR,PBMC in blood from 10 normal individuals were taken as the control.Results There was no statistical significance in the level of expression of retinoic acid receptor(RARα?RARγ?RXRα)mRNA between patients with psoriasis...

Objective To explore the level of expression of retinoic acid receptor mRNA in peripheral blood mononuclear cell(PBMC)of patients with psoriasis vulgaris.Methods The level of retinoic acid receptor mRNA in PMBC of 20 patients with psoriasis vulgaris was investigated by RT-PCR,PBMC in blood from 10 normal individuals were taken as the control.Results There was no statistical significance in the level of expression of retinoic acid receptor(RARα?RARγ?RXRα)mRNA between patients with psoriasis vulgaris and normal controls(P>(0.05)).Conclusion During systemic treatment of psoriasis vulgaris with retinoids, whether the immunocytes are targets of the drug needs to be studied further.

目的 探讨寻常性银屑病患者外周血单一核细胞中维A酸受体 (RARα、RARγ、RXRα)mRNA的表达情况。方法 用RT PCR法对比研究了 2 0例寻常性银屑病患者和 10例正常对照组外周血单一核细胞中维A酸受体mRNA表达情况。结果 寻常性银屑病患者外周血单一核细胞中的维A酸受体mRNA的表达水平与正常对照组无差异。结论 用维A酸治疗寻常性银屑病过程中 ,免疫细胞是否为维A酸的作用靶细胞还不能确定。

 
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