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pathologic     
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  病理
     Theoretical Study on Syndrome of Accumulation of Cold Fluid in the Lung and the Gene Expressions of iNOS and TNF α in the Lung Tissues of Pathologic Rabbit Models
     寒饮蕴肺证的理论研究及家兔病理模型肺组织iNOS与TNFα的基因表达
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     Experimental Study on the Relationship between the Apoptosis and Proliferation of Parathyroid Cell in Primary Hyperparathyroidism and the Imaging and Pathologic Basis in Osteopathy
     原发性甲状旁腺机能亢进甲状旁腺细胞增生、凋亡与骨病影像、病理相关性实验研究
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     The Study on Pathologic Alters and NGF Therapeutic Effects in the Region of Perihematoma by Fundamental Medcine and MR Image after Experimental Intracerebral Hemorrhage
     实验性脑出血血肿灶周病理变化及NGF基因治疗的基础和MR影像学研究
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     Septal Line Appearances on HRCT in Diffuse Lung Diseases:the Pathologic Basis and Clinical Diagnostic Significance
     弥漫性肺病中肺间隔线的HRCT表现、病理基础和临床诊断意义
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     MSCTA and 3D-DCE-MRA in the Evaluation of Receptor's Vessels before Orthotopic Liver Transplantation and Compare with Pathologic Results
     肝移植受体血管术前MSCTA与3D-DCE-MRA评估及病理对照研究
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  病理学
     Expressions of EphB4、EphrinB2、mvd and Ki-67 in Human Brain Tumors and Their Pathologic Significance
     EphB4、EphrinB2、mvd和Ki-67在人脑肿瘤中的表达及其病理学意义
短句来源
     Pathologic Observation on Liver of Hepatitis B Virus Transgenic Mice Strain C57-TgN(HBVadr2.0)SMMU
     乙型肝炎转基因小鼠品系C57-TgN(HBVadr2.0)SMMU肝脏的病理学观察
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     Pathologic positive rate was67.6%(23/34)before treatment and8.8%(3/34)after treatment with significant difference(P<0.05).
     34例治疗前肿瘤表面病理学检查,阳性23例,阳性率67.6%(23/34); 治疗后印片阳性3例,阳性率8.8%(3/34),两者比较差异有显著性(P<0.05)。
短句来源
     Group Ⅲ: Wistar→SD small intestinal transplantation+rhTGF-β1. The pathologic changes of allografts were observed at 3rd day, 5th day, and 7th day after operation and the expression of IL-2, IFN-γ and TGF-β1 mRNA were detected by using semi-quantity RT-PCR.
     Ⅲ组 :Wistar→SD小肠移植 +重组人转化生长因子 β1(rhTGF -β1)。 术后 3、5、7d观察病理学改变并用半定量RT -PCR方法检测干扰素γ(IFN -γ)、白细胞介素 2 (IL -2 )、TGF -β1mRNA。
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     Loss of PTEN expression was correlated significantly with high Gleason score (≥7) and advanced pathologic stage (T3-T4) , P<0.025 and P<0.001 respectively.
     PTEN表达缺失与Gleason评分≥ 7(即低分化腺癌 )、病理学分期 (T3 ~T4)密切相关 ,分别为P <0 0 2 5和P <0 0 0 1。
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  病理性
     Caspase-3 expression were correlated with Survivin (r=-0.400) and P33ING1 (r= 0.602 ) in pathologic scar tissue (P<0.05).
     病理性瘢痕组织中Caspase-3与Survivin(r=-0.400)和P33ING1(r=0.602)表达均具有相关性(P<0.05)。
短句来源
     Results: The positive rates of survivin, P33ING1, and Caspase-3 in pathologic scar, non-pathologic scar, and normal skin tissue were 80.0%,50.0%,35.0%,43.3%,70.0%,85.0% and 30.0%,80.0%,90.0%, respectively.
     结果病理性瘢痕、非病理性瘢痕和正常皮肤组织中Survivin、P33ING1和Caspase-3的阳性表达率分别为80.0%、50.0%、35.0%,43.3%、70.0%、85.0%和30.0%、80.0%、90.0%;
短句来源
     Detection of survivin mRNA and C-myc, P27~(kip1) proteins in pathologic scar tissue
     病理性瘢痕组织中survivin mRNA和C-myc、P27~(kip1)蛋白的表达
短句来源
     Expression of Survivin, P33ING1, and Caspase-3 proteins in pathologic scar tissue
     病理性瘢痕组织中Survivin、P33ING1、Caspase-3蛋白的表达
短句来源
     Aim: To explore the expression of TGF-β1, and its receptors TβRⅠ and TβRⅡ in the pathologic scar tissue.
     目的检测病理性瘢痕组织中TGF-β1及其Ⅰ、Ⅱ型受体(TβRⅠ,TβRⅡ)。
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  病理的
     Methods: The protein expression of CD44V6 and E-Cad was detected by immunohistochemical technique in 48 cases of gallbladder carcinoma,29 cases of gallbladder adenoma polypi and 25 cases of chronic calculous cholecytitis, and the relationship between their expression with the clinical and pathologic characters of gallbladder carcinoma was analyzed.
     方法:应用免疫组织化学的方法检测48例胆囊癌、29例胆囊腺瘤性息肉、25例慢性结石性胆囊炎中CD44V6、E-Cad的表达情况,并分析其表达与胆囊癌临床病理的关系。
短句来源
     The relationship between liver pathologic histology and levels of serum HBV-DNA,ALT in patients with chronic hepatitis B
     慢性乙型病毒性肝炎患者血清HBV DNA水平和谷丙转氨酶与肝组织病理的关系
短句来源
     Relationship Between Expression of Leptin Receptors mRNA in Breast Tissue,Plasma Leptin Level in Breast Cancer Patients with Obesity and Clinical Pathologic Data
     乳腺癌合并肥胖症患者血浆瘦素水平与乳腺癌组织中瘦素受体mRNA的表达及临床病理的关系
短句来源
     Group C was significantly different from group A and B, P <0.001. There were significantly correlation between EDI and pathologic results (r =0.78,P <0.001).
     与A组、B组比较差异均有显著性(P<0.001)。 红细胞变形指数与心脏病理的相关分析显示两者具有显著的相关性(P<0.001,r=0.78)。
短句来源
     Spiral CT enhancement of gastric cancer was correlated with operative pathologic lymph node metastasis (P<0.05), no correlated with serosal invasion and TNM staging.
     螺旋CT的强化特点与手术病理的淋巴结转移相关(P<0.05),与浆膜侵犯及TNM分期不相关。
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      pathologic
    An analysis of clinico-pathologic features of intraductal papillary mucinous neoplasm of the pancreas
          
    Pathologic rereview of each case was performed, and the clinico-pathologic features were examined.
          
    Data recorded included onset, symptoms, signs, laboratory results, endoscopic, radiologic and pathologic findings, the clinical treatment process and follow-up.
          
    Using homogenous enzyme preparations of NADP-IDH isolated from the normal and experimentally ischemized rat myocardium, a number of catalytic properties of the enzyme were characterized for normal and pathologic conditions.
          
    However, under normal and pathologic conditions NADP-IDH was different in the affinity for substrates and in the sensitivity to inhibitory effects of hydrogen peroxide, reduced glutathione, and of Ca2+.
          
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    In normal dogs intragastric administration of the decoction of the leaves of C.trichdtomum induced emesis after a single dose of 20g(crude drug)/kg or more,but no emesis below 10g/kg. Daily administration of 10g/kg for 3 weeks rendered no significant changes in the liver function, blood picture,EKG,and pathologic examination. Five Goldblatt renal hypertensive dogs were used for the experimental therapy.Blood pres- sure was measured by auscultation on the carotid loop.C.trichotomum was given 10g/kg/day...

    In normal dogs intragastric administration of the decoction of the leaves of C.trichdtomum induced emesis after a single dose of 20g(crude drug)/kg or more,but no emesis below 10g/kg. Daily administration of 10g/kg for 3 weeks rendered no significant changes in the liver function, blood picture,EKG,and pathologic examination. Five Goldblatt renal hypertensive dogs were used for the experimental therapy.Blood pres- sure was measured by auscultation on the carotid loop.C.trichotomum was given 10g/kg/day for 4 weeks.Hypotension began in the 2nd week,and became more marked on further medication. The weekly average diastolic pressure decreased 32,17,6,20,and 12 mm Hg(25%,14%,5%, 16%,and 10%) respectively.The liver function and the blood picture were apparendy unaltered. After 3 weeks of medication the T wave in the EKG was found to be inverted in 3 dogs. When compared with the therapeutic activities of the Chinese drugs previously tested on the hypertensive dogs in this laboratory,C.trichotomum is probably less effective than Veratrum Schindleri,Scutellaria baicalcnesis,and the total alkaloids from Rauwolfia wrticillata,is similar to the Compositus Erxian-heji,but is better than Eucommia ulmoides.

    正常狗灌胃海州常山叶水煎剂1次20g/kg以上即嘔吐,10g/kg以下无嘔吐。每天灌胃10g/kg,共3周,肝机能、血象、心电图及病理检查均无明显改变。慢性腎型高血压狗5只,听诊测量颈动脉皮桥血压。每日灌胃10g/kg,共4周。在给药第2周降压作用开始显著,继续给药则降压更多。每周平均舒张压低时分别下降32,17,6,20,12mmHg(25%,14%,5%,16%,10%)。心搏率、肝机能及血象无明显变化、给药第3周以后3只狗心电图T波变为倒置。与本实验室过去以慢性腎型高血压狗口服几种中药相比较,海州常山比藜芦、黄芩及蘿芙木全硷的降压效力可能稍差,与二仙合剂相差不多,但比杜仲较好。

    Cardiac output was determined according to Fick's principle, while renaI blood flow (RBF) and glomerular filtration rate (GFR) were measured from the clearances of PAH and creatinine. One hour after an i.v. injection of guanethidine 5 mg/kg, normal dogs showed a very slight hypotension, which was relatively more noticeable in renal hypertensive dogs. The cardiac output, stroke volume, and ventricular work tended to decrease tn normotensive dogs, but tended to augment in hypertensive dogs. These alterations,...

    Cardiac output was determined according to Fick's principle, while renaI blood flow (RBF) and glomerular filtration rate (GFR) were measured from the clearances of PAH and creatinine. One hour after an i.v. injection of guanethidine 5 mg/kg, normal dogs showed a very slight hypotension, which was relatively more noticeable in renal hypertensive dogs. The cardiac output, stroke volume, and ventricular work tended to decrease tn normotensive dogs, but tended to augment in hypertensive dogs. These alterations, however, were statistically insignificant. The total peripheral resistance was not much influenced by guanethidine in normal dogs, yet markedly diminished in hypertensive dogs. Diuresis was evident during the 1-hour postmedication period in both models. In hypertensive dogs, i.v. administrations of guanethidine caused a conspicuous rise of RBF and GFR, but a great reduction of the renal vascular resistance. In normal rats, following an i.p. injection of 20 mg/kg, the circulating blood volume (studied with I~(131)-labeled serum protein) exhibited a slight but non-significant increase within 3 hours, and returned to the original level at 24 hours. No significant change was found in DOCA-treated rats. Normal rats receiving guanethidine revealed an increase of blood volumes in all organs, especially spleen and kidney. These results demonstrate that the hypotensive action of guanethidine is not via the reduction of blood volume, but by way of a vasodilator action, which particularly amends the ischemic state of kidney and thus alleviates the pathologic process of renal hypertension.

    本文用正常血压及腎型高血压狗研究胍乙啶对心和腎的血流动力作用,并用大白鼠試驗其对循环及器官血容量的影响。根据Fick氏原則測定心輸出量,同时从腎脏对于对氨基馬尿酸及肌酐的清除率計算腎血流量及腎小球滤过率。靜脉注射胍乙啶5毫克/公斤1小时后,正常狗血压略有降低,高血压狗降压則較为明显。胍乙啶对正常血压狗的心輸出量、心搏量及心室作功量有減 低的趋向,而对腎型高血压狗則略有增加,但均不显著。胍乙啶不影响正常狗的外周血管阻力,而能显著降低腎型高血压狗的总外周阻力,扩张其外周血管。注射胍乙啶后,正常血压及腎型高血压狗的尿量增加均非常显著。腎型高血压狗的腎小球滤过率及腎血流量都非常显著地低于正常狗,腎血管阻力則大大地高于正常狗,靜脉注射胍乙啶后,滤过率及血流量均明显增加,而血管阻力則大大降低。正常大白鼠腹腔注射胍乙啶20毫克/公斤后,3小时內循环血量略有增加,但不显著,6小时后开始恢复,2斗小时后回至原水平。对注射DOCA的大白鼠的循环血量則沒有明显影响。正常大白鼠注射胍乙啶后,各器官及組織內合血量普遍有增加趋势,其中以脾及腎的血容量增加最为明显,說明胍乙啶对这些部位的血管有扩张作用。上述資料証明:胍乙啶的降压作用并非通...

    本文用正常血压及腎型高血压狗研究胍乙啶对心和腎的血流动力作用,并用大白鼠試驗其对循环及器官血容量的影响。根据Fick氏原則測定心輸出量,同时从腎脏对于对氨基馬尿酸及肌酐的清除率計算腎血流量及腎小球滤过率。靜脉注射胍乙啶5毫克/公斤1小时后,正常狗血压略有降低,高血压狗降压則較为明显。胍乙啶对正常血压狗的心輸出量、心搏量及心室作功量有減 低的趋向,而对腎型高血压狗則略有增加,但均不显著。胍乙啶不影响正常狗的外周血管阻力,而能显著降低腎型高血压狗的总外周阻力,扩张其外周血管。注射胍乙啶后,正常血压及腎型高血压狗的尿量增加均非常显著。腎型高血压狗的腎小球滤过率及腎血流量都非常显著地低于正常狗,腎血管阻力則大大地高于正常狗,靜脉注射胍乙啶后,滤过率及血流量均明显增加,而血管阻力則大大降低。正常大白鼠腹腔注射胍乙啶20毫克/公斤后,3小时內循环血量略有增加,但不显著,6小时后开始恢复,2斗小时后回至原水平。对注射DOCA的大白鼠的循环血量則沒有明显影响。正常大白鼠注射胍乙啶后,各器官及組織內合血量普遍有增加趋势,其中以脾及腎的血容量增加最为明显,說明胍乙啶对这些部位的血管有扩张作用。上述資料証明:胍乙啶的降压作用并非通过循环血量的減少,而是由于外周血管的扩张所致。胍乙啶能扩张腎血管,改善腎缺血状态,从而緩解腎型高血压的病理生理过程。

    In this paper the antitumour action of 17 phosphoramide nitrogen mustard compounds were studied. It was found that bis-(1-aziridinyl)-[bis-(2-chloroethyl)-amino]-phosphine oxide (AT-222) possessed a marked antineoplastic activity.The main results were as follows: 1.Intraperitoneal injections of 1—2.5 mg/kg of AT-222 produced a marked inhibitory action on mouse sarcoma 180, reticulo-cell sarcoma (L-2), sarcoma AK, spindle cell sarcoma and rat Jensen sarcoma and Walker carcinosarcoma. Intragastric administration...

    In this paper the antitumour action of 17 phosphoramide nitrogen mustard compounds were studied. It was found that bis-(1-aziridinyl)-[bis-(2-chloroethyl)-amino]-phosphine oxide (AT-222) possessed a marked antineoplastic activity.The main results were as follows: 1.Intraperitoneal injections of 1—2.5 mg/kg of AT-222 produced a marked inhibitory action on mouse sarcoma 180, reticulo-cell sarcoma (L-2), sarcoma AK, spindle cell sarcoma and rat Jensen sarcoma and Walker carcinosarcoma. Intragastric administration of this drug brought about a definite inhibition on the growth of Jensen sarcoma in rats. No effect on Ehrlich carcinoma (both ascitic and solid forms) was observed when the drug was injected intraperitoneally. 2.In mice, the acute and subacute LD_(50) of AT-222 were found to be 19 and 4.7mg/kg respectively. In rats the subacute LD_(50) was 2.7mg/kg (observation period= 10 days) or 1.9mg/kg (observation period=17 days) 3.In dogs, intravenous injections of AT-222 at 0.1 mg/kg/day for 10 days caused no significant change in blood picture, urinalysis, stool routine examination and body weight. In the group given 0.3 mg/kg, white cell counts were slightly decreased on the 5th day after drug administration, and gradually recovered after cessation of the drug. Pathologic studies revealed hemorrhagic spots in the intestinal mucosa and pyknotic nuclei in the granulosa cells and in the lymphocytes of the spleen.In the group of 0.9 mg/kg, white cell counts were markedly decreased and the animals died 12--14 days after drug administration, In pathologic examinations diffuse hemorrhage in the internal organs and atrophy of gastric and intestinal glands, adrenal bodies and testis were seen.

    本文研究了17种磷酰胺氮芥类化合物,发現N-双(2-氯乙基)-N'-N"-二乙撐基磷酰胺(以下均簡称AT-222)具有較强的抗癌作用。主要結果如下:(1)腹腔注射AT-2221—2.5毫克/公斤对小白鼠肉瘤180,网織細胞肉瘤,AK肉瘤,梭形細胞肉瘤,大白鼠Jensen肉瘤和Walker癌肉瘤都有明显的抑制作用,口服給药时对Jensen肉瘤也有一定的疗效。但对Ehrlish癌固体型和腹水型則无明显的影响。(2)AT-222对小白鼠的急性和亚急性LD_(50)分別为19和4.7毫克/公斤,大白鼠的亚急性LD_(50)为2.7毫克/公斤(停药后观察3天)和1.9毫克/公斤(停药后观察10天)。(3)給狗靜脉注射AT-222 0.1毫克/公斤,其血象、大小便和体重均无明显改变。在0.3毫克/公斤組,給药第5天时白血球稍有下降,停药后逐渐恢复,解剖发現腸粘膜有出血点,脾淋巴細胞核和卵巢顆粒細胞核有固縮現象。0.9毫克/公斤組,于給药后第5天时白血球卽明显下降,停药后2—4天动物相继死亡,解剖检查发现各脏器均有弥蔓性出血,腸、胃腺体、腎上腺和睾丸均有明显萎縮。

     
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