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nerve toxicity
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  神经毒性
     group B 26 cases, nerve toxicity of 1~3 grade occurred in 9,4,3 cases respectively ,develop ratc was 61.5%.
     3级1例,总发生率28.5%。 B组26例,发生神经毒性1级9例;
短句来源
     Conclusion GIK can lighten the nerve toxicity of Glu,Asp and NO,and protect on the ischemic organisation.
     应用GIK后较缺血组有明显降低。 结论GIK能减轻Glu、Asp、NO的神经毒性,起到对缺血脑组织的保护作用。
短句来源
     The diversity of the two groups’(Ⅰ,Ⅱ) perisensory nerve toxicity is also obvious. 62.9 percent toxicity group and 31.6 percent of HCPT group appear the toxicity (P< 0.05), but the diversity of adverse reaction is not obvious (P> 0.05).
     毒副反应两组Ⅰ~II外周神经毒性有显著性差异,Oxaliplatin组为62.9%,HCPT组为31.6%(P<0.05),其他毒副反应的差异无显著性(P>0.05)。
短句来源
     Study on Nerve Toxicity and Oxidation Damage to Antioxidant Defenses of Mice Induced by Pentachloronitrobenzene (PCNB)
     五氯硝基苯对小鼠的神经毒性和抗氧化防御系统损伤研究
短句来源
     Results: The evaluable cases were 54 cases ,group A 28 cases ,in these group nerve toxicity occurred of 1~3 grade in 5,3,1 cases develop rate was 28.5%。
     结果可评价病例54例,A组28例,发生神经毒性1级5例; 2级2例;
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  “nerve toxicity”译为未确定词的双语例句
     An individual with CYP2C9*3 allele caused the central nerve toxicity after orally routine dose of phenytoin. Therefore CYP2C9 polymorphisms are particularly relevant to the metabolism of drugs with narrow therapeutic indices such as warfarin, tolbutamide and phenytoin.
     其中CYP2C9~*3发现的较早,研究的也最广泛,
短句来源
     IntroductionOchratoxin A(OA) is a toxic metabolite of some Aspergillus and Penicillium. According to some animal experiments, OA has immuno-suppressive toxicity, nerve toxicity, teratogenesis, and carcinogenisis.
     赭曲霉毒素(Ochratoxins,OT)是曲霉属和青霉属的一些菌种产生的有毒代谢产物,是异香豆素联结L-苯丙氨酸在分子结构上类似的一组化合物,包括赭曲霉毒素A、B和C,其中赭曲霉毒素A(Ochratoxin A,OA)因其污染广泛、毒性最大而受到重视。
短句来源
     A review with 11 references is given on the property and effects of Aluminium as an element in human body, such as the characteristics related with the blood system disease, the nerve toxicity, skeleton disease, and so on.
     铝广泛地存在于自然界 ,由于其具有优良的理化性能 ,故普遍地用于工业、医药和日常生活中。 本文拟从铝在体内的吸收、转运、贮存及分布 ,铝的生理机能 ,铝的毒性 ,铝与人体疾病的关系等方面进行综述
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     Formate has been recongnized to produce retinal and optic nerve toxicity by inhibiting the activity of cytochrome oxidase, disrupting mitochondrial energy production, reducing adenosine triphosphate(ATP) synthesis.
     甲酸盐抑制细胞色素氧化酶的活性 ,干扰了线粒体能量代谢 ,ATP合成减少 ,产生视网膜和视神经损害。
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     In this paper, the drugs that are known to induce muscle and/or nerve toxicity are reviewed, the commonly encountered signs and symptoms are described, and the mechanisms underlying these iatrogenic effects are discussed.
     作者综述已知明确能诱发神经肌肉疾病的药物,描述常见的症状和体征,探讨其可能的致病机制。
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  相似匹配句对
     Optic nerve neuropathy by ethambutol toxicity
     乙胺丁醇中毒性视神经损害
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     Nerve growth factors prevent glutamate toxicity in cortical
     神经生长因子在培养的皮质神经细胞中抑制谷氨酸毒性
短句来源
     Toxicity of Vitamine
     维生素的毒性
短句来源
     Nes-B in nerve;
     神经为Nes—B;
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     The Toxicity of Acrylamide
     丙烯酰胺毒性研究进展
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  nerve toxicity
Although facial nerve palsy secondary to paclitaxel is not previously reported, other cranial nerve toxicity has been described.
      
Certain patients, however, may be at high risk for peripheral nerve toxicity due to genetic factors or another underlying neuropathy.
      


Purpose:Clinical research has been done to show whether continuous infusion of navelbine can increase curative effect and decrease toxicity.Methods:Patients studied were non operable NSCLC and recurrent or metastatic breast cancer. Navelbine is given through a catheter in the venae subclavia by continuous infusion for 24 hours. Regimen:NVB 10 mg/iv/day 1+NVB 10 mg/iv continuous infusion 24 h/day 1—5+DDP 40 mg/iv 2h/day 1—3+Gransetron 3 mg/iv day1,3,5 given every 21 days. Results:Among 47 patients 35 patients...

Purpose:Clinical research has been done to show whether continuous infusion of navelbine can increase curative effect and decrease toxicity.Methods:Patients studied were non operable NSCLC and recurrent or metastatic breast cancer. Navelbine is given through a catheter in the venae subclavia by continuous infusion for 24 hours. Regimen:NVB 10 mg/iv/day 1+NVB 10 mg/iv continuous infusion 24 h/day 1—5+DDP 40 mg/iv 2h/day 1—3+Gransetron 3 mg/iv day1,3,5 given every 21 days. Results:Among 47 patients 35 patients were NSCLC and 12 patients were breast cancer. Average age was 58.9 years. Of the NSCLC patients, 12 were squamous cell carcinoma and 23 patients were adenocarcinoma; two patients were stage Ⅱ and 19 patients stage Ⅲ, 19 patients stage Ⅳ. All of the breast cancer cases were infiltrative duct carcinoma. Three patients were stage Ⅱ and nine patients were stage Ⅳ. Of the 47 patients, 44 patients were evaluable for response and 47 patients for toxicity. Response rate of NSCLC was 57%(19 pr) and breast cancer 63% (1 cr, 6 pr). Main toxicity was granulocytopenia and vomiting. WHO Ⅲ—Ⅳ grade granulocytopenia was 40% and vomiting 6.4%. Peripheral nerves toxicity was mild and only 6.4% patients had WHO I grade peripheral sensory nerve damage. No patients had severe nerve toxicity such as enteroplegia.Conclusions:Comparison of continuous infusion Navelbine and Cisplatin with classic usage of navelbine for management of NSCLC and breast cancer showed increased response rate and decreased toxicity. Administration through catheter venae subclavia can avoid chemo phlebitis. [

目的 :临床研究去甲长春花碱 (诺维本 ,Navelbine,NVB)持续静脉输注是否可以提高疗效并减轻毒副反应。方法 :转移或复发的晚期乳腺癌以及不能手术的Ⅲ—Ⅳ期非小细胞肺癌的病人。其中去甲长春花碱的给药方式采用注射泵通过锁骨下深静脉置管进行 2 4小时持续给药。治疗方案 :NVB 10mg静脉一次推注第 1天 ,NVB10mg静脉持续滴注 2 4小时 ,第 1— 5天 ,DDP 40mg静脉滴注 2小时第 1— 3天 ,盐酸格拉司琼 3mg静脉推注第 1,3,5天。 2 1天为 1周期 ,2周期后评价疗效。结果 :47例病人中非小细胞肺癌 35例 ,乳腺癌 12例。平均年龄为 5 8.9岁。非小细胞肺癌中鳞癌病人 12例 ,腺癌病人 2 3例 ;Ⅱ期 2例 ,Ⅲ期 19例 ,Ⅳ期 14例 ;乳腺癌病人均为浸润型导管癌 ,其中Ⅲ期为 3例 ,Ⅳ期为 9例。可评价疗效病人 44例。非小细胞肺癌病人 19例达PR ,总有效率为 5 7%。乳腺癌病人 1例达CR ,6例达PR ,总有效率为 6 3%。可评价毒性反应病人 47例。主要毒性反应为白细胞下降及轻度的消化道反应。其中白细胞Ⅲ—Ⅳ度毒性达 5 1% ,粒...

目的 :临床研究去甲长春花碱 (诺维本 ,Navelbine,NVB)持续静脉输注是否可以提高疗效并减轻毒副反应。方法 :转移或复发的晚期乳腺癌以及不能手术的Ⅲ—Ⅳ期非小细胞肺癌的病人。其中去甲长春花碱的给药方式采用注射泵通过锁骨下深静脉置管进行 2 4小时持续给药。治疗方案 :NVB 10mg静脉一次推注第 1天 ,NVB10mg静脉持续滴注 2 4小时 ,第 1— 5天 ,DDP 40mg静脉滴注 2小时第 1— 3天 ,盐酸格拉司琼 3mg静脉推注第 1,3,5天。 2 1天为 1周期 ,2周期后评价疗效。结果 :47例病人中非小细胞肺癌 35例 ,乳腺癌 12例。平均年龄为 5 8.9岁。非小细胞肺癌中鳞癌病人 12例 ,腺癌病人 2 3例 ;Ⅱ期 2例 ,Ⅲ期 19例 ,Ⅳ期 14例 ;乳腺癌病人均为浸润型导管癌 ,其中Ⅲ期为 3例 ,Ⅳ期为 9例。可评价疗效病人 44例。非小细胞肺癌病人 19例达PR ,总有效率为 5 7%。乳腺癌病人 1例达CR ,6例达PR ,总有效率为 6 3%。可评价毒性反应病人 47例。主要毒性反应为白细胞下降及轻度的消化道反应。其中白细胞Ⅲ—Ⅳ度毒性达 5 1% ,粒细胞下降Ⅲ—Ⅳ度毒性达 40 %。消化道反应较为轻微 ,Ⅲ—Ⅳ度呕吐只占 6 .4%。神经毒性相当轻微 ,只有 6 .4%的病人有Ⅰ度的感觉神经损伤 ,没有病人出现如肠麻庳的严重神经毒性。结论 :去甲长春花碱持

To study the effects of Huangqi(Chinese herb)for prevention of peridural adhesio n after operation. MethodsL 2 and L 5 laminectomy of 22 New Zealan d rabbits were performed in this experim ental study.Partial yellow ligament was sectioned and fat was exposed.Then the p eridural fat was sectioned.The 44 verteb ral lamina seyments were randomly divide d into two groups of a. Huangqi group an d b.Normal Saline(NS)group.The b group wa s control group.Huangqi...

To study the effects of Huangqi(Chinese herb)for prevention of peridural adhesio n after operation. MethodsL 2 and L 5 laminectomy of 22 New Zealan d rabbits were performed in this experim ental study.Partial yellow ligament was sectioned and fat was exposed.Then the p eridural fat was sectioned.The 44 verteb ral lamina seyments were randomly divide d into two groups of a. Huangqi group an d b.Normal Saline(NS)group.The b group wa s control group.Huangqi liquid and NS we re separately injected into the defect p oints of L 2 and L 5 vertebral lamina of the two groups.The speciments were obta ined at 2nd,4th and 8th weeks after oper ation.Optical microscope and transmissio n electron microscope were used for the observation. ResultsThere were many changes in group a:littl e migration of inflammation cells,small number of fibroblast and collagen,no adh esion of peridural scar,no degeneration and demyelination of spinal nerves.But i n group b,adhesion of peridural scar cou ld be seen clearly. ConclusionHuangqi has no nerve toxicity and it cou ld be used as a good medicine to prevent postoperative peridural adhesion.

目的 探讨黄芪预防术后硬膜外瘢痕粘连的效果。方法  2 2只新西兰兔行L2 和L5节段椎板切除术 ,切除部分黄韧带 ,暴露脂肪 ,去除硬膜外脂肪 ,分为两组 :A组为黄芪组 ;B组为生理盐水组 ,分别在L2 和L5椎板缺损区注入黄芪液和生理盐水 ,术后 2、4、8周取材作光镜、透镜观察。结果 黄芪组炎性细胞渗出较少 ,成纤维细胞较少 ,胶原纤维形成较少 ,硬膜外瘢痕无粘连 ,脊髓和神经根未见变性和脱髓鞘。生理盐水组硬膜外瘢痕粘连明显。结论 黄芪无神经毒性作用 ,可以作为一种良好的材料用于预防术后硬膜外瘢痕粘连

Objective To evaluate the effect of chemotherapy mainly contained navelbine in treating advanced tumors.Methods 30 patients with advanced tumor were treated by combined chemotherapy of NVB,among whom 13 patients(accounting for 43.3%)were with NSCLC,6(20%) with breast cancer,4(13.3%)with nasopharyngeal cancer,4(13.3%) patients with NHL,3(10%) with esophageal cancer.NP regimen was applied to NSCLC?nasopharyngeal cancer and esophageal cancer,NA to the breast cancer and CHNP to the NHL respectively.Results The...

Objective To evaluate the effect of chemotherapy mainly contained navelbine in treating advanced tumors.Methods 30 patients with advanced tumor were treated by combined chemotherapy of NVB,among whom 13 patients(accounting for 43.3%)were with NSCLC,6(20%) with breast cancer,4(13.3%)with nasopharyngeal cancer,4(13.3%) patients with NHL,3(10%) with esophageal cancer.NP regimen was applied to NSCLC?nasopharyngeal cancer and esophageal cancer,NA to the breast cancer and CHNP to the NHL respectively.Results The effectiveness as well as tolerable toxicity was estimated in total 30 cases.The general effective rate was about 50%,with CR accounting for 1 case and PR for 14 cases.And decrease of HGB?WBC and PLT occurred in a rate of 37%?76.6% and 33.3% respectively,side effect mostly including nausea, vomiting, constipation,bellyache, nerve toxicity,phlebitis,alopecia, skin rash, fever,oral sore of mucous membrane,damage of liver and kidney function.Conclusion A better response rate is obtained by combination chemotherapy with NVB for treating the advanced tumor,including NSCLC?breast cancer?nasopharyngeal cancer(carcinoma)?NHL and esophageal cancer.NVB is a promising antitumor agent with tolerable toxicity.

目的 观察以异长春花碱 (NVB)为主的联合化疗方案治疗晚期恶性肿瘤的疗效。方法 共收治 30例晚期恶性肿瘤接受以NVB为主的联合化疗 ,其中非小细胞肺癌 13例 (4 3.3% ) ,乳腺癌 6例 (2 0 % ) ,鼻咽癌 4例 (13.3% ) ,恶性淋巴瘤 4例 (13.3% ) ,食道癌 3例 (10 % )。非小细胞肺癌、鼻咽癌、食道癌的化疗方案为NP ,乳腺癌为NA ,恶性淋巴瘤为CHNP。结果  30例患者可评价疗效和毒性。其中CR1例 ,PR14例 ,总有效率为 5 0 %。血红蛋白减少发生率为 37% ,白细胞为 76 .6 % ,血小板为 33.3% ,恶心呕吐发生率为 70 % ,便秘为 5 6 .6 % ,腹痛为 16 .6 % ,神经毒性为 13.3% ,静脉炎为30 % ,脱发为 33.4% ,皮疹为 6 .6 % ,发热为 10 % ,口腔黏膜溃疡为 10 % ,肝功损害为 13.3% ,肾功损害为 6 .6 %。结论 本组观察提示 ,异长春花碱联合治疗非小细胞肺癌、乳腺癌、鼻咽癌、恶性淋巴瘤、食道癌等晚期肿瘤有较好疗效 ,且毒性可耐受 ,对晚期肿瘤患者是个很有前途的肿瘤内科治...

目的 观察以异长春花碱 (NVB)为主的联合化疗方案治疗晚期恶性肿瘤的疗效。方法 共收治 30例晚期恶性肿瘤接受以NVB为主的联合化疗 ,其中非小细胞肺癌 13例 (4 3.3% ) ,乳腺癌 6例 (2 0 % ) ,鼻咽癌 4例 (13.3% ) ,恶性淋巴瘤 4例 (13.3% ) ,食道癌 3例 (10 % )。非小细胞肺癌、鼻咽癌、食道癌的化疗方案为NP ,乳腺癌为NA ,恶性淋巴瘤为CHNP。结果  30例患者可评价疗效和毒性。其中CR1例 ,PR14例 ,总有效率为 5 0 %。血红蛋白减少发生率为 37% ,白细胞为 76 .6 % ,血小板为 33.3% ,恶心呕吐发生率为 70 % ,便秘为 5 6 .6 % ,腹痛为 16 .6 % ,神经毒性为 13.3% ,静脉炎为30 % ,脱发为 33.4% ,皮疹为 6 .6 % ,发热为 10 % ,口腔黏膜溃疡为 10 % ,肝功损害为 13.3% ,肾功损害为 6 .6 %。结论 本组观察提示 ,异长春花碱联合治疗非小细胞肺癌、乳腺癌、鼻咽癌、恶性淋巴瘤、食道癌等晚期肿瘤有较好疗效 ,且毒性可耐受 ,对晚期肿瘤患者是个很有前途的肿瘤内科治疗药物。

 
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