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nerve toxicity
相关语句
  神经毒性
    group B 26 cases, nerve toxicity of 1~3 grade occurred in 9,4,3 cases respectively ,develop ratc was 61.5%.
    3级1例,总发生率28.5%。 B组26例,发生神经毒性1级9例;
短句来源
    The diversity of the two groups’(Ⅰ,Ⅱ) perisensory nerve toxicity is also obvious. 62.9 percent toxicity group and 31.6 percent of HCPT group appear the toxicity (P< 0.05), but the diversity of adverse reaction is not obvious (P> 0.05).
    毒副反应两组Ⅰ~II外周神经毒性有显著性差异,Oxaliplatin组为62.9%,HCPT组为31.6%(P<0.05),其他毒副反应的差异无显著性(P>0.05)。
短句来源
    Clincal observation of the prevention and treatment of the nerve toxicity by combining potassium aspartate and magnesium aspartate and calcium gluconate
    门冬氨酸钾镁与葡萄糖酸钙联用防治奥沙利铂神经毒性的临床观察
短句来源
    WBC and PLT occurred in a rate of 37%? 76.6% and 33.3% respectively,side effect mostly including nausea, vomiting, constipation,bellyache, nerve toxicity,phlebitis,alopecia, skin rash, fever,oral sore of mucous membrane,damage of liver and kidney function. Conclusion A better response rate is obtained by combination chemotherapy with NVB for treating the advanced tumor,including NSCLC?
    血红蛋白减少发生率为 37% ,白细胞为 76 .6 % ,血小板为 33.3% ,恶心呕吐发生率为 70 % ,便秘为 5 6 .6 % ,腹痛为 16 .6 % ,神经毒性为 13.3% ,静脉炎为30 % ,脱发为 33.4% ,皮疹为 6 .6 % ,发热为 10 % ,口腔黏膜溃疡为 10 % ,肝功损害为 13.3% ,肾功损害为 6 .6 %。
短句来源
    The main side effects were myelosppression, GI and peripheral nerve toxicity and phlebitis.
    腺癌疗效比鳞癌稍好 ,主要毒副反应为骨髓抑制、消化道反应、周围神经毒性及静脉炎。
短句来源
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  神经毒性
    group B 26 cases, nerve toxicity of 1~3 grade occurred in 9,4,3 cases respectively ,develop ratc was 61.5%.
    3级1例,总发生率28.5%。 B组26例,发生神经毒性1级9例;
短句来源
    The diversity of the two groups’(Ⅰ,Ⅱ) perisensory nerve toxicity is also obvious. 62.9 percent toxicity group and 31.6 percent of HCPT group appear the toxicity (P< 0.05), but the diversity of adverse reaction is not obvious (P> 0.05).
    毒副反应两组Ⅰ~II外周神经毒性有显著性差异,Oxaliplatin组为62.9%,HCPT组为31.6%(P<0.05),其他毒副反应的差异无显著性(P>0.05)。
短句来源
    Clincal observation of the prevention and treatment of the nerve toxicity by combining potassium aspartate and magnesium aspartate and calcium gluconate
    门冬氨酸钾镁与葡萄糖酸钙联用防治奥沙利铂神经毒性的临床观察
短句来源
    WBC and PLT occurred in a rate of 37%? 76.6% and 33.3% respectively,side effect mostly including nausea, vomiting, constipation,bellyache, nerve toxicity,phlebitis,alopecia, skin rash, fever,oral sore of mucous membrane,damage of liver and kidney function. Conclusion A better response rate is obtained by combination chemotherapy with NVB for treating the advanced tumor,including NSCLC?
    血红蛋白减少发生率为 37% ,白细胞为 76 .6 % ,血小板为 33.3% ,恶心呕吐发生率为 70 % ,便秘为 5 6 .6 % ,腹痛为 16 .6 % ,神经毒性为 13.3% ,静脉炎为30 % ,脱发为 33.4% ,皮疹为 6 .6 % ,发热为 10 % ,口腔黏膜溃疡为 10 % ,肝功损害为 13.3% ,肾功损害为 6 .6 %。
短句来源
    The main side effects were myelosppression, GI and peripheral nerve toxicity and phlebitis.
    腺癌疗效比鳞癌稍好 ,主要毒副反应为骨髓抑制、消化道反应、周围神经毒性及静脉炎。
短句来源
更多       
  神经毒性
    group B 26 cases, nerve toxicity of 1~3 grade occurred in 9,4,3 cases respectively ,develop ratc was 61.5%.
    3级1例,总发生率28.5%。 B组26例,发生神经毒性1级9例;
短句来源
    The diversity of the two groups’(Ⅰ,Ⅱ) perisensory nerve toxicity is also obvious. 62.9 percent toxicity group and 31.6 percent of HCPT group appear the toxicity (P< 0.05), but the diversity of adverse reaction is not obvious (P> 0.05).
    毒副反应两组Ⅰ~II外周神经毒性有显著性差异,Oxaliplatin组为62.9%,HCPT组为31.6%(P<0.05),其他毒副反应的差异无显著性(P>0.05)。
短句来源
    Clincal observation of the prevention and treatment of the nerve toxicity by combining potassium aspartate and magnesium aspartate and calcium gluconate
    门冬氨酸钾镁与葡萄糖酸钙联用防治奥沙利铂神经毒性的临床观察
短句来源
    WBC and PLT occurred in a rate of 37%? 76.6% and 33.3% respectively,side effect mostly including nausea, vomiting, constipation,bellyache, nerve toxicity,phlebitis,alopecia, skin rash, fever,oral sore of mucous membrane,damage of liver and kidney function. Conclusion A better response rate is obtained by combination chemotherapy with NVB for treating the advanced tumor,including NSCLC?
    血红蛋白减少发生率为 37% ,白细胞为 76 .6 % ,血小板为 33.3% ,恶心呕吐发生率为 70 % ,便秘为 5 6 .6 % ,腹痛为 16 .6 % ,神经毒性为 13.3% ,静脉炎为30 % ,脱发为 33.4% ,皮疹为 6 .6 % ,发热为 10 % ,口腔黏膜溃疡为 10 % ,肝功损害为 13.3% ,肾功损害为 6 .6 %。
短句来源
    The main side effects were myelosppression, GI and peripheral nerve toxicity and phlebitis.
    腺癌疗效比鳞癌稍好 ,主要毒副反应为骨髓抑制、消化道反应、周围神经毒性及静脉炎。
短句来源
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  nerve toxicity
Although facial nerve palsy secondary to paclitaxel is not previously reported, other cranial nerve toxicity has been described.
      
Certain patients, however, may be at high risk for peripheral nerve toxicity due to genetic factors or another underlying neuropathy.
      


Purpose:Clinical research has been done to show whether continuous infusion of navelbine can increase curative effect and decrease toxicity.Methods:Patients studied were non operable NSCLC and recurrent or metastatic breast cancer. Navelbine is given through a catheter in the venae subclavia by continuous infusion for 24 hours. Regimen:NVB 10 mg/iv/day 1+NVB 10 mg/iv continuous infusion 24 h/day 1—5+DDP 40 mg/iv 2h/day 1—3+Gransetron 3 mg/iv day1,3,5 given every 21 days. Results:Among 47 patients 35 patients...

Purpose:Clinical research has been done to show whether continuous infusion of navelbine can increase curative effect and decrease toxicity.Methods:Patients studied were non operable NSCLC and recurrent or metastatic breast cancer. Navelbine is given through a catheter in the venae subclavia by continuous infusion for 24 hours. Regimen:NVB 10 mg/iv/day 1+NVB 10 mg/iv continuous infusion 24 h/day 1—5+DDP 40 mg/iv 2h/day 1—3+Gransetron 3 mg/iv day1,3,5 given every 21 days. Results:Among 47 patients 35 patients were NSCLC and 12 patients were breast cancer. Average age was 58.9 years. Of the NSCLC patients, 12 were squamous cell carcinoma and 23 patients were adenocarcinoma; two patients were stage Ⅱ and 19 patients stage Ⅲ, 19 patients stage Ⅳ. All of the breast cancer cases were infiltrative duct carcinoma. Three patients were stage Ⅱ and nine patients were stage Ⅳ. Of the 47 patients, 44 patients were evaluable for response and 47 patients for toxicity. Response rate of NSCLC was 57%(19 pr) and breast cancer 63% (1 cr, 6 pr). Main toxicity was granulocytopenia and vomiting. WHO Ⅲ—Ⅳ grade granulocytopenia was 40% and vomiting 6.4%. Peripheral nerves toxicity was mild and only 6.4% patients had WHO I grade peripheral sensory nerve damage. No patients had severe nerve toxicity such as enteroplegia.Conclusions:Comparison of continuous infusion Navelbine and Cisplatin with classic usage of navelbine for management of NSCLC and breast cancer showed increased response rate and decreased toxicity. Administration through catheter venae subclavia can avoid chemo phlebitis. [

目的 :临床研究去甲长春花碱 (诺维本 ,Navelbine,NVB)持续静脉输注是否可以提高疗效并减轻毒副反应。方法 :转移或复发的晚期乳腺癌以及不能手术的Ⅲ—Ⅳ期非小细胞肺癌的病人。其中去甲长春花碱的给药方式采用注射泵通过锁骨下深静脉置管进行 2 4小时持续给药。治疗方案 :NVB 10mg静脉一次推注第 1天 ,NVB10mg静脉持续滴注 2 4小时 ,第 1— 5天 ,DDP 40mg静脉滴注 2小时第 1— 3天 ,盐酸格拉司琼 3mg静脉推注第 1,3,5天。 2 1天为 1周期 ,2周期后评价疗效。结果 :47例病人中非小细胞肺癌 35例 ,乳腺癌 12例。平均年龄为 5 8.9岁。非小细胞肺癌中鳞癌病人 12例 ,腺癌病人 2 3例 ;Ⅱ期 2例 ,Ⅲ期 19例 ,Ⅳ期 14例 ;乳腺癌病人均为浸润型导管癌 ,其中Ⅲ期为 3例 ,Ⅳ期为 9例。可评价疗效病人 44例。非小细胞肺癌病人 19例达PR ,总有效率为 5 7%。乳腺癌病人 1例达CR ,6例达PR ,总有效率为 6 3%。可评价毒性反应病人 47例。主要毒性反应为白细胞下降及轻度的消化道反应。其中白细胞Ⅲ—Ⅳ度毒性达 5 1% ,粒...

目的 :临床研究去甲长春花碱 (诺维本 ,Navelbine,NVB)持续静脉输注是否可以提高疗效并减轻毒副反应。方法 :转移或复发的晚期乳腺癌以及不能手术的Ⅲ—Ⅳ期非小细胞肺癌的病人。其中去甲长春花碱的给药方式采用注射泵通过锁骨下深静脉置管进行 2 4小时持续给药。治疗方案 :NVB 10mg静脉一次推注第 1天 ,NVB10mg静脉持续滴注 2 4小时 ,第 1— 5天 ,DDP 40mg静脉滴注 2小时第 1— 3天 ,盐酸格拉司琼 3mg静脉推注第 1,3,5天。 2 1天为 1周期 ,2周期后评价疗效。结果 :47例病人中非小细胞肺癌 35例 ,乳腺癌 12例。平均年龄为 5 8.9岁。非小细胞肺癌中鳞癌病人 12例 ,腺癌病人 2 3例 ;Ⅱ期 2例 ,Ⅲ期 19例 ,Ⅳ期 14例 ;乳腺癌病人均为浸润型导管癌 ,其中Ⅲ期为 3例 ,Ⅳ期为 9例。可评价疗效病人 44例。非小细胞肺癌病人 19例达PR ,总有效率为 5 7%。乳腺癌病人 1例达CR ,6例达PR ,总有效率为 6 3%。可评价毒性反应病人 47例。主要毒性反应为白细胞下降及轻度的消化道反应。其中白细胞Ⅲ—Ⅳ度毒性达 5 1% ,粒细胞下降Ⅲ—Ⅳ度毒性达 40 %。消化道反应较为轻微 ,Ⅲ—Ⅳ度呕吐只占 6 .4%。神经毒性相当轻微 ,只有 6 .4%的病人有Ⅰ度的感觉神经损伤 ,没有病人出现如肠麻庳的严重神经毒性。结论 :去甲长春花碱持

Objective To evaluate the effect of chemotherapy mainly contained navelbine in treating advanced tumors.Methods 30 patients with advanced tumor were treated by combined chemotherapy of NVB,among whom 13 patients(accounting for 43.3%)were with NSCLC,6(20%) with breast cancer,4(13.3%)with nasopharyngeal cancer,4(13.3%) patients with NHL,3(10%) with esophageal cancer.NP regimen was applied to NSCLC?nasopharyngeal cancer and esophageal cancer,NA to the breast cancer and CHNP to the NHL respectively.Results The...

Objective To evaluate the effect of chemotherapy mainly contained navelbine in treating advanced tumors.Methods 30 patients with advanced tumor were treated by combined chemotherapy of NVB,among whom 13 patients(accounting for 43.3%)were with NSCLC,6(20%) with breast cancer,4(13.3%)with nasopharyngeal cancer,4(13.3%) patients with NHL,3(10%) with esophageal cancer.NP regimen was applied to NSCLC?nasopharyngeal cancer and esophageal cancer,NA to the breast cancer and CHNP to the NHL respectively.Results The effectiveness as well as tolerable toxicity was estimated in total 30 cases.The general effective rate was about 50%,with CR accounting for 1 case and PR for 14 cases.And decrease of HGB?WBC and PLT occurred in a rate of 37%?76.6% and 33.3% respectively,side effect mostly including nausea, vomiting, constipation,bellyache, nerve toxicity,phlebitis,alopecia, skin rash, fever,oral sore of mucous membrane,damage of liver and kidney function.Conclusion A better response rate is obtained by combination chemotherapy with NVB for treating the advanced tumor,including NSCLC?breast cancer?nasopharyngeal cancer(carcinoma)?NHL and esophageal cancer.NVB is a promising antitumor agent with tolerable toxicity.

目的 观察以异长春花碱 (NVB)为主的联合化疗方案治疗晚期恶性肿瘤的疗效。方法 共收治 30例晚期恶性肿瘤接受以NVB为主的联合化疗 ,其中非小细胞肺癌 13例 (4 3.3% ) ,乳腺癌 6例 (2 0 % ) ,鼻咽癌 4例 (13.3% ) ,恶性淋巴瘤 4例 (13.3% ) ,食道癌 3例 (10 % )。非小细胞肺癌、鼻咽癌、食道癌的化疗方案为NP ,乳腺癌为NA ,恶性淋巴瘤为CHNP。结果  30例患者可评价疗效和毒性。其中CR1例 ,PR14例 ,总有效率为 5 0 %。血红蛋白减少发生率为 37% ,白细胞为 76 .6 % ,血小板为 33.3% ,恶心呕吐发生率为 70 % ,便秘为 5 6 .6 % ,腹痛为 16 .6 % ,神经毒性为 13.3% ,静脉炎为30 % ,脱发为 33.4% ,皮疹为 6 .6 % ,发热为 10 % ,口腔黏膜溃疡为 10 % ,肝功损害为 13.3% ,肾功损害为 6 .6 %。结论 本组观察提示 ,异长春花碱联合治疗非小细胞肺癌、乳腺癌、鼻咽癌、恶性淋巴瘤、食道癌等晚期肿瘤有较好疗效 ,且毒性可耐受 ,对晚期肿瘤患者是个很有前途的肿瘤内科治...

目的 观察以异长春花碱 (NVB)为主的联合化疗方案治疗晚期恶性肿瘤的疗效。方法 共收治 30例晚期恶性肿瘤接受以NVB为主的联合化疗 ,其中非小细胞肺癌 13例 (4 3.3% ) ,乳腺癌 6例 (2 0 % ) ,鼻咽癌 4例 (13.3% ) ,恶性淋巴瘤 4例 (13.3% ) ,食道癌 3例 (10 % )。非小细胞肺癌、鼻咽癌、食道癌的化疗方案为NP ,乳腺癌为NA ,恶性淋巴瘤为CHNP。结果  30例患者可评价疗效和毒性。其中CR1例 ,PR14例 ,总有效率为 5 0 %。血红蛋白减少发生率为 37% ,白细胞为 76 .6 % ,血小板为 33.3% ,恶心呕吐发生率为 70 % ,便秘为 5 6 .6 % ,腹痛为 16 .6 % ,神经毒性为 13.3% ,静脉炎为30 % ,脱发为 33.4% ,皮疹为 6 .6 % ,发热为 10 % ,口腔黏膜溃疡为 10 % ,肝功损害为 13.3% ,肾功损害为 6 .6 %。结论 本组观察提示 ,异长春花碱联合治疗非小细胞肺癌、乳腺癌、鼻咽癌、恶性淋巴瘤、食道癌等晚期肿瘤有较好疗效 ,且毒性可耐受 ,对晚期肿瘤患者是个很有前途的肿瘤内科治疗药物。

To evaluate the short term effect of cisplatin_based combined chemotherapy NP regimen and MVP regimen for non_small cell lung cancer(NSCLC). One hundred and six cases of advanced NSCLC were treated with either vinorelbine/cisplatin (NP) (n=48) or mitomycin/vindesine/cisplatin (MVP) (n=58) regimen. In NP Group 12 cases were phase Ⅲb and 36 cases are phase Ⅳ. There were 12 cases of squamous carcinoma and 30 of adenocarcinoma and 6 of mixed type(NVB 25mg/m2 iv day 1,8; cisplatin 90mg/m2 iv infusion day 1). In...

To evaluate the short term effect of cisplatin_based combined chemotherapy NP regimen and MVP regimen for non_small cell lung cancer(NSCLC). One hundred and six cases of advanced NSCLC were treated with either vinorelbine/cisplatin (NP) (n=48) or mitomycin/vindesine/cisplatin (MVP) (n=58) regimen. In NP Group 12 cases were phase Ⅲb and 36 cases are phase Ⅳ. There were 12 cases of squamous carcinoma and 30 of adenocarcinoma and 6 of mixed type(NVB 25mg/m2 iv day 1,8; cisplatin 90mg/m2 iv infusion day 1). In MVP group 8 cases were phase Ⅲb and 50 cases are phase Ⅳ. There were 14 cases of squamous carcinoma and 36 of adenocarcinoma and 8 of mixed type(MMC 6mg/m2 iv day 1; VDS 3mg/m2 iv day1,8; cisplatin 90mg/m2 iv infusion day 1). The two regimens were given every three weeks as one cycle.Effect and toxicity were evaluated after two cycles. The response rates of NP and MVP were 37.5% and 32.1%, respectively. There were no significant difference between the two regimens (P>0.05). The response rate in adenocarcinoma was higher than that in squamous carcinoma. The main side effects were myelosppression, GI and peripheral nerve toxicity and phlebitis.[Conclusion] NP and MVP regimens maybe as the first line chemotherapy regimens for NSCLC,and also applied in the treatment of refractory advanced NSCLC and community hospitals.

[目的]评价含顺铂的联合方案NP与MVP对复治的晚期非小细胞肺癌的近期疗效。[方法]106例晚期非小细胞肺癌随机被分为两组。NP组48例 ,其中Ⅲb期12例 ,Ⅳ期36例 ,鳞癌12例 ,腺癌30例 ,鳞腺混合型6例 ,采用诺维本25mg/m2 静脉推注 ,第1,8天 ;顺铂90mg/m2 静脉滴注 ,第1天 (配合水化 )。MVP组58例 ,其中Ⅲb期8例 ,Ⅳ期50例 ,鳞癌14例 ,腺癌36例 ,鳞腺混合型8例 ,采用丝裂霉素6mg/m2 静脉推注 ,第1天 ;VDS3mg/m2 静脉推注 ,第1,8天 ;顺铂90mg/m2 ,静脉滴注 ,第1天 (配合水化 )。两方案均为每3周为1周期 ,治疗2周期后评价疗效与毒副反应。[结果]NP组有效率(RR)为37.5% ,MVP组RR为31.0% ,差异无显著性 (P>0.05)。腺癌疗效比鳞癌稍好 ,主要毒副反应为骨髓抑制、消化道反应、周围神经毒性及静脉炎。目前均能采取相应的防治措施。[结论]NP与MVP方案均为治疗非小细胞肺癌的第一线治疗方案 ,也适用于复治的晚期非小细胞肺癌 ,更适用于基层医院的治疗

 
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