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bone marrow     
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  骨髓
     A study on T cell clones from bone marrow of an aplastic anemia patient
     再生障碍性贫血骨髓T淋巴细胞克隆的研究
短句来源
     Effects of Ly49A transfected lymphocytes on experimental graft versus host disease post allogeneic bone marrow transplantation
     转移杀伤细胞抑制性受体Ly49A的淋巴细胞对异基因骨髓移植后移植物抗宿主病的作用
短句来源
     Experimental Studies and Clinical Significance of Bone Marrow Angiogenesis and Related Mechanism in Adult Patients with Acute Leukemia
     成人急性白血病患者骨髓血管新生及相关机理的实验研究和临床意义
短句来源
     Study on Homing Law of Bone Marrow Cells after Bone Marrow Transplantation in Mice
     小鼠骨髓移植后骨髓细胞回巢规律研究
短句来源
     Cloning and Characterization of Two Novel Molecules, Siglec-10 and PHDP, from Human Dendritic Cells and Bone Marrow Stromal Cells
     人树突状细胞来源的新分子Siglec-10和人骨髓基质细胞来源的新分子PHDP的克隆与功能研究
短句来源
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  骨髓细胞
     An Experimental Study on Implantation of Bone Marrow Cells into Infarct Myocardium in Rats
     骨髓细胞梗死心肌内移植的实验研究
短句来源
     Study on Homing Law of Bone Marrow Cells after Bone Marrow Transplantation in Mice
     小鼠骨髓移植后骨髓细胞回巢规律研究
短句来源
     PRELIMINARY STUTY ON IN VITRO INCORPORATION OF BONE MARROW CELLS OF ACUTE LEUKEMIA WITH ~3H-TDR
     急性白血病治疗前后骨髓细胞~3H-胸腺嘧啶核苷掺入试验的初步观察
短句来源
     Study on the Functions of Bone Marrow Cells in Benzene Poisoning
     苯中毒时骨髓细胞功能的实验研究
短句来源
     PRESERVATION OF BONE MARROW CELLS: LABORATORY STUDY AND PRELIMINARY CLINICAL APPLICATION
     骨髓细胞低温(4℃)保存的实验研究和临床初步应用
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  骨髓腔
     Methods: Whole marrow cells of donor mice C57BL/6(H-2 b)were injected directly into the tibia bone marrow of recipient BalB/c(H-2 d)mice which were lethally irradiated.
     方法:将供鼠C57BL/6(H2b)骨髓细胞经微量注射器直接注入到经致死量照射后的受鼠BalB/c(H2d)胫骨骨髓腔
短句来源
     Group A(IBM-BMT),directly inject 30 μl BMC of donor mice into the tibia bone marrow of recipient mice with a microsyringe;
     A组,IBM-BMT组,将骨髓细胞30μl经微量注射器直接注射到受鼠胫骨骨髓腔;
短句来源
     KGS could also improve the pathological changes in microstructure of bone,increase the thickness of trabecula and cortex (P <0.05) , reduce the trabecular gap and bone marrow cavity (P<0 . 05) .
     还能明显改善骨显微结构的病理变化,使骨小梁厚度(高剂量)明显增加(P<0.05),骨小梁间隙和骨髓腔明显缩小(P<0.05)。
短句来源
     Treatment of bone defects or bone unities with the free bone grafts through bone marrow cavity
     骨髓腔游离植骨治疗骨缺损和骨不连的探讨
短句来源
     The HE-staining of bone tissue revealed that bone marrow fatty tissue were extremely few in 6 month-old rats and almost filled 40% marrow cavity in 18 month-old rats (P<0.01). The fatty marrow were positively correlated with aging (r=0.762) and negatively correlated with BMD (r=-0.626) .
     骨组织HE染色,6月龄大鼠骨髓腔中脂肪极少,而在18月龄约占40%骨髓腔空间,组间比较差异有统计学意义(P<0.01),脂肪髓的发生与年龄呈正相关(r=0.762),与骨密度呈负相关(r=-0.626);
短句来源
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  将骨髓
     Objective To compare in vitro proliferation ability of bone marrow mesenchymal stem cells derived from SD rat,Wistar rat and C57BL/6J mouse and to differentiate bone marrow mesenchymal stem cells derived from SD rat into muscle-like cells.
     目的比较SD大鼠、Wistar大鼠和C57BL/6J小鼠骨髓间质干细胞在体外的增殖及在体外将骨髓间质干细胞诱导分化成肌样细胞的情况。
短句来源
     Group A(IBM-BMT),directly inject 30 μl BMC of donor mice into the tibia bone marrow of recipient mice with a microsyringe;
     A组,IBM-BMT组,将骨髓细胞30μl经微量注射器直接注射到受鼠胫骨骨髓腔;
短句来源
     In that context,efforts were made to generate natural killer (NK) cells from bone marrow byincubating with interleukin-2 (IL-2) in vitro, known as IL-2 activated bonemarrow (IL-2 ABM).
     针对上述两点,有人将骨髓置于IL-2环境中孵育以诱生并活化骨髓来源的NK细胞,称之为IL-2激活的骨髓(IL-2 ABM)。
短句来源
     Objective To compare the clinical effectiveness of treatment injured brain by transplanting NSCs induced from rat bone marrow and brain.
     目的 将骨髓来源和脑来源神经干细胞(NSCs)移植入大鼠脑损伤模型,比较两种细胞移植治疗脑外伤的效果和临床应用价值。
短句来源
     BMT can be divided into autologous or syngeneic bone marrow transplantation and allogeneic bone marrow transplantation according to bone marrow sources.
     根据骨髓来源的不同,可以将骨髓移植分为自体骨髓移植(autologous BMT)、同基因骨髓移植(syngeneic BMT)、同种异体骨髓移植(allogeneic BMT)。
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      bone marrow
    The effects of hematopoietic stem/progenitor cells (HSPCs) expanded in the two step coculture with human bone marrow mesenchymal stem cells (hMSCs) on the hematopoietic reconstruction of irradiated NOD/SCID mice were studied.
          
    Effects of malondialdehyde on growth and proliferation of human bone marrow mesenchymal stem cells in vitro
          
    Malondialdehyde (MDA) is a well known inducer of carbonyl stress in a variety of human cells, however, its effects on human bone marrow mesenchymal stem cells (hMSCs) have not been documented.
          
    In this study, murine mononuclear cells (MNCs) were isolated from bone marrow and cultured in suspension, and then Lin-CD117+ HSCs were isolated by immunomagnetic beads.
          
    Cytokines mRNA in bone marrow-derived dendritic cells in asthmatic mouse
          
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    In this paper the stimulating effects of nikethamide and cardiazol on the chemoreceptors of the carotid body,spleen,intestine and bone marrow of the tibia were studied in cats,with reflex changes in respiration and arterial blood pressure as tha indicator.The results may be summarized as follows: (1)0.2—0.4 ml of 5% nikethamide introduced into the perfusate entering the carotid sinus produced momentary respiratory inhibition.When 0.1—0.2ml of 25% were introduced,momentary inhibition,or apnea or mild stimulation...

    In this paper the stimulating effects of nikethamide and cardiazol on the chemoreceptors of the carotid body,spleen,intestine and bone marrow of the tibia were studied in cats,with reflex changes in respiration and arterial blood pressure as tha indicator.The results may be summarized as follows: (1)0.2—0.4 ml of 5% nikethamide introduced into the perfusate entering the carotid sinus produced momentary respiratory inhibition.When 0.1—0.2ml of 25% were introduced,momentary inhibition,or apnea or mild stimulation after inhibition were observed.Similar results were obtained with cardiazol. (2)0.2—0.5ml of 1—5% nikethamide or cardiazol introduced into the per- fusate entering the spleen and intestinal loop,stimulated their chemoreceptors and evoked respiratory excitation and a rise of arterial blood pressure. (3)O.1 ml of 0.1—0.2% nikethamide or cardiazol instilled into the bone mar- row of the tibia through drilled openings produced respiratory stimulation and a rise of blood pressure. (4)The excitatory effects of these drugs on the chemoreceptors described could be abolished by previous application of procaine, but they reappeared when the action of procaine was over. From the above it may be concluded that nikethamide,like cardiazol,has little stimulating action on the carotid chemoreceptors,but they stimulate the chemoreceptors of the spleen,intestine and bone marrow and cause a reflex rise of the arterial blood pressure and augmentation of respiration.

    本项工作研究了尼可刹米和卡地阿佐刺激猫的颈动脉体、脾臟、小赐和骨髓化学感受器对于呼吸血压的影响。(一)5%尼可刹米0.2—0.4毫升注入颈动脉竇灌注液内,就能作用于颈动脉体化学感受器产生暂短的呼吸抑制。25%的溶液0.1—0.2毫升,或出现暂短的呼吸抑制或暂停,或在抑制之后产生轻度的呼吸兴奋。卡地阿佐对于颈动脉体化学感受器的作用也相似地不明显:(二)2—5%尼可刹米或卡地阿佐0.2一O.4毫升注入脾臓灌注液内,能作用于脾臟 化学感受器产生呼吸兴奋与血压升高。1—2%的溶液0.4—0.5毫升洼入小肠灌注液内,产生与脾臟化学感受器完全相同的结果。(三)0.1—0.2%尼可刹米或卡地阿佐0.1毫升直接注入胫骨骨髓腔内,能作用于骨髓化学感受器而产生呼吸兴奋和血压升高(四)尼可刹米和卡地阿佐对于脾臟、小肠和骨髓化学感受器的作用,当向灌注液内注入适量的奴佛卡因时会被消除,待奴佛卡因的作用消失后,这些药物的作用又恢复。从上述结果得出结論,尼可刹米和卡地阿佐一样,对于颈动脉体化学感受器无明显作用。与此相反,它们却刺激脾臟、小肠和骨髓化学感受器产生反射性呼吸兴奋及血压升高。

    AT-290, p-bis (2-chloroethyl) aminomethyl phenylalanine, synthesized at our Institutc, is a new derivative of nitrogen mustard. Animal experiments showed that AT-290 had a significant antitumor activity. The results on toxicity and antitumor activity were as follows: 1. The acute and subacute intraperitoneal LD_(50) for mice were 4 and 1.6 mg/kg/day respectively. The subacute oral LD_(50) in mice was 11 mg/kg/day and the subacute intraperitoneal LD_(50) in rats was 1 mg/kg/day. 2. In 3 dogs, intravenous injections...

    AT-290, p-bis (2-chloroethyl) aminomethyl phenylalanine, synthesized at our Institutc, is a new derivative of nitrogen mustard. Animal experiments showed that AT-290 had a significant antitumor activity. The results on toxicity and antitumor activity were as follows: 1. The acute and subacute intraperitoneal LD_(50) for mice were 4 and 1.6 mg/kg/day respectively. The subacute oral LD_(50) in mice was 11 mg/kg/day and the subacute intraperitoneal LD_(50) in rats was 1 mg/kg/day. 2. In 3 dogs, intravenous injections of 75 γ/kg/day of AT-290 for 10 days produced no remarkable influence on the general behavior, erythrocyte, leukocyte and platelet counts, bleeding and coagulation time, urinalysis and EKG, but caused a significant lymphocytopenia in the peripheral blood. In another 6 dogs, AT-290 at the dosages of 150 and 300 γ/kg exhibited an inhibiting effect upon the bone marrow, as evidenced by a peripheral leukopenia and thrombopenia, delayed bleeding time, and hematopoitic depression in the bone marrow. The animals treated with 75 and 150 γ/kg gradually recovered after cessation of the drug, while those given 300 γ/kg died in 13—19 days. 3. AT-290 inhibited significantly the growth rate of Jensen sarcoma and fibrosarcoma M-57 in rats. Experiments on 3 ascites tumors of mice (Ehrlich ascites carcinoma, spindle cell sarcoma and mammary adenocarcinoma) showed that AT-290 significantly prolonged the survival time of the tumor-bearing mice.

    本文介绍新的氮芥衍生物 AT-290 卽对-双(β-氯乙基)氨甲基苯丙氨酸二盐酸盐的毒性试验及实验治疗的结果。 1.本药在小鼠腹腔注射的急性LD_(50)为4毫克/公斤,亚急性口服和腹腔注射的LD_(50)分别为11及1.6毫克/公斤,大鼠腹腔注射的亚急性LD_(50)为1毫克/公斤。 2.狗毒性试验证明,AT-290 在75微克/公斤静脉注射每天1次连续10天,对狗的一般状态、体重、红、白血球数、血小板数、出血时间、凝血时间、尿及心电图检查均无明显影响;但却对淋巴细胞表现出明显抑制作用。150及300微克/公斤时,可抑制动物的骨髓机能,主要表现为白血球总数及血小板减少、出血时间延长、骨髓中幼稚细胞消失,对淋巴球的作用与75微克/公斤组同。这些情况在150微克/公斤组停药后一定时间自行恢复,而大剂量组(300微克/公斤)则动物死亡。 3.本药腹腔注射时对三种小白鼠腹水型肿瘤(Ehrlich腹水癌、梭形细胞肉瘤腹水型及腹水型乳腺癌)均有明显抑制作用,可延长动物的生存时间至2倍以上,对小白鼠实体型肿瘤(淋巴白血病L-2、Ehrlich癌、Crocker肉瘤及梭形细胞肉瘤) 均无明显抑制作用。对大白鼠Jensen肉...

    本文介绍新的氮芥衍生物 AT-290 卽对-双(β-氯乙基)氨甲基苯丙氨酸二盐酸盐的毒性试验及实验治疗的结果。 1.本药在小鼠腹腔注射的急性LD_(50)为4毫克/公斤,亚急性口服和腹腔注射的LD_(50)分别为11及1.6毫克/公斤,大鼠腹腔注射的亚急性LD_(50)为1毫克/公斤。 2.狗毒性试验证明,AT-290 在75微克/公斤静脉注射每天1次连续10天,对狗的一般状态、体重、红、白血球数、血小板数、出血时间、凝血时间、尿及心电图检查均无明显影响;但却对淋巴细胞表现出明显抑制作用。150及300微克/公斤时,可抑制动物的骨髓机能,主要表现为白血球总数及血小板减少、出血时间延长、骨髓中幼稚细胞消失,对淋巴球的作用与75微克/公斤组同。这些情况在150微克/公斤组停药后一定时间自行恢复,而大剂量组(300微克/公斤)则动物死亡。 3.本药腹腔注射时对三种小白鼠腹水型肿瘤(Ehrlich腹水癌、梭形细胞肉瘤腹水型及腹水型乳腺癌)均有明显抑制作用,可延长动物的生存时间至2倍以上,对小白鼠实体型肿瘤(淋巴白血病L-2、Ehrlich癌、Crocker肉瘤及梭形细胞肉瘤) 均无明显抑制作用。对大白鼠Jensen肉瘤及纤维肉瘤M-57疗效则很显著。

    The ethyl ester of N-formyl-sarcolycine-phenylalanine (FSPA) was synthetized in this institute. At a daily dosage of 100-200 mg/kg FSPA markedly inhibited the growth of Yoshida ascites sarcoma. The intraperitoneal LD_(50) for mice was 4.5 gm/kg. When the drug was administered orally to normal monkeys at 100 mg/kg daily for 14 days, no change in blood picture or impairment of liver and kidney functions was noted. However, at 200 mg/kg FSPA showed definite inhibitory effect on the bone marrow. This compound...

    The ethyl ester of N-formyl-sarcolycine-phenylalanine (FSPA) was synthetized in this institute. At a daily dosage of 100-200 mg/kg FSPA markedly inhibited the growth of Yoshida ascites sarcoma. The intraperitoneal LD_(50) for mice was 4.5 gm/kg. When the drug was administered orally to normal monkeys at 100 mg/kg daily for 14 days, no change in blood picture or impairment of liver and kidney functions was noted. However, at 200 mg/kg FSPA showed definite inhibitory effect on the bone marrow. This compound has been recommended for clinical trial.

    N-甲酰溶肉瘤素酰苯丙氨酸乙酯(FSPA)对动物肿瘤影响的实驗,得到如下的結果:FSPA 100—200毫克/公斤/日能显著的抑制大自鼠吉田腹水肉瘤的生长.FSPA一次腹腔注射,观察二天的LD_(50)为4.5克/公斤.FSPA 100毫克/公斤/日連續14天对猴无明显毒性;200毫克/公斤/日,則对末稍血液中的白血細胞有抑制作用.

     
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