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et     
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  内皮素
     CORRELATIONS AMONG PLA2, TXA2/PGI2,FREE RADICALS AND ET IN RATS WITH CEREBRAL POSTISCHEMIC REPERFUSION
     脑缺血再灌注损伤中内皮素、自由基PLA_2、TXA_2/PGI_2的相互作用
短句来源
     Clinical study of ET_1 level in plasma from patients with diabetic retinopathy
     血浆内皮素-1与糖尿病视网膜病变发病关系的临床研究
短句来源
     Study of rotated magaetic field for phospholipase A2 (PLA2 ) and eadothelin ( ET ) during the blood reperfusion after cerebral ischemia
     旋磁场拮抗脑缺血再灌注损伤中磷脂酶A_2和内皮素作用的研究
短句来源
     Objective To observe the depressor effect of Zhenganxifeng Decoction in rats with essential hypertension and the influence on brain endothelin (ET) content and the expression of peroxisome proliferating activator receptor γ (PPARγ) mRNA.
     目的观察镇肝熄风汤对自发性高血压大鼠(SHR)的降压效果及其对血浆、脑组织中内皮素(ET)含量,脑组织中过氧化物酶体增殖物激活受体γ(PPARγ)mRNA表达的影响。
短句来源
     ③drug intervention group: 150 mg/L ox-LDL and 100 mg/L captopril were added. ADMA, nitric oxide (NO), endothim (ET), L-citorulline (L-cit) concentrations and the activity of NOS in the medium were measured after 24 h exposure. ADMA concentration in the medium was determined by high-performance liquid chromatography.
     ③ox-LDL加卡托普利组:同时加入150mg/Lox-LDL及卡托普利100mg/L,共孵24h后,检测上清液中一氧化氮(NO)、内皮素(ET)、一氧化氮合酶(NOS)活性、ADMA含量、反应DDAH酶活性的L-胍氨酸(L-cit)浓度,采用Western blot测定细胞裂解液中DDAH的蛋白表达。
短句来源
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  血浆et
     Content change of ET,CGRP in hypothalamus and plasma of spontaneously hypertensive rats.
     自发性高血压大鼠下丘脑和血浆ET、CGRP含量变化的研究
短句来源
     PLASMA ENTHETIN(ET)、TXB2、6-K-PGF(1α) LEVELS IN 52 CORONAKY ARTERY DISEASE
     冠心病患者血浆ET、TXB_2、6-K-PGF_(1α)浓度变化
短句来源
     Dynamic changes of plasma ET 1 content and myocardial contractility during early stage of burn shock
     猫烫伤休克早期血浆ET-1含量和心肌收缩性的变化
短句来源
     Results The rats in SO group experienced long-term survival and lowest levels in plasma ET,serum AMY and pathological score versus the highest levels in these indicators shown by SAP group. Both Shuangligan and Glycine treatment groups showed statistical improvement in plasma ET,serum AMY and pathological score compared with SAP group.
     结果SO组大鼠血浆ET、血清AMY、病理评分最低,长期存活,SAP组各项指标最高,双利肝和甘氨酸治疗组各项指标与SAP组相比具有统计学意义。
短句来源
     The concentration of ET,PRA and ANGⅡ decreased from 126.25±40.36 ng/L,186.32±68.74 ng/L,253.48±106.57ng/L to 84.52±28.15 ng/L,89.92±35.46 ng/L,159.65±62.42 ng/L(P<0.01) respectively.
     血浆ET、PRA、ATⅡ浓度分别为(84.52±28.15)、(89.92±35.46)、(159.65±62.42)ng/L,与术前的(126.25±40.36)(、186.32±68.74)、(253.48±106.57)ng/L比较,均P<0.01。
短句来源
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  et
     The concentration of ET 1 and TNFα in the culture medium were 1.42 pg/ml and 0.58 ng/ml respectively.
     细胞培养上清中ET1 和TNFα含量分别为1.42 pg/ml 和0 .58 ng/ml;
短句来源
     Arrhythmia score in CGRP 1200pmol/kg+ ET 1 group was lower than that in ET 1 group ( P < 0. 01) .
     CGRP1200pmol/kg+ET1组心律失常评分显著低于ET1对照组(P<0.01)。
短句来源
     Lipopolysaccharide(LPS)(5~10 mg/L) , epinephrine (EP)(10~8 mol/L) and endotheline1(ET1)(10~9~10~7 mol/L) all dosedependently elevated Adm release from normal aorta.
     脂多糖(LPS)(5~10mg/L)、肾上腺素(EP,108mol/L)和内皮素1(ET1,109~107mol/L)均可浓度依赖性刺激正常主动脉释放Adm增加。
短句来源
     Results Expression of ET 1 mRNA and TNFα mRNA from renal tubular epithelial cells was obtained (546 bp and 415 bp) respectively as well as the relevant ET 1 and TNFα proteins.
     结果 肾小管上皮细胞既有ET1mRNA和TNFαmRNA 的表达(RTPCR的扩增片段分别为546 bp 和415 bp) ,还有ET1 及TNFα的蛋白合成及分泌;
短句来源
     (1) Intracarotid administration of ET 1 (0 3 nmol/kg) increased the discharge firing rate from 17 8±1 5 to 20 9±1 4 spikes/s ( P <0 01) in 30 out of 36 RVLM neurons, while blood pressure and heart rate had no significant change.
     所得结果如下:(1)颈动脉注射ET1(03nmol/kg)时,36个单位放电中有30个放电频率由178±15升至209±14spikes/s(P<001),血压和心率则无明显变化(P>005);
短句来源
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  乙基
     N,N-Diisopropylethylamine(DIPEA) was prepared from diisopropylamine (DIPA) and diethyl sulfate (Et_2SO_4).
     以二异丙胺 (DIPA)、硫酸二乙酯 (Et2 SO4 )为原料合成N ,N 二异丙基乙基胺 (DIPEA)。
短句来源
     The complex of the EtIn(diket)2 has higher thermal stability than th at of the Et2 In(diket).
     因此,含有β-二酮基和乙基的有机铟配合物的热稳定性大小为:EtIn(β-diket)2>Et2In(β-diket).
短句来源
     Recently, Tang et al reported that compound N-(3-chloro-4-methyphenyl)-N'-{2-[({5-[(dimethylamino)-methyl]-2-furan}-methyl)-sulfanyl]ethyl}urea (CAP-1), can bind to the N-terminal domain of the HIV-1 capsid protein and inhibit capsid assembly in vitro.
     N-(3-氯-4-甲基苯基)-N’-{2-[({5-[(二甲基氨基)甲基]-2-呋喃基}甲硫基)乙基]}脲(CAP-1)在体外可以抑制HIV-1衣壳蛋白的装配,在体内具有显著的抗病毒作用。
短句来源
     The method for the synthesis of ten new phosphorodiamidoates with a general formula: EtO(R,R2N)P(O)N(CH2CO2Et)SO2C6H4X ( I ), (where R,,R2 = H and lower alkyl groups, X = Me, halogen and nitro groups) is described.
     本文报告了10种新的O-乙基-N-烷基-N′-乙氧羰基甲基-N′-苯磺酰基磷酰二胺酯类化合物EtO(R_1R_2N)P(O)N(CH_2CO_2Et)SO_2(Ⅰ)的制各方法,经~1H NMR己及元素分析证明了(Ⅰ)的结构;
短句来源
     Nine R_2 SnL_2-type(R=Et,n-Bu and Ph;HL=Benzohydroxamic acid,p-Hydro-xybenzo-hydroxamic acid and Salicylhydroxamic acid) and six [R_2Sn (L)]_2O-type diorganotin complexes have been prepared and characterized by elemental analysis,molecular weight,IR and 1 ̄H NMR spectra.
     合成了9个R_2SnL_2型(R=乙基、正丁基和苯基;HL=苯甲酰异羟肟酸,对羟基苯甲酰异羟肟酸和水杨酰异羟肟酸)和6个[R_2SnL]_2O型(R=乙基、正丁基;HL同上)二烃基锡新配合物。
短句来源
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      et
    On the basis of these solutions, two types of elliptic quantum groups have been introduced (Foda et al.
          
    Points rationnels sur les espaces homogenes et leurs
          
    Connexite et densite des representations irreductibles des groupes de surface dans le groupe general lineaire
          
    Aliasing error bounds are derived for one- and two-channel sampling series analogous to the Whittaker-Kotel'nikov-Shannon series, and for the multi-band sampling series, and a "derivative" extension of it, due to Dodson, Beaty, et al.
          
    We show that in this case any frame is a Riesz basis and our characterization of Riesz bases may be considered as a generalization of the theorems established by Coifman, et al.
          
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    This is a continuation of a previous study (Li, L. Y, et al. 1951, Fukien Agr. Jour., 12(3, 4): 107-112) on the outdoor culture of straw mushroom in Fukien. The present work includes: (1) investi- gations on the analysis of fresh Fukien grown straw mushroom, (2) isolation and culture of Volvaria esculenta and our trials in using pure-culture spawns to grow mushroom, and (3) preliminary obser- vations made on the environmental requirements of Volvaria esculcnta The results are briefly summarized as follows:...

    This is a continuation of a previous study (Li, L. Y, et al. 1951, Fukien Agr. Jour., 12(3, 4): 107-112) on the outdoor culture of straw mushroom in Fukien. The present work includes: (1) investi- gations on the analysis of fresh Fukien grown straw mushroom, (2) isolation and culture of Volvaria esculenta and our trials in using pure-culture spawns to grow mushroom, and (3) preliminary obser- vations made on the environmental requirements of Volvaria esculcnta The results are briefly summarized as follows: 1. Our analytical work shows that the straw mushroom con- tains 92. 39% water, 206. 275mg. of ascorbic acid in 100g. of fresh mushroom, 2. 6024% sugar, 2. 6603% protein, 2. 2406% oil, and 0. 9118% ash. 2. Pure cultures of Volvaria esculenta could be readily obtained by innoculation with spores from fresh unopened mushroom. Cultures grow well on potato, corn, rice and rice-kernel husk media. 3. By employing pure-culture spawns, it takes only ten days for the first appearance of mushroom after spawnning while it takes three weeks usually if mixed cultures are used instead. The total period of mushroom production is likewise prolonged by the use of pure-culture spawns. 4. Preliminary observations indicate an atmospheric tempera- ture of 70°to 80°F., and a humidity of above 80% are favorable for the growth of straw mushroom. Production of mushroom stops when the atmospheric temperature falls below 70°F. The period of outdoor culture in Fcochow is from the latter part of April till the end of October.

    本文旨在介绍草菰的营养价值,纯种培植的方法,及草菰生长状况。经分析结果,草菰的营养价值较一般蔬菜为高,尤以丙种维生素更为丰富。用纯种培植草菰较普通方法培植的不仅可以提早一半时间出菰,且产菰日期延长,菰之产量亦提高一倍。草菰生长速度从菰纽露面至菰伞平张需经过四十八小时,采为食用,以在菰疱破裂后十小时左右采收为佳。

    (1) Sodium salt of reduced codehydrogenase I has been obtained in good yield as a dry powder from codehydrogenase I by reduction with alcohol and alcohol dehydrogenase. This preparation was stable for at least 5 months when kept dry at -15℃. (2) The properties of the particle-bound codehydrogenase I cytochrome reductase system in heart muscle preparation were found to differ considerably from those of the soluble enzyme as obtained by Mahler et al. Among other things, the affinity for cytochrome c of the...

    (1) Sodium salt of reduced codehydrogenase I has been obtained in good yield as a dry powder from codehydrogenase I by reduction with alcohol and alcohol dehydrogenase. This preparation was stable for at least 5 months when kept dry at -15℃. (2) The properties of the particle-bound codehydrogenase I cytochrome reductase system in heart muscle preparation were found to differ considerably from those of the soluble enzyme as obtained by Mahler et al. Among other things, the affinity for cytochrome c of the particle-bound enzyme is much greater than the soluble enzyme. The Michaelis constant for cytochrome c of the former is only one twelfth of that of the latter.(Fig. 2A). (3) With either oxygen or excess cytochrome c as electron acceptor, it was found that the overall activity, in terms of rate of oxygen consumption or cytochrome c reduction, when both succinate and reduced codehydrogenase I were oxidized simultanously, did not represent the sum of the rates of oxidation when these two substrates were separately oxidized but equalled only the faster of the two separate oxidation rates(Fig. 5, Tables 1, 2). If 2,6-dichlorophenol indophenol was used as the electron acceptor, the overall rate of simultaneous oxidation of these two substrates was found to equal exactly the sum of the rates of separate oxidation(Table 3). (4) When either oxygen or excess cytochrome c was used as the electron acceptor, reduced codehydrogenase I and succinate each inhibited the rate of oxidation of the other(Figs 4, 6 & 7). Evidence has been presented to show that the inhibition of succinate oxidation by reduced codehydrogenase I is not due to the accumulation of oxaloacetate. (5) When malonate was also added to the reaction mixture, succinate no longer produced any inhibition of the oxidation of reduced codehydrogenase I(Fig. 8). (6) It is therefore concluded that in heart muscle preparation both succinate and reduced codehydrogenase I are oxidized by cytochrome c through a common, velocity limiting factor. This is in accordance with the view previously reached by some workers from studies on the action of certain inhibitors. However, it should be noted that in our experiments no agents which might produce any conceivable change in the colloidal structure of the enzyme system has been employed. (7) It should be emphasized that our results clearly show that great caution must be exercised in drawing conslusion on the role an enzyme might play in a complex enzyme system from studies of the properties of a solubilized enzyme. (8) It is believed that the competition of two enzyme systems for a common linking factor as demonstrated in this report has provided a new method for studies on the mutual relations of two or more enzyme systems.

    (一)本報告提供了一個從輔酶Ⅰ,用酶還原法製備還原輔酶Ⅰ的方法。我們所製得的還原輔酶Ⅰ鈉鹽乾粉,可以在低温保存數月而不被氧化。 (二)與心肌製劑中顆粒相結合的輔酶Ⅰ細胞色素還原酶系,和用乙醇抽出的水溶性的輔酶Ⅰ細胞色素還原酶的性質頗不相同。其中比較重要的不同點是對於細胞色素c的親力,前者遠大於後者,其米氏常數僅約為後者的十二分之一。 (三)用一心肌顆粒製劑作為材料,無論用氧或過量之細胞色素c作為氫受體,還原輔酶Ⅰ與琥珀酸同時氧化時的總速度,不等於二者分別氧化時速度之和,而僅等於其中氧化較快者單獨氧化時之速度。但如用[2,6]二氯靛酚作為氫受體時,二者共同氧化時之總速度完全等於二者分別氧化時速度的和。 (四)當用氧或過量之細胞色素c作為氫受體時,琥珀酸與還原輔酶Ⅰ能彼此互相抑制對方氧化的速度。有足夠的實驗材料說明,還原輔酶Ⅰ對於琥珀酸氧化的抑制,不是由於草醯乙酸聚集的緣故。 (五)如果在反應混合物中同時含有琥珀酸脫氫酶的專一抑制劑,丙二酸,則琥珀酸對於還原輔酶Ⅰ氧化作用的抑制即被解除。 (六)根據以上的實驗結果,可以認為,還原輔酶Ⅰ及琥珀酸先通過一個共同的因子與細胞色素c作用。這個共同的因子在一般情形之下,也是...

    (一)本報告提供了一個從輔酶Ⅰ,用酶還原法製備還原輔酶Ⅰ的方法。我們所製得的還原輔酶Ⅰ鈉鹽乾粉,可以在低温保存數月而不被氧化。 (二)與心肌製劑中顆粒相結合的輔酶Ⅰ細胞色素還原酶系,和用乙醇抽出的水溶性的輔酶Ⅰ細胞色素還原酶的性質頗不相同。其中比較重要的不同點是對於細胞色素c的親力,前者遠大於後者,其米氏常數僅約為後者的十二分之一。 (三)用一心肌顆粒製劑作為材料,無論用氧或過量之細胞色素c作為氫受體,還原輔酶Ⅰ與琥珀酸同時氧化時的總速度,不等於二者分別氧化時速度之和,而僅等於其中氧化較快者單獨氧化時之速度。但如用[2,6]二氯靛酚作為氫受體時,二者共同氧化時之總速度完全等於二者分別氧化時速度的和。 (四)當用氧或過量之細胞色素c作為氫受體時,琥珀酸與還原輔酶Ⅰ能彼此互相抑制對方氧化的速度。有足夠的實驗材料說明,還原輔酶Ⅰ對於琥珀酸氧化的抑制,不是由於草醯乙酸聚集的緣故。 (五)如果在反應混合物中同時含有琥珀酸脫氫酶的專一抑制劑,丙二酸,則琥珀酸對於還原輔酶Ⅰ氧化作用的抑制即被解除。 (六)根據以上的實驗結果,可以認為,還原輔酶Ⅰ及琥珀酸先通過一個共同的因子與細胞色素c作用。這個共同的因子在一般情形之下,也是這兩個酶系統的速度限制因子。應該指出在我們的實驗中,並未使用任何可能影響酶系統結構的條件,因此我們的結果是在一個比較接近於生理狀態的情形之下獲得的。 (七)應該着重指出,從本報告的結果可以看到,一個用人為的方法從複雜酶系上溶解下來的酶的性質,有時並不能代表這個酶在有組織的酶系統中的真實情况。 (八)我們相信,本報告所說明的兩酶系競爭一個共同因子的一些現象,將为研究複雜酶系之間的相互關係,提供一個新的方法。

    In continuing our work on sulfabenzothiazoles containing salt-forming groups, 2-sulfanilylamino-benzothiazole 6- and 5-(or 7-)carboxylic acids were obtained. Their sodium salts are very soluble in water and give neutral solutions. Through the same route,it failed to synthesize the corresponding 4-carboxylic acid,starting either from anthranilic acid or its ethyl ester.They did not give o-thioureidobenzoic acid or its ester,but cyclized to benzoylene thiourea(2- sulfhydryl 4-hydroxyl quinazoline).The same compound...

    In continuing our work on sulfabenzothiazoles containing salt-forming groups, 2-sulfanilylamino-benzothiazole 6- and 5-(or 7-)carboxylic acids were obtained. Their sodium salts are very soluble in water and give neutral solutions. Through the same route,it failed to synthesize the corresponding 4-carboxylic acid,starting either from anthranilic acid or its ethyl ester.They did not give o-thioureidobenzoic acid or its ester,but cyclized to benzoylene thiourea(2- sulfhydryl 4-hydroxyl quinazoline).The same compound was obtained from the hydrolysis of α-o-carboxyphenyl β-benzoyl thiourea and from the ammoniolysis of o-isothiocyanobenzoic acid. Attempt to cyclize α-o-carboxyphenyl β-benzoyl thiourea by bromine to 2- benzamido-benzothiazole 4-carboxylic acid also failed,and the desulfured cyclized compound was identified to be 2-benzoyl benzoylene urea. We have,at the same time,cleared up the diversed results of H.Rupe and G.M.Dyson et al.and identified the structure of the Douglass and Dains' compound.

    1.自对位和间位氨基苯甲酸综合了相应的具有羧基的磺胺苯并噻唑。它们的钠盐在水中溶解度极大,溶液呈中性。2.白间-硫脲基苯甲酸导出的苯并噻唑,其环化并合地位没有确定。3.自邻-氨基苯甲酸或它的乙酯依同样途径综合,得不到相应的苯并噻唑,产物是苯并嘧啶类型化合物。

     
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