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virus
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  病毒
    A Study on CTL clone with specificity of Hantaan virus nucleocapsid protein from peripheral blood of patients with HFRS
    我国疫区HFRS患者汉滩病毒核蛋白特异性CTL克隆的建立及其初步研究
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    Clinical Significance of Gene Quasispecies of Transfusion Transmitted Virus
    输血传播病毒(TTV)基因变异的临床意义
短句来源
    Expression and Immunological Characterization of the Chimeric G1S0.7 and G2S0.7 Gene of Hantaan Virus 76-118 Strain
    汉滩病毒76-118株G1S0.7和G2S0.7不同嵌合基因的表达及免疫学特性研究
短句来源
    Molecular Epidemiological Study on the Intrauterine Transmission of Hepatitis B Virus Through Placental Infection
    乙肝病毒经胎盘感染致宫内传播的分子流行病学研究
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    Use of colloidal gold probes in studies of the expression of viral antigens in the liver of individuals with chronic asymptomatic hepatitis B virus infection
    胶体金法观察慢性无症状乙型肝炎病毒感染者肝组织内病毒抗原的表达
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  肝炎病毒
    Polarized Populations and Natural Killer Cells of T Helper Cells in Patients with Chronic Hepatitis B Virus Infection
    Th细胞极化群体及自然杀伤性T细胞在慢性乙型肝炎病毒感染中的作用
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    The Inhibitor Activity of Internal Ribosome Entry Site (IRES) Specific Inhibitor RNA on Hepatitis C Virus Gene Expression in Vitro and in Vivo
    IRES特异性抑制性RNA阻断丙型肝炎病毒基因表达的研究
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    Study on Risk Factors That Affecting Intrauterine Transmission of Hepatitis B Virus
    乙型肝炎病毒宫内感染危险因素研究
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    Study on the Mechanism of Mother-to-infant Transmisson of Hepatitis B Virus
    乙型肝炎病毒母婴传播机制的初步研究
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    Inhibition of Hepatitis B Virus Expression by Multi-target Ribozymes
    多位点核酶抑制乙型肝炎病毒基因表达的研究
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  病毒性
    147 cases of cutaneous virus diseases treated with aciclovir cream
    阿昔洛韦外用治疗病毒性皮肤病147例
短句来源
    VIROLOGIC STUDY ON AN OUTBREAK OF ECHO 30 VIRUS ENCEPHALITIS IN SHANGHAI,1991
    1991年上海暴发流行病毒性脑炎的病毒学研究
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    Image Diagnosis of Virus Encephalitis (Analysis of 9 Cases Examined by CT and MRI)
    病毒性脑炎的影像学诊断(附9例CT和MR检查对比分析)
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    Establishment of seminested polymerase chain reaction for detecting Coxsackie B virus RNA and the application in clinical diagnosis of viral myocarditis
    半巢式聚合酶链反应检测柯萨奇B组病毒方法的建立及其在病毒性心肌炎诊断中的应用
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    The Imbalance of Serum IgG Subclass in Children with Coxsackie B Virus Encephalitis
    柯萨奇B组病毒性脑炎患儿血清IgG亚类水平的变化
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  “virus”译为未确定词的双语例句
    SNP Screening of Five Candidate Genes and Study of Their Genetic Association with Chronic Hepatitis B Virus Infection
    五个慢性HBV感染相关候选基因的SNP筛查及遗传易感性研究
短句来源
    In Vitro Infection of Human Trophoblasts with Hepatitis B Virus and Enhancement Effects of TNFα
    HBVF体外感染人胎盘绒毛膜滋养层细胞及TNFα的促进作用
短句来源
    Research on Early Events of Hepatitis B Virus Infection with HepG2 Cells
    HBV感染HepG2细胞早期过程研究
短句来源
    Association of Polymorphisms of TNF-α-238G/A, HLA-DRB1 and HLA-DQA1 Gene with Outcomes of Hepatitis B Virus Infection in Han Population of North China
    中国北方汉族人群TNF-α-238G/A、HLA-DRB1及HLA-DQA1基因多态性与HBV感染不同结局的关联研究
短句来源
    1. Association of Polymorphisms of TNF-α and VDR Genes and HBV Genotype with Outcomes of Hepatitis B Virus Infection in Han Population of North China 2. Genetic Polymorphisms of TNF-α, VDR and elf-2α Genes and Response to Interferon Therapy in Patients with Chronic Hepatitis B: A Pilot Sduty
    一、中国北方汉族人群TNF-α、VDR基因多态性及HBV基因型与HBV感染不同结局的关联研究 二、慢性乙肝病人干扰素治疗临床疗效与TNF-α、VDR和elF-2α基因多态性关系研究
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  virus
Human immunodeficiency virus type 1 (HIV-1) integrase is a potential target for anti-HIV therapy.
      
It is an essential enzyme required for replication of the acquired immunodeficiency syndrome (AIDS) virus.
      
Efavirenz is a trifluoromethylated inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) that shows good results in anti-HIV chemotherapy.
      
Derivatives on Herpes simplex virus type 1 (HSV-1), Mayaro virus (MAY) and vesicular stomatitis virus (VSV) were investigated.
      
Compounds 2d, 3f, 3a, and 3c exhibited antiviral activity against HSV-1, MAY, and VSV virus with EC50 values of 6.8, 2.2, 4.8, 0.52, 2.5, and 1.0.
      
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Recent studies on viral hepatitis showed that the pathogenesis and the out-come of viral hepatitis are closely related to the immunologic reactions of the patients.Since 1974 we have observed the immunologic states of normal subject, acute hepatitis, chronic hepatitis and cirrhosis with 7 different immunologic tests including those of cellular immunity, humoral immunity and auto-immunity. The results were as follows: Acute hepatitis had a relative good immunologic conditions. While that of chronic hepatitis...

Recent studies on viral hepatitis showed that the pathogenesis and the out-come of viral hepatitis are closely related to the immunologic reactions of the patients.Since 1974 we have observed the immunologic states of normal subject, acute hepatitis, chronic hepatitis and cirrhosis with 7 different immunologic tests including those of cellular immunity, humoral immunity and auto-immunity. The results were as follows: Acute hepatitis had a relative good immunologic conditions. While that of chronic hepatitis were rather complex (effect of virus, formation of antigen-antibody complex, auto immune reactions, immuno-pathologic lesions act to different extents on the mechanism and pathogenesis of chronic hepatitis.) Cirrhosis showed depression of cellular immunity and disterbances of humoral immunity.

近年来关于病毒性肝炎的研究表明,其发病机理及转归与机体的免疫反应密切相关。五年来我们应用七项免疫学检查指标(包括细胞免疫、体液免疫、自家免疫),对正常人、急性肝炎、慢性肝炎,肝硬化患者的机体免疫状态进行了观察。其结果:急性肝炎患者机体免疫状况尚好,慢性肝炎患者机体免疫情况较复杂。病毒的作用,免疫复合物的产生,自身免疫反应,免疫病理损害不同程度地参与慢性肝炎的发病;肝硬化患者是细胞免疫低下,体液免疫失调。

~3H-Tdr incorporation in lymphocyte transformation test (~3H-Tdr. LCT) with PHA as stimulating antigen was used to study the cellular immunity patterns in 90 cases of various types of viral hepatitis, 13 asymptomatic HBsAg carriers and 41 normal adults. The mean value of ~3H-Tdr. LCT in 18 cases of chronic active hepatitis, 13 carriers, and 5 gravis form were 86.9±9.3, 74.9±8.7 and 23.4±4.8, respectively. As compared with that of normal adults (105.5±10.2), there was a significant difference (p<0.01). The mean...

~3H-Tdr incorporation in lymphocyte transformation test (~3H-Tdr. LCT) with PHA as stimulating antigen was used to study the cellular immunity patterns in 90 cases of various types of viral hepatitis, 13 asymptomatic HBsAg carriers and 41 normal adults. The mean value of ~3H-Tdr. LCT in 18 cases of chronic active hepatitis, 13 carriers, and 5 gravis form were 86.9±9.3, 74.9±8.7 and 23.4±4.8, respectively. As compared with that of normal adults (105.5±10.2), there was a significant difference (p<0.01). The mean value of ~3H-Tdr. LCT in acute icteric form was significantly lower than that of acute anicteric form (p<0.05), and the mean value in the early stage of 5 acute icteric hepatitis was significantly lower than that of the late stage (p<0.01). 4 of these 5 were re-examined during the course of disease, 3 returned to normal level associated with a complete clinical recovery, the other one with persistent low level progressed into gravis form. 4 of the 5 gravis form died, the only survived patient was one whose ~3H-Tdr. LCT value returned to normal level. The results indicated that there was a positive correlation between the cellular immunologic response of the patient and the clinical manifestation and the outcome of the disease. When the individual was infected by the hepatitis virus, his cellular immunity was significantly inhibited. If the immunity was rapidly restored, the disease ended in recovery, whereas if the immunity was seriously inhibited, the patient could be prompted to death ultimately, and if inhibition of cellular immunity persisted or if the patient had pre-existing lowered cellular immunity, the test reaction would reveal a subnormal level for a long time, and a chronic form of hepatitis may develop. However, the mean value of lymphocyte transformation test presented no significent difference between the various types of hepatitis patients and the carriers. Though the erythrocyte rosette cycle formation test may also be used to study the immunity, it is not so sensitive as ~3H-Tdr. LCT.

本文报道应用植物血凝素(PHA)为刺激原的氚化胸腺嘧啶核苷掺入淋巴细胞转化试验(~3H-TdR·LCT)检测90例各型肝炎、13例无症状HBsAg携带者,以及41名正常人的细胞免疫状况,并与形态学淋巴细胞转化试验(LCT)、玫瑰花环形成试验(E·RFC)相比较.结果提示,细胞免疫状态与病情预后关系密切.机体受肝炎病毒感染后,细胞免疫受明显抑制,若能迅速恢复,则病程终止;若抑制非常严重,终将促使患者死亡;若受持续抑制或原来机体细胞免疫功能较差,长期未能恢复正常者,则导致慢性化.在各型肝炎及携带者中,LCT均值无明显差异;E·RFC的结果虽与~3H—TdR·LCT相近,但灵敏性不及后者.本文并讨论了细胞免疫增强剂的可能适应证。

A virus has been isolated by ultracentrifugation from sera of the ducks more than 2 years old. This virus is spherical in form and approximately 50 nm in diameter and shows endogenous DNA polymerase activity. The livers of the ducks showed histologically pathogenic changes parallel to the virus positive sera. By radioimmunoassay, some of the virus preparations revealed an ability of competing with the combining of HBsAg to anti-HBs. By mixing the viral preparations with anti-HBs, aggregation...

A virus has been isolated by ultracentrifugation from sera of the ducks more than 2 years old. This virus is spherical in form and approximately 50 nm in diameter and shows endogenous DNA polymerase activity. The livers of the ducks showed histologically pathogenic changes parallel to the virus positive sera. By radioimmunoassay, some of the virus preparations revealed an ability of competing with the combining of HBsAg to anti-HBs. By mixing the viral preparations with anti-HBs, aggregation was observed by electron microscopy. It is postulated that there is a class of virus associated with hepatitis and hepatoma in nature. The virus in the ducks thus obtained is possibly a member of them.

本文报告从鸭血清中分离到一种可能与鸭肝炎和肝癌有关的病毒,此病毒为直径50毫微米左右的球形颗粒,含有内源DNA聚合酶。含有病毒颗粒的肝组织都发现不同程度的病理变化。含有病毒颗粒的某些血清对HBsAg与抗-HBs的结合率有抑制作用,抗-HBs能使病毒颗粒聚集。作者提出,自然界中可能存在一类与肝炎和肝癌相关的病毒,此文报告的鸭病毒可能是这类病毒之一。

 
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