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chronic toxicity     
相关语句
  慢性毒性
     In the chronic toxicity experiment, the chickens were affected with feeding a fixed dose of azithromycin (1/20LD_(50), 1/40LD_(50), 1/80LD_(50)) .
     慢性毒性试验同样采用固定剂量(1/20LD_(50)、1/40 LD_(50)、1/80LD_(50))连续染毒法。
短句来源
     Studies on the chronic toxicity of bimolane (AT-1727)
     乙双吗啉(AT—1727)慢性毒性实验
短句来源
     Experimental Study on Chronic Toxicity of Preventive Anti Fluorine Agent(Ⅰ-1)
     预防型抗氟剂(Ⅰ型-1)慢性毒性的实验研究
短句来源
     Acute, sublethal and chronic toxicity of two representative intermediates of anthraquinone dyestuffs, 1,8-dihydroxyanthraquinone (1,8-dihAQ) and 1-aminoanthraquinone (1-aAQ), to Daphnia magna were assessed.
     实验研究了两种代表性蒽醌染料中间体(1,8-二羟基蒽醌(1,8-dihAQ)和1-氨基蒽醌(1-aAQ))对大型溞(Daphnia magna)的急性、亚致死性及慢性毒性效应。
短句来源
     In order to study the chronic toxicity of preventive anti fluorine agent(Ⅰ\|1),64 healthy Wistar rats were randomly divided into 4 groups. Group A(400 mg/kg d),B(80 mg/kg d),and C(16 mg/kg d)were treated with preventive anti fluorine agent(Ⅰ-1),and group D served as negative control.
     为探讨预防型抗氟剂 (Ⅰ型 - 1) [PAA (Ⅰ - 1) ]的慢性毒性 ,选用 6 4只健康Wistar大鼠 ,随机分成 4组 ,即A组 (4 0 0mg/kg d) ,B组 (80mg/kg d) ,C组 (16mg/kg d)和D组 (对照组 )。
短句来源
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  长期毒性
     In chronic toxicity ,Zhishixiaopitang Granule(25、12.5、6.25g/kg)was gived to rats by gavage for 32 days,the toxic affection during treatment and the recovery addition within 14 days of stopping treatment were observed.
     长期毒性实验:用枳实消痞汤颗粒(25、12.5、6.25g/kg)给大鼠连续灌服32天,停药14天,观察大鼠的生长发育、血液学和血液生化学指标、脏器系数并作组织病理学检查。
短句来源
     Multibioactive substances of Mytilus edulis L (MSM ) are active extracts from Mytilus edulis L. Their acute and chronic toxicity was studied on Kunming mice and Wistar rats.
     贻贝多活素(multibioactive substances of Mytilus edulis L,MSM)是从紫贻贝肉提取的多种活性物质。 选用昆明种小鼠和Wistar大鼠,对MSM进行了急性、长期毒性试验。
短句来源
     Acute toxiclty tests In mice given CHIMEHERB artificial skin 10. 2g/kg orally, showed no significant abnormality and chronic toxicity test in rats given CHIMEHERB artificial skin 9. 6g/kg, 2. 98g/kg, 0. 96g/kg orally, showed no significant abnormality either.
     用CHIMEHERB人工皮肤对小白鼠和大白鼠等实验动物分别以10.20g/kg,9.60g/kg,2.98g/kg和0.96g/kg的口服剂量进行了急性毒性和长期毒性试验,结果指出:对动物的行为,体重、肝、肾等内脏器官的功能未发现任何中毒现象.
短句来源
     Experimental study on chronic toxicity of Xuelian injection
     雪莲注射液长期毒性实验研究
短句来源
     The Chronic Toxicity Study on Nao Xue Kang Tablets in Rats(I) --A Observed Report on Urine and Reversible observe
     脑血康片对大鼠的长期毒性研究(I)——尿液与可逆性观察报告
短句来源
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  慢性中毒
     As the ratio of inhibition is 40—70%, it will lead fish to be subacute poisoning The result shows phosphor is not only a strong toxicant which can lead fish to be acute toxicity, but also a stable accumulatable toxicant which will destroy fish liver ceils, inhibit fish normal metabolism, poison fish nerve and thus leading fish to die by subacute toxicity and chronic toxicity.
     当抑制率为40%~70%时,即可导致鱼类亚急性中毒死亡。 结果表明:元素磷不但是一种剧毒物质,能引起鱼类的急性中毒,而且是一种稳定的可积累的毒物,它能破坏鱼类的肝细胞,抑制正常代谢,造成神经毒性,以致引起鱼类的亚急性和慢性中毒死亡。
短句来源
     Acrylonitrile,acetonitrile,NaSCN and dimethyl formadia discharged from chemical industrial plants are the hazardous and toxic organic pollutants,which will cause acute and chronic toxicity to aquatic organisms and destroy the bio-variability and functions of aquatic ecosystems.
     硫氰酸钠、二甲基甲酰胺、乙腈和丙烯腈是化工生产中排放的有毒有害污染物,会造成水生生物的急性死亡和慢性中毒,破坏水生态系统的生物多样性和功能。
短句来源
     Objective: To detect changes in cell circle of lung tissue in mice after chronically contaminated by breathing in SO2. Methods: Kunming mice were chosen to make the chronic toxicity model and assigned to be three dose groups of SO2 and one negative control group at radon.
     目的:检测小鼠吸入二氧化硫(SO2)慢性中毒后肺组织细胞周期的变化。 方法:以昆明种小鼠作为实验对象,设计SO23个剂量组和1个阴性对照组,通过动式吸入染毒,于染毒6个月后,采用流式细胞仪检测肺组织的细胞周期。
短句来源
  慢性毒性试验
     In the chronic toxicity experiment, the chickens were affected with feeding a fixed dose of azithromycin (1/20LD_(50), 1/40LD_(50), 1/80LD_(50)) .
     慢性毒性试验同样采用固定剂量(1/20LD_(50)、1/40 LD_(50)、1/80LD_(50))连续染毒法。
短句来源
     in the chronic toxicity test of Daphnia magma, the level of 1.6mg/L had affected the reproduction of Daphnia magma, and 0.8mg/L had no significant difference compared with control group;
     在21天大型蚤慢性毒性试验中,浓度为1.6mg/L时对大型蚤的繁殖产生了影响,而浓度为0.8mg/L时与对照组相比未见显著性差异;
短句来源
     To Find out the dose which is harmful with a long period contact and evaluate the contacting danger of 2,2,6,6-Tetramethyl-4-Piperidone(TMPD) to mice in vivo. Research the acute and chronic toxicity of TMPD to mice.
     为了探讨小鼠长期接触2,2,6,6-四甲基哌啶酮(TMPD)引起有害效应的剂量,以评价对其进行长期接触的危险性,对小鼠进行TMPD的急性和亚慢性毒性试验
短句来源
     PHARMACOLOGICAL STUDIES OF A LONG-ACTING ORAL CONTRACEPTIVE——COMPOUND QUINESTROL Ⅱ. SUBACUTE AND CHRONIC TOXICITY TESTS
     口服长效避孕药复方炔雌醚的药理研究——Ⅱ.亚急性和慢性毒性试验
短句来源
     An Assessment on the Safety of Cottonseed Meal from Bt-trans- genic Cotton Plant on the Chronic Toxicity Test with Carp
     转Bt-基因抗虫棉棉子安全性评价──鲤鱼慢性毒性试验
短句来源
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  chronic toxicity
The chronic toxicity of the alcoholic extract of the seeds was determined in term of its haematological and symptomatical effects on mice upon intraperitoneal injection for a period of two months.
      
This paper gives a review of the results of the study of the chronic toxicity and carcinogenicity of chemical compounds using the JSM method for automatic generation of hypotheses.
      
For analysis of the existence and degree of carcinogenicity, as well as of the class of hazard by chronic toxicity, a new version of the intelligent JSM system was used.
      
By a series of toxicological experiments, including studies on chronic toxicity, teratogenesis and reproduction, Ames' assay and carcinogenic observation, the non-effective level of tetrachlorvinphos (TCVP) was determined to be 0.15 mg/kg wt.
      
Lead-induced abnormalities in blood-brain barrier permeability in experimental chronic toxicity
      
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The root of Astragalus membranacesis Bge. is used in Chinese medicine as a cure for chronic renal edema. The present work was conducted to study its diuretic and some other related effects. A dose of 0.5 g/kg was found to have a marked diuretic action either in rats ad- ministered hypodermically or in anaesthetized dogs intravenously. Following oral ad- ministration to normal persons, it also showed a diuretic action. Such an action persisted for 7 days following a hypodermic injection into rats. No tolerance...

The root of Astragalus membranacesis Bge. is used in Chinese medicine as a cure for chronic renal edema. The present work was conducted to study its diuretic and some other related effects. A dose of 0.5 g/kg was found to have a marked diuretic action either in rats ad- ministered hypodermically or in anaesthetized dogs intravenously. Following oral ad- ministration to normal persons, it also showed a diuretic action. Such an action persisted for 7 days following a hypodermic injection into rats. No tolerance appeared on hypo- dermic injection in rats once daily for 7 days. The diuretic potency seen at 0.5 g/kg was similar to aminophyllin at 0.05 g/kg or hydrochlorothiazide at 0.2 mg/kg. The drug given intravenously or by stomach tube to anaesthetized dogs at 0.5 g/kg produced a remarkable fall of blood pressure. Repeated intravenous injection caused tachyphylaxis. A dose of 75 g/kg orally showed no toxic effect in mice. The LD_(50) in mice by in- traperitoneal injection had been found to be 40±5g/kg. No side effect in rats was found on chronic toxicity test.

给大白鼠皮下注射及麻醉狗静脉注射黄耆0.5克/公斤后,均可产生显著的利尿作用;给正常人口服0.2克/公斤后亦可产生显著的利尿作用.黄耆的利尿作用持续时间较长,给大白鼠皮下注射后,利尿作用可持续7天,连续给药7天后无耐受性.大白鼠皮下注射0.5克/公斤的利尿效价与氨茶碱0.05克/公斤及双氢氯噻嗪0.2毫克/公斤者相当.给麻醉狗静脉注射或灌胃黄耆0.5克/公斤后,均可引起明显的降压作用,重复静脉注射时出现快速耐受性.黄耆的毒性很小,给小白鼠灌胃75克/公斤无异常症状,小白鼠的半数致死量(腹腔注射)为40±5克/公斤,大白鼠慢性毒性试验未出现不良反应.

The styptic fibres are made by spinning a mixture of gelatin and a synthetic low molecular polymer. The fibres are soaked in a solution of herbal medicine. It is of good chemical stability, with broad medicinal sources and convenient for use.More than 2000 tests done in 412 experimental animals have shown that the styptic effect of the fibres are rapid and reliable. According to the method used in this paper, the average styptic time is 1.5 min. on partial splenectomy and about 4 min. on femoral arteriotomy...

The styptic fibres are made by spinning a mixture of gelatin and a synthetic low molecular polymer. The fibres are soaked in a solution of herbal medicine. It is of good chemical stability, with broad medicinal sources and convenient for use.More than 2000 tests done in 412 experimental animals have shown that the styptic effect of the fibres are rapid and reliable. According to the method used in this paper, the average styptic time is 1.5 min. on partial splenectomy and about 4 min. on femoral arteriotomy of the dogs. The examinations of acute, subacute and chronic toxicity are carried out by putting the styptic fibres in the muscles, livers, spleens and abdominal cavities of four kinds of animals. There was no systemic or local adverse reaction observed in these experimental animals. Pathological examinations under the light and electron microscopy revealed that the fibres could be digested and absorbed gradually by the organisms.

本文报告了止血纤维一些实验研究的结果。证明该药对动物脏器手术创面的止血效果迅速、可靠;对四种实验动物的局部和全身未见显著毒性作用;可以逐渐被组织消化和吸收。作者还对止血纤维的作用原理进行了初步探讨。

Since 4-(ethoxycarbophenyl) retinamide (abbr. RI)was shown to possess cancer chernopreventive activity in vivo, a comparative study of the toxicities of RI and some other retinoids was carried out. Acute toxicity tests in mice indicated that retinoic acid (5 mM/kg) may induce CNS toxicity, hair loss and death of part of the animals, but these were not seen with RI (25 mM/kg). Comparison of the subacute toxicity in mice was also studied for 2 weeks with two levels of daily oral dose. Experimental evidences indicated...

Since 4-(ethoxycarbophenyl) retinamide (abbr. RI)was shown to possess cancer chernopreventive activity in vivo, a comparative study of the toxicities of RI and some other retinoids was carried out. Acute toxicity tests in mice indicated that retinoic acid (5 mM/kg) may induce CNS toxicity, hair loss and death of part of the animals, but these were not seen with RI (25 mM/kg). Comparison of the subacute toxicity in mice was also studied for 2 weeks with two levels of daily oral dose. Experimental evidences indicated that retinoic acid, Ro 10-9359 and Ro 11-1430 at doses of 0.5 mM/kg caused serious hypervitaminosis A symptoms such as weight loss, hair loss and bone fractures. These toxic effects were not seen for Ro 43780 and 4-(hydroxycarbophenyl) retinamide (abbr. RII) at 1.5 mM/kg, but both inhibiied the increase of body weight. However, RII caused liver damage and a decrease of spermatozoa. Compound RI (2 mM/kg) caused neither hypervitaminosis A nor influence the increase of body weight. The results of subacute toxicity tests of RI and retinoic acid in rats were similar to the results obtained in mice. Chronic toxicity studies of RI and retinoic acid in mice were carried out for 3 months with daily oral administration. Differences were observed in the weight gain between the treated and control mice for RI (300mg/kg) and retinoie acid (60 mg/kg). In chronic toxicity tests of RI in dos at 60 mg/kg×2 months plus 240 mg/kg×1 month, no abnormality was observed beside occasional anorexia. These results indicate that the acute toxicity of compound RI is very low and that the subacute and chronic toxicity of RI in mice and rats are much lower than those of the other retinoids by oral administration.

本文比较了我所合成的N-(4-乙氧羰基苯基)维生素甲酰胺(简称RI)及N-(4-羧酸苯基)维生素甲酰胺(简称RII)与维生素甲酸及其已知衍生物Ro10-9359、Ro 11-1430及Ro 4-3780的毒性。维生素甲酸、Ro10-9359及Ro11-1430可引起维生素甲过多症等毒性。Ro11-1430对精子有抑制作用。Ro4-3780对动物体重增长有影响。RII可导致肝组织损伤和脂肪变性,对精子亦有抑制作用。RI比维生素甲酸、Ro10-9359及Ro11-1430剂量高达4倍以上,比Ro4-3780剂量高33%,比RII剂量高1倍仍未见明显毒性。

 
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