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hepatitis fibrosis
相关语句
  肝纤维化
     Serum markers and pathological evaluation in hepatitis fibrosis of chronic hepatitis B treated with interferon alpha
     α干扰素治疗慢性乙型肝炎肝纤维化血清标记与病理评价
短句来源
     Transforming growth factor-β1 gene polymorphisms in Caucasians and Asians with post hepatitis fibrosis
     TGF-β1基因多态性与肝炎后肝纤维化的相关性研究
短句来源
     Objective:To study the association between polymorphisms at coding region of transforming growth factor-β1 (TGF-β1) gene and post hepatitis fibrosis in Caucasians and Asians.
     目的:探讨TGF-β1基因多态性与肝炎后肝纤维化的关系。
短句来源
     Conclusion: β-carotene can prevent hepatitis fibrosis.
     结论:β-胡萝卜素对肝纤维化有预防作用。
短句来源
  肝炎纤维化
     Objective:To observe the therapeutic effect on the indexes of chronic hepatitis fibrosis with Dan-shen.
     目的 :观察丹参对慢性肝炎纤维化指标的疗效。
短句来源
     Objective To study the expression and significance of platelet derived growth factor (PDGF) and its receptor (PDGER) in liver tissues of patients with chronic hepatitis fibrosis and liver cirrhosis.
     目的 研究血小板衍生生长因子(PDGF)及受体(PDGFR)在慢性肝炎纤维化和肝硬化患者肝组织中的表达、分布和意义。
短句来源
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  hepatitis fibrosis
In early chronic HCV hepatitis (fibrosis scores F0-F2), HCV NS3 antigen localized focally to only a small number of hepatocytes.
      
Objective: To study the effect of Xuesaitong soft capsule (XST) on liver fibrosis criteria in patients with post-hepatitis fibrosis.Methods: Sixty-four patients with such fibrosis were randomly divided into the treated group and control group.
      
Clinical observation of the effect of Xuesaitong soft capsule on post-hepatitis fibrosis
      


Objective:To observe the therapeutic effect on the indexes of chronic hepatitis fibrosis with Dan-shen. Method:The patients were divided into two groups: a treatment group and a control group. And each group has 20 patients with chronic Hepatitis B. The indexes of liver function and serum fibrosis were compared between these two groups. Results: After treatment, the indexes of hepatic fibrosis of the treatment group decreased obviously. The results of the treatment group were better than...

Objective:To observe the therapeutic effect on the indexes of chronic hepatitis fibrosis with Dan-shen. Method:The patients were divided into two groups: a treatment group and a control group. And each group has 20 patients with chronic Hepatitis B. The indexes of liver function and serum fibrosis were compared between these two groups. Results: After treatment, the indexes of hepatic fibrosis of the treatment group decreased obviously. The results of the treatment group were better than that of the control group. And there was no toxic and side effect. Conclusion: Fufang Dan-shen has an obvious effect on lowering the indexes of serum fibrosis.

目的 :观察丹参对慢性肝炎纤维化指标的疗效。方法 :应用复方丹参治疗 ,分别选择20例慢性乙型肝炎 ,设置治疗组与对照组 ,对肝功能及血清纤维化指标进行对比。结果 :治疗组肝纤维化指标治疗后显著低于治疗前水平 ,治疗组疗效显著优于对照组 ,疗程中未发现毒副作用。结论 :复方丹参对改善血清纤维化指标有明显作用。

Objective To study the expression and significance of platelet derived growth factor (PDGF) and its receptor (PDGER) in liver tissues of patients with chronic hepatitis fibrosis and liver cirrhosis. Methods The expression, distribution, quantitation, and correlation of PDGF-A, PDGF-B, PDGFR-α, PDGFR-β, and α -SMA in the liver tissues were analyzed by immunohistochemical techniques in 21 patients with chronic hepatitis and 42 patients with liver cirrhosis. Results In the liver tissues of chronic hepatitis...

Objective To study the expression and significance of platelet derived growth factor (PDGF) and its receptor (PDGER) in liver tissues of patients with chronic hepatitis fibrosis and liver cirrhosis. Methods The expression, distribution, quantitation, and correlation of PDGF-A, PDGF-B, PDGFR-α, PDGFR-β, and α -SMA in the liver tissues were analyzed by immunohistochemical techniques in 21 patients with chronic hepatitis and 42 patients with liver cirrhosis. Results In the liver tissues of chronic hepatitis and liver cirrhosis, PDGF and its receptor and x-SMA mainly distributed in the fibrotic septa and the infiltration area of inflammation, particularly in branch spindle-shaped cells (activated HSC). The expression of PDGF-B and PDGFR-β was stronger than that of PDGF-A and PDGFR-α. with a significant difference between them (P<005-0.0l). The expression and distribution of α-SMA was basically identical with the expression and distribution of PDGF-A, -B and PDGFR- α,-βand quantitative analysis showed a positive correlation (r=0.606, P<0.00l). Conclusions PDGF and PDGFR play a key role in liver fibrogenesis and development. The biologic effects of PDGF are elicited through activising HSC. Inhibiting PDGF and its receptor is a new approach to the treatment of liver fibrosis.

目的 研究血小板衍生生长因子(PDGF)及受体(PDGFR)在慢性肝炎纤维化和肝硬化患者肝组织中的表达、分布和意义。方法 用免疫组织化学方法检测了21例慢性肝炎、42例肝硬化患者肝组织中PDGF—A、PDGF-B、PDGFR-α、PDGFR-β及α-平滑肌肌动蛋白(α-SMA)的表达、分布状况、定量和相关性分析。结果 慢性肝炎和肝硬化组织PDGF及其受体和α-SMA的表达主要分布于汇管区、纤维间隔和炎细胞浸润聚集区,尤其见带分支突起的梭形细胞(活化的HSC)有大量表达。PDGF-B和PDGFR-β表达分别强于PDGF-A和PDGFR-α,两组间差异有显著性(P<0.05~0.01)。α-SMA与 PDGF-A PDGF-B及PDGFR-α、PDGFR-β的表达、分布基本一致,定量分析呈正相关,相关系数分别为 0.606(P<0.001)、0.772(P<0.001)、0.684(P<0.001)、0.825(P<0.001)。结论 PDGF及其受体在肝纤维化发生发展中起重要作用,是通过活化 HSC发挥效应,研究抑制PDGF及其受体的产生和作用是防治肝纤维化的新途径。

Objective:To study the association between polymorphisms at coding region of transforming growth factor-β1 (TGF-β1) gene and post hepatitis fibrosis in Caucasians and Asians. Methods: A novel approach for analyzing the polymorphisms of TGF-β1 gene was developed by combining real time fluorescence PCR and melting curve analysis in LightCycler system. Leu10Pro(T>C),Arg25Pro(G>C) and Thr26311e(OT) of TGF-β1 were analyzed with the above mentioned approach. The TGF-β1 genotypes were determined in Caucasians(210)...

Objective:To study the association between polymorphisms at coding region of transforming growth factor-β1 (TGF-β1) gene and post hepatitis fibrosis in Caucasians and Asians. Methods: A novel approach for analyzing the polymorphisms of TGF-β1 gene was developed by combining real time fluorescence PCR and melting curve analysis in LightCycler system. Leu10Pro(T>C),Arg25Pro(G>C) and Thr26311e(OT) of TGF-β1 were analyzed with the above mentioned approach. The TGF-β1 genotypes were determined in Caucasians(210) and Asians(90) with post hepatitis fibrosis and the results were compared with those of 104 Asian normal controls and 50 Caucasian normal controls. Results: There was no gene polymorphisms at codon 25 and 263 in the Asian ancestry,which was significantly different from that of Caucasians. Meanwhile,in Asians the frequency of C at codon 10 was higher in patients with chronic hepatitis C infection(T/C =0. 444/0. 556) than in that of the controls(T/C = 0. 514/0. 486),but the difference was not statistically significant. In Caucasians,the frequencies of genetic variations at codon 10 and codon 25 in patients with chronic hepatitis C infection were closely associated with the progression of liver fibrosis (Average METAVIR-Scores). Conclusion: This study suggests that TGF-β1 polymorphisms are associated with fibrosis progression in hepatitis C in the Caucasians, while its association with liver fibrosis in Asians remains to be further confirmed.

目的:探讨TGF-β1基因多态性与肝炎后肝纤维化的关系。方法:以实时荧光PCR结合熔点曲线分析,建立可高通量检测TGF-β1编码区3个单核苷酸多态性(SNPs)位点的LightCycler方法,这3个位点分别为Leu10Pro(T>C)、Arg25Pro(G>C)、Thr263Ile(C>T),并对亚洲人群中HBV感染导致的肝纤维化患者(90例)及高加索人群中HCV感染导致的肝纤维化患者(210例)进行SNP分析,并分别与104例亚洲人群和50例高加索人群正常献血员进行比较。结果:亚洲人群中病患组与正常对照组TGF-β1编码区第25、263位氨基酸皆无基因多态性,与高加索人群的检测结果有显著差异;而亚洲人群第10位氨基酸基因多态性出现频率相对较高,病患组(T/C=0.444/0.556)较正常对照组(T/C=0.514/0.486)突变频率稍高,但无显著差异。在高加索人群HCV感染导致的肝纤维化患者中第10、25位氨基酸基因多态性出现的频率与肝纤维化发展程度(average METAVIR-Score)密切相关。结论:提示TGF-β1基因多态性与高加索人群肝炎后肝纤维化的发生具有重要相关性;与亚洲人群肝炎后肝...

目的:探讨TGF-β1基因多态性与肝炎后肝纤维化的关系。方法:以实时荧光PCR结合熔点曲线分析,建立可高通量检测TGF-β1编码区3个单核苷酸多态性(SNPs)位点的LightCycler方法,这3个位点分别为Leu10Pro(T>C)、Arg25Pro(G>C)、Thr263Ile(C>T),并对亚洲人群中HBV感染导致的肝纤维化患者(90例)及高加索人群中HCV感染导致的肝纤维化患者(210例)进行SNP分析,并分别与104例亚洲人群和50例高加索人群正常献血员进行比较。结果:亚洲人群中病患组与正常对照组TGF-β1编码区第25、263位氨基酸皆无基因多态性,与高加索人群的检测结果有显著差异;而亚洲人群第10位氨基酸基因多态性出现频率相对较高,病患组(T/C=0.444/0.556)较正常对照组(T/C=0.514/0.486)突变频率稍高,但无显著差异。在高加索人群HCV感染导致的肝纤维化患者中第10、25位氨基酸基因多态性出现的频率与肝纤维化发展程度(average METAVIR-Score)密切相关。结论:提示TGF-β1基因多态性与高加索人群肝炎后肝纤维化的发生具有重要相关性;与亚洲人群肝炎后肝纤维化发生的相关性有待进一步研究。

 
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