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insecticides    
相关语句
  杀虫剂
    Widespread investigations on resistance of Culex quinquefasciatus fo 4 insecticides were undertaken during 1978-1981 and 1992-1994 two periods in Yunnan Province.
    云南省分别在1978—1981 年和1992—1994 年间开展了致乏库蚊对杀虫剂的敏感性调查。
短句来源
    EINE ISOLIERUNDSMETHODE UND EINIGE HALBMIKROCHEMISCHEN REAKTIONEN DES INSECTICIDES DIPTEREX IN DER TOXIKOLOGISCHEN ANALYSE
    毒物分析中杀虫剂敌百虫的分离及其半微量化学鉴识法
短句来源
    A PRELIMINARY INVESTIGATION ON THE INHIBITION OF ESTERASE-ISOZYMES OF ADULT PERIPLANERA AMERICANA BY SIX INSECTICIDES
    乙酰甲胺磷等六种杀虫剂对美洲大蠊酯酶同工酶酶谱抑制试验初步探讨
短句来源
    INVESTIGATION ON THE INHIBITION OF ESTERASE-ISOZYMES OF CULEX PIPIENS PALLENS BY TWELVE INSECTICIDES
    12种杀虫剂对淡色库蚊酯酶同工酶谱抑制试验探讨
短句来源
    THE PHYSIOLOGIGAL BEHAVIOUS OF THE GERMAN COCKROACH EXPOSED WITH DRIP METHOD TO INSECTICIDES
    杀虫剂点滴处理后德国小蠊的生理行为反应
短句来源
更多       
  农药
    SYNTHESIS OF ANTIDOTES FOR ORGANOPHOSPHORUS INSECTICIDES——4-(t-BUTYL)-1-[(3-SUBSTITUTED ACYL) PYRIDINO]-METHYOXYMETHYLENE-PYRIDINIUM DIIODIDE
    有机磷农药解毒剂——4-叔丁基-1-[(3-取代酰基)吡啶基]甲氧甲基-吡啶季铵碘盐的合成
短句来源
    Effect of three organophosphorous insecticides unmetabolized and metabolized by S9 on lymphocyte proliferation
    三种有机磷农药和经S9代谢后对淋巴细胞转化的影响
短句来源
    Ten bis-pyridinium salts as antidotes for organophosphorus insecticides were synthesized. A by-product with melting point of 135℃ was obtained during the preparation of intermediate 4-(1,1-dimethylethyl) pyridine (2) and its chemical structure was proved to be 2-(4-pyridyl)-propanol-2 (5) by means of IR, NMR, MS and elemental analysis. A possible mechanism was suggested.
    为了寻找有机磷农药解毒剂,合成了10个未见文献报道的双吡啶季铵盐化合物,Ⅰ_(1~100)制备中间体4-叔丁基吡啶(2)时,得一副产物,熔点135℃,通过光谱测定,确定其结构为2-(4-吡啶基)-丙醇-2。
短句来源
  杀虫剂
    Widespread investigations on resistance of Culex quinquefasciatus fo 4 insecticides were undertaken during 1978-1981 and 1992-1994 two periods in Yunnan Province.
    云南省分别在1978—1981 年和1992—1994 年间开展了致乏库蚊对杀虫剂的敏感性调查。
短句来源
    EINE ISOLIERUNDSMETHODE UND EINIGE HALBMIKROCHEMISCHEN REAKTIONEN DES INSECTICIDES DIPTEREX IN DER TOXIKOLOGISCHEN ANALYSE
    毒物分析中杀虫剂敌百虫的分离及其半微量化学鉴识法
短句来源
    A PRELIMINARY INVESTIGATION ON THE INHIBITION OF ESTERASE-ISOZYMES OF ADULT PERIPLANERA AMERICANA BY SIX INSECTICIDES
    乙酰甲胺磷等六种杀虫剂对美洲大蠊酯酶同工酶酶谱抑制试验初步探讨
短句来源
    INVESTIGATION ON THE INHIBITION OF ESTERASE-ISOZYMES OF CULEX PIPIENS PALLENS BY TWELVE INSECTICIDES
    12种杀虫剂对淡色库蚊酯酶同工酶谱抑制试验探讨
短句来源
    THE PHYSIOLOGIGAL BEHAVIOUS OF THE GERMAN COCKROACH EXPOSED WITH DRIP METHOD TO INSECTICIDES
    杀虫剂点滴处理后德国小蠊的生理行为反应
短句来源
更多       
  杀虫剂
    Widespread investigations on resistance of Culex quinquefasciatus fo 4 insecticides were undertaken during 1978-1981 and 1992-1994 two periods in Yunnan Province.
    云南省分别在1978—1981 年和1992—1994 年间开展了致乏库蚊对杀虫剂的敏感性调查。
短句来源
    EINE ISOLIERUNDSMETHODE UND EINIGE HALBMIKROCHEMISCHEN REAKTIONEN DES INSECTICIDES DIPTEREX IN DER TOXIKOLOGISCHEN ANALYSE
    毒物分析中杀虫剂敌百虫的分离及其半微量化学鉴识法
短句来源
    A PRELIMINARY INVESTIGATION ON THE INHIBITION OF ESTERASE-ISOZYMES OF ADULT PERIPLANERA AMERICANA BY SIX INSECTICIDES
    乙酰甲胺磷等六种杀虫剂对美洲大蠊酯酶同工酶酶谱抑制试验初步探讨
短句来源
    INVESTIGATION ON THE INHIBITION OF ESTERASE-ISOZYMES OF CULEX PIPIENS PALLENS BY TWELVE INSECTICIDES
    12种杀虫剂对淡色库蚊酯酶同工酶谱抑制试验探讨
短句来源
    THE PHYSIOLOGIGAL BEHAVIOUS OF THE GERMAN COCKROACH EXPOSED WITH DRIP METHOD TO INSECTICIDES
    杀虫剂点滴处理后德国小蠊的生理行为反应
短句来源
更多       

 

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  insecticides
The molecular design, synthesis and optimization of lead compounds are important to the development of insecticides.
      
The preparation is compatible with insecticides (carbofos, vismetrin, talstar, and applaud) and certain fungicides (such as baitan).
      
Effects of p-Nitrophenol and Organophosphorous Nitroaromatic Insecticides on the Respiratory Activity of Free and Immobilized Ce
      
Improving the Selectivity of the Determination of Organophosphorus Insecticides and Carbamates by Enzyme Assay
      
The structures, properties, methods of chemical synthesis, and insect hormonal activities of insecticides of a new 1-alkyl-1,2-diacylhydrazine series are reviewed.
      
更多          


Zum toxikologischen Nachweis des Insecticides Dipterex in dem biologischen Material werden eine Isolierungsmethode und einige halbmikrochemischen Reaktionen angegeben. Dipterex wird dutch Wasserdampfdestillation aus biologischem Material isoliert. Im Destillat wird Dipterex durch Behandeln mit alkoholischer Kaliumhydroxydlosung in O,O-Dimethyl-2,2-dichlorvinylphosphat bzw. Dichloracetaldehyd, Methylalkohol und Phosphat hydrolysiert. Das entstehende Dichloracetaldehyd, das fur Dipterex ziemlich spezifisch...

Zum toxikologischen Nachweis des Insecticides Dipterex in dem biologischen Material werden eine Isolierungsmethode und einige halbmikrochemischen Reaktionen angegeben. Dipterex wird dutch Wasserdampfdestillation aus biologischem Material isoliert. Im Destillat wird Dipterex durch Behandeln mit alkoholischer Kaliumhydroxydlosung in O,O-Dimethyl-2,2-dichlorvinylphosphat bzw. Dichloracetaldehyd, Methylalkohol und Phosphat hydrolysiert. Das entstehende Dichloracetaldehyd, das fur Dipterex ziemlich spezifisch ist, wird durch Reduktion mit Zink und Schwefelsaure in Acetaldehyd ubergefuhrt und als solch mit Jona's Methode in Mikroform nachgewiesen. Das gleichzeitig gebildete Methanol wird durch Behandeln mit Kaliumpermanganat in Formaldehyd oxydiert und mit Chromotropsaure gepruft. In Verbindung mit den Proben der anderen 2 Komponenten, namlich organisch gebundenes Phosphors und Chlors, kann in der toxikologischen Analyse bei dem positiven Ausfall der Reaktionen aller oben erwahnten Komponenten als sicher positiven Befund fur Dipterex gehalten werden.

提出敌百虫在毒物分析上从食物中或其他复杂的生物性检体中分离的方法,以及几个新的半微量化学鉴別方法。敌百虫通过用酒精性氫氧化鉀水解的作用,生成的二氯乙醛,用硫酸及鋅还原,发生乙醛,同时敌百虫构造上的两个甲氧基也被水解,生成甲醇,氧化后变为甲醛,試驗乙醛及甲醛的反应,同时結合磷酸根及有机氯的反应,間接証明敌百虫的存在。

Dipterex is an organophosphorus insecticide, characterized by its anticholinesterase property. The present study is concerned with its toxicity and experimental therapy for schistosomiasis japonica, as well as the antidotal effects of atropine and PAM. The intragastric and subcutaneous LD_(50) of dipterex in mice were found to be 0.8 and 0.6 g/kg, respectively. In mice, concomitant injections of atropine and PAM 1/2 hour prior to dipterex yielded a better detoxicating effect than either antidote given...

Dipterex is an organophosphorus insecticide, characterized by its anticholinesterase property. The present study is concerned with its toxicity and experimental therapy for schistosomiasis japonica, as well as the antidotal effects of atropine and PAM. The intragastric and subcutaneous LD_(50) of dipterex in mice were found to be 0.8 and 0.6 g/kg, respectively. In mice, concomitant injections of atropine and PAM 1/2 hour prior to dipterex yielded a better detoxicating effect than either antidote given alone. Rabbits receiving dipterex 30 or 60 mg/kg/day by stomach tube for 2 weeks showed a 70%-inhibition of plasma cholinesterase. Monkeys were daily fed dipterex, the dosage of which being started from 4 mg/kg and increased by 4 mg/kg successively each day. On the 6th day the monkeys refused food and the cholinesterase activity was depressed markedly. They collapsed on the 7th day, but recovered 5 days after discontinuance of dipterex. Mice infected with Schistosoma japonicum were fed dipterex 0.2 g/kg/day for 2 weeks. The average number of worms remained in each mouse of the treated group was found to be 13± 5, and that of the control group 24±6. The difference was highly significant. Infected rabbits receiving daily 30 mg/kg intragastrically or 40 mg/kg hypodermically for 2 weeks also showed a reduction of the number of helminths. Five infected dogs were daily fed dipterex for 2 weeks. All the fecal examinations for ova became no longer positive. After a holding period of 2 weeks, the average number of worms remained in each dog was reduced to 8±9, whereas that of the 6 control dogs was 47±29. The difference was significant. During the course of treatment in dogs, there appeared no conspicuous alterations in serum BSP retention and blood picture. The plasma cholinesterase activity fell to 25% of the original level, and restored to 75% subsequent to a 2-week holding period. The combined therapy with dipterex and tartar emetic resulted in a better effect than either drug alone. Atropine and PAM did not attenuate the therapeutic efficacy of dipterex. In conclusion, definite therapeutic action of dipterex for schistosomiasis japonica was revealed. It is cheap and can be taken by mouth. Despite certain toxic reactions, dipterex has surely opened up a new terrain for searching non-antimonial remedies.

敌百虫是有机磷杀虫剂,又是胆碱酯酶抑制剂。本文試驗动物內用敌百虫的毒性和对日本血吸虫病的疗效,以及阿託品和PAM对敌百虫毒性与疗效的影响。小白鼠灌胃和皮下注射敌百虫1次的LD_(50)分別为0.8和0.6克/公斤。小白鼠在服敌百虫前30分钟注射阿託品和PAM的解毒效能比单用阿託品或单用PAM为佳。家兔每天灌胃30或60毫克/公斤共2周,抑制血浆胆碱酯酶活力70%左右。猴子灌胃剂量从4毫克/公斤开始,逐日递增4毫克/公斤,至第6天不食,胆碱酯酶活力也明显受到抑制,第7天躺臥不动,停药5天后恢复。小白鼠每天灌胃敌百虫200毫克/公斤,經2周后平均每鼠余存虫13±5条,和对照组24±6条相差非常显著.兔每天灌胃30毫克/公斤或皮下注射40毫克/公斤历2周后虫数也有减少.狗口服敌百虫2周后粪便转为阴性.然后停药2周解剖,平均每狗余存虫8±9条,比对照组6狗平均47±29条显著减少。在病狗治程中,血清磺溴酞钠存留率与血象无明显改变,血浆胆碱酯酶活力降为原来水平的25%左右.停药2周后恢复至原来水平的75%左右。敌百虫与吐酒石合并使用比单独应用一药治疗的效果要更好。阿品及PAM并不减弱敌百虫的疗效。敌百虫对动物的日本血吸...

敌百虫是有机磷杀虫剂,又是胆碱酯酶抑制剂。本文試驗动物內用敌百虫的毒性和对日本血吸虫病的疗效,以及阿託品和PAM对敌百虫毒性与疗效的影响。小白鼠灌胃和皮下注射敌百虫1次的LD_(50)分別为0.8和0.6克/公斤。小白鼠在服敌百虫前30分钟注射阿託品和PAM的解毒效能比单用阿託品或单用PAM为佳。家兔每天灌胃30或60毫克/公斤共2周,抑制血浆胆碱酯酶活力70%左右。猴子灌胃剂量从4毫克/公斤开始,逐日递增4毫克/公斤,至第6天不食,胆碱酯酶活力也明显受到抑制,第7天躺臥不动,停药5天后恢复。小白鼠每天灌胃敌百虫200毫克/公斤,經2周后平均每鼠余存虫13±5条,和对照组24±6条相差非常显著.兔每天灌胃30毫克/公斤或皮下注射40毫克/公斤历2周后虫数也有减少.狗口服敌百虫2周后粪便转为阴性.然后停药2周解剖,平均每狗余存虫8±9条,比对照组6狗平均47±29条显著减少。在病狗治程中,血清磺溴酞钠存留率与血象无明显改变,血浆胆碱酯酶活力降为原来水平的25%左右.停药2周后恢复至原来水平的75%左右。敌百虫与吐酒石合并使用比单独应用一药治疗的效果要更好。阿品及PAM并不减弱敌百虫的疗效。敌百虫对动物的日本血吸虫病确有疗效,价格低廉,且可口服,为找寻有效的非锑剂开辟了新的途径。

The stimulation and inhibition of pentobarbital biotransformation in mice and rats by a series of chemical agents have been reported in a previous communication. This paper reports the effects of two insecticides, technical DDT and γ-hexachlorocyclohexane (666), on the hepatic pentobarbital metabolism. Prior (2 hours) treatment of mice and rats with DDT (100 mg/kg, P. O.) or 666 (25 mg/kg) confers prolongation of pentobarbital sleeping time upon these animals. This effect is believed to be attributable...

The stimulation and inhibition of pentobarbital biotransformation in mice and rats by a series of chemical agents have been reported in a previous communication. This paper reports the effects of two insecticides, technical DDT and γ-hexachlorocyclohexane (666), on the hepatic pentobarbital metabolism. Prior (2 hours) treatment of mice and rats with DDT (100 mg/kg, P. O.) or 666 (25 mg/kg) confers prolongation of pentobarbital sleeping time upon these animals. This effect is believed to be attributable to alteration of pentobarbital metabolism rather than the central action of these insecticides. In spite of the lower ED_(50) (dose of pentobarbital for 50% of animals to lose righting reflex) of pentobarbital for the treated mice, these mice woke up at the same brain levels of the hypnotic as the untreated controls. One hour after intravenous administration of pentobarbital, the tissue levels of both the DDT and the 666 treated mice were much higher than the control animals. In vitro experiments employing liver slices or 9000g supernatant of liver homogenate also indicated that the hepatic pentobarbital metabolism was lowered by pretreatment with DDT or 666. Further experiments indicate that when the interval between the administration of the insecticides and the barbiturate in rats was prolonged to 48 hours, however, the duration of the pentobarbital narcosis was shortened. It appears that the effect of these two insecticides on pentobarbital sleeping time is actually biphasic in rats. In mice, the effect of 666 was found to be biphasic, while DDT exhibited predominantly the inhibitory phase. Repeated administrations of DDT (20mg/kg) or 666 (10 mg/kg) to rats also caused shortening of the duration of pentobarbital action and this appeared to be attributable to an increase in liver weight in addition to an enhancement of the activity of the hepatic drug metabolizing enzymes. In rats chronically treated with DDT, prior phenobarbital administration shortened the pentobarbital sleeping time still further, while in rats treated with 666 chronically, phenobarbital failed to affect the duration of pentobarbital action. Both DDT and 666 treatment markedly increased the urinary excretion of ascorbic acid in rats. In this aspect, the effect of a single dose (25mg/kg, p. o.)of 666 lasted more than 25 days, while the effect of a dose of DDT (50 mg/kg) disappeared the next day.

滴滴涕和六六六对大鼠肝脏转化戊巴比妥的作用都是双相的,卽先抑制而后刺激;对小鼠的作用,六六六是双相的,滴滴涕则只有抑制相,连续多次给与滴滴涕和六六六的所以能缩短大鼠戊巴比妥睡眠时间,除刺激药物转化酶外,部分由于肝脏重量的增加。苯巴比妥能进一步缩短滴滴涕处理大鼠的戊巴比妥睡眠时间,而对六六六处理动物则无明显影响。六六六和滴滴涕都能使大鼠尿中的维生素C排泄增加。

 
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