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abnormal immunity
相关语句
  免疫异常
    These results strongly suggest that the abnormal immunity involved in the liver cell necrosis in the model.
    上述结果说明此模型与免疫异常有着密切关系,是研究肝坏死免疫发生机理的较理想模型。
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  abnormal immunity
Thus, considerable work remains to be done in determining the nature and cause of abnormal immunity in MCNS prior to investigating its potential role in the pathogenesis of proteinuria.
      
In addition to abnormal immunity, oxidative imbalance possibly existed in MAIDS model, as lipid peroxide increased significantly in spleen and whole blood glutathione peroxidase (GSH-Px) activity decreased markedly.
      
Unusual organisms, or unusual presentations, may prompt the clinician to look for evidence of abnormal immunity.
      


With human chromosomes,as antigen,anti—human—chromosome antibodies (AhChrA)were detected specifically from SLE patients sera by the methods of immunogold—silver staining(IGSS)and immnuofluorescenee tese (IFT)。To SLE,the sensitivity and specificity of serumAhChrA was 58.1%and98.5%respeetively in IGSS,34.9%and99.5%respectively in IFT。Boththe incidence and titer of AhChrA were found to be colsely related to the pathoactivity and thedamages of some important organs or tissues,such as kidney damage,abnormal immunity...

With human chromosomes,as antigen,anti—human—chromosome antibodies (AhChrA)were detected specifically from SLE patients sera by the methods of immunogold—silver staining(IGSS)and immnuofluorescenee tese (IFT)。To SLE,the sensitivity and specificity of serumAhChrA was 58.1%and98.5%respeetively in IGSS,34.9%and99.5%respectively in IFT。Boththe incidence and titer of AhChrA were found to be colsely related to the pathoactivity and thedamages of some important organs or tissues,such as kidney damage,abnormal immunity andhematocytopenia.A preliminary analysis of the antigen components reacting to AhChrA was alsoperformed。

以人染色体为抗原,用免疫金银染色(IGSS)与免疫荧光试验(IFT)相对照,自SLE 患者血清中检出抗人全染色体抗体(Ah ChrA)。其对SLE 的敏感性和特异性,IGSS 法分别为58.1%和98.5%,IFT 法分别为34.9%和99.5%;其阳性率及滴度与SLE 活动及肾损、免疫功能异常等密切相关。对与该抗体起反应的抗原成份亦进行了初步分析。

In present studies, we established the model of massive liver cell necrosis in mice which were injected with propionibacterium acnes (P. acnes) and subsequently 7 days later with a small dose of lipopolysaccharide-endotoxin (LPS). The findings were as follows:①The mortality was 83% after 24 h of the injection of LPS in the model. The infiltration of mononuclear cells and massive liver cell necrosis were found in the liver lobules. ②The proliferative spleen cells of P. acnes treated-mice responding to PHA or...

In present studies, we established the model of massive liver cell necrosis in mice which were injected with propionibacterium acnes (P. acnes) and subsequently 7 days later with a small dose of lipopolysaccharide-endotoxin (LPS). The findings were as follows:①The mortality was 83% after 24 h of the injection of LPS in the model. The infiltration of mononuclear cells and massive liver cell necrosis were found in the liver lobules. ②The proliferative spleen cells of P. acnes treated-mice responding to PHA or ConA were significantly lower than that of control mice,③The productions of tumor necrosis factor and interleukinlin the supernates of culture of Kupffer cell dissociated P. acnes treated-mice were significantly higher than that of control mice.④Influences of interleukin-2 enhancing proliferative spleen cells dissociated P. acnes treated-mice responding to PHA were not found. These results strongly suggest that the abnormal immunity involved in the liver cell necrosis in the model.

本研究利用丙酸杆菌和内毒素建立了肝坏死动物模型。其结果:①24小时死亡率为83%(20/24)。肝组织学检查所见肝小叶中有大量单核吞噬细胞浸润,并出现大片肝坏死;②脾细胞对PHA和ConA反应明显降低;③肝枯否氏细胞肿瘤坏死因子和白细胞介素1生成能明显增高;④白细胞介素2不能调节脾细胞对PHA的反应。上述结果说明此模型与免疫异常有着密切关系,是研究肝坏死免疫发生机理的较理想模型。

 
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