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clinical
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  临床
    Effect of homoharringtonine on apoptosis in leukemic cells,related mechanism and clinical significance
    高三尖杉酯碱诱导原代白血病细胞凋亡、相关机理及临床意义
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    A Clinical Review of Lymphatic Metastasis of Oral SCC and a Study of Cancer's Impacts on Lymphangiogenesis
    口腔癌淋巴转移规律临床回顾及肿瘤对淋巴管生成作用研究
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    CLINICAL STUDY ON LOCAL IMMUNE RESPONSE TO ULTRASONICALLY GUIDED SUPERANTIGEN INJECTION WITH MICROWAVE COAGULATION THERAPY FOR LIVER CANCER AND ITS RELATION WITH PROGNOSIS
    超声引导超抗原瘤区注射协同微波治疗肝癌后局部免疫应答与预后关系的临床研究
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    Value of ~(18)FDG-PET in the diagnosis of lung cancer and expression and clinical significance of glucose transporter 1 in lung cancer
    18FDG-PET在肺癌诊断中的价值和GLUT1在肺癌细胞中的表达及其临床意义的相关研究
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    The Experimental Studies and Clinical Application of Transplantation of Microencapsulated Bovine Chromaffin Cell for Pain Treatment
    微囊嗜铬细胞移植治疗疼痛的实验研究和临床应用
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    p16 Methylation of Lung Cancer and Its Clinical Significance for the Early Diagnosis of Lung Cancer
    肺癌p16基因甲基化改变及对肺癌早期诊断的价值
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    Clinical Significance of Molecular Diagnosis of Micrometastatic Tumor Cells in Lymph Nodes in the Surgical Treatment of Patients with Stage Ⅰ Non-small Cell Lung Cancer
    Ⅰ期非小细胞肺癌淋巴结微转移分子诊断在肺癌外科治疗中的作用
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    The Prepration of ~(99)T_c~m-octreotide and Clinical Diagnostic Application of ~(99)T_c~m-octreotide Scintigraphy in Tumour
    ~(99)T_c~m-奥曲肽的制备、纯化、鉴定及~(99)T_c~m-奥曲肽显像技术在肿瘤诊断中的应用
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    The Expression and Clinical Significance of Hypoxia Induced Factor 1α and Glucose Transporters 1 in Lung Cancer Tissues
    低氧诱导因子1α和糖转运蛋白1在肺癌组织中的表达及其意义的研究
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    PTEN Regulates the Expression of Pleiotrophin and Their Clinical Implications in Breast Cancers of Chinese Patients
    肿瘤抑制基因PTEN调控Pleiotrophin的表达及与乳腺癌关系的研究
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  clinical
Guanidine-type compounds that reached clinical status include amongst others the potassium channel opener, pinacidil and the histamine H2-receptor antagonists (e.g.
      
(ii) Other compounds have proceeded through preclinical and/or clinical development: CXCR4 antagonists (i.e.
      
(iii) Yet other compounds, acting by novel mechanisms, have recently been identified as anti-HIV agents that seem worthy of further (pre)clinical development: cell receptor CD4 downmodulators (i.e.
      
PRE-CLINICAL AND CLINICAL PHARMACOKINETICS OF THE DIASTEREOMERS OF ARTEETHER, A POTENT ANTIMALARIAL
      
Pre-clinical studies were carried out (N=3) by oral, intramuscular and intravenous routes, while clinical studies (N=13) were performed intramuscularly.
      
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This paper reports the results of the clinical use of Corydalis B as an analgesic in 72 patients with various forms of pain. In 64 cases the drug was used in a single dose, usually of 75 mg. by oral route, while in the other 8 cases repeated doses were given orally over a period of 3 to 21 days. The pain was completely abolished or definitely improved in 50 cases (78.1%) of the former group and in all 8 cases of the latter group. The analgesic effect appeared to be most marked in medical cases with dull...

This paper reports the results of the clinical use of Corydalis B as an analgesic in 72 patients with various forms of pain. In 64 cases the drug was used in a single dose, usually of 75 mg. by oral route, while in the other 8 cases repeated doses were given orally over a period of 3 to 21 days. The pain was completely abolished or definitely improved in 50 cases (78.1%) of the former group and in all 8 cases of the latter group. The analgesic effect appeared to be most marked in medical cases with dull pain in the chest or abdomen, as in cases of peptic ulcer and lobar pneumonia. Drowsiness was found as a side-effect in 28% of the cases after a single dose of the drug and in 6 of the 8 cases treated with repeated doses. In no case was any serious toxic action noted. According to the preliminary Observations herein reported, further clinical trial with the use of Corydalis B as an analgesic agent seems warranted.

本文报告72例试用延胡索素乙硫酸盐作为鎮痛剂的临床观察,其中64例为单剂用药,主要为一次口服75毫克,另8例为长期口服。单剂用药64例中完全止痛及疼痛减轻者共50例,占78.1%,长期服药8例均有效,鎮痛作用在内科胸腹部鈍痛病例较著。用药后未見重要副作用,单剂用药者28%发生嗜睡。长期用药的8例中6例有嗜睡,血与尿常規、大便次数、血压、心率等均无明显改变。据本文病例的初步临床应用结果,延胡索素乙对钝痛有一定的镇痛效果值,得进一步试用。

In 1976, we successfully installed a 300w Carbon Dioxide Vaporization Laser Unit. Animal experiments showed that squamous ceil carcinoma, adenocarcinoma and melanoma can be instantaneously vaporized or carbonized on application of a laser beam of 170w or above with a beam-diameter of 1 cm, passing through beam manipulator. After vaporization an analysis of the carbonized tissue showed remnants of some intact cancer cells, which were found to have lost their vitality to regrow under tissue culture. Basing on...

In 1976, we successfully installed a 300w Carbon Dioxide Vaporization Laser Unit. Animal experiments showed that squamous ceil carcinoma, adenocarcinoma and melanoma can be instantaneously vaporized or carbonized on application of a laser beam of 170w or above with a beam-diameter of 1 cm, passing through beam manipulator. After vaporization an analysis of the carbonized tissue showed remnants of some intact cancer cells, which were found to have lost their vitality to regrow under tissue culture. Basing on these findings, we began to conduct clinical application.From 1976 to 1977 we used the 300wsustained Carbon Dioxide Laser beam for treatment of 30 cases of malignant growths on the head and face. Of these 30 cases, 23 of them who had had surgical treatment, chemotherapy and/or radiation therapy previously without any improvement were all considered as failures. The follow-up results showed that 12 of these 23 cases had no relapse and were in sound health 1 to 2 years after laser treatment, 3 of them recurred and 8 of them died of metastases. In view of these preliminary results, we consider that the use of laser vaporization for treatment of malignant growths appears to be promising and worthy of further investigation.

本室自1976年至1977年间开始应用300瓦连续波CO_2激光汽化治疗以头面部为主的恶性肿瘤30例。大部属于用常规放射疗法、化学疗法(以下简称放疗、化疗)或手术无效病例。用本法探索,收到一定疗效。从本文资料来看,激光汽化作用对恶性肿瘤是一种有前途的治疗方法,值得进一步探索。

Five cases of primary leiomyosarcoma in the oral and maxillo-facialregions were presented. The diagnosis of all the five cases was made byhistologic examination. The author described in detail in clinical andhistologic characteristics of the tumour; and, along with a review ofthe literature, a brief discussion on its occurrence、biological characteri-stics and prognosis was given.

本文报导了5例罕见且经病理检查证实的原发于口腔及颌面部的平滑肌肉瘤,结合国内外文献复习对其发病、生物学特性及预后等进行了简要讨论。

 
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