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 Conclusion The pENTRTM/U6-p498 siRNA expression vector can specifically and efficiently inhibit 4-1BB gene expression,which may provide a foundation to construct 4-1BB Lentivirus and study 4-1BB gene function in mouse T lymphocytes. 其余siRNA载体,几乎无干扰效应,与无关干扰组比较,差异无统计学意义(P>0.05)。 结论我们所构建的p498 siRNA真核表达载体,能明显干扰m4-1BB蛋白的瞬时表达,可望用于m4-1BB Lentivirus干扰表达系统的构建,进一步在小鼠原代T淋巴细胞内实现高效4-1BB表达沉默,以深入研究4-1BB对T淋巴细胞的生物学影响。 短句来源 Conclusions These scaffolds may provide a framework for PH domain, which may play an important role in the structure of 17 PH domains. 结论在这17个PH结构域中存在由保守氨基酸残基构成的框架结构。 短句来源 Conclusion The expression plasmid pET-28a-SEC2 is constructed and the recombinant superantigen is expressed successfully, which may provide a foundation for the further research of the anticancer activity of SEC2. 结论成功构建了pET-28a-SEC2表达质粒,获得了与天然SEC2有着类似超抗原活性的高纯度rSEC2,为进一步研究该蛋白的抗肿瘤活性奠定了基础。 短句来源 Therefore,the precise physiological role of ACE2 remains further research,but it may provide novel therapeutics for the treatment of cardiovascular disease by modulating ACE2 activity. 因此,ACE2精确的生理作用有待进一步明确,但调节ACE2的活性可能为心血管疾病的治疗提出了新的思路。 短句来源 This review focus on the new technology provide a platform for HPV research,exploit the role of E6E7 protein in mechanism of HPV infection,study drug targets of paclitaxel,5-FU,find novel marker to develop vaccine for the prevention and treatment of HPV infection. 综述了蛋白质组学在HPV研究中的应用,探索E6E7蛋白在HPV致病机制中的作用,研究紫杉醇、5-FU等化疗药物的作用靶位及耐药产生机制,寻找新的蛋白靶点开发疫苗用于预防和治疗HPV感染。 短句来源 更多

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 provide
 Gindikin that complex analytic objects related to these domains will provide explicit realizations of unitary representations ofH?. Here we provide certain conditions (more general than those in [Ka1]) which guarantee preservation of the topology under a modification. We investigate conditions on kernel operators in order to provide prescribed orders of approximation in the Triebel-Lizorkin spaces. We provide a direct computational proof of the known inclusion ${\cal H}({\bf R} \times {\bf R}) \subseteq {\cal H}({\bf R}^2),$ where ${\cal H}({\bf R} \times {\bf R})$ is the product Hardy space defined for example by R. The space spanned by the translates of φv can only provide approximation order if the refinement maskP has certain particular factorization properties. 更多