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provide
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    Objective To investigate the expression of vascular endothelial growth factor C(VEGF-C) and vascular endothelial growth factor receptor-3(VEGFR-3) in rat colorectal cancer,and to provide an experimental material for the role of VEGF-C and its receptor VEGFR-3 in cancer progression and metastasis via lymphatics.
    目的观察大鼠大肠癌组织内血管内皮生长因子-C(VEGF-C)及其受体3(VEGFR-3)的表达情况,探讨VEGF-C及其受体VEGFR-3在肿瘤淋巴转移中的作用。
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    Combined detection of the expression of CD44v6 and Ki-67 may provide some value to know the biological behavior of colorectal carcinoma and to estimate the prognosis of patients.
    结论大肠癌CD44v6、Ki-67表达与其发生发展和浸润转移密切相关,联合检测对了解大肠癌的生物学行为和判断患者预后有一定的实用价值。
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    Conclusions Cell spheres containing brain tumor stem cells,which had capacities of self renewal and multi directional differentiation potentials,can be obtained both from long term in vitro cultured glioma cell lines and fresh glioma tissues by CD133 magnetic cell sorting and cultured in serum free medium. CD133~+ cells were the minority in the cell spheres,while nestin~+ cells were the majority. These findings may help to provide experimental materials for further studies on brain tumor stem cells.
    结论在胶质瘤细胞系和胶质瘤组织中均存在CD133~+的脑肿瘤干细胞,具有自我更新和多向分化潜能、在无血清培养下细胞球体中CD133~+细胞仍占少数,而nestin~+细胞占多数,可作为进一步研究脑肿瘤干细胞生物学特性的实验材料在相关领域中的应用。
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    Objective To sift associated proteins of drug fast in human's acute promyelocytic leukemia(APL) retinoicacid sensitive cell strain(NB4 cell strain) and retinoicacid resistent cell strain(NB4-R1 cell strain) by means of proteomic methods,so as to provide experimental foundation and theoretical basis of retinoicacid's drug fast reversion.
    目的应用蛋白质组学方法筛选人急性早幼粒细胞白血病(APL)维甲酸敏感细胞株(NB4细胞株)和维甲酸耐药细胞株(NB4-R1细胞株)的耐药相关蛋白。
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    Aim: To establish the functional expression of TAp63γ with doxycycline (Dox) induced Tet-on regulating system in human esophageal squamous carcinoma cell EC9706, and provide an ideal experimental platform for further studies of TAp63γ.
    目的:利用Tet-on基因表达调控系统建立由强力霉素(Dox)诱导TAp63γ基因表达的EC9706细胞系,为进一步研究TAp63γ基因的功能奠定基础。
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  provide
Gindikin that complex analytic objects related to these domains will provide explicit realizations of unitary representations ofH?.
      
Here we provide certain conditions (more general than those in [Ka1]) which guarantee preservation of the topology under a modification.
      
We investigate conditions on kernel operators in order to provide prescribed orders of approximation in the Triebel-Lizorkin spaces.
      
We provide a direct computational proof of the known inclusion ${\cal H}({\bf R} \times {\bf R}) \subseteq {\cal H}({\bf R}^2),$ where ${\cal H}({\bf R} \times {\bf R})$ is the product Hardy space defined for example by R.
      
The space spanned by the translates of φv can only provide approximation order if the refinement maskP has certain particular factorization properties.
      
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In connection with the study of the mechanism of carcinogenesis,we have underta-ken an investigation on the relative changes in activities of the proliferating enzymesuch as aspartate carbamyl transferase(ACT)and the tissue-specific enzymes such asornithine carbamyl transferase(OCT)and carbamyl phosphate synthetase(CPS_1)in amodel system of hepatocarcinogenesis of rats induced by diethylnitrosamine(DENA).Similar observations have also been made during development of rat liver.(1)Based on the pathological study...

In connection with the study of the mechanism of carcinogenesis,we have underta-ken an investigation on the relative changes in activities of the proliferating enzymesuch as aspartate carbamyl transferase(ACT)and the tissue-specific enzymes such asornithine carbamyl transferase(OCT)and carbamyl phosphate synthetase(CPS_1)in amodel system of hepatocarcinogenesis of rats induced by diethylnitrosamine(DENA).Similar observations have also been made during development of rat liver.(1)Based on the pathological study and enzymatic changes of liver in the presentexperiment,the process of carcinogenesis may be tentatively divided into three stages:(1)stage of simple hyperplasia—the early 6 weeks of DENA feeding.Changes in therelative ratio of ACT,OCT,and CPS_1 activities in this stage are reversible,similar tothose observed in the regenerating liver.(2)stage of malignant transformation—fromthe 6th to the 16th week of feeding the carcinogen.In this stage there appears anaplastichyperplasia of liver cells characterized by an irreversible change of the relative ratioof enzyme activities and (3)stage of the development of hepatocellular carcinoma—fromthe 16th to the 30th week of carcinogenesis.(2)During carcinogenesis of rat liver(after the 6th week of feeding DENA),activities of OCT and CPS_1 decreased while those of ACT increased gradually till theformation of cancer.In hepatocellular carcinoma the activities of OCT and CPS_1 areabout 10~20% of the normal liver,while those of ACT being about 2~3 times higher than the normal liver.The pattern of relative changes in activities of both groups ofenzyme during carcinogenesis was found to be the reverse of those observed in thedevelopment of rat liver.(3)The above enzymes in hepatocellular carcinoma and normal liver are probablyidentical entities,as shown by the similarities of pH optima and distribution patternsof enzyme activity in polyacrylamide gel electrophoresis.Similar K_m values anddifferent V_m values of OCT and ACT in hepatocellular carcinoma and normal liverpreparations suggested that changes in enzyme activities during carcinogenesis maypossibly be the result of an alteration in the amount of enzyme proteins.Furthermore,the specific activities of OCT and CPS_1 in the mitochondria of hepatocellular carcinomahave been found to be much lower than those of normal liver,although the proteincontent in the mitochondria of hepatocellular carcinoma decreased to an extent of about40% of that of normal liver.(4)The possible correlation between cell proliferation and differentiation to themechanism of carcinogenesis is discussed.As seen from Fig.3,the process of carcinogenesisseems to be a reversal of that of normal differentiation(development).Changes in enzymeactivities during carcinogenesis may be explained as a result of repression andderepression of the tissue-specific operons and mitotic operons,which are closelylinked and mutually repressed.It appears likely that cell proliferation may provide afundamental condition for the malignant transformation of the hepatocytes,while lossor decrease in the activities of tissue-specific function may be of primary importance tothe initiation of carcinogenesis.It is thus concluded that carcinogenesis would be dueto a random impairment of the control mechanism for gene activities of certain tissue-specific operons,leading to irreversible changes in nucleic acid biosynthesis and intissue-specific metabolism and their key enzyme activities which in turn give rise to anirreversible disturbance of the normal balance between cell proliferation and tissue-specific function,resulting in an abnormal growth and finally the formation of cancer.

本实验以二乙基亚硝胺诱发大鼠肝癌为动物模型,结合病理形态学研究了细胞增殖与组织特异代谢关键性酶ACT 及OCT,CPS_1活性的相互改变及其与癌变的关系,同时作了鼠肝发育过程中酶活性变化的比较研究。(1)根据DENA 引癌过程中酶活性CPS_Ⅰ/ACT,OCT/ACT 及ACT/CPS_Ⅰ,ACT/OCT 相对比值的变化,以及病理形态观察结果,DENA 引癌过程大致可分为三个阶段:喂DENA6周以内为单纯性增生期。此时期酶活性相对比值的改变是可逆的,与再生肝相似。第6周以后至16周为癌变期。此时期出现肝细胞异型性增生及癌变病灶。酶活性相对比值的改变是不可逆的。16周到30周为癌变细胞发展成为肝细胞癌期。(2)癌变过程中(喂DENA6周以后),OCT 及CPS_Ⅰ活性持续降低,同时ACT 活性持续增高。肝癌结节中OCT 及CPS_Ⅰ活性约为正常肝的10~20%,ACT 活性约为正常肝的2倍。癌变过程中这两类酶活性的相互改变与发育过程中的情况正好相反。在发育过程中,胚胎肝内OCT 及GPS_Ⅰ活性较成年水平低,而ACT 活性则较高。新生后CPS_Ⅰ及OCT 活性升高,同时ACT 活性降低。(3)肝与肝癌上述酶可能...

本实验以二乙基亚硝胺诱发大鼠肝癌为动物模型,结合病理形态学研究了细胞增殖与组织特异代谢关键性酶ACT 及OCT,CPS_1活性的相互改变及其与癌变的关系,同时作了鼠肝发育过程中酶活性变化的比较研究。(1)根据DENA 引癌过程中酶活性CPS_Ⅰ/ACT,OCT/ACT 及ACT/CPS_Ⅰ,ACT/OCT 相对比值的变化,以及病理形态观察结果,DENA 引癌过程大致可分为三个阶段:喂DENA6周以内为单纯性增生期。此时期酶活性相对比值的改变是可逆的,与再生肝相似。第6周以后至16周为癌变期。此时期出现肝细胞异型性增生及癌变病灶。酶活性相对比值的改变是不可逆的。16周到30周为癌变细胞发展成为肝细胞癌期。(2)癌变过程中(喂DENA6周以后),OCT 及CPS_Ⅰ活性持续降低,同时ACT 活性持续增高。肝癌结节中OCT 及CPS_Ⅰ活性约为正常肝的10~20%,ACT 活性约为正常肝的2倍。癌变过程中这两类酶活性的相互改变与发育过程中的情况正好相反。在发育过程中,胚胎肝内OCT 及GPS_Ⅰ活性较成年水平低,而ACT 活性则较高。新生后CPS_Ⅰ及OCT 活性升高,同时ACT 活性降低。(3)肝与肝癌上述酶可能是相同的。因为酶活性的最适pH 和在聚丙烯酰胺凝胶电泳图上的分布都是一致的。肝与肝癌OCT 及ACT 的K_m 相同而V_m 不同,说明癌变过程中酶活性的变化,主要是由于酶蛋白量的改变。此外,肝癌线粒体的蛋白量减少,但OCT 及CPS_Ⅰ的比活性(单位/毫克线粒体蛋白)仍较正常肝线粒体的低。(4)讨论了增生和分化与癌变的关系。初步认为,肝细胞的癌变是反分化(分化逆转)问题,和正常分化一样系由于基因表现的改变,不一定包含基因结构的改变。就与癌变有关的细胞增殖和分化的矛盾而言,细胞增殖及其有关酶活性的增高,可能是癌变发生的基础,而组织特异功能及其关键性酶活性的降低,可能与癌变的关系更为密切。因此癌变的发生,可能是由于在细胞分裂过程中致癌物使肝细胞特异功能基因的调节控制失常,从而引起增生代谢与特异代谢关键性酶活性不可逆的改变,使之失去肝细胞增殖与特异功能的正常平衡,而代之以不受控制的增生,最后形成癌细胞。

The administration of Bleomycin did not produce any morphological change on the normal esophageal epithelium of rats,but marked innhibitory effects were observed in the hyperplastic and precancerous lesions.Besides this,Bleomycin decreased the cancer incidence.The pathological changes caused by Bleomycin in the hyperplastic andprecancerous epithelia were as follows:nuclear pyknosis,karyorrhexis,chro-matolysis and vacuolar formation around or at one side of the nucleus,an indication of necrobiosis and necrosis...

The administration of Bleomycin did not produce any morphological change on the normal esophageal epithelium of rats,but marked innhibitory effects were observed in the hyperplastic and precancerous lesions.Besides this,Bleomycin decreased the cancer incidence.The pathological changes caused by Bleomycin in the hyperplastic andprecancerous epithelia were as follows:nuclear pyknosis,karyorrhexis,chro-matolysis and vacuolar formation around or at one side of the nucleus,an indication of necrobiosis and necrosis of cells.Furthermore,there were loca-lized areas of liquefaction and inhibition on the hyperplastic epithelia.Beside the occurrence of nephrosis in some cases,there were no other visceral changes.The selective inhibitory effects of Bleomycin against the hyperplastic and precancerous epithelia of the esophagus would provide a useful drug in the prophylatic therapy of the esophageal carcinoma.

长期输入为人体治疗用量20倍的争光霉素,没有引起大鼠正常的食管上皮细胞的形态改变,但对甲基苄基亚硝胺引起的增生及癌前病变(乳头状瘤)具有较为明显的抑制作用。争光霉素对癌的发生也有阻断作用。争光霉素引起的食管异常上皮的病理改变,主要表现为核固缩、核周空晕、核旁空泡、核碎裂等细胞的渐进性坏死和死亡。同时还看到上皮的液化灶与灶性的增生抑制区。重要的内脏器官除发现肾变性之外,其他未见异常。争光霉素对食管上皮的增生和癌前病变选择性的抑制与破坏作用,也为食管癌的予防性治疗提供一项有用的药物。争光霉素是我国自己生产的,与博莱霉素(Bleomycin)相类似的抗菌素,在临床上已证明对鳞状上皮癌,如皮肤癌与食管癌等有疗效。为了探索争光霉素能否阻断亚硝胺诱发食管鳞状上皮的癌变,特别是对增生与癌前病变有无抑制作用,我们进行了以下的试验。

Percutaneous transhepatic cholangiography (PTC) by anterior approach was used in 6 patients with severe progressive obstructive jaundice to demonstrate the sites of obstruction with dilatations of the proximal biliary tree.Two cases of carcinoma of ampulla of vater, 3 of carcinoma of distal choledochus and 1 of hepatocholedochus (HB) were diagnosed preoperatively by the X-ray findings which included serrated or irregular margins at corresponding portions and "bird's beak" appearance of distal portion of bile...

Percutaneous transhepatic cholangiography (PTC) by anterior approach was used in 6 patients with severe progressive obstructive jaundice to demonstrate the sites of obstruction with dilatations of the proximal biliary tree.Two cases of carcinoma of ampulla of vater, 3 of carcinoma of distal choledochus and 1 of hepatocholedochus (HB) were diagnosed preoperatively by the X-ray findings which included serrated or irregular margins at corresponding portions and "bird's beak" appearance of distal portion of bile duct (BD).Five cases were confirmed at operation and by histological studies. Another case with probable diagnosis of cancer of HB died in less than one month.Shadows of gallstones were clearly shown in 2 cases.Confluent cystic dilatation of HB and LHD in one and multiple intrahepatic segmental biliary tract dilatations and strictures in another case were well presented in the films.Diagnosis of choledochal cholelithiasis, secondary confluent dilatation of left hepatocholedochus and segmental intrahepatic sclerosing cholangitis were made preoperatively and confirmed by pathological examinations.Thus PTC is considered to be helpful in preoperative differential diagnosis in patients with obstructive jaundice.It may provide additional information for differentiating obstructive or non-obstructive jaundice and benign lesions or malignancies.

重度进行性梗阻性黄疸6例,应用前进路PTC,分别显示梗阻段近侧的胆管支扩张,判明不同梗阻部位,并根据相应段胆道阴影的锯齿状或不规则形表面以及远端呈“鸟喙状”等所见,于术前诊断壶腹癌、胆总管远端癌及肝胆总管癌各2、3及1例;5例经手术及活检证实;1例未剖腹,于拟诊后不及一月死亡。另2例清晰显示胆总管内结石阴影,2例各示肝胆总管左肝管囊形扩张和肝内胆管节段性扩张和狭窄,各根据阴影形态等分别作出胆总管结石、肝外肝门胆道扩张症及硬化性节段性肝内胆管炎的拟诊,均经手术、活检确诊。说明PTC可用于黄疸患者的诊断。

 
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