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bone
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    The clinic and experiment research on related factor of bone metastasis of bresat cancer
    乳腺癌转移相关因素的实验与临床研究
短句来源
    The Related Research on the Application of the Antitumor Active Artificial Bone in the Spine Tumor
    抗肿瘤活性人工在脊柱肿瘤中应用的相关研究
短句来源
    Experimental and Clinical Study of Spinal Metastases Treatment by PVP with ~(153)Sm-EDTMP Incorporated into Bone Cement
    水泥掺入~(153)Sm-EDTMP后PVP治疗脊柱转移瘤实验与临床研究
短句来源
    The Effects and Its Mechanism of Endothelin-1 in Prostate Cancer Bone Metastasis
    Endothelin-1在前列腺癌转移中的作用及其机制研究
短句来源
    The Discuss of Early Events for Bone Metastasis in Breast Cancer
    乳腺癌转移早期事件的探讨
短句来源
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  骨骼
    Approach of age-related changes of whole body bone distribution using ~(99m)Tc-MDP bone scintigraphy in women
    ~(99m)Tc-MDP在女性全身骨骼分布随年龄相关改变初探
短句来源
    X-ray and CT differential diagnosis between multiple myeloma and tumor of bone metastasis in thoracic bones
    胸部骨骼多发性骨髓瘤和骨转移瘤的X线及CT鉴别
短句来源
    The imaging diagnosis of primary lymphoma of bone
    原发性骨骼淋巴瘤的影像学诊断
短句来源
    (4) Pleural effusion,ascites of destruction of bone.
    (4)胸水、腹水或骨骼破坏。
短句来源
    Aim: To search for different X and CT appearances of thoracic bone invasion between multiple myeloma (MM) and tumor of bone metastasis (BM).
    目的 :探讨多发性骨髓瘤 (MM)与骨转移瘤 (BM)胸部骨骼受侵的X线及CT所见的不同。
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  “bone”译为未确定词的双语例句
    CENTRAL GIANT CELL GRANULOMA OF THE JAW BONE
    颌骨中心性巨细胞肉芽肿
短句来源
    Inhibitory Effect of the Stromal Cell Supernatant from Mouse Bone Marrow on P388 Cell line
    SCS对P388细胞株生长增殖的影响
短句来源
    EFFECT OF THE POLYSACCHARIDE-PROTEIN OF SPIRULINA PLATENSIS ON RADIATION INDUCING MICRONUCLEUS FREQUENCY IN MOUSE BONE MARROW POLYCHROMATOPHILIO ERYTHROBLASTE AND LEUKOCYTE
    螺旋藻(Spirulina Platensis)多糖蛋白对辐射诱发小鼠PCE微核率及白细胞数的影响
短句来源
    STUDIES ON BONE TUMOR THERAPEUTIC RADIOPHARMACEUTICALSⅡ.BIOLOGICAL EVALUATION OF  ̄(153)Sm-EDTMP
    骨肿瘤治疗药物的研究 Ⅱ.~(153)Sm-EDTMP的生物性质评价
短句来源
    Primary chondroid chordoma of the base of the temporal bone
    颞骨底原发性软骨脊索瘤二例报告
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  bone
Biomimetic strengthening polylactide scaffold materials for bone tissue engineering
      
The novel composite mainly consists of nano-hydroxyapatite (n-HA), which is the main inorganic content in natural bone tissue for the PLA.
      
The crystal degree of the n-HA in the composite is low and the crystal size is very small, which is similar to that of natural bone.
      
The biomimetic three-dimensional porous composite can serve as a kind of excellent scaffold material for bone tissue engineering because of its microstructure and properties.
      
The effects of hematopoietic stem/progenitor cells (HSPCs) expanded in the two step coculture with human bone marrow mesenchymal stem cells (hMSCs) on the hematopoietic reconstruction of irradiated NOD/SCID mice were studied.
      
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We first and foremost used the micronucleus test to rapidly evaluate the effects of cystamine and H2O2 administered separately or in combination, on radiation induced chromosomal damage in bone-marrow cells and Ehrish ascites tumour cells. The results of chromosomal damage examined by micronucleus test are as follow:1. Tumor bearing mice are administered with cystamine either orally or intrape-ritoneally, and then exposed to double or single dose irradiation. The radioprotective effect of cystamine on...

We first and foremost used the micronucleus test to rapidly evaluate the effects of cystamine and H2O2 administered separately or in combination, on radiation induced chromosomal damage in bone-marrow cells and Ehrish ascites tumour cells. The results of chromosomal damage examined by micronucleus test are as follow:1. Tumor bearing mice are administered with cystamine either orally or intrape-ritoneally, and then exposed to double or single dose irradiation. The radioprotective effect of cystamine on bone-marrow cells is significant, but not significant on Ehrish ascites tumor cells.2. H2O2 can increase the radiosensitivity of chromosomal damage in Ehrish ascites tumor cells, but has no effect in bone-marrow cells.3. When cystamine and H2O2 are simultaneously administered to tumor-bearing mice, H2O2 does not decrease the radioprotective effect of cystamine on bone-marrow cells, but the cystamine can decrease the radiosensitive effect of H2O2 on Ehrish ascites tumor cells.

本研究工作首次应用微核测定技术快速评价胱胺和H_2O_2在照射前分别或合并使用时,它们对带瘤小鼠的骨髓细胞和艾氏腹水癌细胞染色体辐射损伤的影响。微核测定的结果表明: (1)照前口服或腹注胱胺对受一次或分次照射的腹水癌小鼠骨髓细胞的染色体损伤均有显著性的保护作用,而对其癌细胞的染色体损伤无明显的防护效果。(2)H_2O_2能够提高腹水癌细胞染色体辐射损伤的敏感性,而对其骨髓细胞的染色体损伤无明显的影响。(3)胱胺和H_2O_2合并使用时,H_2O_2不降低胱胺对骨髓细胞的防护作用,而胱胺却能削弱H_2O_2对癌细胞的致敏作用。

Recently,the dynamic changesof cytostatic and cytocidal effect ofspleen cells of tumor-bearing mice ontarget tumor cells were studied withthe technigue of ~(125)IUdR assay,Lym-phocyte transformation of similarspleens by Con A and PWM wasalso studied.In most experiments,Ehrlich ascitic tumor cells were usedand each C57BL mouse was inocula-ted intramuscularly with 5×10~6 viabletumor cells in the right thight as atumor bearer.In other experiments,Sarcoma 180 ascitic cells in C57BLmice and Hepatoma acitic cells...

Recently,the dynamic changesof cytostatic and cytocidal effect ofspleen cells of tumor-bearing mice ontarget tumor cells were studied withthe technigue of ~(125)IUdR assay,Lym-phocyte transformation of similarspleens by Con A and PWM wasalso studied.In most experiments,Ehrlich ascitic tumor cells were usedand each C57BL mouse was inocula-ted intramuscularly with 5×10~6 viabletumor cells in the right thight as atumor bearer.In other experiments,Sarcoma 180 ascitic cells in C57BLmice and Hepatoma acitic cells inTienjing No 1 albino mice were alsoemployed.Results of our experiments indic- ated that spleen cells of tumor-bearingmice inhibited strongly DNA syn-thesis of tumor cells in vitro.Suchcytostatic effect was already quitemanifested at the 7th day after tumorinoculation and increased henceforthin parallel with the growth of tumorand an enlargement of spleen.Afterthe surgical removal of tumor,cytost-atic effect decreased rapidly and couldno longer be detected on the 21thday after amputation and consequen-tly the spleen returned almost to itsnormal size.Moreover,we have alsoinoculated ascitic tumor cells intothymectomized,X-irrdiated,bone-marrow-reconstituted mice,and theirspleen cells were also shown to bestrongly cytostatic to tumor cells.On the other hand,our datapointed out that the spleen cells ofmice bearing large Ehrlich tumor couldnot kill in vitro ~(125)IUdR labelledEhrlich tumor cells as determined by~(125)IUdR release assay.Furthermore,these spleen cells were also found tobe suppressed with respect to theirresponse to lymphocyte mitogens ConA and PWM.In fact,spleen cells from micebearing Ehrlich tumor inhibited the~(125)IUdR uptake of Sarcoma 180cells and Hepatoma ascitic cells to asimilar extent.Similarly,the spleencells from mice bearing solid Hep-atoma and Sarcoma 180 also inhibitedstrongly the ~(125)IUdR uptake ofEhrlich tumor cells.Thus,cytostaticeffect of spleen cells of tumor-bearingmice against tumor cells in vitro isa kind of non-specific inhibition.Histopathologic studies showedthat the increase in the amount ofreticulum cells and macrophages inthe spleen of tumor-bearing mice hada good correlation with its increasein cytostatic effect on tumor cells.At the same time,there was a conco-mitant decrease in the number ofsmall lymphocytes and an incrase inthe number of immature haematopoie-tic cells.This latter fact might ex-plain the general absence of cytocidaleffect of spleen cells on tumor cellsas well as the deficient response ofspleen cells to lymphocyte mitogenslike ConA and PWM in the tumor-bearing mice.Taken together all the above re-sults,we tentatively suggest that theeffector cells of cytostatic effect intumor-bearing mouse spleen are notT、B lymphocytes.The exact natureof these suppsessor cells as well astheir possible mechanisms of actionare now under investigation.

应用5-~(125)碘-2’-脱氧尿嘧啶核苷(~(125)IUdR)参入抑制试验,证明带Ehrlich实体瘤的C57BL 小鼠脾脏细胞可在体外对同一移植肿瘤细胞的DNA 合成产生显著的抑制。随着肿瘤的增长,带瘤小鼠的脾脏进行性增大,脾细胞对肿瘤细胞的抑制效应也随之增强。这种对肿瘤细胞DNA合成的抑制作用是非特异的。肿瘤切除后,抑制效应也随之下降,到术后21天,细胞静止效应已不能测得。本文还应用~(125)IUdR技术同时测定了带瘤小鼠脾脏的T 杀伤细胞,脾脏淋巴细胞对致分裂原Con A 与PWM 的转化反应的动态变化,实验表明带瘤小鼠脾脏T、B 淋巴细胞的功能是受抑制的。组织病理学观察提示,带瘤动物脾脏的网织细胞和巨噬细胞的增多可能与细胞静止效应的增强有关。

Normal mouse bone marrow cell suspensions sealed in diffusion chambers were implanted intraperitoneally into normal mice and mice rendered neutropenia by pretreatment with vincristine or irradiation with 750 rad ~(60)Co. After five days' 'intraperitoneal incubation the diffusion chambers were removed and the number of colonies was scored. Our experiments showed that mouse bone marrow colonies were able to grow in unirradiated hosts as well as in hosts treated with irradiation or cytotoxic drugs....

Normal mouse bone marrow cell suspensions sealed in diffusion chambers were implanted intraperitoneally into normal mice and mice rendered neutropenia by pretreatment with vincristine or irradiation with 750 rad ~(60)Co. After five days' 'intraperitoneal incubation the diffusion chambers were removed and the number of colonies was scored. Our experiments showed that mouse bone marrow colonies were able to grow in unirradiated hosts as well as in hosts treated with irradiation or cytotoxic drugs. The samples assayed in our experiments yielded about 80~90 colonies per 10~5 cells cultured. There were no significant differences in the number of colonies among these three groups. Some reports suggested that serum from the animals irradiated or pretreated with cytotoxic drugs contained a higher CSF activity, but this has not been demonstrated in the present report. Probably, the endogenous CSF activity in normal mouse used in over experiments was sufficient to stimulate the colony formation of mouse bone marrow CFU-C.

本文报道了采用不同寄主小鼠进行小鼠造血干细胞体内扩散盒琼脂培养的结果比较。寄主小鼠在植入扩散盒1~2小时前接受750拉德~(60)Co照射或在植入前24小时注射VCR1.6毫克/公斤并未能提高CFU-C细胞团产率。这种情况是否是由于正常小鼠体液内的CSF水平已足以有效地刺激小鼠骨髓CFU-C生成细胞团,故提高CSF浓度不能再增加细胞团的产率。有待在掌握本实验小鼠的种属特性及调整照射剂量后作进一步研究。

 
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