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chromosome aberrations     
相关语句
  染色体畸变
     Methods(AT5B1VA(AT) cells) and GM0639(GM)cells at G_1 phase were exposed to a priming dose of 2 cGy ()~(60)Co γ- rays 6 hours before irradiation with a challenge dose of 1.0 Gy or 3.0 Gy ()~(60)Co γ-rays,and then chromosome aberrations were analyzed.
     方法用2cGy60Coγ射线预先照射进入G1期的AT5B1VA(AT)细胞和GM0639(GM)细胞,培养6h后再照射1.0Gy或3.0Gy60Coγ射线,分析染色体畸变
短句来源
     Comparative Studies of the Dose effects on in vitro Culture Human Blood to Induce Chromosome Aberrations by lrradiation of 60kv,180kv and 10MV X-rays
     60kV、180kV和10MV X线照射离体人血诱发染色体畸变剂量效应的比较
短句来源
     The Chromosome Aberrations in Barley M_1 Pollen Mother Cells after Radiation Treatment and Its Relationship with M_2 Mutation
     辐照大麦M_1花粉母细胞染色体畸变及其与M_2性状变异的关系
短句来源
     The results showed that the frequency of chromosome aberrations increased after aluminum treatment in the range of 30 μmol/L to 50 000 μmol/L at pH5.8.The frequency of chromosome aberrations also increased at low concentrations(30 μmol/L、100 μmol/L、300 μmol/L) and at pH4.5,but splitting cells was not be found in root tips above 1 000 μmol/L.
     pH 4.5时,用浓度30μm o l/L~300μm o l/L的铝处理组诱发的染色体畸变同样随铝浓度的升高而增加,但铝浓度为1 000μm o/L~50 000μm o l/L时抑制根尖细胞分裂,几乎没有中期相.
短句来源
     Trisomy 7 and trisomy 12 are common chromosome aberrations in lymphoma.
     +7和+12是淋巴瘤常见的染色体畸变
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  染色体畸变的
     (3) chromosome aberrations of human blood lymphocytes by 1.5 Gy X irradiation 6 h after MMC (final concentration is 35 ng/mL) applied.
     (3)预先给予 MMC(终浓度为 35 ng/ m L)处理 ,6 h后给予 1.5 Gy X射线照射 ,可诱导人血淋巴细胞染色体畸变的交叉适应性反应 ;
短句来源
     STUDIES ON CHROMOSOME ABERRATIONS IN DOGS IRRADIATED WITH LOW DOSE RATE OF ~(60)Coγ-RAYS
     ~(60)Co-γ线低剂量率照射狗染色体畸变的观察
短句来源
     COMPARISONS OF CHROMOSOME ABERRATIONS INDUCED BY IN VITRO 60 Coγ-RAY IRRADIATIONS IN HUMAN SPERM AND LYMPHOCYTES
     60Coγ射线离体照射诱发人精子和淋巴细胞染色体畸变的比较
短句来源
     Results showed that cross adaptive response could be induced of (1) chromosome aberrations of bone marrow cells when MMC with different concentrations (0.5, 2.5 and 5.0 mg/kg) were i.p. injected into mice 3 h after irradiation to 10 mGy X rays.
     结果表明 ,(1)预先给予 10 m Gy的 X射线照射 ,3h后予以不同浓度的 MMC(0 .5、2 .5、5 .0 mg/ kg) ,可诱导小鼠骨髓细胞染色体畸变的交叉适应性反应 ;
短句来源
     Studies on Chromosome aberrations lnduced by 4 Nitroquionoline 1 oxide in Broad Bean(Vicia Faha)
     4-硝基喹啉-1-氧化物诱发蚕豆染色体畸变的研究
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  染色体异常
     Conclusion:+8 and -7/7q- karyotypes are still most frequent chromosome aberrations in MDS.
     结论:+8和-7/7q-核型仍是MDS最为常见的染色体异常
短句来源
     The number of chromosome aberrations is correlated with lymphoma stages,and it's more common in patients at Ⅲ-Ⅳ stage than patients at Ⅰ-Ⅱ stage(P=0.0145).
     染色体异常数目的多少与分期有关,Ⅲ-Ⅳ期患者的染色体异常数目多于Ⅰ-Ⅱ期患者(P=0.0145)。
短句来源
     Results Among the 780 consultants 35 (4. 5 %, male: 25; female: 10) had chromosome aberrations, and 75 (9.6 %) had abnormal chromosome shapes.
     结果 染色体异常占受检人数的4.5%(35/780)(男性25例,女性患者10例); 染色体异态,占受检人数的9.6%(75/780);
短句来源
     Chromosome aberrations were identified in 70% of the patients,with t(15; 17),t (8; 21),t(9; 22) more frequently found. Specific Chromosome translocations were closely correlated with the type of leukemia and therapeutic effect. Patients with t(15;17) and t(8; 21 ) showed the best effect while those with normal karyotype the next and other chromosome translocations and nemerical anomalies the poorest effect after chemotherapy.
     结果:染色体异常率为70.0%.染色体异常以t(15;17),t(8;21),t(9;22)易位较常见,且特定的染色体改变与白血病类型、疗效密切相关.t(15;17)和t(8;21)易位的疗效最佳,正常核型次之,其他染色体易位及数目异常最差。
短句来源
     The chromosome aberrations were found in 62/80 case (77.5%), of them 44/62 cases (71.0%) showed characteristic abnormalities.
     染色体异常 (6 2 80例 )检出率为77 5 % ; 其中 (44 6 2例 ) 71 0 %为特异性异常。
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  “chromosome aberrations”译为未确定词的双语例句
     ANALYSES OF CHROMOSOME ABERRATIONS IN LYMPHOCYTES AND BONE MARROW CELLS INDUCED BY RADIATION OR BENZENE
     ANALYSES OF CHROMOSOME ABERRATIONS IN LYMPHOCYTES AND BONE MARROW CELLS INDUCED BY RADIATION OR BENZENE
短句来源
     The M1, M2 and M3 had complicated structural chromosome aberrations: del(7)(p15)/del(7)(q22), t(1;3)(p11;q11) and del(7)(q32).
     结果 显示了 M1、M2和 M3有复杂的染色体结构畸变 :del(7) (p15 ) / del(7)(q2 2 ) ; t(1;3) (p11;q11)和 del(7) (q32 )。
短句来源
     The average number of chromosome aberrations was 2.60±1.85 compared to 5.10±2.13 in the control group.
     高生存期组畸变染色体平均数目(2.60±1.85)显著少于肺癌对照组(5.10±2.13)。
短句来源
     The activation of oncogene HOX11 was detected in 9 ALL cases and 8 AML cases, with or without other chromosome aberrations in 7 ALL cases , 7 AML cases and 2 ALL cases , 1 AML cases simply.
     9例ALL、8例AML患儿有HOX11原癌基因活化,7例ALL、7例AML患儿为单纯表达HOX11原癌基因活化,2例ALL、1例AML同时伴有其他融合基因表达。
短句来源
     Results Among the detected chromosome aberrations, +8 was the most frequent (42.8%)and then -7/7q-(15.0%);
     结果在同期173例有异常克隆的患者中,+8患者最多42.8%(74例),其次-7/7q-为15.0%(26例);
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  chromosome aberrations
Effect of Geomagnetic Field Changes on the Rate of Spontaneous Chromosome Aberrations in Human Somatic Cells
      
Uninemic regions have an exceedingly high frequency of spontaneous chromosome aberrations, due to blockage of the mechanism of underlying repair of the DNA double break in the absence of a second DNA copy.
      
Cytogenetic homeostasis in natural populations under natural conditions and anthropogenic stress was estimated according to the frequency of chromosome aberrations in somatic cells for six species of small mammals.
      
The embryos were characterized by an unexpectedly high frequency of mosaic variants of monosomies for chromosomes 7, 15, 21, and 22, which amounted to 19% of all chromosome aberrations.
      
Based on analysis of the cell karyotype during prenatal diagnosing of chromosome aberrations in tissues of both extraembryonic and embryonic origin, in 1996, Wolstenholme proposed a model of CPM for individual chromosomes.
      
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The investigation reported here was undertaken to obtain informations concerning the relative merits of the direct and indirect exposure of testis to X-irradiation on the chromosome aberrations in the spermatogenesis of the monkey, Macaca mulatta. The materials used consisted of 8 adult male monkeys, which were set into 4 groups with 2 animals each as follows: in the first group, the 2 testes of same animal were taken out at two separate operations with 10 days apart. They were intended to serve as controls...

The investigation reported here was undertaken to obtain informations concerning the relative merits of the direct and indirect exposure of testis to X-irradiation on the chromosome aberrations in the spermatogenesis of the monkey, Macaca mulatta. The materials used consisted of 8 adult male monkeys, which were set into 4 groups with 2 animals each as follows: in the first group, the 2 testes of same animal were taken out at two separate operations with 10 days apart. They were intended to serve as controls as well as to find out whether precastration of one testis would affect the frequency of chromosome aberrations in the retained testis. In the second, 10 days after the precastration of the left testis, the animals were exposed to 200r X-irradiation with right testis unshielded. In the third, 10 days after the precastration of left testis, the animals were exposed to 200r X-irradiation with right testis shielded by a 6 mm thick lead housing. In the fourth, animals were exposed to 200r X-irradiation, with right testis shielded and left testis unshielded. At the time of exposure, testes were all pushed backed from the scrotum into the abdominal cavity to receive X-ray treatment, and the irradiated testes were all taken out 10 days after exposure.Statistical analysis of the frequencies of chromosome aberrations obtained here together with our previous data (Chang, Chao, Tan and Liu 1963) shows while either whole body or local testicular region exposure to 200r X-irradiation produces similar effects on the increase of the frequencies of chromosome aberrations, the result with the shielded testis is essentially the same as the controls. This suggests that chromosome aberrations induced by X-irradiation are resulted from the direct effect of X-rays on the chromosomes and the protective function of lead housing renders the testis to prevent from radiation injury to the chromosomes. The data further show that precastration of one testis could hardly affect the frequencies of chromosome aberrations in the other testis retained in the same animal. Hence, it is safe to use 2 testes of a same animal, one for control and the other for experimental purpose, or both for treatment but with ditferent dosages. This information is of special value in the design of experiments to eliminate possible errors due to individual differences, especially when the number of such experimental animal as monkey could not often be very large.

本文用的8只性成熟雄性猕猴(Macaca mulatta)分成4组,每组二只猴子,分组处理如下:(1)一个个体的二个睾丸分别经二次外科手术阉取,前后手术相隔10天,用作对照材料并验证先阉割一个睾丸对剩留体腔的另一个睾丸的染色体畸变有无影响;(2)左睾阉割10天后,全身照射200仑;(3)左睾阉割10天后,在右睾用6毫米厚的铅室屏蔽的条件下全身照射200仑;(4)在右睾用6毫米厚铅室屏蔽,而左睾直接接受射线的条件下全身照射200仑.照射后第10天取出睾丸,以细胞学方法观察生殖细胞的染色体畸变,并进行变量分析和t测验,将这些数据连同我们过去局部地直接照射睾丸所得的资料一并考察,旨在探讨直接与间接照射的辐射细胞遗传学效应.根据分析结果,可得出如下结论:(1)全身照射与局部照射睾丸对于增高染色体畸变率的效应是相同的,而全身照射时保护睾丸则与对照组没有差别,所以辐射诱发染色体畸变是射线直接作用于染色体的结果,与间接作用是无关的.(2)证明铅室遮盖睾丸对诱发染色体畸变有保护作用.(3)同一个体的二个睾丸先取出一个,对留于体内的另一个睾丸的染色体畸变并无影响.所以一个睾丸作对照,另一个睾丸作处理,或二个睾丸分别作不同处理,...

本文用的8只性成熟雄性猕猴(Macaca mulatta)分成4组,每组二只猴子,分组处理如下:(1)一个个体的二个睾丸分别经二次外科手术阉取,前后手术相隔10天,用作对照材料并验证先阉割一个睾丸对剩留体腔的另一个睾丸的染色体畸变有无影响;(2)左睾阉割10天后,全身照射200仑;(3)左睾阉割10天后,在右睾用6毫米厚的铅室屏蔽的条件下全身照射200仑;(4)在右睾用6毫米厚铅室屏蔽,而左睾直接接受射线的条件下全身照射200仑.照射后第10天取出睾丸,以细胞学方法观察生殖细胞的染色体畸变,并进行变量分析和t测验,将这些数据连同我们过去局部地直接照射睾丸所得的资料一并考察,旨在探讨直接与间接照射的辐射细胞遗传学效应.根据分析结果,可得出如下结论:(1)全身照射与局部照射睾丸对于增高染色体畸变率的效应是相同的,而全身照射时保护睾丸则与对照组没有差别,所以辐射诱发染色体畸变是射线直接作用于染色体的结果,与间接作用是无关的.(2)证明铅室遮盖睾丸对诱发染色体畸变有保护作用.(3)同一个体的二个睾丸先取出一个,对留于体内的另一个睾丸的染色体畸变并无影响.所以一个睾丸作对照,另一个睾丸作处理,或二个睾丸分别作不同处理,这种同体对照的方法是可行的,可以在供试个体不多的情况下既满足实验设计要求又减少了个体差异所可能造成的误差.

1. In order to study the effects of X-irradiation on the morphology, mitosis and meiosis of the male sexual cells of the white mouse, the male animals (Strain Kunming) were given whole-body exposure of 400 r of X-rays and killed at 1, 3, 6, 12, and 24 hours after irradiation. Their testes were fixed according to Dietrich-Parat's method, and cut into paraffin sections of 3 ft in thickness, which were stained by PAS technique and counterstained with Carazzi's method. The number of cells of various types in the...

1. In order to study the effects of X-irradiation on the morphology, mitosis and meiosis of the male sexual cells of the white mouse, the male animals (Strain Kunming) were given whole-body exposure of 400 r of X-rays and killed at 1, 3, 6, 12, and 24 hours after irradiation. Their testes were fixed according to Dietrich-Parat's method, and cut into paraffin sections of 3 ft in thickness, which were stained by PAS technique and counterstained with Carazzi's method. The number of cells of various types in the tubular cross-sections of stages Ⅱ, Ⅳ, Ⅵ and Ⅻ of the cycle of the seminiferous epithelium has been calculated and subjected to comparative analyses. The criteria for the classification of developmental stages of the cycle of the seminiferous epithelium and those for the stages of spermatogenesis are the same as employed by Oakberg (1956), Leblond and Clermont (1952) and by us in one of our papers (Ouang Te-Yio et al,, 1964).2. After irradiation the various necrotic and abnormal cells which appear in the male sexual cells of the white mouse may be roughly classified into four types: cell necrosis, chromosome aberrations, abnormal mitosis and giant cell formation. Similar necrotic and abnormal cells have been observed in all specimens of the control animals, but their frequencies of incidence are much lower.3. Based upon the changes in the total number of cells, the cell number at different stages of the division cycle as well as the frequency of cell necrosis, the early effects (before 24 hours) of X-irradiation on spermatogonia may be roughly divided into three steps: period of initial effects, period of recovery and period of inflection; the characteristics of each period have been discussed.4. The causal factor of decreasing in the number of spermatogonia is mainly the death of the cells, which is induced by irradiation and bears a definite relationship to a certain stage of the mitotic cycle. However, when the cells are free from the mitotic inhibition, spermatogonia may die at any stage of the mitotic cycle.5. In the first hour after X-irradiation, all three types (A, In, B) of spermatogonia immediately exhibit the phenomenon of mitotic lagging, and at the same time there are stimulating effects seen in these cells at the meta-anaphasic stage. The experimental results suggest that the mitotic inhibition of spermatogonia induced by X-rays is reversible. The inhibition time might occur at two phases of the mitotic cycle, i.e., at the beginning of and before the prophase, these two phases corresponding to "the point of no return" of the mitotic cycle, as suggested by Mazia (1961).6. There is little influence of X-irradiation on the number and the microscopic structures of the cells of the meiotic prophase as well as spermatids, but the number of cells undergoing the normal meiotic meta-anaphase have greatly decreased, and yet a great number of abnormal meta-anaphasic cells develop into spermatids. In all respects, the spermatocytes and meiosis are belived to possess a lower radiosensitivity than the spermatogonia and mitosis; and, furthermore, in the spermatocytes there are not found any different steps of responses analogous to those present in spermatogonia at the early period (before 24 hours) after irradiation. The meiosis, however, is similarly subjected to a reversible inhibition by X-irradiation as in mitosis, although the stages inhibited in meiosis may probably be different from those in the mitotic cycle.

1.以400伦X射线全身照射昆明种雄性小白鼠,照射后隔1、3、6、12、24小时分别将动物杀死,以Dietrich-Parat法固定其睾丸。制成石蜡切片。观察第Ⅱ、Ⅳ、Ⅵ、Ⅻ期精小管横切面中各类细胞数量的变化。 2.X射线照射后,小白鼠雄性生殖细胞中出现各种坏死及异常细胞,按其性质可大致分为四类:细胞坏死、染色体畸变、异常分裂、巨细胞。类似的坏死及异常细胞在正常睾丸中几乎都能发现,但频率低得多。 3.根据细胞数量、细胞分裂周期各类细胞和细胞坏死频率的变化,可以把X射线对精原细胞的早期(24小时内的)效应大致分为三个阶段:原发效应期、恢复期和转折期。 4.精原细胞数量的减少主要由于细胞死亡。它们的辐射致死和细胞分裂周期有一定的关系。然而,当分裂抑制解除时,精原细胞可以在细胞分裂周期的各个时期中死亡。 5.X射线照射后1小时,三种精原细胞都出现了分裂延滞的现象,但对中-后期细胞分裂有一定的促进作用。实验结果表明X射线对精原细胞有丝分裂的抑制是可逆的。抑制的时期可能是在间-前期之间和分裂之前(前期)两个时期。这两个时期与细胞有丝分裂周期中的“不可逆点”(Point of no return)相符。 6.X射线对减数...

1.以400伦X射线全身照射昆明种雄性小白鼠,照射后隔1、3、6、12、24小时分别将动物杀死,以Dietrich-Parat法固定其睾丸。制成石蜡切片。观察第Ⅱ、Ⅳ、Ⅵ、Ⅻ期精小管横切面中各类细胞数量的变化。 2.X射线照射后,小白鼠雄性生殖细胞中出现各种坏死及异常细胞,按其性质可大致分为四类:细胞坏死、染色体畸变、异常分裂、巨细胞。类似的坏死及异常细胞在正常睾丸中几乎都能发现,但频率低得多。 3.根据细胞数量、细胞分裂周期各类细胞和细胞坏死频率的变化,可以把X射线对精原细胞的早期(24小时内的)效应大致分为三个阶段:原发效应期、恢复期和转折期。 4.精原细胞数量的减少主要由于细胞死亡。它们的辐射致死和细胞分裂周期有一定的关系。然而,当分裂抑制解除时,精原细胞可以在细胞分裂周期的各个时期中死亡。 5.X射线照射后1小时,三种精原细胞都出现了分裂延滞的现象,但对中-后期细胞分裂有一定的促进作用。实验结果表明X射线对精原细胞有丝分裂的抑制是可逆的。抑制的时期可能是在间-前期之间和分裂之前(前期)两个时期。这两个时期与细胞有丝分裂周期中的“不可逆点”(Point of no return)相符。 6.X射线对减数分裂前期细胞及精细胞的数量和显微结构影响不大,但大大地减少减数分裂中-后期正常细胞的数量?

The present paper is dealing with a rapid method of micronuclei test for testing chromosomal damage.This method was used for testing the time-effect and dose-effect of the Co60 r-irradiation on the frequence of micronuclei of the lymphocytes in rat blood.And the late effect of 265 rads Co60 r-irradiation in dogs was observed.The results showed that the effect of the radiation on the frequence of micronuclei of lymphocytes in blood and nucleated cell of bone marrow was consistent with the effect on chromosome...

The present paper is dealing with a rapid method of micronuclei test for testing chromosomal damage.This method was used for testing the time-effect and dose-effect of the Co60 r-irradiation on the frequence of micronuclei of the lymphocytes in rat blood.And the late effect of 265 rads Co60 r-irradiation in dogs was observed.The results showed that the effect of the radiation on the frequence of micronuclei of lymphocytes in blood and nucleated cell of bone marrow was consistent with the effect on chromosome aberrations.

本文介绍了用明胶-离心法分离和浓缩血液中淋巴细胞而后制片观察分析其微核出现率,并以此来测定染色体损伤的新方法。应用这种方法测定了大鼠受Co~(60)-r射线照射的剂量-效应和时间-效应;还对受265拉特照射后活存狗的远期效应进行观察。结果表明,与骨髓有核细胞微核测定以及染色体畸变分析的结果是一致的。本文还对其应用价值作了初步的讨论。

 
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