he recombinate protein C11 derived from the C region of HCV genome and C7 derived from the nonstructural region NS3 of the HCV genome were used in ELISA to study 442 cases of liver diseases,including chronic hepatitis,cirrhosis and hepatocellular carcinoma in Beijng District.
The activities of superoxide dismutase(SOD),Glutathione peroxidase(GSH Px) and the content of lipid in erythrocyte and the rosette rate of erythrocyte C3b receptor (C3b.R) and immunity complex receptor(IC.R) were measured in 30 patients with decompensated post hepatitis cirrhosis using chemistry method,and using immunity method.
Results (1)The plasma and ascitic levels of TNF-α,IL-6 and endotoxin were significantly higher in hepatitis cirrhosis patients with spontaneous bacterial peritonitis(SBP) than those without SBP in admitting hospital(P<0.001).
The results show that fibronectin level was higher inacute hepatititis group than that in the normal subject group(P>0.5),slightly lower in chronicacute group than that in the normal subject group(P>0.5)and significantely lower in severehepatitis and post hepatitis cirrhosis(PHC)groups than that in the normal group(P<0.01). The quantitive estimation of this parameter has evaluative and prognostic value.
Methods:178 viral hepatitis patients were divided into 5 groups as mild,moderate,severe hepatitis,cirrhosis and liver failure. Blood cholesterol,triglyceride,high density lipoprotenin,apolipoprotein A1 (APOA1),apolipoprotein B100 (APOB100),total bilirubin and prothrombin activity were determined.