Several 1-(substituted phenoxy)-3-{[4-(4-trifluoromethyl) phenoxy] piperidin-1-yl} propan-2-ols (str.II) were prepared in a six-step reaction sequence starting from methylamine and ethyl acrylate and evaluated for antidepressant activity.
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Substituents at the 4th and 5th positions of the target thiazoles were introduced by a Hantzsch reaction, and the chain at the second position was extended through a Sandmeyer reaction, formylation, and Wittig olefination.
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A series of ortho- meta- and para-N9-[(chloromethylphenyl)methyl]chloropurines 4-12 and N7-[(chloromethylphenyl)methyl]chloropurines 13-21 were obtained by the reaction of various substituted chloropurines with α,α'-dichloroxylenes.
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A series of 1-[(sub)]-6-fluoro-3- [(sub)]-1, 3, 4-oxadiazol-2-yl-7-piperazino-1, 4-dihydro 4-quinolinones were synthesized by the reaction between ciprofloxacin and norfloxacin with an appropriate acid hydrazide in phosphorous oxychloride.
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The pyrazolo[4,3-d]oxazinone 4 was obtained from direct reaction of the acid 1 with hydroxylamine hydrochloride.
This communication reports the results of a study of the gravimetric deter- mination of lead as normal phosphate, known as Vortmann and Bader method, which has been recently examined by Hubicki and Rys. According to our findings, tartaric acid should be added only when antimony is present. With the addition of tarearic acid unusual large excess of precipitant as suggested by Vortinann and Bader is required for complete precipitation. The suitable pH range for the precipitation of tertiary lead phosphate is ...
In connection with our work on “sulfabenzothiazoles”,several tertiary am- inophenyl-thioureas are required.The usual procedure of rearranging substituted ammonium thiocyanates failed to give satisfactory results.They were prepared, according to Douglass and Dains' procedure,by the reaction of benzoyl isothiocy- anate on p-ter.-amino-aniline followed by hydrolyzing the benzoyl thioureas formed.Among the products obtained,p-diethylamino-,p-N-piperidyl- and p-N- morpholinyl-thioureas and most of the inte...
The current methods for the preparation of ethyl orthosilicate do not give satisfactory results.It is found that the low yield is due to the use of excess alcohol,which,in presence of hydrogen chloride,produces water and causes the ethyl orthosilicate to undergo a hydrolytic polycondensation.The condensation products have been isolated and identified as 1,3-hexaethoxydisiloxane and 1,3,5- octaethoxytrisiloxane. An improved method,consisting of the addition of equivalent quantities of silicon tetrachloride a...