[Purpose] To investigate the impact of 9-cis-retinoic acid(9-cis-RA) on transcriptional changes of RARβ in lung cancer tissue and controlled lung tissue, and to evaluate the effects of smoking on 9-cis-retinoic acid induced RARβ transcription.
AIM:To investigate the mechanism of 9-cis-RA inhibiting the growth of lung adenocarcinoma cells, and we detect the expressional changes of cyclinD1 and cdk4 in lung adenocarcinoma cells PG, A_(549), SPC-A_1 before and after being treated with 9-cis-retinoic acid(9-cis-RA).
Objective:To study the effects of9-cis-retinoic acid(9-cis-RA)on the expression of CyclinD1and Cdk4in non-small-cell lung cancer PG,A 549 and SPC-A1,and to investigate the correla-tion between inhibition of cell growth by9-cis-RA and interference with the expression of CyclinD1and Cdk4in non-small-cell lung cancers.
Objective To investigate the synergistic effects of 9-cis-retinoic acid(9-cis-RA) and 8-cl-cAMP on growth inhibition and apoptosis induction in H460 and H292 cell lines of non-small-cell lung cancer(NSCLC).
To investigate the influence of thyroid hormone status on the regulation of UGTs expression by 9-cis-retinoic acid in cultured rat primary hepatocytes.
9-cis-Retinoic Acid Regulation of Four UGT Isoforms in Hepatocytes from Rats with Various Thyroid States
The retinoylation reaction was inhibited by 13-cis-retinoic acid and 9-cis-retinoic acid with IC50 values of 0.9 μM and 0.65 μM, respectively.
Vitamin A and its metabolites, e.g., all trans-retinoic acid (atRA) and 9-cis-retinoic acid have attracted considerable attention as compounds that have a broad range of immune modulating effects on both humoral and cellular immune responses.
The retinoylation process was inhibited by 13-cis-retinoic acid and 9-cis-retinoic acid with IC50 values of 0.6 and 1.2 μM respectively.