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carcinoma in situ
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  原位癌
    Objective To explore the significance of expression of P63,Actin,CK in the diagnosis and differential diagnosis of breast carcinoma in situ or early invasive carcinoma.
    目的:探讨单克隆抗体P63 Actin CK在乳腺原位癌及早期浸润性癌中的表达及意义。
短句来源
    Methods Elivision labeling technique was used to study expression of P63 Actin CK in 18 cases of breast carcinoma in situ and 24 cases of early invasive carcinoma.
    方法:采用免疫组化Elivision法检测18例乳腺原位癌,24例乳腺早期浸润性癌中P63 Actin CK的表达。
短句来源
    Type Ⅱ-Nodal Type in 23 cases, 18 cases with IC and 4 cases with EIC and one with carcinoma in situ(CIS), and the concordance was 87.0% (20/23);
    Ⅱ型(结节型)23例,病理为浸润性癌18例,早期浸润性癌4例和原位癌1例,超声与病理诊断符合20例(8.7%);
短句来源
    In normal breast tissues, carcinoma in situ and invasive cancer, the positive rates of sFas and sFasL were 40.0%, 52.9%, 69.2% and 0.0%, 100.0%, 100.0%.
    正常乳腺上皮、原位癌、浸润性癌中表达阳性率分别为40.0%,52.9%,69.2%; 0.0%,100.0%,100.0%。
短句来源
    However, the positive expression rate of HIF-1α in the ductal carcinoma in situ (DCIS) was 55.0% (11/20) and the infiltrative breast cancer was 85.0% (51/60).
    在乳腺导管内原位癌中表达阳性率为55.0%(11/20),浸润性乳腺癌中为85.0%(51/60); HIF-1α表达与淋巴结转移及雌激素受体状态有关(P<0.01)。
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  “carcinoma in situ”译为未确定词的双语例句
    Histologic features and c erbB 2, p53, PCNA expression of breast ductal carcinoma in situ
    乳腺导管原位癌病理形态及c-erbB-2、p53和PCNA表达
短句来源
    Negative rate of FHIT expression in early invasive ductal carcinoma in situ group was obviously lower than that in invasive ductal carcinomas group(48.08%),but the difference wasn't significant.
    FHIT蛋白在导管内癌局部浸润组的阴性表达率为30%,明显低于浸润性导管癌组(48.08%),但是没有统计学差异;
短句来源
    Methods The expression of CD147,MMP-9 and p-ERK was immunohistochemically examined in 96 cases of IDC of breast,34 cases of ductal carcinoma in situ(DCIS) and 10 cases of breast adenosis.
    方法应用免疫组化EnvisionTM二步法检测96例乳腺浸润性导管癌(invasive ductal carcinoma,IDC)、34例导管内癌(ductal carcinoma in situ,DCIS)及10例乳腺腺病中CD147、MMP-9及p-ERK蛋白的表达,并分析其与临床病理参数的相关性。
短句来源
    Methods In 64 cases of IDC,15 cases of ductal carcinoma in situ(DCIS),15 cases of benign breast tissue and 15 cases of adjacent normal breast tissues,the expression of p57KIP2 proteins was detected by immunohistochemical S-P methods.
    方法采用免疫组织化学S-P法检测64例IDC、15例乳腺导管内癌(ductal carcinoma in situ,DCIS)、15例乳腺良性病变和15例癌旁正常乳腺组织中p57KIP2蛋白的表达。
短句来源
    Expression of Fas and FasL in normal breast epthelia cells,carcinoma in situ and invasive breast cancer and their significance
    正常乳腺及乳腺癌中Fas与FasL的表达及意义
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  carcinoma in situ
Results: Cox-2 protein was not observed in normal esophageal squamous and glandular epithelium, hyperplasia from mild to severe dysplasia lesions and carcinoma in situ.
      
Expression of E2F-1, Rb and ER in peripheral papilloma and ductal carcinoma in situ of the breast and its significance
      
Does tamoxifen improve the outcome of patients who have undergone lumpectomy and radiation for ductal carcinoma in situ
      
The primary role of immunotherapy for bladder cancer is to treat superficial transitional cell carcinomas (ie, carcinoma in situ, Ta, and T1).
      
Premalignant lesions that affect other organs have been identified and are treated when diagnosed such that the premalignant lesions itself are a disease ( eg, carcinoma in situ of the bladder, colon polyps, and cervical dysplasia).
      
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In all of the 22 cases of patients with pancreatic carcinoma, diffuse chronic pancreatitis, intraductal hypertension, and epithelial hyperplasia are found in the surrounding pancreatic tissue. Three types of hyperplastic changes are present: intraductal papillary hyperplasia, periductal adenomatous hyperplasia and ductular hyperplasia, all of these being regarded as precancerous lesions and containing carcinoma in situ. In addition, pyloric-glandular cell, squamous cell, and globlet cell metaplasia are...

In all of the 22 cases of patients with pancreatic carcinoma, diffuse chronic pancreatitis, intraductal hypertension, and epithelial hyperplasia are found in the surrounding pancreatic tissue. Three types of hyperplastic changes are present: intraductal papillary hyperplasia, periductal adenomatous hyperplasia and ductular hyperplasia, all of these being regarded as precancerous lesions and containing carcinoma in situ. In addition, pyloric-glandular cell, squamous cell, and globlet cell metaplasia are seen in the ducts. The significance of these histologic changes as related to multicentricitv of pancreatic carcinoma is discussed.

本文报告22例胰腺癌周围胰腺的组织学变化。癌周胰腺可见弥漫性慢性炎症及导管内高压征。胰腺导管有导管内乳头状增生、导管旁腺瘤样增生及小叶内小导管增生三种癌前期表现;三种增生导管均有原位癌形成。胰腺导管上皮有幽门腺化生、鳞状上皮化生及杯状细胞化生。本文对胰腺癌周胰腺的各种组织学变化的意义及胰腺癌的多中心性起源问題进行了讨论。

During 1954-1972, 157 patients with stage I breast cancer were treated by surgical procedures. In 31 cases the tumors were ≤1 cm in greatest diameter, and in 126 cases >1 cm-≤2 cm. Simple mastectomy was done in 4 cases. Halsted radical mastecto- my in 94, extended radical mastectomy in 14, and modified radical mastectomy in 45. 1/5 of No cases and 1/3 of N_1a cases were of positive pathology. The 5-year rate of NED* in this series was 86%, and the 10-year rate 76.3%. The 10-year NED rate of specific type of...

During 1954-1972, 157 patients with stage I breast cancer were treated by surgical procedures. In 31 cases the tumors were ≤1 cm in greatest diameter, and in 126 cases >1 cm-≤2 cm. Simple mastectomy was done in 4 cases. Halsted radical mastecto- my in 94, extended radical mastectomy in 14, and modified radical mastectomy in 45. 1/5 of No cases and 1/3 of N_1a cases were of positive pathology. The 5-year rate of NED* in this series was 86%, and the 10-year rate 76.3%. The 10-year NED rate of specific type of carcinoma (92%) was much better than non- specific type (68%) (P<0.01). A significant statistical difference in 10-year cure ra- tes of the three types of operation was not discernible, as the number of patients in each group was small. According to our experience, Certain types of stage I breast cancer, such as papi- llary cystic adenocarcinoma, typical medullary carcinoma, non-infiltrative intraductal carcinoma, lobular carcinoma in situ, Paget′s disease of the nipple without duct car- cinoma in breast tissue, and early carcinomatous change in cystic hyperplasia, simple mastectomy appears to be sufficient. In other types of breast cancer, modified radical mastectomy may be the treatment of choice.

I期乳腺癌系指T_1N_0-laMo的乳腺癌而言。我院自1954到1972年共手术治疗157例I期乳腺癌,其中~1cm者31例,1~+~2cm者126例。行单纯全乳切除术4例,Halsted根治术94例,扩大根治术14例和改良根治术45例。临床为N_0者约1/5腋淋巴结阳性,N_1a者约1/3病理阳性。157例的5年健在率86%,156例的10年健在率为76.3%。特殊型癌的10年健在率为92%,明显优于非特殊型癌的68%(P<0.01)。因本组例数较少,故三种术式的10年疗效未见明显的统计学差异。本组经验认为某些Ⅰ期乳腺癌(如乳头状囊腺癌、典型髓样癌、无管外浸润的管内癌、无乳腺实质腺癌的乳头湿疹样癌、小叶原位癌和囊性增生病早期癌变等)可仅行单纯全乳切除术,其它则宜行改良根治术。

A total of 658 breast biopsy and mastectomy specimens were revi-ewed(benign,647;carcinoma in situ,11 cases).Among the 658breast specimens,68(10.30%)atypical lobules(AL)were identifedand studied histopathologically.In addition to H & E staining,someslides were stained for AB/PAS,by Phosphotungstic acid Hemato-xylin and Gomori Silver.The results show that atypical lobules ty-pe A(ALA,54 cases)was more frequnent that atypical Iobulestype B(ALB.14 cases)Females of 31~45-year age group havethe highest incidence...

A total of 658 breast biopsy and mastectomy specimens were revi-ewed(benign,647;carcinoma in situ,11 cases).Among the 658breast specimens,68(10.30%)atypical lobules(AL)were identifedand studied histopathologically.In addition to H & E staining,someslides were stained for AB/PAS,by Phosphotungstic acid Hemato-xylin and Gomori Silver.The results show that atypical lobules ty-pe A(ALA,54 cases)was more frequnent that atypical Iobulestype B(ALB.14 cases)Females of 31~45-year age group havethe highest incidence of ALA and ALB There was only quantitativedifference in AB/PAS staining between AL grades IV and carcinomain situ(CIS),and of no qualitive significance.It is considered thatthe histologic criteria of distinction between AL grades IV and CISwere the degree of cell atypia and the presence or absene of cent-ral necrosis.Besides ALA and ALB of variable degrees found in thevicinity of 11 cases of CIS,2 cases of ALB were also found inDCIS.It suggests that AL is closely related to malignant change &ALA and ALB may progress to DCIS & LCIS respectively.In thispaper,the typing,grading and histogenesis of AL are discussedwith review of literatures

从乳腺活检和手术切除标本切片658例(良性病变647例和原位癌11例)中,检出68例(10.3%)乳腺异型小叶(AL)进行病理组织学探讨。部分切片尚采用AB/PAS、磷钨酸苏木素和镀银染色,结果显示甲型异型小叶(ALA,54例)比乙型异型小叶(ALB,14例)常见。31~45岁中年妇女组检出率最高。AB/PAS染色在AL和原位癌(CIS)之间只有量的差异,并无定性意义。区别ALⅣ级与CIS的主要组织学依据是细胞异型性程度以及有否坏死。除11例CIS癌旁检出不同级别的ALA和ALB外,并在导管原位癌(DCIS)旁发现ALB2例。从而提示AL与癌变关系密切,ALA和ALB可分别发展为DCIS和小叶原位癌(LCIS)。本文着重讨论了AL的分型、分级与组织发生。

 
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