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genetic
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  遗传
    Study of human FEN-1 gene function and its role in the development of genetic instability
    FEN-1基因功能及其在遗传不稳定形成中的作用研究
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    Genetic Modification of CHO Cells for Biopharmaceutical Production
    CHO表达系统的遗传改造
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    Studies on Association between HIV-1 Biological Characteristics and Host Genetic Background with Disease Progression
    HIV-1生物学特性及宿主遗传背景与疾病进展关系的研究
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    Structural and Genetic Analysis of Human RH Gene
    人类RH基因结构与遗传特点研究
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    Genetic and Evolutionary Study of O-antigen Gene Clusters of Shigella and Escherica Coli and Structures of Some Important O-antigens
    志贺氏菌和大肠杆菌O抗原基因簇的遗传进化及重要O抗原结构的研究
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  基因
    Study of human FEN-1 gene function and its role in the development of genetic instability
    FEN-1基因功能及其在遗传不稳定形成中的作用研究
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    Study on the expression and genetic immunization of chimeric competent fragments of Hantaan virus M and S segments
    汉滩病毒M基因G2片段与S基因0.7Kb片段嵌合基因的表达及基因免疫的研究
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    Study on chimeric genetic immunization of HBV and HCV
    HBV与HCV融合基因免疫的实验研究
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    Study f genetic abnormalities and polymorphisms of human platelet membrane glycoproteins
    血小板膜糖蛋白基因突变和基因多态性研究
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    Study of a Novel Genetic Vaccine Based on Alpha Virus Vector
    基于α-病毒载体的新型肿瘤基因疫苗的研究
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  遗传学
    Study on the Biological Characteristics and Molecular Genetic Basis for the Yuyi Hairless Mice
    豫医无毛小鼠的生物学特征及其分子遗传学研究
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    The Genetic Study of Conotruncal Heart Defects
    圆锥动脉干畸形遗传学研究
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    Genetic Characteristics of the Chinese Isolates of Rabies Virus
    中国狂犬病毒的遗传学特征
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    THE GENETIC EFFECTS OF LONG ACTING ORAL CONTRACEPTIVE Ⅰ. CYTOGENETIC INVESTIGATION ON WOMEN TAKING OC
    长效口服避孕药“复方炔雌醚”的遗传学效应——Ⅰ.对服药妇女的细胞遗传学研究
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    Genetic Study on the Native Cretinism in the Districts of Qinghai Province
    青海地区地方性克汀病的遗传学研究
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  “genetic”译为未确定词的双语例句
    The construction of general tetracycline-regulatable AAV vectors and the study of its application in genetic therapy of PD
    通用型四环素调控腺相关病毒载体的构建及其治疗帕金森病的应用研究
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    Generation of Genetic Antibody Against Epitope PreS1 of HBV: Construction of Na?ve and Immune Human Single Chain Antibody Library
    乙型肝炎病毒表位PreS1基因工程抗体的获得——天然及免疫人源单链抗体库的构建
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    Experimental Study on Genetic Engineering Vaccine with Peb1 Protein of Campylobacter Jejuni
    空肠弯曲菌粘附蛋白基因工程疫苗的实验研究
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    Construction, Expression, and Activity of a Genetic Engineered Anti-HER2/neu×Anti-CD16 Bispecific Antibody
    基因工程抗HER2/neu ×抗CD16双特异性抗体的构建、表达及其功能的初步研究
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    Familial and Genetic Study in a Kindred with UT-B Gene Mutation and Correlated Research
    UT-B基因突变家族的基因型分析、家系调查及相关研究
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  genetic
More particularly, Genetic Algorithms, Artificial Neural Networks and Fuzzy Logic methods seem to be the most promising tools to speed up and optimize the search for new leads and focused libraries.
      
Herein we describe the 3D QSAR study of 4-anilinoquinoline-3-carbonitrile by Genetic Function Approximation (GFA) and Comparative Molecular Field Analysis (CoMFA).
      
In this paper a hybrid algorithm which combines the pattern search method and the genetic algorithm for unconstrained optimization is presented.
      
The algorithm is a deterministic pattern search algorithm, but in the search step of pattern search algorithm, the trial points are produced by a way like the genetic algorithm.
      
Novel Quantum Genetic Algorithm and Its Applications
      
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The paper presents in detail the technique of leucocytes culture from human peripheral blood for the study of human chromosomes. The techniques involve both the standard method and the semi-micro method with some modifications which have been developed in this laboratory to suit our purposes. With the aid of these techniques, cytogenetic analyses for 7 different cases belonging to 4 different types of congenital defects were made, and the main results are briefly described as follows:1. Down's syndrome (4 cases)....

The paper presents in detail the technique of leucocytes culture from human peripheral blood for the study of human chromosomes. The techniques involve both the standard method and the semi-micro method with some modifications which have been developed in this laboratory to suit our purposes. With the aid of these techniques, cytogenetic analyses for 7 different cases belonging to 4 different types of congenital defects were made, and the main results are briefly described as follows:1. Down's syndrome (4 cases). Most of the cells analyzed in each case showed 47 chromosomes, and the extra chromosome was found to be one of the smallest chromosome in the karyotype. This finding is apparently in agreement with trisomic G-type as previously reported in the literatures. It is highly probable that the origin of this aberration may arise from non-disjunction of one pair of the smallest chromosomes occured in o?genesis, since there is an indication in the rise of the frequencies of Down's syndrome with the age of the mother.2. Testicular feminization syndrome (1 case). The case reported here involves the finding of the same syndrome in 3 successive generations in one family. Chromosomal analysis was available from only one patient and the result demonstrated that most cells showed a chromosome number of 46 with the normal male XY complement, which was found to be in conformity with the discovery that the chromatin was negative on nuclear sexing. This finding is in obvious disagreement with XXY constitution as suggested by some authors to account for the clinical manifestations of this syndrome. Together with the reports of some other workers, analysis of the familial history of the case gives further evidence in support of the suggestion by Grumbach and Barr that this syndrome may be inherited as due to either a sex-linked recessive or a sex-limited dominant factor, though the existing genetic evidence does not suffice to distinguish between the two possibilities.3. Anorchism (1 case). Chromosome analysis of the patient in question revealed the diploid chromosome number to be 46, including an X and a Y chromosome. The nuclear chromatin pattern was also demonstrated to be of male type. Since this case was a sporadic one, it could be assumed to have been originated by mutation. 4. Female pseudohermaphroditism (1 case). A preliminary analysis of the patient revealed the possibility of being an XO(45)/XY(46) mosaic. But this can not be ascertained without further verification from the observations on the skin and bone marrow cultures.

本文详细地介绍了以外周血液培养来研究人类染色体的技术,这些都是我们实验室几年来根据国外文献作了一些修改,以适合于我们的具体条件而拟订的.同时应用这些方法对若干病例作了细胞遗传学的研究,主要结果如下:1.四例先天愚型:在这些病例中,绝大多数中期细胞的染色体数均为47.核型分析表明为G-三体型.一般认为这是由于母亲在卵细胞形成时发生了染色体不分离的结果.2.睾丸女性化:这里报导了一个很大的家系,这一综合症的患者在该家系中已络续出现了三代.其中的一个病人用于白细胞的染色体研究.结果是正常人的双倍体数(2n=46), 具有正常男性的核型,即XY.口腔粘膜及多形核嗜中性球的性染色质扦查为阴性.这种结果显然不符合于这样的假设,即认为该种综合症的性染色体组成是XXY.结合以往一些作者的研究,我们认为该综合症是以伴性隐性或限性的常染色体显性而遗传的.但从现有证据尚不足以区分这两种的可能性.3.无睾畸形:白细胞的双倍体数为2n=46,显示正常的男性核(XY).性染色质为阴性.鉴于该病例为散发性的,我们认为它有可能起因于基因突变.4.女性假两性畸形:由白细胞的初步分析,认为可能是XO(45)/XY(46)嵌合体.但为了肯定其确切...

本文详细地介绍了以外周血液培养来研究人类染色体的技术,这些都是我们实验室几年来根据国外文献作了一些修改,以适合于我们的具体条件而拟订的.同时应用这些方法对若干病例作了细胞遗传学的研究,主要结果如下:1.四例先天愚型:在这些病例中,绝大多数中期细胞的染色体数均为47.核型分析表明为G-三体型.一般认为这是由于母亲在卵细胞形成时发生了染色体不分离的结果.2.睾丸女性化:这里报导了一个很大的家系,这一综合症的患者在该家系中已络续出现了三代.其中的一个病人用于白细胞的染色体研究.结果是正常人的双倍体数(2n=46), 具有正常男性的核型,即XY.口腔粘膜及多形核嗜中性球的性染色质扦查为阴性.这种结果显然不符合于这样的假设,即认为该种综合症的性染色体组成是XXY.结合以往一些作者的研究,我们认为该综合症是以伴性隐性或限性的常染色体显性而遗传的.但从现有证据尚不足以区分这两种的可能性.3.无睾畸形:白细胞的双倍体数为2n=46,显示正常的男性核(XY).性染色质为阴性.鉴于该病例为散发性的,我们认为它有可能起因于基因突变.4.女性假两性畸形:由白细胞的初步分析,认为可能是XO(45)/XY(46)嵌合体.但为了肯定其确切的核型,还有待于对病者的皮肤和骨髓作进一步的研究.

Studies on 5,500 metaphase plates from 103 members of 5 high risk cancer families and 1,567 metaphase plates from 30 members of 4 low risk cancer families were carried out. The investigated individuals of both groups lived in close proximity. Although the modal number and Karyotype were normal diploid (2n = 46), many more cells from members of high cancer families were found to show aneuploid and various types of structural aberrations than those from members of low risk families. In the high risk group, 1.6%...

Studies on 5,500 metaphase plates from 103 members of 5 high risk cancer families and 1,567 metaphase plates from 30 members of 4 low risk cancer families were carried out. The investigated individuals of both groups lived in close proximity. Although the modal number and Karyotype were normal diploid (2n = 46), many more cells from members of high cancer families were found to show aneuploid and various types of structural aberrations than those from members of low risk families. In the high risk group, 1.6% of the cells showed numerical aberrations and 3.25% structural aberrations, while the corresponding figurs for the low risk group were 0.5% and 0.72% respectively (p < 0.01). The 101 chromatid breaks found in the high risk cancer families were mostly distributed among chromosomes of A, B and C groups and occurred more frequently in long arms (q) than in short arms (p). During karyo-typing it was found that chromosomes A2 could not be matched with each other in 10 cells out of 300. The interaction between genetic and environmental factors in the carcinogenesis of esophageal cancer in Linxian County was briefly discussed.

从林县5个食管癌高癌家族成员103名及与之毗邻的4个低癌家族成员31名的淋巴细胞所作的染色体对比分析结果表明:高癌和低癌家族成员淋巴细胞染色体众数及其核型均属正常二倍体(2n=46)。但在高癌组中查到1.6%和3.25%具有染色体数目和结构异常的细胞,与低癌组比较有非常显著的差别(P<0.01)。核型分析发现有少数假二倍体、G组三体性和第2号染色体不配对现象。101个染色单体断裂主要集中在A、B、C三组,断裂部位长臂比短臂为多。对肿瘤发生中遗传和环境(内因和外因)因素的相互作用进行了讨论。

In China, the research on prenatal diagnosis of human genetic diseases has just begun. The results of diagnosis of 100 pregnancies are presented in this report. Among these cases, 71% (71 out of 100 eases) were chromosome analysis. The remainders (29%) were neural tube defects (table 1). Four cases of neural tube defects, one case of balanced chromosomal translocation [i.e. 46, XY, t(4;5) (4pter →4q 35:: 5q 13→ 5qter; 5pter→5q 13:: 4q 3 5→4qter) ], and two cases of sex-linked diseases were aborted. The...

In China, the research on prenatal diagnosis of human genetic diseases has just begun. The results of diagnosis of 100 pregnancies are presented in this report. Among these cases, 71% (71 out of 100 eases) were chromosome analysis. The remainders (29%) were neural tube defects (table 1). Four cases of neural tube defects, one case of balanced chromosomal translocation [i.e. 46, XY, t(4;5) (4pter →4q 35:: 5q 13→ 5qter; 5pter→5q 13:: 4q 3 5→4qter) ], and two cases of sex-linked diseases were aborted. The prenatal diagnosis of balanced translocation and X-linked diseases were discussed.

遗传疾病的产前诊断技术在我国才刚刚开展。本文报道总结一百例染色体和甲胎蛋白宫内检查的结果。其中一例平衡易位、4例无脑畸形及两例性连锁遗传疾病,胎儿被流产。由此表明产前诊断是预防某些遗传疾病的有效措施之一。

 
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