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fsh
相关语句
  卵泡刺激素
    Research on FSH in Rat Pancreas
    大鼠胰腺卵泡刺激素的研究
短句来源
    Follicle-stimulating hormone receptor (FSHR) is a G protein-coupled receptor, which is mainly expressed on Sertoli cells and granular cells of gonad. It has a large extracellular doman at N-terminal to combine with FSH.
    卵泡刺激素受体(follicle-stimulating hormone receptor,FSHR)是一种具有七个跨膜结构的G蛋白耦联受体,主要分布于睾丸支持细胞和卵巢颗粒细胞,其N末端拥有一个大的细胞外结构域,用以结合FSH。
短句来源
    Follicle-stimulating-hormone (FSH) is a glycoprotein genesial hormone which was secreted by basophilic cell of anterior pituitary, it was composed of α and β subunits;
    经典理论认为卵泡刺激素(follicle-stimulating hormone,FSH)是由垂体前叶嗜碱性细胞分泌的一种糖蛋白生殖激素,由α、β亚单位构成,其分泌受GnRH的调控,经血液循环作用于性腺,进而调节性腺的发育和配子的形成,对性激素的产生和生殖功能起重要调节作用。
短句来源
    (2) Significant negative correlation was found between plasma IGF 1 and plasma E 2 and also between FF IGF 1 and FF follicle stimulating hormone (FSH) druing ovum pick up ( P <0.01).
    (2)卵泡液内IGF-1与卵泡刺激素(FSH)、同期末梢血清中IGF-1与雌二醇(E2)呈显著的负相关(P<0.01)。
短句来源
    Methods: The appearance time of FSH binding、LH binding、LHR in 32 fetal ovaries were investigated using anti FSH polyantiody、anti LH polyantibody and LHR antibody by LSAB immunohistochemistry.
    方法 :利用抗卵泡刺激素 (Anti FSH)、抗黄体生成素 (Anti LH)多克隆抗体和黄体生成素受体 (LHR)抗体 ,采用免疫组化法 (LSAB)测定胎儿卵巢促卵泡素结合位点 (FSH binding)、黄体生成素结合位点 (LH binding)、黄体生成素受体(LHR)出现的具体时间。
短句来源
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  “fsh”译为未确定词的双语例句
    Study on the Purification of Human Pituitary Gonadotropins (FSH and LH)
    人垂体生殖激素(FSH和LH)纯品的研制
短句来源
    Objective To study the effects of FSH on the phosphorylation of Smad2/Smad3 protein in rat ovarian granulosa cells.
    目的研究Smad2/Smad3蛋白在大鼠卵巢颗粒细胞中的表达及FSH对其活化的影响。
短句来源
    Methods The granulosa cells of 21-day-old SD female rats were cultured with TGFβRⅡ antibody and FSH of different concentrations,and then the cells were obtained at defined points to determine the phosphorylation of Smad2/Smad3 by immunocytochemistry.
    方法21dSD雌性大鼠,注射PMSG 20IU,48h后对卵巢颗粒细胞进行原代培养,用TGFβRⅡ抗体及不同浓度的FSH对细胞进行不同时间的处理,通过免疫细胞化学方法观察TGFβ信号通路中Smad2/Smad3和P-Smad2/P-Smad3(磷酸化Smad2/3)表达的变化。
短句来源
    2.The treatment with FSH increased the nuclear transfer of Smad2/Smad3 and the expression of P-Smad2/P-Smad3 in granulosa cells,The effects of FSH were time and dose dependent;
    2.经FSH处理后,Smad2/Smad3向核内转移增多,P-Smad2/P-Smad3的表达增强,并与FSH的作用时间及剂量呈正相关性;
短句来源
    3.The antibody-neutlised TGFβRⅡ inhibited the stimulation of FSH on Smad2/3 in granulosa cells.
    3.TGFβRⅡ被抗体完全中和后再用FSH处理,Smad2/Smad3的核阳性率无显著增多,P-Smad2/P-Smad3的表达未见明显增强。
短句来源
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  fsh
The dynamics of follicle-stimulating hormone (FSH) luteinizing hormone (LH), prolactin (PRL), estradiol (E2), and progesterone were studied in left- and right-handed women having a stable 28-day menstrual cycle.
      
The data showed that bllod serum levels of FSH, LH, PRL, and E2are higher in left-handed in comparison to right-handed women (p>amp;lt; 0.001).
      
The experimental data for the case of resonance excitation attest to an interference character of the interaction of optical nonlinearities of different orders in the process leading to the formation of the FSH signal.
      
An insertion fragment in porcine FSHβ subunit gene was cloned by PCR.
      
With the combination of genotype and litter size of sows, it was demonstrated that FSHβ locus is closely associated with major gene controlling litter size in commercial pig breeds, such as Yorkshire, Landrace, Durco.
      
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The hormonal control of the hypothalamo-pituitary-ovary(ocular graft)axis was investigated in the rabbits.Autotransplantation of the ovary to theanterior chamber of the eye was performed immediately after bilateral ovariec-tomy.The FSH,LH,cAMP and Progesterone content in the blood of the controlrabbits and the rabbits with ocular ovarian grafts were determined by RIA andcompetitive protein-binding assay method.The experiments disclosed thatafter exogenous intravenous administration of 5 μg/kg of GnRH,there...

The hormonal control of the hypothalamo-pituitary-ovary(ocular graft)axis was investigated in the rabbits.Autotransplantation of the ovary to theanterior chamber of the eye was performed immediately after bilateral ovariec-tomy.The FSH,LH,cAMP and Progesterone content in the blood of the controlrabbits and the rabbits with ocular ovarian grafts were determined by RIA andcompetitive protein-binding assay method.The experiments disclosed thatafter exogenous intravenous administration of 5 μg/kg of GnRH,there was a gra-dual increment in both FSH and LH content at 30,60 and 240 mins intervals,with basically similar pattern.When the graft-bearing animals were mated withmales,the FSH,LH and cAMP content in the blood at 30,60,120 and 240 minsintervals also showed conspicuous increase of similar magnitude in both the con-trol and the experimental,groups of animals.The characteristic hemorrhagic spots on the surface of the graft,designatedas the ovulatory response,might be initiated by mating,copper acetateHCG orGnRH.The blood Progesterone content measured on the second,fourth andsixth day after the ovulatory response increased 5-6 times above normal.Further-more,the ovulatory response could be suppressed by the administration of theantifertility solution no.1 or 18-megestrol.Taken all these experimental datatogether,it is believed that the integrity of the hypothalamo-pituitary-ovary(ocular)axis is essentially normal as compared with that of the normal.The transparent cornea(‘window’)furnishes a very convenient means of carry-ing out direct and long-term observations,particularly useful for screening an-tifertility drugs and in the delineation of the relations of the different componentsof the axis.

本文研究了家兔下丘脑—垂体—(眼前房)卵巢轴的激素调节特点。实验用成年雌兔,在摘除两侧卵巢后立即将一片卵巢组织移植于眼前房。分别用放射免疫法及竞争性蛋白结合法测定正常对照组兔与移植组兔静脉血中FSH、LH、cAMP 及孕酮含量。结果表明,移植兔与正常兔一样,静脉注射GnRH(5微克/公斤)后30、60及240分钟,血中FSH 与LH 含量有逐渐增加趋势并显著高于基础水平。与雄兔交配后30、60、120及240分钟内,血中FSH、LH 及cAMP 的含量也明显上升,两组动物三项指标变化的幅度相似。交配,静脉注射醋酸铜、HCG 或GnRH,均可使移植卵巢发生典型点状出血,称为排卵反应。在出现排卵反应后的第二、第四与第六天,血中孕酮含量较给药前增加5—6倍。上述排卵反应,在不同程度上可被避孕一号与复方18甲基炔诺酮所抑制。证明了移植动物的下丘脑—垂体—(眼前房)卵巢轴的激素调节与正常物动相比,是基本一致的。通过透明的角膜(橱窗)可长期直接观察排卵进程的变化,为研究下丘脑—垂体—卵巢轴活动规律与筛选抗排卵药物,提供简便的慢性动物模型。

Immunomicrospheres prepared by covalent binding of sheep anti-rabbit IgG to car-boxylated polystyrene latex was used as solid phase second antibody in radioimmunoassay (RIA). It was compared with another solid phase second antibody "Immunosorbent" in the determination of LH, FSH and PEL. "Immunosorbent" and classical liquid phase double antibody RIA Kits for LH, FSH and PRL were supplied by WHO.It was found that in all these determinations the results obtained by solid phase methods and liquid phase...

Immunomicrospheres prepared by covalent binding of sheep anti-rabbit IgG to car-boxylated polystyrene latex was used as solid phase second antibody in radioimmunoassay (RIA). It was compared with another solid phase second antibody "Immunosorbent" in the determination of LH, FSH and PEL. "Immunosorbent" and classical liquid phase double antibody RIA Kits for LH, FSH and PRL were supplied by WHO.It was found that in all these determinations the results obtained by solid phase methods and liquid phase method were closely correlated, the coefficients of correlation were 0.97-0.99. The assays were more simple and precise by using solid phase second antibody, and Immunomicrospere was even better than "Immunosorbent" in some respects.

共价交联羊抗兔IgG到羧化聚苯乙烯胶乳上而制得的免疫微球,在放射免疫测定中被用作固相第二抗体。在 LH、FSH和PRL的测定中将免疫微球和另一个固相第二抗体“Immunosorbent”作了比较。“Immunosorbent”和LH、FSH、PRL放免液相双抗体法测定药盒均由世界卫生组织供应。在所有这些测定中,用固相法和液相法所获得的结果呈密切相关,相关系数在0.97~0.99之间。使用固相第二抗体可使测定更为精确、简便,而免疫微球在某些方面的效果比“Immunosorbent”更好些。

The purpose of the present study was to examine the gonadotropic control of follicu-lar development in the Diestrus (Day 4) and Proestrus (Day 1) phases of goldenhamsters in organ culture. Explants of ovaries from adult golden hamsters in Diestrus (Day 4) and Proestrus(Day 1)were maintained in plastic dishes containing 80% Earle's synthetic medium, with 20% fetal calf serum and antibiotic. 4 groups of media were prepared: (1) medium(without hormone), (2) medium containing 3.75 μg/ml Porcine Follicle Stimulating...

The purpose of the present study was to examine the gonadotropic control of follicu-lar development in the Diestrus (Day 4) and Proestrus (Day 1) phases of goldenhamsters in organ culture. Explants of ovaries from adult golden hamsters in Diestrus (Day 4) and Proestrus(Day 1)were maintained in plastic dishes containing 80% Earle's synthetic medium, with 20% fetal calf serum and antibiotic. 4 groups of media were prepared: (1) medium(without hormone), (2) medium containing 3.75 μg/ml Porcine Follicle Stimulating Hor-mone (FSH), (3) medium containing 8 μg/ml Equine Luteini zing Hormone (LH), and(4) medium containing 3.75μg/ml FSH+8μg/ml LH. Histological studies showed thatmarked changes occured in the ovary explant after 3 days in vitro. In ovary explantscultured with FSH or LH alone or without gonadotropin hormone, follicular growth wasseverely retarded and the granulosa cells were pyknotic and darkly stained as comparedwith the controls, and the oocyte displayed degenerative changes. The specimens fromDay 4 were stimulated by the addition of FSH plus LH to the medium; the action ofgonadotropin seemed to promote diestrus follicular growth, their diameters reaching morethan 477μm. Since the diameters of diestrus follicles were from 393 to 476μm. andthose of proestrus follicles from 477 to 560μm or>560μm, the size of the follicles inDiestrus after FSH plus LH treatment in vitro was almost the same as that in theProestrus phase. It has thus been shown that both FSH and LH are required for thelarger follicles of the Proestrus specimens. These results indicate that the growth of thehamster follicle in vitro is relevant to the endocrinological state of the animals, and theaddition of gonadotropins to the culture medium influences the follicular growth of theovary explants.

本文利用器官培养方法观察了成年金黄色田鼠排卵前Day 4(间情期)和Day 1(动情前期)的卵巢。按培养液中所含激素不同,分四组体外培养三天,观察卵泡生长的变化。结果培养液内未加激素、加促卵泡刺激素(FSH)和加促黄体生成素(LH)组的标本,卵泡生长受抑制,卵母细胞退化。培养液内同时加有促卵泡刺激素(FSH 3.75微克/毫升)和促黄体生成素(LH 8微克/毫升)的标本,在Day 4(间情期)大卵泡直径明显增大至477微米以上、卵泡生长近似动情前期大卵泡大小;Day 1(动情前期)大卵泡生长仍在动情前期阶段,未见有排卵现象。表明成年金黄色田鼠卵巢在体外培养条件下,能反映FSH和LH对卵泡生长的影响。

 
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