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metabolism
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  代谢
    Study on Microbial Models of Verapamil Metabolism
    维拉帕米代谢的微生物模型研究
短句来源
    Study on the Mechanism and Species Differences of Roxithromycin Metabolism
    罗红霉素代谢机理及种属差异研究
短句来源
    Identification of a Novel Cytochrome P450 2C9 Allele and Its Impact on Drug Metabolism
    细胞色素P450 2C9新等位基因的发现及其对药物代谢的影响
短句来源
    Percutaneous Penetration and Metabolism of Ketoprofen Isopropyl Ester Through a Tissue Engineering Skin Reconstructed with HaCaT Cells and Its Molecule Mechanism
    酮洛芬异丙酯经HaCaT细胞构建的组织工程皮肤的渗透、代谢及分子机制
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    The Clinical and Experimental Study of Glucocorticoid Effects on Vitamin D and Bone Metabolism
    糖皮质激素对维生素D和骨代谢影响的临床和基础研究
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  代谢作用
    B9-serine residue is crucial for insulin actions in glucose metabolism
    B9位丝氨酸残基是胰岛素的葡萄糖代谢作用所必需的(英文)
短句来源
    Objective: To study the skin metabolism of leflunomide in neonatal SD rat skin homogenate.
    目的:研究来氟米特在新生SD大鼠皮肤匀浆中的代谢作用,为来氟米特经皮给药制剂的研究提供实验依据。
短句来源
    CONCLUSION: B9-serine residue is crucial for insulin actions in glucose metabolism.
    结论:B9位丝氨酸残基是胰岛素的葡萄糖代谢作用所必需的。
短句来源
    Effects of Gantaile injection on the metabolism of acetaminophen in mice
    肝泰乐注射液对小鼠体内对乙酰氨基酚代谢作用的研究
短句来源
    Recent studies show that although the metabolism of propofol by the liver is absent in the anhepatic phase during liver transplantation, its metabolism is not affected obviously, suggesting the existence of extrahepatic metabolism and an enhanced extrahepatic metabolism of propofol in the anhepatic phase. But this postulation is to be confirmed.
    目前研究发现肝移植无肝期异丙酚虽失去肝脏的主要代谢作用,但其代谢状况未受明显影响,这提示异丙酚存在肝外代谢并且无肝期的肝外代谢可能增强,但尚未证实。
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  “metabolism”译为未确定词的双语例句
    The Metabolism and DNA Binding of ~3H-Fusarin C in Rats
    ~3H-镰刀菌素C在大鼠体内的分布及与DNA的结合
短句来源
    Effects of vitamin E and zinc on lipid peroxidation and glucose metabolism in cirrhotic rats
    维生素E和锌对肝硬化大鼠脂质过氧化和糖代谢的影响
短句来源
    The Effect of 764-3 on Platelet Aggregation and the Activity of Enzymes in Arachidonic Acid Metabolism
    丹参有效成份764-3对血小板聚集和花生四烯酸代谢产物的影响
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    Effect of Combined Norethisterone Enantate 50mg Monthly Injectable Contraceptive on Carbohydrate Metabolism
    Effect of Combined Norethisterone Enantate 50mg Monthly Injectable Contraceptive on Carbohydrate Metabolism
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    A study of the effect of lithium carbonate on glucose metabolism and its mechanism in NIDDM
    碳酸锂对NIDDM的作用及其机制探讨
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  metabolism
But there appeared to be species difference in arteether metabolism, highest conversion being recorded with humans followed by rats and monkeys.
      
The fibrate class drugs effect on lipid metabolism through PPARα receptor.
      
Effects of soil drought on seedling growth and water metabolism of three common shrubs in Loess Plateau, Northwest China
      
The growth and water metabolism of three common shrubs on the Loess Plateau were studied under soil with different water contents.
      
Few data are available on the effects of being exposed to this pollutant on the molecular mechanism, although some biochemical changes in lipid metabolism, intermediary metabolism and oxidative stress have been detected.
      
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Coronary blood flow was measured by N_2O desaturation method in anesthetized dogs. Coronary sinus catheterization was made under fluoroscopic guidance. Myocardial consumptions of oxygen, glucose, lactic acid and pyruvic acid were calculated from the differences between arterial and coronary sinus blood concentrations. This study was designed in paired experiments, and the results were analyzed by t test of individual comparisons. Normal values (mean±s.d.) of 9 dogs were: 143±17 and 8±3 mm Hg for arterial and...

Coronary blood flow was measured by N_2O desaturation method in anesthetized dogs. Coronary sinus catheterization was made under fluoroscopic guidance. Myocardial consumptions of oxygen, glucose, lactic acid and pyruvic acid were calculated from the differences between arterial and coronary sinus blood concentrations. This study was designed in paired experiments, and the results were analyzed by t test of individual comparisons. Normal values (mean±s.d.) of 9 dogs were: 143±17 and 8±3 mm Hg for arterial and coronary sinus pressures, 88±21 ml/100 g myocardium/min for coronary blood flow, 1.7±0.4 mm Hg/ml/100 g myocardium/min for coronary vascular resistance, 18.1±1.9 and 5.6±1.1 vol % for arterial and coronary sinus oxygen contents, 116±24 and 109±20 mg% for arterial and coronary sinus glucose, 24±7 and 16±5 mg % for arterial and coronary sinus lactic acid, and 1.7±0.5 and 0.8±0.3 mg % for arterial and coronary sinus pyruvic acid, respectively. The total alkaloids of the root of R. verticillata were injected i.v. 0.1 mg/kg. The arterial blood pressure was lowered about 25% and restored after 1/2 hour. There was no remarkable alteration in coronary blood flow, but the coronary vascular resistance tended to decrease, which inferred that the coronary vessels had an inclination to dilate. The myocardial consumptions of oxygen, lactic acid and pyruvic acid were higher than that of glucose, indicating that the myocardium gained its energy mainly from the aerobic metabolism of carbohydrates. Following the injection of the alkaloids, the lactate and pyruvate levels in the arterial blood rose significantly. Since the alkaloids increased the left ventricular work but not the oxygen consumption, the mechanical efficiency of myocardium was elevated from 15% for the premedicated heart to 20%. En resume, the total alkaloids have certain effects in dilating coronary vessels, in augmenting the myocardial efficiency, and in enriching its energy supply. Hence the alkaloids exert a beneficial influence on the compensatory capacity of the hypertensive heart.

本文介紹了N_2O減飽和法測定不开胸狗冠脉血流量的方法,并研究了海南島萝芙木根总碱的作用,及其对心肌糖代謝的影响。在X光透視下經靜脉插管至冠状資,从冠状动、靜脉血N_2O減飽和速率之差,計算心肌血流量,并从动、靜脉血氧、糖、乳酸及丙酮酸合量之差,計算心肌的消耗量及利用率。实驗設計采用配对法,进行t測驗个别比較,以分析除去动物个体差异及对照溶剂的影响后萝芙木碱本身的作用。 9只狗之各項正常数值平均数±标准差为:动脉平均压143±17毫米汞柱,冠状竇平均压8±3毫米汞柱,冠脉血流量88±21毫升/100克心肌/分,冠脉阻力1.7±0.4毫米汞柱/毫升/100克心肌/分,动脉血氧合量18.1±1.9容积%,冠状竇血氧含量5.6±1.1容积96,动脉血糖116±24毫克%,冠状竇血糖109±20毫克%,动脉乳酸24±7毫克%,冠状寶乳酸16±5毫克%,动脉丙酮酸1.7±0.5毫克%,冠状竇丙酮酸0.8±0.3毫克%。 靜脉注射萝芙木碱0.1毫克/公斤后,血压立即明显下降約25%,半小时后回升,冠脉血流量变化不显著,冠脉阻力有减低趋势,說明萝芙木碱降压时并不引起冠脉血流减少,冠状血管趋于扩张。心肌对氧、乳酸和丙酮酸的利...

本文介紹了N_2O減飽和法測定不开胸狗冠脉血流量的方法,并研究了海南島萝芙木根总碱的作用,及其对心肌糖代謝的影响。在X光透視下經靜脉插管至冠状資,从冠状动、靜脉血N_2O減飽和速率之差,計算心肌血流量,并从动、靜脉血氧、糖、乳酸及丙酮酸合量之差,計算心肌的消耗量及利用率。实驗設計采用配对法,进行t測驗个别比較,以分析除去动物个体差异及对照溶剂的影响后萝芙木碱本身的作用。 9只狗之各項正常数值平均数±标准差为:动脉平均压143±17毫米汞柱,冠状竇平均压8±3毫米汞柱,冠脉血流量88±21毫升/100克心肌/分,冠脉阻力1.7±0.4毫米汞柱/毫升/100克心肌/分,动脉血氧合量18.1±1.9容积%,冠状竇血氧含量5.6±1.1容积96,动脉血糖116±24毫克%,冠状竇血糖109±20毫克%,动脉乳酸24±7毫克%,冠状寶乳酸16±5毫克%,动脉丙酮酸1.7±0.5毫克%,冠状竇丙酮酸0.8±0.3毫克%。 靜脉注射萝芙木碱0.1毫克/公斤后,血压立即明显下降約25%,半小时后回升,冠脉血流量变化不显著,冠脉阻力有减低趋势,說明萝芙木碱降压时并不引起冠脉血流减少,冠状血管趋于扩张。心肌对氧、乳酸和丙酮酸的利用率很高,而对血糖消耗很少,說明心肌主要从糖的有氧代謝获取能量。靜脉注射萝芙木碱后,动脉血的乳酸及丙酮酸含量均显著增高,因此能增加心脏的能源供应,改善心肌的营养。萝芙木碱能加強左心室作功量,而心肌氧消耗量并未增高,故計算出心肌机械作功率从15%提高到20%。总結本文結果:萝芙木碱在扩张冠状血管、提高心肌作功率及增加心肌能源供应三方面都有一定的作用,因此对高血压心脏的代偿能力的提高是有利的。

Experiments on the metabolism of nucleic acids have shown that N- formyl-sarcolysin(N-F)may reduce the content of DNA both in normal animal tissues and in transplantable tumors.In view of these findings,the effect of N-F upon p~(32) incorporation into nucleic acids was investigated,and this was compared with the effect of sarcolysin. Mice and rats were used in the experiments.Fifteen μc of P~(32) in the form of Na_2HP~(32)O_4 solution were injected intraperitoneally into the animals 24 hours after the...

Experiments on the metabolism of nucleic acids have shown that N- formyl-sarcolysin(N-F)may reduce the content of DNA both in normal animal tissues and in transplantable tumors.In view of these findings,the effect of N-F upon p~(32) incorporation into nucleic acids was investigated,and this was compared with the effect of sarcolysin. Mice and rats were used in the experiments.Fifteen μc of P~(32) in the form of Na_2HP~(32)O_4 solution were injected intraperitoneally into the animals 24 hours after the last dose of N-F.The animals were sacrificed 5—6 hours after the isotope injection, RNA and DNA were isolated by the procedure described in our previous paper.Sam- ples were plated and their radioactivities were counted,and the results obtained were expressed according to the method of Davidson and Freeman. The results indicate that N-F(80mg/kg)and sarcolysin(10mg/kg)administered once daily for 4 consecutive days inhibited markedly the incorporation of P~(32) into RNA and DNA of the spleens in normal rats and in mice bearing Ehrlich ascites car- cinoma.A marked depression of P~(32) incorporation into DNA of Yoshida ascites sar- coma was also noted when N-F was administered orally at 50 or 160 mg/kg,and sarco- lysin at 5 or 20mg/kg respectively for 2 consecutive days.However,these two drugs failed to produce any significant depression of P~(32) incorporation into RNA.It is very interesting that N-F produced marked depression of P~(32) incorporation into both RNA and DNA of Yoshida solid tumors with three doses of 160 mg/kg,while with a single dose of 160 mg/kg only depression of incorporation into DNA was observed.N-F had no effect upon P~(32) incorporation into the RNA and DNA in mice bearing Ehrlich solid tumors at daily doses of 50 or 100 mg/kg for 7—9 days,as well as in mice bearing reticulo-sarcoma L_2 at daily doses of 50 or 80 mg/kg.However,under the same con- ditions N-F and sarcolysin inhibited markedly the incorporation of P~(32) into DNA of the Ehrlich ascites cells.It thus appears that N-F and sarcolysin exert a similar pattern of influence upon nucleic acid metabolism.

本文报告 N-甲对 P~(32)参入正常及肿瘤组织(或细胞)中核酸的影响。N-甲在治疗剂量下对 P~(32)参入大鼠吉田肉瘤(腹水及实体型)及小鼠艾氏癌腹水型的肿瘤细胞(或组织)核酸有明显抑制作用,且以对参入 DNA 的影响最强。N-甲对 P~(32)参入小鼠艾氏癌实体型肿瘤组织核酸无影响;在小剂量下对 P~(32)参入小鼠网织细胞肉瘤组织核酸亦无明显影响。N-甲对 P~(32)参入正常及肿瘤动物脾脏核酸有明显抑制作用。N-甲与溶肉瘤素对 P~(32)参入正常及肿瘤组织核酸的影响类似,但在等毒性剂量下其作用较溶肉瘤素稍弱。

It is well known that β-diethylaminoethyl diphenylpropylacetate HCl(SKF 525A) is a potent inhibitor of hepatic microsomal drug-metabolizing enzymes. However, our present study indicates that the effect of SKF 525A on these enzyme systems is actually biphasic. Sodium pentobarbital sleeping-time was used as an indirect criterion of the activity of the drug-transforming enzymes in mice and rats. The rate of disappearance of pentobarbital from whole mouse was determined to assess the effect of SKF 525A on the in...

It is well known that β-diethylaminoethyl diphenylpropylacetate HCl(SKF 525A) is a potent inhibitor of hepatic microsomal drug-metabolizing enzymes. However, our present study indicates that the effect of SKF 525A on these enzyme systems is actually biphasic. Sodium pentobarbital sleeping-time was used as an indirect criterion of the activity of the drug-transforming enzymes in mice and rats. The rate of disappearance of pentobarbital from whole mouse was determined to assess the effect of SKF 525A on the in vivo metabolism of the hypnotic. The amount of pentobarbital metabolized after incubating with rat liver slices was also determined. Goldbaum's method was used for the assay. It was found that either prolongation or shortening of pentobarbital sleeping-time could occur depending upon the length of the time interval between the administrations of SKF 525A(40-80 mg/kg, ip.) and pentobarbital(60 mg/kg, ip.). When pentobarbital was administered to mice within 12 hours after SKF 525A, prolongation of sleeping time was observed. On the other hand, if the mice were treated with SKF 525A 48 hours beforehand, a shortening of sleeping time was noted. Similar results were obtained for both rats and mice receiving daily injections of SKF 525A(10-40 mg/kg/day) for 3-10 days. Further studies showed that the decrease in pentobarbital sleeping time was associated with an increase in the rate of metabolism of the hypnotic. In mice receiving SKF 525A 48 hours prior to injection of pentobarbital, the whole body concentrations of the hypnotic were found to be significantly lower than those of control mice. Furthermore, liver slices from rats treated with a dose of SKF 525A 48 hours previously metabolized more pentobarbital than slices from control animals. However, the minimal body pentobarbital levels required to maintain the mice asleep seemed to be similar in both the experimental and the control groups. This fact indicates that the change in sleeping time cannot be attributed to changes in sensitivity of the central nervous system to pentobarbital. With diethylbarbital(a drug which is not metabolized in vivo), neither sleeping time nor the rate of disappearance of the drug from whole mouse was changed by SKF 525A pretreatment. The ascorbic acid contents of rat urine and mouse liver were also determined by the method of Roe and Kuther. It was found that pretreatment of animals with SKF 525A 12-24 hours before sacrifice led to elevated excretion and higher hepatic levels of ascorbic acid. This effect of SKF 525A disappeared 48 hours after injection. These results show that the enhancing effect of SKF 525A on ascorbic acid metabolism occurs before the stimulatory effect on liver drug-metabolizing enzymes.

已知二苯基丙基乙酸β-二乙基氨基乙酯(SKF 525A)为肝微粒体药物轉化酶的抑制剂。我們以戊巴此妥鈉睡眠时間为指标,发現SKF 525A的作用是双相的。小鼠注射一剂SKF 525A(40—80毫克/公斤)后0—12小时为莉酶受抑制期,表現为戊巴比妥鈉睡眠时間明显延长;但注射后48小时,小鼠戊巴比妥鈉睡眠时間不仅不延长,反而縮短。SKF 525A的双相效应在雌雄小鼠均能看到。小鼠及大鼠經連續多次注射SKF 525A后48小时,同样也出現第二相效应。下述进一步的实驗表明第二相效应是由于肝脏药物轉化酶活性加強的結果:(1)48小时前接受过一剂SKF 525A的小鼠,戊巴比妥鈉自体內消失的速率此正常动物者明显加快。(2)不論48小时前是否接受过SKF 525A,小鼠戊巴比妥鈉睡眠刚醒时,体內催眠药含量无显著差別。(3)48小时前曾經注射SKF 525A的大鼠肝切片轉化戊巴比妥鈉的速率比正常动物肝切片者快。(4)48小时前注射SKF525A并不改变二乙基巴比妥鈉(一个在体內不經轉化的莉物)引起的小鼠睡眠时間及其自体內消失的速度。 給小鼠(或大鼠)注射相当剂量的SKF 525A后12—24小时,肝脏(及尿)中的維生素C...

已知二苯基丙基乙酸β-二乙基氨基乙酯(SKF 525A)为肝微粒体药物轉化酶的抑制剂。我們以戊巴此妥鈉睡眠时間为指标,发現SKF 525A的作用是双相的。小鼠注射一剂SKF 525A(40—80毫克/公斤)后0—12小时为莉酶受抑制期,表現为戊巴比妥鈉睡眠时間明显延长;但注射后48小时,小鼠戊巴比妥鈉睡眠时間不仅不延长,反而縮短。SKF 525A的双相效应在雌雄小鼠均能看到。小鼠及大鼠經連續多次注射SKF 525A后48小时,同样也出現第二相效应。下述进一步的实驗表明第二相效应是由于肝脏药物轉化酶活性加強的結果:(1)48小时前接受过一剂SKF 525A的小鼠,戊巴比妥鈉自体內消失的速率此正常动物者明显加快。(2)不論48小时前是否接受过SKF 525A,小鼠戊巴比妥鈉睡眠刚醒时,体內催眠药含量无显著差別。(3)48小时前曾經注射SKF 525A的大鼠肝切片轉化戊巴比妥鈉的速率比正常动物肝切片者快。(4)48小时前注射SKF525A并不改变二乙基巴比妥鈉(一个在体內不經轉化的莉物)引起的小鼠睡眠时間及其自体內消失的速度。 給小鼠(或大鼠)注射相当剂量的SKF 525A后12—24小时,肝脏(及尿)中的維生素C含量比对照动物者显著增加。但在給药后48小时,此作用即已消失。可見SKF525A对动物体內維生素C合成的促进作用出現在对肝脏莉物轉化酶的刺激作用之前。

 
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