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biliary cirrhosis
相关语句
  胆汁性肝硬化
     Study on the CD4~+CD25~+ T Regulatory Cells in Patients with Primary Biliary Cirrhosis
     原发性胆汁性肝硬化患者中CD4~+CD25~+免疫调节性T细胞的研究
短句来源
     The prevalence of anti ASGPR in primary biliary cirrhosis, viral hepatitis, posthepatitic cirrhosis, hepatic cancer, cholecystitis were 21.4%(9/42)、 16.8% (16/95)、16.1%(10/62)、10.7%(3/28), and 14.3%(1/7), respectively.
     原发性胆汁性肝硬化、病毒性肝炎、肝炎后肝硬化、肝癌、胆囊炎患者中阳性检出率分别为 2 1.4 % (9/42 )、16 .8% (16 /95 )、16 .1%(10 /6 2 )、10 .7% (3/2 8)、14 .3% (1/7)。
短句来源
     Relations of peripheral blood CD11c~+ and CD123~+ dendritic cells with hepatic injury in patients with primary biliary cirrhosis
     原发性胆汁性肝硬化患者CD11c~+和CD123~+树突状细胞与肝功能损伤的关系
短句来源
     Correlation analysis of primary biliary cirrhosis with HLA-DRB1 alleles polymorphism
     原发性胆汁性肝硬化与HLA-DRB1等位基因的相关分析
短句来源
     Screening of analogue peptides antagonizing PDC-E2 specific T cells in patients with primary biliary cirrhosis
     原发性胆汁性肝硬化PDC-E2特异性T细胞拮抗性模拟肽的筛选
短句来源
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  胆汁性肝硬变
     Cloning and Expression of PDC-E2 and PCD-E3BP in E.coli and Preliminary Study of Pathogenesis of Primary Biliary Cirrhosis
     PDC-E2和E3BP的克隆、表达、活性鉴定以及原发性胆汁性肝硬变发病机理的初步探讨
短句来源
     Varying degrees of focal biliary cirrhosis were identified in 850 or 50 percent of the KSD autopsies and 85 or 5 per cent developed severe lobular cirrhosis.
     其中850例(50%)表现出不同程度的灶性胆汁性肝硬变,85例(5%)发展成严重的小叶性肝硬化。
短句来源
     Relationship between HLA-DRB alleles and primary biliary cirrhosis in patients living in northern China
     中国北方汉族人原发性胆汁性肝硬变与HLA-DRB基因相关性的初步研究
短句来源
     Result 15 cases treated by intracavitary irradiation therapy diedfrom liver function failure with biliary cirrhosis 3~18 months (average 8 months) later.
     结果 腔内放疗 15例随访中均因慢性胆汁性肝硬变肝功能衰竭死亡 ,但无狭窄再发生和肝内胆管再度扩张病例。 死亡时间术后 3~ 18个月 ,平均 8个月。
短句来源
     Objective: To investigate the surgical treatment of 15 patients with portal hypertension of secondary biliary cirrhosis due to hepatolithiasis(PHSBCH).
     目的 :探讨 15例因肝胆管结石至胆管狭窄合并胆汁性肝硬变门脉高压症 (PHSBCH)的外科治疗。
短句来源
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  “biliary cirrhosis”译为未确定词的双语例句
     In the hepatitis virus cases,HBV(+) were 86 88%,HCV(+) were 6 38%,HDV(+) were 0 71%; Schistosomiasis cirrhosis were 2 84%,alcoholic cirrhosis were 2 13%,other type cirrhosis(biliary cirrhosis?cirrhosis concealed cause of disease et al) were 1 06%.
     HBV (+) 86 .88% ,HCV (+) 6 .38% ,HDV (+) 0 .71% ,血吸虫性肝硬化 2 .84% ,酒精性肝硬化 2 .13% ,其他类型肝硬化 (胆汁性、隐源性肝硬化等 ) 1.0 6 %。
短句来源
     Methods The percentage of CD4+CD8+T cells and CD4+CD25+T cells in peripheral blood from patients with primary biliary cirrhosis(PBC) (n=27)、26 patients with other hepatic desease、30 normal individuals were measured by flowcytometry.
     方法采用流式细胞术检测北京协和医院住院和门诊PBC患者(n=27)外周血CD4+CD8+T细胞、CD4+CD25+T细胞群比例,以26例其他肝脏疾病患者作为疾病对照组,30例健康体检者作为正常对照,观察调节性T细胞亚群与患者的肝功能指标及自身抗体如AMAM2、ANA的关系。
短句来源
     Conclusion High efficient expression vector of PDC-E2 lays the foundation for serum assay of primary biliary cirrhosis patients with prokaryotic expressing PDC-E2.
     结论 获得PDC-E2蛋白的高效表达,为利用原核表达PDC-E2对PBC患者进行血清学检测奠定了基础。
短句来源
     Methods ELISA and S_P assay were used to detect the levels of IL_2,IFN_γ,IL_4,IL_10 and TNF_α in serum and T lymphocyte subsets in peripheral blood in 25 patients with primary biliary cirrhosis and 20 healthy persons with age and gender matched.
     以双抗体夹心ELISA法检测外周血细胞因子IL_2、IFN_γ、IL_4、IL_10、TNF_α水平。 以S_P法检测外周血T淋巴细胞亚群。
短句来源
     Methods The recombined expression plasmids pExSecI/PDC-E2 and pET28/ E3BP were expressed under the reasonable condition. The expression products were used to assay the serum of primary biliary cirrhosis patients ,healthy people and other hepatopathy patients.
     方法 以适当的条件诱导PDC-E2和PDC-E3BP表达质粒pExSecI/PDC-E2和pET28/E3BP,利用表达产物通过酶联免疫吸附试验检测PBC、正常人及其他原因肝硬变患者血清,并与欧盟的检测试剂盒比较。
短句来源
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  biliary cirrhosis
A genetic predisposition has been suggested in primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC).
      
This prevalence is much higher than that observed in the general population, and in patients with other chronic liver diseases such as hepatitis B virus, alcoholic liver disease, and primary biliary cirrhosis.
      
Biliary tract inflammatory disorders: Primary sclerosing cholangitis and primary biliary cirrhosis
      
Primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC) are chronic progressive cholestatic diseases that frequently lead to biliary cirrhosis.
      
Treatment of primary biliary cirrhosis and primary sclerosing cholangitis: Use of ursodeoxycholic acid
      
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Five cases of acute obstuctive suppurative cholangitis (AOSC) treated with mini-laparotomy open transhepatic biliary drainage (OTD) are reported. The general condition rapidly improved in all cases within 24 hours after OTD, and temperature returned to normal within 4 to 9 days. Gholangiogram through the retention catheter was successful in 3 cases, and it was helpful to further diagnosis and treatment.Since OTD was carried out under direct vision, major complications such as biliary leakge, bleeding from the...

Five cases of acute obstuctive suppurative cholangitis (AOSC) treated with mini-laparotomy open transhepatic biliary drainage (OTD) are reported. The general condition rapidly improved in all cases within 24 hours after OTD, and temperature returned to normal within 4 to 9 days. Gholangiogram through the retention catheter was successful in 3 cases, and it was helpful to further diagnosis and treatment.Since OTD was carried out under direct vision, major complications such as biliary leakge, bleeding from the liver or biliary duct and injury to other organs could be avoided. OTD is a simple, safe and helpful method in treating patients suffering from AOSC, who are critically ill or associated with biliary cirrhosis and portal hypertension, or with massive adhesion around the common bile duct due to previous operation which makes the operation field difficult to expose.

对5例重症急性胆管炎患者使用了经腹小切口肝穿刺胆道引流术,全部患者均于24小时内病情缓解,4—9天内体温正常。3例患者经导管造影,获胆道系统较精确的诊断。本法在直视下操作,避免了胆汁渗漏和出血,适用于病情危笃或胆总管探查有困难的患者。

Immunoglobulin abnormalities were investigated in patients with autoimmune diseases in digestive system. Chronic liver disease (22 cases), primary biliary cirrhosis ( 5 cases ) , ulcerative colitis ( 7 cases ) , Crohn's disease (10 cases ) and normal individuals ( 11 cases ) were studied. Serum immuno-globulin levels were detected, and Lymphocytes from heparinised peripheral blood were separated and cultured in complete RPMI 1640 medium in vitro for 7 days with or without pokeweed mitogen. IgG, IgA. and...

Immunoglobulin abnormalities were investigated in patients with autoimmune diseases in digestive system. Chronic liver disease (22 cases), primary biliary cirrhosis ( 5 cases ) , ulcerative colitis ( 7 cases ) , Crohn's disease (10 cases ) and normal individuals ( 11 cases ) were studied. Serum immuno-globulin levels were detected, and Lymphocytes from heparinised peripheral blood were separated and cultured in complete RPMI 1640 medium in vitro for 7 days with or without pokeweed mitogen. IgG, IgA. and IgM concentrations were detected in the supernatant by Immunoradiometric assay.Hyperimmunoglobulinemia is charateristic of patients with chronic liver disease. Increased serum IgG ( 68.2% ) IgA. ( 57.1% ) and IgM ( 54.5% ) were found in this group, and their lymphocytes from peripheral blood synthesized more IgG(987±167 vs 323±40ng/ml ) and IgA (768±144 vs 288±48ng/ ml) ( P<0.01 ) .Under the stimulation of pokeweed mitogen, the production of IgG and IgA increased further ( p<0.05 ) .In patients with ulcerative colitis, Crohn's disease and primary biliary cirrhosis, hyperimmunoglobulinemia was not so common, though increasedserum IgM was frequently found in 3/7, 4/6 and 3/5 cases respectively. The production of immunoglobulins in vitro was just the same as in control group, except IgM, which was synthesised slightly more. From the above, it is clear that the B cell functions in different autoimmune diseases may be different.

本文系研究消化系统某些自身免疫性疾病的免疫球蛋白异常。除测定患者血中各种免疫球蛋白水平外,还用外周血中的淋巴细胞体外培养,观察自发性和PWM刺激下各种免疫球蛋白的合成情况。结果表明:慢性肝病时常出现高免疫球蛋白血症,IgG、IgA和IgM均升高。体外淋巴细胞合成IgG、IgA常比正常者增多(P<0.01);在PWM刺激下合成的IgG和IgA更多(P<0.05)。溃疡性结肠炎,Crohn病及原发性胆汁性肝硬化患者血中免疫球蛋白升高者较少,体外淋巴细胞合成免疫球蛋白亦仅IgM稍多,而IgG和IgA则与正常人无明显差别,说明消化系统某些自身免疫性疾病的B细胞功能状态是各不相同的。

Needle biopsies of the liver from 4 patients with primary biliary cirrhosis were studied ultrastructurally with special reference to intrahepatic bile ducts.A septal duct with a diameter of 160μ from case 2 revealed three patterns of changes of the epithelia.Cells which were located close to the basement membrane showed features representing regenerating process.The second pattern of alteration present in most of the cells included marked increase of cytoplasmic den-sity,condensation of the nuclei and...

Needle biopsies of the liver from 4 patients with primary biliary cirrhosis were studied ultrastructurally with special reference to intrahepatic bile ducts.A septal duct with a diameter of 160μ from case 2 revealed three patterns of changes of the epithelia.Cells which were located close to the basement membrane showed features representing regenerating process.The second pattern of alteration present in most of the cells included marked increase of cytoplasmic den-sity,condensation of the nuclei and retention of exocrine granules.A few cells showed "oncocytic" changes which were characterized by large amount of mitochondria packed within their relatively abundant cytoplasm.No such cells were observed in the interlobular ducts from other 3 cases.The,changes observed suggest that both degeneration and regeneration processes were constantly going on in intrahepatic bile ducts due to the persistence of etiologic factor(s) in this condition,resulting in the diminishment of bile ducts.The large number of mitochondria and striking changes of mitochondrial cristae in oncocytes raises the possibility that these cells could trigger the formation of antimjtochondria antibody which is present in virtually all of the patients with primary biliary cirrhosis.

本文对4例原发性胆汁性肝硬化肝穿组织肝内小胆管进行了光镜和电镜观察。结果显示,肝内间隔和小叶间胆管上皮主要呈现三种变化,一少部分上皮细胞呈再生特征;大部分细胞则呈退行性变化;间隔胆管内还有为数甚少,以胞浆内充满大量线粒体为特征的嗜酸性细胞出现。上述变化提示,在致病因子作用下,肝内小胆管上皮同时存在损伤与修复再生过程,本研究首次在肝内间隔胆管内发现的嗜酸性细胞,对进一步阐明本病的发病机制具有一定意义。

 
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