Our results indicate that tumor necrosis factor α overexpression, sphingomyelin cycle activation, and lipid peroxidation intensification may cause apoptosis of hepatocytes at the late stages of cholestasis.
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Restored bile flow after a 9-day hepatic cholestasis normalized sphingomyelinase (SMase) activity and levels of TNFα and LPO products.
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The removal of a cholestatic factor after a 12-day cholestasis did not normalize the studied parameters: SMase activity and the levels of TNFα and LPO products remained much higher compared to control.
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The obtained data indicate that hepatocyte apoptosis after bile outflow restoration in late cholestasis can be due to the activation of the sphingomyelin cycle, LPO, and TNFα expression.
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Influence of Obstructive Cholestasis and Sex Hormones on the Ratio of mRNA of Two Alternative Prolactin Receptor Isoforms in Rat Hepatocytes
Abstract:To study the curative effect of Chinese medicine in treating severe cholestatic hepatitis (SCH).Methods: Three hundred and fifty patients of SCH with total bilirubin level≥171μmol/L were treated with Chinesemedicines. For those with Blood Stasis Syndrome, treated with the recipe mainly consisted of Radix Paeoniae Rubra,and for which accompanied with blood Heat, fluid retention in epigastric region, Dampness dissenubated in Sanjiao(三焦 ) or both Spleen and Kidney Yang-Defidency Syndrome, the recipe w...
Acute intrahepatic cholestasis(AIC)is not often seen in clinic and is difficultly diagnosed and treated.6 cases of AIC were treated with the method of integrated traditional and wes tern medicine.The inducing factor of the group was mainly the infections of the biliary system(4/6),which was quite different from that reported before.The actions of blood activating and stasis dispersing and of dispersing heat of the liver and gallbladder and regulat...
Objective:To explore the therapeutic efficacy of the integrated Traditional Chinese and Western Medicine in the treatment of intrahepatic cholestasis.Methods:96 cases of intrahepatic cholestasis were divided at random into two groups:The integrated group(52 cases)and the control group (44 cases)treated with dexamethasone.Results:The effective rate in the integrated group was 94.23% while in the control group it was 86.36% with statistical ...