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bupivacaine
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  布比卡因
    Morphine 10~20mg and haloperidol 5~10mg were added into 0.75 % bupivacaine 40ml and the doses and interval used were strictly controlled.
    一般为0.75%布比卡因40ml药液中加入吗啡10mg~20mg、氟哌啶5~10mg。 同时,应严格锁定每次注液量及间隔时间。
短句来源
    A Comparison between 0.75% Ropivacaine and 0.5% Bupivacaine in Epidural for Rectal Cancer Section
    直肠癌根治术采用075%罗哌卡因和05%布比卡因行硬膜外阻滞的比较
短句来源
    In group C, postoperative analgesia was produced with epidural lappaconitine 16 mg + 0.75% bupivacaine 45mg for 48 hour.
    C组术后连接硬膜外镇痛泵(WZ-6522-05型),药液为高乌甲素16mg加入0.75%布比卡因45mg,用生理盐水稀释至200ml,注入速度5ml/h,连续48小时镇痛。
短句来源
    The treatment sequence of bupivacaine before heat (BH sequence) afforded more pronounced thermosensitizing effect than that of drug after heat (HB sequence). As compared with BH Sequence, the cell survival rate of HB sequence dropped from 63.0% to 47.7% (P<0.01) and the cell death rate increased from 22.75% to 31.5% (P<0.01).
    先布比卡因后加温组(BH序贯)与先热后药组(HB序贯)相比,细胞存活率明显下降(BH47.7%,HB63%,P<0.01),细胞死亡率由22.75%增至31.5%(P<0.01),提示BH序贯所产生的热增敏效应强于NB序贯。
短句来源
    in the third one ,at first, the patients were given 5mg of morphine by the interval epiduralinjetion(IEI)after thoracotomy,and then,followed by a continuous epidural infusion(CEI )of combination of morphine and bupivacaine(morphine5mp+7.5% bupivacaine 2ml + 0.9% NaCl,to toed 100ml),at a dose of 2 ml/hour.
    Ⅲ组:术后用吗啡于硬膜外推注(IEI)十硬膜外微量泵连续输往(CEI)镇痛,具体为术后于硬膜外推注吗啡5mg,后接局麻药混合液(吗啡5mg+7.5%布比卡因2ml+生理盐水至100ml)以2ml/h的速度持续输注。
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  “bupivacaine”译为未确定词的双语例句
    MethodsWe injected a total of 100 ug palsmid DNA of pcDNA3.1-VNTR/Myc-his(+) A in 100 ul of 0.9% NaCl distributed into the anterior tibialis muscle of C57BL/6(H-2b)female mice (V group, n=15) 3 days after the injection of 100 ul bupivacaine (0.25%)as a facilitator compound.
    为了进一步提高疫苗的免疫效果,在pcDNA3.1-VNTR/Myc-his(+) A质粒中插入了HBcAg(1-144)基因(C144基因),构建了pcDNA3.1-VNTR-C144/Myc-his(+) A质粒,进一步以GM-CSF为免疫佐剂,免疫C57BL/6小鼠,研究GM-CSF和C144基因在疫苗诱发免疫应答中的作用。
短句来源
    Both Bupivacaine and Lidocaine injected at dosage of 2mg/0.1ml/mouse intratumorally enhanced thermal response on the tumor xenograft. The TER (Thermal Enhacement Ratio) was 1.4 in the case of Eupivacaine and 1.3 in Lidocaine.
    加温前肿瘤局部注射布比卡固(2mg/0.1ml/只)和利多卡因(2mg/0.1ml/只),均能增大MA737乳腺癌42.5℃的高温反应,前者增强比较高(分别为1.4和1.3),但皮肤的增强比无异(均为1.04)。
短句来源
    Methods 30 patients (ASAⅠ~Ⅱ)were divided into two groups randomly:Group Ⅰ:0.75% Ropivacaine (n=15),group Ⅱ:0.5% Bupivacaine (n=15).
    方法  30例直肠癌 (ASAⅠ~Ⅱ级 )随机分二组 :Ⅰ组 0 75 %罗哌卡因 (n =15例 ) ;
短句来源
    Using the linear array ultrasound endoscope and a needle catheter,transgastric injection of the celiac plexus with bupivacaine and 98% dehydrated absolute alcohol was accomplished. Results Pain scores for pancreatic cancer and gallbladder as well as gastric cancer were 6.76±0.39,5.9,5.53±1.24 and 4.92±2.31 respectively,prior to CPN.
    注射前疼痛分数(0~10分级):胰腺癌为(6.76±0.39)分、胆囊癌5.9分、胃癌(5.53±1.24)分、肝癌(4.92±2.31)分;
短句来源
    In group C, postoperative analgesia was produced with epidural lappaconitine + bupivacaine.
    C组为硬膜外高乌甲素镇痛组。
短句来源
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  bupivacaine
Effects of levobupivacaine and bupivacaine on rat myometrium
      
Objective: To study the effect of levobupivacaine and bupivacaine on the contractility of isolated uterine muscle strips from pregnant and non-pregnant female rats.
      
In the myometrium from non-pregnant rats,-logIC50 of levobupivacaine and bupivacaine were 4.85 and 4.25 respectively.
      
In the myometrium from pregnant rats, similar concentrations of levobupivacaine and bupivacaine were observed,-logIC50 were 2.7 and 2.9 respectively.
      
Levobupivacaine produced an increase in amplitude of contractions, while bupivacaine showed an increased trend in frequency.
      
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A Preliminary study was carried out with gastric carcinoma cell line MGTC80- 3 to determine whether local anesthetics would modify the thermosensitivity of tu- mor cells. Bupivacaine and lidocaine showed obvious enhancing effects on the ther- mosensitivity of tumor cells whereas procaine afforded minimum effect to the po- tential hyperthermic killing of cells, as measured by both cell growth curves and cell death rates. The results of cell morphology and cell electrophoresis study indi- cated that thermosensitizing...

A Preliminary study was carried out with gastric carcinoma cell line MGTC80- 3 to determine whether local anesthetics would modify the thermosensitivity of tu- mor cells. Bupivacaine and lidocaine showed obvious enhancing effects on the ther- mosensitivity of tumor cells whereas procaine afforded minimum effect to the po- tential hyperthermic killing of cells, as measured by both cell growth curves and cell death rates. The results of cell morphology and cell electrophoresis study indi- cated that thermosensitizing effects of local anaesthetics were most likely related to interaction with the cell membrane.

本实验初步研究了局部麻醉药对胃癌细胞系MGC80-3热敏感性的影响。细胞生长曲线和细胞死亡率结果均证实布比卡因和利多卡因具有明显的热增敏效应,但普鲁卡因增效作用不显著。形态学及细胞电泳结果提示局部麻醉药可能主要通过作用于细胞膜而发挥其热增敏效应。

Effects of varied sequences of bupivacaine combined with 44℃ 30 minute hyper- thermia on human cervix carcinoma cell line Hela were investigated. The treatment sequence of bupivacaine before heat (BH sequence) afforded more pronounced thermosensitizing effect than that of drug after heat (HB sequence). As compared with BH Sequence, the cell survival rate of HB sequence dropped from 63.0% to 47.7% (P<0.01) and the cell death rate increased from 22.75% to 31.5% (P<0.01). The observation of cell morphology...

Effects of varied sequences of bupivacaine combined with 44℃ 30 minute hyper- thermia on human cervix carcinoma cell line Hela were investigated. The treatment sequence of bupivacaine before heat (BH sequence) afforded more pronounced thermosensitizing effect than that of drug after heat (HB sequence). As compared with BH Sequence, the cell survival rate of HB sequence dropped from 63.0% to 47.7% (P<0.01) and the cell death rate increased from 22.75% to 31.5% (P<0.01). The observation of cell morphology also showed that the cell injury inflicted by BH sequence treatment was much more severe than that of HB sequence.

本实验采用人宫颈癌细胞系Hela对布比卡因合并44℃,30分钟高温的序贯效应进行了研究。先布比卡因后加温组(BH序贯)与先热后药组(HB序贯)相比,细胞存活率明显下降(BH47.7%,HB63%,P<0.01),细胞死亡率由22.75%增至31.5%(P<0.01),提示BH序贯所产生的热增敏效应强于NB序贯。细胞形态学观察也表明BH序贯产生的细胞损伤程度明显高于相反序贯。

The thermosensitizing effect of local anesthetics (Bupivacaine and Lidocaine) on transplanted MA737 mammary carcinoma in inbred mice TA_2 was studied.Tumor Growth Time (TGT) and Average Peak Reaction (APR) were used as indicators to evaluate the thermosensitization effect of local anesthetics on tumor and normal tissue (skin) as well.Both Bupivacaine and Lidocaine injected at dosage of 2mg/0.1ml/mouse intratumorally enhanced thermal response on the tumor xenograft.The TER (Thermal Enhacement Ratio)...

The thermosensitizing effect of local anesthetics (Bupivacaine and Lidocaine) on transplanted MA737 mammary carcinoma in inbred mice TA_2 was studied.Tumor Growth Time (TGT) and Average Peak Reaction (APR) were used as indicators to evaluate the thermosensitization effect of local anesthetics on tumor and normal tissue (skin) as well.Both Bupivacaine and Lidocaine injected at dosage of 2mg/0.1ml/mouse intratumorally enhanced thermal response on the tumor xenograft.The TER (Thermal Enhacement Ratio) was 1.4 in the case of Eupivacaine and 1.3 in Lidocaine.Whereas,the TER of the skin was similar for the two agents,around 1.04.Then it was calculated that the TGF (Therapeutic Gain Factor) for Bupivacaine was 1.36 which was higher than that of Lidocaine,1.23.These results showed that Bupivacaine as compared with Lidocaine increased selectively the thermal sensitivity of tumor.The impact of Bupivacaine on thermosensitization of any tissue as demonstrated in our work is related to the intensity of heat applied.With tumor tissue the TERs obtained at heat of 41.5℃,42.5℃ and 43.5℃ for 60 minutes were 1.26,1.38 and 1.52 respectively.

实验用TAⅡ纯系小鼠及其可移植性MA737乳腺癌,观察了局麻药布比卡因和利多卡因的热增敏作用。实验分别用肿瘤生长时间(TGT)和最大平均反应分别评价药物对肿瘤和正常组织热敏性的影响。加温前肿瘤局部注射布比卡固(2mg/0.1ml/只)和利多卡因(2mg/0.1ml/只),均能增大MA737乳腺癌42.5℃的高温反应,前者增强比较高(分别为1.4和1.3),但皮肤的增强比无异(均为1.04)。布比卡因的治疗增强比1.36优于后者的1.23。故而提示,布比卡因较利多卡因能更有选择地增强肿瘤组织的热敏性。同时发现,布比卡因对组织热敏性的影响与治疗温度有关。随温度的升高,从41.5℃,42.5℃到43.5℃,肿瘤增强比提高(ER分别为1.26,1.38和1.52)。但因温度对皮肤的最大平均反应影响较小,因而较高温度43.5℃,治疗增强比较大(1.41)。

 
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