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bupivacaine
相关语句
  布比卡因
    GAS-CHROMATOGRAPHIC DETERMINATION OF LIDOCAINE BUPIVACAINE PROCAINE AND DICAINE IN HUMAN PLASMA
    气相色谱法测定人血浆中的利多卡因、布比卡因、普鲁卡因和丁卡因
短句来源
    Pharmacokinetics of bupivacaine after 6 patients Interpleural administration
    6例手术患者应用布比卡因胸膜间阻滞后的药物动力学
短句来源
    SECOND ORDER DERIVATIVE UV SPECTROPHO-TOMETRY OF BUPIVACAINE HYDROCHLORIDE IN COMPOUND GENTAMICIN SULFATE INJECTION
    复方硫酸庆大霉素注射液中盐酸布比卡因的二阶导数分光光度测定
短句来源
    Clinical Observation on Local Analgesic Effects of Bupivacaine in 52 Patients after Thoracotomy
    52例开胸术后采用布比卡因局部镇痛临床观察
短句来源
    ANALGESIC EFFECTS OF CONTINUOS EPIDURAL INFUSING OF BUPIVACAINE AND FENTANYL MIXTURE AFTER THORACOTOMY
    剖胸术后硬膜外持续输注布比卡因和芬太尼镇痛
短句来源
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  丁哌卡因
    Safety application of 0.75% bupivacaine in epidual block
    合理应用0.75%丁哌卡因于硬脊膜外阻滞
短句来源
    The experiment of recirculating perfusion device showed that nicorandil (Nic) 0.15 mmol / L could significantly increase the tolerance to bupivacaine toxicity;
    循环式血液灌注装置实验表明,尼可地尔0.15mmol/L可明显增加离体兔心对丁哌卡因中毒的耐受量;
短句来源
    Method:Sixteen ASA gradeⅠ-Ⅱadult patients undergoing shoulder or upper limbs operation were randomly divided into two groups (n=8)). The plexus block was induced with 0.75% bupivacaine 2 mg/kg or 0.75% bupivacaine 2mg/kg plus 1:200 000 adrenaline.
    方法:选择ASA Ⅰ~Ⅱ级肩部或上肢择期手术患者16例,随机分成两组,试验组与对照组各8例,分别用含或不含肾上腺素的0.75%丁哌卡因2mg/kg行肌间沟臂丛阻滞。
短句来源
    Results:20mg pethidine of postoperative 7 hours analgesia fine rate was 80%. If using with 0.125% bupivacaine together, it's fine rate was 90%,the average analgesia time prolong to more than 8 hours,and side effecft were little.
    结果:哌替啶20mg术后7小时镇痛优良率达80%,如与0125%丁哌卡因合用则达90%,平均镇痛时间延长至8小时余,且副作用少。
短句来源
    Conclusion:epidural postoperative analgesia will be better using 20mg pethidine with 0.125% bupivacaine together in lumbar dics neuclectomy.
    结论:腰椎间盘髓核摘除术病人术后镇痛用哌替啶20mg+0125%丁哌卡因为好
短句来源
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  布吡卡因
    Bupivacaine (0.5 -1.5mg/kg iv ) could significantly antagonize arrhythmias. induced by aconitine and BaCI2 in rats(P<0.05 or P< 0. 01 ), prevent ventricular fibrillation induced by chloroform in mice (P<0. 05 or P<0. 01 ), increase tolerance dose of ouabain to produce arrhythmias and cardiac arrest in guinea pigs (P<0. 05 or P<0. 01 ).
    布吡卡因0.5、1.0、1.5mg/kg静注能明显对抗乌头碱和氯化钡诱发大鼠的心律失常,预防氯仿诱发小鼠的室颤,增加哇巴因引起豚鼠心律失常及死亡耐受量,与生理盐水对照组比较有显著差异(P<0.05或P<0.01)。
短句来源
    The antiarrhythmic actions of bupivacaine (1.0mg/kg ) was similar to that of lidocaine (4. 0mg/kg).
    布吡卡因1.0mg/kg抗心律失常作用与利多卡因4.0mg/kg效应相似。
短句来源
    The analgesic solution contained fentanyl 0.1 mg (groupⅠ), morphine 10 mg (groupⅡ) or pethidine 100 mg (groupⅢ) in 0.1% bupivacaine 40 ml, respectively.
    镇痛药液为0.1%布吡卡因40ml中加入芬太尼0.1mg(Ⅰ组)、吗啡10mg(Ⅱ组)或哌替啶100mg(Ⅲ组)。
短句来源
    1 h after the operation, all patients received 4 mg·L -1 fentanyl, 0.5 g·L -1 bupivacaine and 2 mg·L -1 adrenarine as PCEA.
    A组 :芬太尼 (4 mg· L- 1 ) +布吡卡因 (0 .5 g· L- 1 ) +肾上腺素 (2 mg· L- 1 ) .
短句来源
    CONCLUSION Patients received fentanyl and bupivacaine mixture as PCEA are effectively relived of postoperative pain and the adding of naloxone (0.3~0.45 μg·kg -1 ·h -1 ) not only ensures the good quality of analgesia, but also attenuates the side effects, and appears to reduce the postoperative opioid requirements.
    结论  PCEA泵注芬太尼与布吡卡因 ,伍用纳络酮 (0 .3~0 .45μg· kg- 1 · h- 1 )既保证镇痛质量 ,又明显降低阿片类副反应发生率及评分
短句来源
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  “bupivacaine”译为未确定词的双语例句
    78 ASA physical status ⅠorⅡ patients undergoing cholecystectomy were randomly assigned to either P group, receiving PCEA with small dose of morphine and bupivacaine, or the control group (C group)to observe the effects of PCEA on the gastroinestinal function.
    将78例ASAⅠ~Ⅱ级硬膜外阻滞效果满意的胆囊切除术患者。 随机分为P组(PCEA组)、C组(对照组)。
短句来源
    Methods 66 adult patients undergoing lower abdominal surgery were randomly divided into 3 groups by double-blind: group R with 0 01% morphine and 0 2% ropivacaine, group B with 0 01% morphine and 0 2% bupivacaine and group C with 0 01% morphine and 0 9% normal saline.
    方法 选择经腹子宫全切术的病人66 例(ASAⅠ~Ⅱ级),随机分成三组双盲对照观察,R组(n= 22):镇痛药为0-2% Rop +0-01% Mor,采用英国Graseby- 9300 PCA泵,以LCP模式给药;
短句来源
    Methods 212 cases operated on the lower abdomen, lower limbs and perineum and given combined spinal epidural anaesthesia were classified into A and B groups, each having 106 cases. The bupivacaine dosage was given in group A and B according to the length of vertebral column and clinical experience respectively.
    方法在复合腰麻硬膜外麻醉下行下腹部、下肢及会阴部手术患者212例,按腰麻根据脊柱长度给药和凭临床经验给药分为A、B两组,各106例。
短句来源
    RESULTS The established method had good linearity and precision within the range of 0.1~1.0 μg·ml -1 of bupivacaine. The detection limit was 0.02 μg·ml -1 .CONCLUSION This assay was simple,rapid and sensitive.
    结果 本法在 0 .1~ 1.0 μg·ml-1范围内呈良好的线性关系和重现性 ,方法的检测限为 0 .0 3μg·ml-1。
短句来源
    Influence of combinative treatment of dexamethasone with lidocaine and bupivacaine on the anesthetic and postoperative analgesic time in three approaches of brachial plexus block were observed,304 patients were randomly divided into three experimental groups (A1,B1,C1) and three control groups (A2,B2,C2).
    为观察不同径路臂丛阻滞对麻醉和术后镇痛时间的影响 ,对 30 4例病人分别采用肌间沟、锁骨上和腋窝内三种径路 ,随机分为A、B、C三组 ,根据药液中是否加用地塞米松又随机双盲法分为 1、2两组。
短句来源
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  bupivacaine
Effects of levobupivacaine and bupivacaine on rat myometrium
      
Objective: To study the effect of levobupivacaine and bupivacaine on the contractility of isolated uterine muscle strips from pregnant and non-pregnant female rats.
      
In the myometrium from non-pregnant rats,-logIC50 of levobupivacaine and bupivacaine were 4.85 and 4.25 respectively.
      
In the myometrium from pregnant rats, similar concentrations of levobupivacaine and bupivacaine were observed,-logIC50 were 2.7 and 2.9 respectively.
      
Levobupivacaine produced an increase in amplitude of contractions, while bupivacaine showed an increased trend in frequency.
      
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A HPLC method for the determination of lidocaine, bupivacaine and tetracaine in human plasma with verapamil as internal standard has been established. This method was carried out on an ODS column using modified methanol (0.51 ml of n-butylamine and 0.3 ml of glacial acetic acid added to 300 ml of MeOH)-water (75:25) as mobile phase operated in recycling mode. The procedure is as follows: transfer 1.0 ml of plasma into a 12 ml glass centrifuge tube, add one drop of 2 N NaOH solution (if tetracaine is present,...

A HPLC method for the determination of lidocaine, bupivacaine and tetracaine in human plasma with verapamil as internal standard has been established. This method was carried out on an ODS column using modified methanol (0.51 ml of n-butylamine and 0.3 ml of glacial acetic acid added to 300 ml of MeOH)-water (75:25) as mobile phase operated in recycling mode. The procedure is as follows: transfer 1.0 ml of plasma into a 12 ml glass centrifuge tube, add one drop of 2 N NaOH solution (if tetracaine is present, one drop of 10% sodium metabisulfite solution and 0.1 ml of 2 N NaOH solution must be added to the specimen tube before collecting the sample in order to prevent hydrolysis), add 40μ1 of the internal standard (0.16μg/μ1)and 8 ml of ethyl ether-dichloromethane (10/8,V/V). shake for 10 minutes and centrifuge for 5 minutes at 3000g. Transfer the organic phase into another tube and evaporate to dryness at 50℃. Reconstitute the residuew ith 50μl of mobile phase and inject 20μl into the chromatograph using the following conditions: column, 15×0.46 cm packed with ODS (YWG-C_(18)H_(37), 10μm); flow rate, 1.5 ml/min; UV detector, 220 nm; range 5 mV; Chart speed, 5 mm/min.This method is simple, rapid, sensitive and has a good linearity. The absolute recoveries were found to be 101±3.6% for lidocaine, 89.3±4.1% for bupivacaine and 80±10.1% for tetracaine. Precisioin studies for both within day and day-to-day at different concentrations provided CV values of less than 10% except tetracaine which produced a CV of 10.5% for within day precision at high concentration.

应用改性甲醇—水为流动相,在YWG—C_(18)H_(37)反相柱上,以异搏定(verapamil)为内标,建立了适合于临床生化研究和药物代谢动力学研究的同时或分别测定人血浆中利多卡因(lidocaine),布比卡因(bupivacaine)和丁卡因(tetracaine)的高效液相色谱法。本法简便、快速、灵敏、重现性好,流动相可循环使用。利多卡因、布比卡因和丁卡因的平均回收率分别为101±3.6%,89.3±4.1%和80±10.1%,不同浓度水平测定结果的日内和日间变异系数一般小于10%,其检定限度(信噪比>3)分别为0.03,0.05和0.1μg/ml。

Using Clark oxygen electrode, the normal rate of respiration of Schistosoma japonicum were determined in vitro. The rate of respiration of adult schistosomes was found to be 1.47+0.19 nmol O2/pair of worm/min or 6.89+1.13 nmol O_2/mg dry wt/min. It was 2.5 fold higher than that obtained by manometric method. This indicates that S. japonicum did have an active aerobic metabolism. Both in vitro and in vivo experiments showed that potassium antimony tartrate inhibited markedly the respiration of the worms, whereas...

Using Clark oxygen electrode, the normal rate of respiration of Schistosoma japonicum were determined in vitro. The rate of respiration of adult schistosomes was found to be 1.47+0.19 nmol O2/pair of worm/min or 6.89+1.13 nmol O_2/mg dry wt/min. It was 2.5 fold higher than that obtained by manometric method. This indicates that S. japonicum did have an active aerobic metabolism. Both in vitro and in vivo experiments showed that potassium antimony tartrate inhibited markedly the respiration of the worms, whereas the rate of glycolysis was affected only slightly. Our results seemed to be inconsistent with those suggested by Bueding who had attributed the mode of action of antimonial drugs to the inhibition of phosphofructokinase.Diamide, a well-known specific sulfhydryl agent, was shown to inhibit similarly the respiration of schistosomes. This led us to assume that antimonial drugs might act on important enzyme systems containing SH-groups.Pyquiton was similar to local anesthetics (lidocaine and bupivacaine) in that they stimulated the respiration of worms in vitro. It is interesting to note that all these compounds have a glycinamide structure (Fig 1). Thus, it appears that the mode of action of pyquiton may be related to that of local anesthetics, acting on worm tegument and influencing the permeability of cations.Pyquiton did show a slight effect on the glycolysis of schistosomes. But the ratio of the amount of lactic acid formed to that of the combined consumption of glycogen and glucose remained to be 1.

在应用氧电极技术测定日本血吸虫呼吸率的基础上,观察了酒石酸锑钾和吡喹酮对血吸虫呼吸和糖酵解的影响。结果表明:酒石酸锑钾对虫的呼吸呈明显的抑制;吡喹酮对虫的呼吸先刺激,在作用1 h后则表现为轻度抑制;在对呼吸有显著影响的浓度下,对虫的糖酵解并无明显影响。此外,用巯基抑制剂双酰胺、局部麻醉药利多卡因、布比卡因对血吸虫的呼吸进行了比较观察。

In this report, it is found that pcntobarbital, whether in the sedative or in the anaesthetic dose, has a prophylatic effect on bupivacaine intoxication in mice or rats, and the synergetic toxic reaction can be observed if the dose of pentobarbital is further increased. However the sodium hydro-xybutyrate and diazepam arc possessed of prophylactic efficacy in bupivacaine intoxication.

本文以小鼠、大鼠进行药理实验发现:戊巴比妥钠的镇静剂量和麻醉剂量均不能预防丁吡卡因的毒性反应,而更大剂量,不但没有防护效应,反而出现协同的毒性作用,γ-羟丁酸钠对丁吡卡因的毒性有较明显的防护作用;γ-羟丁酸钠、安定能明显提高耐缺氧能力,其预防丁吡卡因毒性作作较强,可能与此何关。临床预防局麻药的毒性反应,γ-羟丁酸钠应该是值得考虑的药物。

 
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