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malignant
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  恶性
    The Study of PTEN/MMAC1/TEP1 Tumol Suppressor Gene in Human Malignant Melanoma and its Significance
    PTEN/MMAC1/TEP1肿瘤抑制基因在人恶性黑色素瘤中的研究及其意义
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    Expression of Human Telomerase Reverse Transcriptase Gene (hTERT) in Bladder Cancer and Reversal of the Malignant Phenotype of Bladder Cancer Cell Line T24 by the Antisense Gene Therapy Targeted Against Telomerase
    端粒酶逆转录酶基因hTERT在膀胱癌组织中的表达及端粒酶反义基因治疗逆转T24膀胱癌细胞恶性表型的研究
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    Effects of CD40 Signaling on the Biological Behavior of Malignant B Lymphocytes
    CD40信号对恶性B细胞生物学行为的影响及其机制
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    Investigation of the Roles Play by TRP-1 in Melanocytes and Malignant Melanoma Cells
    TRP-1在正常黑素细胞及恶性黑素瘤细胞中的作用研究
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    The Effects and Related Mechanisms of Smad7 in the Process of Human Bronchial Epithelial Cells Malignant Transformation Induced by α-particles
    在辐射诱发人支气管上皮细胞发生恶性转化过程中Smad7基因的作用机制研究
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  恶性肿瘤
    Study of Diagnostic Imaging and Comparison with Pathology in Malignant Tumor of Urinary System
    泌尿系恶性肿瘤的影像学诊断与病理对照研究
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    Comparative Study on the Invasive Properties between Malignant Tumor Cells and Tropholbastic Cells
    恶性肿瘤细胞与囊胚滋养层细胞侵袭性生物学行为的比较性研究
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    Detection and Significance of MUC1 in Breast Tissues and Antibodies Against MUC1 VNTR Core Peptides in Sera of Patients with Benign and Malignant Breast Tumors
    乳腺良恶性肿瘤病人乳腺组织MUC1和血清MUC1 VNTR核心肽抗体检测及意义
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    Fundamental Studies on the Effect of Antisense HIF-1α Gene Therapy in Improving the Radiosensitivity of Salivary Gland Malignant Tumors
    反义HIF-1α基因治疗提高涎腺恶性肿瘤放疗敏感性的相关基础研究
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    Pre-clinical Study on Bio-therapy of Malignant Tumor with Human Wild-Type p-53, GM-CSF and B7-1 Genes Mediated by Recombinant Adenovirus Vector
    重组腺病毒介导人野生型p53、GM-CSF和B7-1基因对恶性肿瘤生物治疗的临床前研究
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  恶性的
    Differential Diagnosis of Malignant and Benign Ovarian Masses with Transvaginal Color Doppler Flow Imaging and Serum CA125
    经阴道彩色多普勒系统显像及CA125联合诊断卵巢肿块良恶性的价值
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    Differentiation of malignant and benign breast lesions with 99m [KG1*6]Tc MDP scintomammography
    ~(99m)Tc-MDP显像用于乳房肿块良恶性的诊断研究
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    The Clinical Value of Intraoperative Detecting the Distribution of ~(99)Tc~m-MIBI to Differentiate the Benign or Malignant Foci and Lymph Node of Lung
    术中探测~(99)Tc~m-MIBI分布判断肺部肿瘤及淋巴结良恶性的临床价值
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    Predicting the Malignant Degree of Astrocytoma with Use of Artificial Neural Networks:Pilot Study
    人工神经元网络鉴别星形胶质细胞瘤良恶性的初步研究
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    Results: 1.Qualitative and semi-quantitative results: The expressionlevels of integrin α_5β_1 and Fn in the ovarian epithelial neoplasms havedownward tendency in the order of benign, boundary and malignant neoplasms.
    结果:1.定性及半定量结果:整合素 α_5β_1、Fn 的表达按良性、交界性及恶性的顺序呈递减趋势;
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  “malignant”译为未确定词的双语例句
    Study of Pathological Change and CT Manifestation in Experimental Rats' Malignant Pleural Mesothelioma
    实验性大鼠胸膜间皮瘤病理改变与CT表现的研究
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    The Significance of Mt DNA Mutation and Its Detection to Diagnosis of Malignant Tumor
    线粒体DNA突变在肿瘤诊断中的意义
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    Evaluation of Low MI Real-time Ultrasonography in Assessing the Residual Tumor, Recurrence of Metastasis After Treatment for Malignant Tumors: Experimental and Clinical Study
    低机械指数实时灰阶超声造影评价治疗后残存肝癌及复发转移的实验及临床研究
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    The Sky Gene Suppresses the Malignant Growth and Metastasis of Human Breast Cancer
    候选抑癌基因Syk抑制乳腺癌的生长和转移
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    A Study on the Role of CXCR4 in Invasion and Angiogenesis of Human Malignant Glioma
    趋化因子受体CXCR4在恶性胶质瘤侵袭和血管生成中的作用研究
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  malignant
Inhibitive Effect of Prodigiosin on the Proliferation of Human Malignant Pancreatic Cancer Cells
      
Most branch duct IPMNs are benign, whereas the other two types are often malignant.
      
The prognosis is more favorable after complete resection of benign and non-invasive malignant IPMNs.
      
Malignant IPMNs that become more aggressive after parenchymal invasion necessitate adequate lymph node dissection.
      
Significant predictors of malignant IPMNs included weight loss, jaundice, a high level of serum CA19-9, a large pancreatic duct and main-duct type carcinoma.
      
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In connection with the study of the mechanism of carcinogenesis,we have underta-ken an investigation on the relative changes in activities of the proliferating enzymesuch as aspartate carbamyl transferase(ACT)and the tissue-specific enzymes such asornithine carbamyl transferase(OCT)and carbamyl phosphate synthetase(CPS_1)in amodel system of hepatocarcinogenesis of rats induced by diethylnitrosamine(DENA).Similar observations have also been made during development of rat liver.(1)Based on the pathological study...

In connection with the study of the mechanism of carcinogenesis,we have underta-ken an investigation on the relative changes in activities of the proliferating enzymesuch as aspartate carbamyl transferase(ACT)and the tissue-specific enzymes such asornithine carbamyl transferase(OCT)and carbamyl phosphate synthetase(CPS_1)in amodel system of hepatocarcinogenesis of rats induced by diethylnitrosamine(DENA).Similar observations have also been made during development of rat liver.(1)Based on the pathological study and enzymatic changes of liver in the presentexperiment,the process of carcinogenesis may be tentatively divided into three stages:(1)stage of simple hyperplasia—the early 6 weeks of DENA feeding.Changes in therelative ratio of ACT,OCT,and CPS_1 activities in this stage are reversible,similar tothose observed in the regenerating liver.(2)stage of malignant transformation—fromthe 6th to the 16th week of feeding the carcinogen.In this stage there appears anaplastichyperplasia of liver cells characterized by an irreversible change of the relative ratioof enzyme activities and (3)stage of the development of hepatocellular carcinoma—fromthe 16th to the 30th week of carcinogenesis.(2)During carcinogenesis of rat liver(after the 6th week of feeding DENA),activities of OCT and CPS_1 decreased while those of ACT increased gradually till theformation of cancer.In hepatocellular carcinoma the activities of OCT and CPS_1 areabout 10~20% of the normal liver,while those of ACT being about 2~3 times higher than the normal liver.The pattern of relative changes in activities of both groups ofenzyme during carcinogenesis was found to be the reverse of those observed in thedevelopment of rat liver.(3)The above enzymes in hepatocellular carcinoma and normal liver are probablyidentical entities,as shown by the similarities of pH optima and distribution patternsof enzyme activity in polyacrylamide gel electrophoresis.Similar K_m values anddifferent V_m values of OCT and ACT in hepatocellular carcinoma and normal liverpreparations suggested that changes in enzyme activities during carcinogenesis maypossibly be the result of an alteration in the amount of enzyme proteins.Furthermore,the specific activities of OCT and CPS_1 in the mitochondria of hepatocellular carcinomahave been found to be much lower than those of normal liver,although the proteincontent in the mitochondria of hepatocellular carcinoma decreased to an extent of about40% of that of normal liver.(4)The possible correlation between cell proliferation and differentiation to themechanism of carcinogenesis is discussed.As seen from Fig.3,the process of carcinogenesisseems to be a reversal of that of normal differentiation(development).Changes in enzymeactivities during carcinogenesis may be explained as a result of repression andderepression of the tissue-specific operons and mitotic operons,which are closelylinked and mutually repressed.It appears likely that cell proliferation may provide afundamental condition for the malignant transformation of the hepatocytes,while lossor decrease in the activities of tissue-specific function may be of primary importance tothe initiation of carcinogenesis.It is thus concluded that carcinogenesis would be dueto a random impairment of the control mechanism for gene activities of certain tissue-specific operons,leading to irreversible changes in nucleic acid biosynthesis and intissue-specific metabolism and their key enzyme activities which in turn give rise to anirreversible disturbance of the normal balance between cell proliferation and tissue-specific function,resulting in an abnormal growth and finally the formation of cancer.

本实验以二乙基亚硝胺诱发大鼠肝癌为动物模型,结合病理形态学研究了细胞增殖与组织特异代谢关键性酶ACT 及OCT,CPS_1活性的相互改变及其与癌变的关系,同时作了鼠肝发育过程中酶活性变化的比较研究。(1)根据DENA 引癌过程中酶活性CPS_Ⅰ/ACT,OCT/ACT 及ACT/CPS_Ⅰ,ACT/OCT 相对比值的变化,以及病理形态观察结果,DENA 引癌过程大致可分为三个阶段:喂DENA6周以内为单纯性增生期。此时期酶活性相对比值的改变是可逆的,与再生肝相似。第6周以后至16周为癌变期。此时期出现肝细胞异型性增生及癌变病灶。酶活性相对比值的改变是不可逆的。16周到30周为癌变细胞发展成为肝细胞癌期。(2)癌变过程中(喂DENA6周以后),OCT 及CPS_Ⅰ活性持续降低,同时ACT 活性持续增高。肝癌结节中OCT 及CPS_Ⅰ活性约为正常肝的10~20%,ACT 活性约为正常肝的2倍。癌变过程中这两类酶活性的相互改变与发育过程中的情况正好相反。在发育过程中,胚胎肝内OCT 及GPS_Ⅰ活性较成年水平低,而ACT 活性则较高。新生后CPS_Ⅰ及OCT 活性升高,同时ACT 活性降低。(3)肝与肝癌上述酶可能...

本实验以二乙基亚硝胺诱发大鼠肝癌为动物模型,结合病理形态学研究了细胞增殖与组织特异代谢关键性酶ACT 及OCT,CPS_1活性的相互改变及其与癌变的关系,同时作了鼠肝发育过程中酶活性变化的比较研究。(1)根据DENA 引癌过程中酶活性CPS_Ⅰ/ACT,OCT/ACT 及ACT/CPS_Ⅰ,ACT/OCT 相对比值的变化,以及病理形态观察结果,DENA 引癌过程大致可分为三个阶段:喂DENA6周以内为单纯性增生期。此时期酶活性相对比值的改变是可逆的,与再生肝相似。第6周以后至16周为癌变期。此时期出现肝细胞异型性增生及癌变病灶。酶活性相对比值的改变是不可逆的。16周到30周为癌变细胞发展成为肝细胞癌期。(2)癌变过程中(喂DENA6周以后),OCT 及CPS_Ⅰ活性持续降低,同时ACT 活性持续增高。肝癌结节中OCT 及CPS_Ⅰ活性约为正常肝的10~20%,ACT 活性约为正常肝的2倍。癌变过程中这两类酶活性的相互改变与发育过程中的情况正好相反。在发育过程中,胚胎肝内OCT 及GPS_Ⅰ活性较成年水平低,而ACT 活性则较高。新生后CPS_Ⅰ及OCT 活性升高,同时ACT 活性降低。(3)肝与肝癌上述酶可能是相同的。因为酶活性的最适pH 和在聚丙烯酰胺凝胶电泳图上的分布都是一致的。肝与肝癌OCT 及ACT 的K_m 相同而V_m 不同,说明癌变过程中酶活性的变化,主要是由于酶蛋白量的改变。此外,肝癌线粒体的蛋白量减少,但OCT 及CPS_Ⅰ的比活性(单位/毫克线粒体蛋白)仍较正常肝线粒体的低。(4)讨论了增生和分化与癌变的关系。初步认为,肝细胞的癌变是反分化(分化逆转)问题,和正常分化一样系由于基因表现的改变,不一定包含基因结构的改变。就与癌变有关的细胞增殖和分化的矛盾而言,细胞增殖及其有关酶活性的增高,可能是癌变发生的基础,而组织特异功能及其关键性酶活性的降低,可能与癌变的关系更为密切。因此癌变的发生,可能是由于在细胞分裂过程中致癌物使肝细胞特异功能基因的调节控制失常,从而引起增生代谢与特异代谢关键性酶活性不可逆的改变,使之失去肝细胞增殖与特异功能的正常平衡,而代之以不受控制的增生,最后形成癌细胞。

In 1976, we successfully installed a 300w Carbon Dioxide Vaporization Laser Unit. Animal experiments showed that squamous ceil carcinoma, adenocarcinoma and melanoma can be instantaneously vaporized or carbonized on application of a laser beam of 170w or above with a beam-diameter of 1 cm, passing through beam manipulator. After vaporization an analysis of the carbonized tissue showed remnants of some intact cancer cells, which were found to have lost their vitality to regrow under tissue culture. Basing on...

In 1976, we successfully installed a 300w Carbon Dioxide Vaporization Laser Unit. Animal experiments showed that squamous ceil carcinoma, adenocarcinoma and melanoma can be instantaneously vaporized or carbonized on application of a laser beam of 170w or above with a beam-diameter of 1 cm, passing through beam manipulator. After vaporization an analysis of the carbonized tissue showed remnants of some intact cancer cells, which were found to have lost their vitality to regrow under tissue culture. Basing on these findings, we began to conduct clinical application.From 1976 to 1977 we used the 300wsustained Carbon Dioxide Laser beam for treatment of 30 cases of malignant growths on the head and face. Of these 30 cases, 23 of them who had had surgical treatment, chemotherapy and/or radiation therapy previously without any improvement were all considered as failures. The follow-up results showed that 12 of these 23 cases had no relapse and were in sound health 1 to 2 years after laser treatment, 3 of them recurred and 8 of them died of metastases. In view of these preliminary results, we consider that the use of laser vaporization for treatment of malignant growths appears to be promising and worthy of further investigation.

本室自1976年至1977年间开始应用300瓦连续波CO_2激光汽化治疗以头面部为主的恶性肿瘤30例。大部属于用常规放射疗法、化学疗法(以下简称放疗、化疗)或手术无效病例。用本法探索,收到一定疗效。从本文资料来看,激光汽化作用对恶性肿瘤是一种有前途的治疗方法,值得进一步探索。

In this article, we described a procedure of isolation of basic proteins from brain glioma and stomach cancer, and presented the results of detecting tumor antigenicity by means of a macrophage electrophoretic mobility (MEM) test with lymphocytes isolated from 623 subjects,which consisted of 95 normal persons, 167 cases of brain tumor 65 cases of stomach cancer, 161 cases of miscellaneous malignant tumor, 25 cases of benign tumor and 120 cases suffering from other diseases.Using"glioma basic protein" (GBP)...

In this article, we described a procedure of isolation of basic proteins from brain glioma and stomach cancer, and presented the results of detecting tumor antigenicity by means of a macrophage electrophoretic mobility (MEM) test with lymphocytes isolated from 623 subjects,which consisted of 95 normal persons, 167 cases of brain tumor 65 cases of stomach cancer, 161 cases of miscellaneous malignant tumor, 25 cases of benign tumor and 120 cases suffering from other diseases.Using"glioma basic protein" (GBP) as an antigen, the incidence of positive reactions in the MEM test was 1.2% (1/85) in normal persons, 92 % (145/158) in brain tumors, 94% (16/17) in stomach cancers,91.1% (92/101) in miscellaneous malignancies, 20% (5/25) in benign tumors and 9.1% (8/88) in the rest cases. When using "stomach cancer basic protein"(SBP)as antigen,the positive incidence was found as follows :0% in 10 normal persons, 89% (8/9) in brain tumors, 95% (36/38) in stomach cancers, 92% (55/60) in miscellaneous malignancies and 6.3% (2/32) in the others.The above results demonstrated that more than 90% lymphocytes from patients with brain tumor, stomach cancer, or miscellaneous malignancies, when allowed to react with GBP or SBP, displayed a slowing effect on MEM while that from normal persons or non-tumor patients more than 90% did not show such an effect. Our results are broadly in accord with the observations of Field et al but contrary to that of Forrester et al.

本文介绍了从人脑胶质瘤和胃癌中提取硷性蛋白的方法,并用总数为623人的淋巴细胞(包括健康人95人、脑瘤167例、胃癌55例、其他部位癌肿161例、良性肿瘤25例以及非肿瘤性疾病120例),对以上两蛋白制剂的肿瘤抗原性进行巨噬细胞电泳试验(MEM)的检查。 用脑胶质瘤硷性蛋白(GBP)作为抗原时,MEM试验的阳性率为:正常人为1.2%(1/85)、脑瘤为92%(145/158)、胃癌为94%(16/17),其他部位癌症为91.1%(92/101)、非肿瘤性疾病为9.1%(8/88)、良性肿瘤为20%(5/25)。当用胃癌硷性蛋白(SBP)作为抗原时,其阳性率为:正常人为0%(0/10)、脑瘤为89(8/9)、胃癌为95%(36/38),其他部位癌症为92%(55/60)、非肿瘤性疾病为6.3%(2/32)。 上述结果表明90%以上脑瘤、胃癌及其他部位癌症病人的淋巴细胞,当接触GBP或SBP时,有使巨噬细胞电泳减缓的作用;而在相同条件下90%以上的正常人及非肿瘤性疾病患者无此作用。以上结果初步看来与Field等人所观察到的结果相一致,而与Forres-ter等人的结果却相反。

 
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