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graves disease
相关语句
  graves病
     The Dynamic State Research of Serum TNF-α、IFN-γ、IL-2 and IL-6 in Patients with Graves Disease
     Graves病患者血清TNF-α、IFN-γ、IL-2及IL-6的动态研究
短句来源
     Clinical significance of determination of sera FT3、FT4、STSH、TGAb、TPOAb、TRAb in exophthalmos patients with Graves disease
     Graves病眼球突出患者血清FT3、FT4、STSH、TGAb、TPOAb、TRAb检测的临床意义
短句来源
     CHANGES IN IL-2/IL-2R SYSTEM IN GRAVES DISEASE
     Graves病患者IL-2/IL-2R系统的改变
短句来源
     Study of HLA-DQA_1~*0301 allele in patients with Graves disease in China
     Graves病与HLA-DQA_1~*0301等位基因的相关性研究
短句来源
     Advances of ~(131)I to Treat Graves Disease
     ~(131)I治疗Graves病的进展
短句来源
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  格雷夫斯病
     The association between the CTLA-4 gene polymorphism in chromosome 2q31-q33 and Graves disease
     染色体2q31-q33区CTLA-4基因多态性与格雷夫斯病关系的研究
短句来源
     Comprehensive evaluation of ~(131)I and antithyroid drugs to treat the Graves disease with a thyroid enlargement below grade-Ⅱ
     ~(131)碘和抗甲状腺药物治疗甲状腺肿大Ⅱ度以下的格雷夫斯病的综合评价
短句来源
     Investigation of serum leptin levels in Graves disease
     格雷夫斯病血清瘦素水平研究
短句来源
     Objective To investigate the changes of serum leptin levels in Graves disease and study the relationship between leptin and pituitary-thyroid axis.
     目的 探讨格雷夫斯病 (Graves′disease ,GD)患者血清瘦素水平 ,分析瘦素与垂体 -甲状腺轴的关系。
短句来源
     The human major histocompatibility complex region is not a major susceptibility locus for Graves disease among the Hans in north of China
     中国北方汉族格雷夫斯病主要易感位点的检测及意义
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  “graves disease”译为未确定词的双语例句
     The correlation between serum BGP,urinary HOP and FT3 in Graves disease group were positive (r=0.35,P< 0.05; r=0.34,P< 0.05) and higher than normal group significantly;
     血清BGP、尿HOP浓度与血清FT3浓度呈正相关(r=0.35,P<0.05;r=0.34,P<0.05),明显高于缓解组和正常对照组(P<0.01);
短句来源
     Positive expession of CD83 in Hashimoto Thyroiditis> Graves Disease was also increased with (22.58 + 13.96 VS 5.19?.08,P< 0.001) and (29.92 + 14.43 VS 5.19 + 8.08,P <0.001) respectively.
     2,CD83在桥本甲状腺炎及甲状腺功能亢进症表达增多,分别为(22.58±13.96 VS 5.19±8.08,P<0.001)及(29.92±14.43 VS 5.19±8.08,P<0.001),而在甲状腺癌无表达。
短句来源
     the bone loss happened in Graves disease patients was 41% (39/96).
     患者骨量丢失发生率为41%(39/96)。
短句来源
     The ratios of Graves disease patients with positive IAA、ICA and GADA were 3.7%、9.26% and 11.1%.
     IAAI、CA、GADA阳性率分别为3.7%、9.26%、11.1%。
短句来源
     The Changes of Serum IL-1、IL-2 and IL-6 Levels in Graves Disease Patients
     毒性弥漫性甲状腺肿患者血清IL-1、IL-2、IL-6水平变化的分析
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  graves disease
Concomitant Graves' disease and primary hyperparathyroidism: clinical implications and preoperative localization of parathyroid
      
Association of Graves' disease and Graves' ophthalmopathy with the polymorphisms in promoter and exon 1 of cytotoxic T lymphocyt
      
This case report deals with severe congestive heart failure, dilatation of the left ventricle, and tachyarrhythmia without preexisting heart disease in a patient with Graves disease.
      
Effect of Jiazhongxiao on Interleukin in Patients with Graves' disease
      
Mechanism and significance of abnormal blood level of β2-microglobulin in patients with Graves' disease
      
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Thyroid stimulating antibody(TSAb)was detected by radioreceptor assay of TSHin patients with Graves' disease.The ability of serum Ig to displace the labelled TSHfrom the receptors is referred to as“TSH displacement activity(TDA)”.In untreatedGraves' disease,TDA was above normal in 24(85.7%)of 28 cases,and in patientswith Graves' disease treated with anti-thyroid drugs for less than 3 months,TDA waspositive in 7 of 10 cases.Among Graves' disease patients with symptoms...

Thyroid stimulating antibody(TSAb)was detected by radioreceptor assay of TSHin patients with Graves' disease.The ability of serum Ig to displace the labelled TSHfrom the receptors is referred to as“TSH displacement activity(TDA)”.In untreatedGraves' disease,TDA was above normal in 24(85.7%)of 28 cases,and in patientswith Graves' disease treated with anti-thyroid drugs for less than 3 months,TDA waspositive in 7 of 10 cases.Among Graves' disease patients with symptoms controlledby maintenance dose of anti-thyroid drugs and those in remission without anti-thyroiddrug maintenance,TDA was positive in only 2 of 12 cases.Among 3 patients withrecurrence of hyperthyroidism,TDA was positive in 2 cases.All the 5 patients withsimple goiter had normal TDA.TDA levels correlated well with 4-hour thyroidal ~(131)Iuptake in 20 Graves' disease patients.Thus,TSAb appears to be a prerequisite ofhyperthyroidism manifestations of Graves' disease,and this method may be employedto detect immunological remission of Graves' disease.

本文报道用促甲状腺激素(TSH)放射受体分析法测定 Graves 病病人血清甲状腺刺激抗体抑制或置换~(125)I-TSH 与人甲状腺细胞膜受体结合的活力,以 TSH 置换活力(TDA)表示之.在53例 Graves 病中,未治疗的28例,TDA 高于正常者占85.7%;治疗不满3个月的10例,有7例TDA 阳性;治疗一年以上并服用维持量的7例和已停止治疗而临床缓解的5例中,仅2例 TDA 阳性;复发的3例,有2例 TDA 阳性,5例单纯性甲状腺肿和10名正常对照者,TDA 均正常。Gra-ves 病的 TDA 水平与4小时吸~(131)碘率值密切相关(r=0.91,P<0.01)。以上资料表明:本试验可望成为检测 Grayes 病及判断治疗效果和预后的一种可靠方法.

In this communication, studies on the action of LATS-IgG on isolated thyroid gland from normal mice are presented. The two lobes of thyroid gland from each mouse were separated into two groups and incubated in Earle's medium. To one group LATS-IgG was added and to the other normal IgG was added as a control. After inoubation, it was found that (1) the iodine uptake by the thyroid, (2) the conversion of inorganic into organic iodine, (3) the thyronine synthesized and (4) the thyroid peroxidase activity in the...

In this communication, studies on the action of LATS-IgG on isolated thyroid gland from normal mice are presented. The two lobes of thyroid gland from each mouse were separated into two groups and incubated in Earle's medium. To one group LATS-IgG was added and to the other normal IgG was added as a control. After inoubation, it was found that (1) the iodine uptake by the thyroid, (2) the conversion of inorganic into organic iodine, (3) the thyronine synthesized and (4) the thyroid peroxidase activity in the LATS-IgG group were 37%,85%, 2.5 times and 3 times higher, respectively, than those of the control group.The effect of LATS-IgG on the release of T_3 and T_4 by the isolated thyroids was also studied. When compared with normal human serum, LATS-IgG serum resulted in a 10 times increase of T_3 and T_4. In another experiment, mice were injected with ~(125)I. Two hours later their thyroids were taken out and inoubated in Earle's medium. After incubation, it was found that in the LATS-IgG group the radioactivities of T_3 and T_4 were 16.6% and that of inorganio iodine 83.4% of the total activities, respectively, whereas in the control group they were 2.1% and 97.9%, respectively. These results indicated that LATS not only increases the total thyroid release but also affects the composition of the components secreted. Thus, our results may account for, at least in part, the pathogenesis of Graves' disease.

本文研究了长效甲状腺刺激物(简称LATS)对离体正常小鼠甲状腺合成和释放甲状腺激素的影响。用配对实验法,将小鼠甲状腺两叶分别放入两个培养瓶内,一组加LATS-IgG,另一组加正常人IgG作对照,在其他条件相同的情况下,实验组的摄碘率、碘的有机化作用和甲状腺激素的合成,分别增加37.5%、85%和150%。在相同的培养条件下,大鼠甲状腺过氧化物酶(简称TPO)活性,实验组比对照组增高了约三倍。说明LATS可能通过促进摄碘和活化TPO酶,促进甲状腺激素的合成。用离体培养和放射免疫测定方法证明,每毫升培养液中加50μlLATS血清(McKenzie活性为4,000%),正常小鼠甲状腺释放T_4和T_3均可增加十多倍。如果先用~(125)Ⅰ体内标记2小时,再将甲状腺摘出体外培养,则LATS组不仅总的释放率增加,而且释放物的组成成分,也有所不同,激素碘占16.6%,无机碘占83.4%;而对照组分别为2.1%和97.9%。

In this communication, studies on the action of LATS-IgG on isolated thyroidgland from normal mice are presented. The two lobes of thyroid gland from each mousewere separated into two groups and incubated in Earle's medium. To one group LATS-IgG was added and to the other normal IgG was added as a control. After incubation,it was found that (1)the iodine uptake by the thyroid, (2)the conversion of inorganiointo organic iodine, (3)the thyronine synthesized and(4)the thyroid peroxidase activityin the LATS-IgG...

In this communication, studies on the action of LATS-IgG on isolated thyroidgland from normal mice are presented. The two lobes of thyroid gland from each mousewere separated into two groups and incubated in Earle's medium. To one group LATS-IgG was added and to the other normal IgG was added as a control. After incubation,it was found that (1)the iodine uptake by the thyroid, (2)the conversion of inorganiointo organic iodine, (3)the thyronine synthesized and(4)the thyroid peroxidase activityin the LATS-IgG group were 37%, 85%, 2.5 times and 3 times higher, respectively,than those of the control group. The effect of LATS-IgG on the release of T_3 and T_4 by the isolated thyroids wasalso studied. When compared with normal human serum, LATS-IgG serum resultedin a 10 times increase of T_3 and T_4. In another experiment, mice were injected with~(125)I. Two hours later their thyroids were taken out and incubated in Earle's medium.After incubation, it was found that in the LATS-IgG group the radioactivities of T_3and T_4 were 16.6% and that of inorganic iodine 83.4% of the total activities, respe-ctively, whereas in the control group they were 2.1% and 97.9%, respectively. Theseresults indicated that LATS not only increases the total thyroid release but also affectsthe composition of the components secreted. Thus, our results may account for, atleast in part, the pathogenesis of Graves' disease.

本文研究了长效甲状腺刺激物(简称LATS)对离体正常小鼠甲状腺合成和释放甲状腺激素的影响。用配对实验法,将小鼠甲状腺两叶分别放入两个培养瓶内,一组加LATS-IgG,另一组加正常人IgG作对照,在其他条件相同的情况下,实验组的摄碘率、碘的有机化作用和甲状腺激素的合成,分别增加37.5%、85%和150%。在相同的培养条件下,大鼠甲状腺过氧化物酶(简称TPO)活性,实验组比对照组增高了约三倍。说明LATS可能通过促进摄碘和活化TPO酶,促进甲状腺激素的合成。用离体培养和放射免疫测定方法证明,每毫升培养液中加50μILATS血清(McKenzie活性为4,000%),正常小鼠甲状腺释放T_4和T_3均可增加十多倍。如果先用~(125)I体内标记2小时,再将甲状腺摘出体外培养,则LATS组不仅总的释放率增加,而且释放物的组成成分,也有所不同,激素碘占16.6%,无机碘占83.4%;而对照组分别为2.1%和97.9%。

 
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