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  oligospermia
One male patient complained about mild hypogonadism and oligospermia.
      
In 57% of men with idiopathic oligospermia, the prolactin level is higher than the average, which may be evidence of the important role of this hormone in the pathogenesis of male infertility.
      
Three subgroups were defined: severe oligospermia (≤5 million motile sperm/ml), moderate oligospermia (6 to >amp;lt;12 million motile sperm/ml), and abnormal sperm morphology (>amp;gt;60% atypical).
      
Thirty-one patients whose infertility was attributed to oligospermia were included for treatment by in vitro fertilization and embryo transfer.
      
The limitations of in vitro fertilization from males with severe oligospermia and abnormal sperm morphology
      
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Testicular dysfunction is one of the primary causes of male infertility.Ultrastruc-tural observation of testicular biopsies provides useful approach to the diagnosis of male in-fertiaity.This paper presents an ultrastructural study on tesicular biopsies from 25 caseswith oligospermia or azoospermia.Five kinds of changes were noted in the limiting mem-brane of the seminiferous tubule:(1)thickening and layering of the basal lamina or fold-ing into the seminiferous tubule;(2)thickening of the peritubular...

Testicular dysfunction is one of the primary causes of male infertility.Ultrastruc-tural observation of testicular biopsies provides useful approach to the diagnosis of male in-fertiaity.This paper presents an ultrastructural study on tesicular biopsies from 25 caseswith oligospermia or azoospermia.Five kinds of changes were noted in the limiting mem-brane of the seminiferous tubule:(1)thickening and layering of the basal lamina or fold-ing into the seminiferous tubule;(2)thickening of the peritubular tissue resulting fromincseased intercellular matenials;(3)degeneration of myoid cells;(4)widening of the limit-ing membrane due to diffuse deposition of basement membranoid substance;(5)mast cellsexisting in the lim(?)ting membrane.The endothelial cells of small blood vessels showed sig-nificant thickening,which led to progressive encroachement upon the lumen.The Ser-toli cells contained large amounts of lipid droplets and two kinds of Sertoli cells could beseen:mature and immature Sertoli cells.The mature sertoli cells were joined by typicalSertoli-Sertoli junctions,while the immature Sertoli cells were connected simply by inter-digitating processes and without any blood-testis barrier.The possible significance of thesechanges was discussed.

本文对25例男性不育症患者的睾丸活检组织进行了超微结构观察。结果表明不育症患者睾丸曲细精管界膜有显著变化,主要为界膜增厚、界膜纤维化、基膜样物质沉积、肌样细胞变性及肥大细胞增多。间质中可见结缔组织增生或小血管内皮细胞肿胀。支持细胞有空泡变性,支持细胞综合症患者的支持细胞呈未成熟型,支持细胞间未形成复合连接,而在其它病例,则有血睾屏障存在。

The concentration of immunoglobulins(IgG, IgA, IgM)and complement C3, C4 in the serum and seminal fluid from 130 men with bacterial prostatitis,nonbacterial prostatitis,antisperm-antibody, azoospermia and oligospermia were determined.The concentrations of Igs and complement in serum of all study groups are normal. IgG and SIgA were detected in all seminal samples. IgM can't be found in any seminal samples. In all study groups only IgG, SIgA, complement 03 and C4 are increased significantly in seminal fluid...

The concentration of immunoglobulins(IgG, IgA, IgM)and complement C3, C4 in the serum and seminal fluid from 130 men with bacterial prostatitis,nonbacterial prostatitis,antisperm-antibody, azoospermia and oligospermia were determined.The concentrations of Igs and complement in serum of all study groups are normal. IgG and SIgA were detected in all seminal samples. IgM can't be found in any seminal samples. In all study groups only IgG, SIgA, complement 03 and C4 are increased significantly in seminal fluid of men with bacterial prostatitis. They are valuable in diagnosis of bacterial prostatitis.The titer of T-T spermagglutinating antibody in serum of antisperm-antibody positive patients was higher than the titer in seminal plasma and they are correlative. The investagation indicates that T-T antibody(IgG and IgA)may transude inth semen. But no significant changes of Igs and complement in serum and seminal fluid from antisperm-antibody positive men have been demonstrated. The mechanism and immunokinetics are discussed. It is important that antibody and complement of antisperm in serum, seminal fluid and on surface of spermatozoa should be detected for study and diagnosis of immunologic infertility.

本文报告应用琼脂单向扩散法和放射免疫法对细菌性前列腺炎、非细菌性前列腺炎、抗精子抗体阳性、无精子症、少精子症病人共130例的血清及精浆IgG、IgA、IgM、补体C_3和C_4进行定量研究。各研究组血清免疫球蛋白和补体含量在正常范围。精浆IgG和SIgA的检出率是100%,在所有精浆标本中未测到IgM。各研究组中仅细菌性前列腺炎患者精浆IgG、SIgA、补体C_3和C_4的含量有意义地增高,具有临床诊断价值。抗精子抗体阳性患者血清T-T精子凝集抗体滴度高于精浆呈正相关,说明T-T精子抗体(IgG或IgA)可以进入精浆,但其血清及精浆Igs和补体量无明显改变。作者对其机理和免疫动力学进行了讨论,认为研究诊断免疫性不育症,检测血清、精浆、精子表面的抗精子抗体和补体是重要的。

This paper covered the serum and semen levels of pituitary gouadotrophin(ICSHFSH),prolactin and testosterone (T) in fertile and infertile men with azoospermia(55 cases),oligospermia (12 cases) and sperm abnormality (12 cases).Hormones weredetermined by RIA.Results obtained revealed that the serum level of ICSH & FSHmarkedly increased in patients with azoospermia but decreased in men with oligo-spermia & sperm abnormality,there were no significant difference in seminal fluid(P>0.05).The serum level of prolactin...

This paper covered the serum and semen levels of pituitary gouadotrophin(ICSHFSH),prolactin and testosterone (T) in fertile and infertile men with azoospermia(55 cases),oligospermia (12 cases) and sperm abnormality (12 cases).Hormones weredetermined by RIA.Results obtained revealed that the serum level of ICSH & FSHmarkedly increased in patients with azoospermia but decreased in men with oligo-spermia & sperm abnormality,there were no significant difference in seminal fluid(P>0.05).The serum level of prolactin was slightly higher than those of normalexcepted the patients with oligospermia,but in patients with azoospermia and spermabnormality were markedly lower than normal male (P<0.01).The seminal level ofPRL in infertile male was similar as in normal (P>0.05),on the other hand theT/ICSH and ICSH/FSH ratios in blood and semen had a significant difference,therefore count of this ratio will be valuable for clinical diagnosis.

本文用放射免疫分析法以25名具正常生育力男性为对照,对55例无精症,12例少精症及12例精子异常症不育男性进行了血清及精液中 ICSH,FSH,PRL,及 T 的测定结果提示:血清中 ICSH 及 FSH 无精症者较正常人明显升高(P<0.01),而少精症及精异症患者均降低而精液中 ICSH 及 FSH 则无明显差异(P<0.05)。血清催乳素水平除少精症者稍高于正常人外,无精及精异症者均显著低于正常人(P<0.05),精液 PRL 水平不育症患者与正常人无明显差异(P>0.05),此外 T/ICSH 及 ICSH/FSH 两项比值关系不育症者与正常人均有差异,该项计算比例具诊断价值。

 
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