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dispersible
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  分散
    Objective To study the relative bioavailability and bioequi-valence of sertraline hydrochloride dispersible tablets in healthy volunteers.
    目的研究盐酸舍曲林分散片(抗抑郁药)在健康人体的相对生物利用度和生物等效性。
短句来源
    RESULTS:The pharmacokinetic parameters of MMF dispersible tablets and capsules were t_(max) (0.62±s0.21),(0.74±0.23)h;
    结果:MMF分散片与胶囊麦考酚酸的药动学参数如下:t_(max)分别为(0.62±s 0.21),(0.74±0.23)h;
短句来源
    Aim To establish a method for determination of sparfloxacin dispersible tablets by HPLC.
    目的建立司帕沙星分散片含量及有关物质的HPLC测定方法。
短句来源
    Results The data for fluoxetine HCl dispersible tablets and its capsule were expressed respectively as following:Cmax was(16.96±5.40) and (17.02±4.73)ng/mL;
    结果口服盐酸氟西汀分散片或胶囊后, 氟西汀的Cmax分别为(16.96±5.40)和(17.02±4.73)ng/ml;
    Determination of Cefaclor Dispersible Tablets by RP-HPLC
    RP—HPLC法测定头孢克罗分散片的含量
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  “dispersible”译为未确定词的双语例句
    Results The standard curve of dispersible valaciclovir chloride tablets was linear in the concentration of 10-60 μg/mL(r=0.999 9),the average recovery rate was 99.20%,RSD=0.50%(n=5).
    结果盐酸伐昔洛韦质量浓度在10~60μg/mL范围内与峰面积呈现良好线性关系,r=0.9999,平均回收率99.20%,RSD=0.50%(n=5)。
短句来源
    The relative bioavailability of diflunisal dispersible tablets was(97.0±13.1)%.
    相对生物利用度为(97.0±13.1)%。
短句来源
    The relative bioavailability of enoxacin dispersible tablets was(102±9) %.
    受试制剂的相对生物利用度为(102±9)%。
短句来源
    Bioequivalence of Amoxicillin and Clavulante Potassium Dispersible Tablet in Healthy Volunteers
    阿莫西林克拉维酸钾复合制剂生物等效性研究
短句来源
    METHODS: A reversed-phase HPLC wasestablished for determination of the dispersible tablets by using YWG-C18 column and phenacetin as the internal standard. The mobilephase consisted of methanol, water and 36 % (v/v) acetic acid(70 : 30 : 2 ) and the detection wavelength was 260 nm.
    方法:采用高效液相色谱法(HPLC),其测定条件为YWG-C18色谱柱,甲醇-水-36%(V/V)醋酸(70:30:2)为流动相,检测波长为260nm,非那西丁为内标。
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  dispersible
Water-dispersible carboxymethylcellulose acetate butyrate (CMCAB) has been shown to improve flow and levelling, and reduce cratering, picture framing, and other defects in water-borne paints.
      
Statistical methods were used to develop hydroxy functional acrylic emulsions for use with a water-dispersible polyisocyanate crosslinker.
      
New high performance two-component wood coatings comprised of a hydroxy functional acrylic emulsion and a water-dispersible poly
      
Lubricant-dispersible nanoparticles are prepared via a surface modification synthetic way and characterized by state of the art tools such as TEM.
      
Dispersions of a totally dispersible AlOOH powder have been studied.
      
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Using uniform design method,we selected Chinese make excipients for Dispersible Aspirin Tablets,and established three percentages of excipients:5%,7%,5%.The results show that:when disintegration time<3 min,uniforminty of dispersion is up to the standard of B.P.1993.The results of disollution are:T50=1.161min,Td=2.109min.The disollution rate of Dispersible Aspirin Tablets is faster than that of Aspirin Tablets.All parts of Aspirin in dispersible tablets are disolluted in about 30 min.

采用国产药用辅料,运用均匀设计方法对阿司匹林分散片处方进行筛选,给出三种崩解剂或溶胀性辅料占处方的比例分别为5%,7%,5%.经过对优选处方的实验表明:崩解时间小于3min,分散均匀性试验能通过710μm筛网,均达到英国药典(1993年版)要求;体外溶出试验表明:T50=1.161min,Td=2.109min,与阿司匹林普通片溶出参数比较有显著差异,分散片溶出速度快,30min内几乎全部溶出.

A RP-HPLC method was established for the determination of cefaclor in its dispersible tablets with acetanilid as internal standard.Cefaclor can be separated on ODS column with a mixture of water,3 86 % sodium acetate solution and methyl alcohol(1380∶29∶591)as mobile phase and detected at 254 nm.The flow rate was 0 8 mL/min.The standard curve was linear in the concentration range of 0 1 to 0 5 mg/mL and the correlation coefficient was 0 9996.The average recovery and relative standard deviation were...

A RP-HPLC method was established for the determination of cefaclor in its dispersible tablets with acetanilid as internal standard.Cefaclor can be separated on ODS column with a mixture of water,3 86 % sodium acetate solution and methyl alcohol(1380∶29∶591)as mobile phase and detected at 254 nm.The flow rate was 0 8 mL/min.The standard curve was linear in the concentration range of 0 1 to 0 5 mg/mL and the correlation coefficient was 0 9996.The average recovery and relative standard deviation were 99 83 % and 0 72 % respectively.The detection limit was 1 6×10 -4 μg.The method is simple,rapid,accurate and reliable.

报道了头孢克罗分散片中头孢克罗的反相高效液相色谱法 ,采用ODS柱 (2 5 0mm×4 6mm) ,水— 3 86 %醋酸钠溶液—甲醇 (1380∶2 9∶5 91)为流动相 ,乙酰苯胺为内标 ,用紫外检测器于 2 5 4nm波长处检测。平均回收率为 99 83% ,RSD =0 72 % (n=5 ) ,线性范围为 0 1~ 0 5mg/mL (r=0 9996 )。检测限为 1 6× 10 -4μg。本法具有快速、简便、灵敏、准确等优点

Following oral administrations of a single dose of 150 mg roxithromycin dispersible tablet (formulation A, a new formulation for clinical trial) and conventional tablet (formulation B, purchased from the market) to each of 10 healthy male volunteers in a randomized crossover design, the plasma levels of active drug at different times were determined by a microbial assay with Micrococcus luteus CMCC (B) 28001 and the plasma concentration—time profiles were obtained. The T_(max) values of formulation...

Following oral administrations of a single dose of 150 mg roxithromycin dispersible tablet (formulation A, a new formulation for clinical trial) and conventional tablet (formulation B, purchased from the market) to each of 10 healthy male volunteers in a randomized crossover design, the plasma levels of active drug at different times were determined by a microbial assay with Micrococcus luteus CMCC (B) 28001 and the plasma concentration—time profiles were obtained. The T_(max) values of formulation A and B obtained were 1.7±0.9 and 3.7±1.6 h, the C_(max) values were 4.97±1.17 and 204±1.26 μg·ml-1 and the AUC0→∞ values were 62.2±11.9 and 35.0±16.9 μg·h·ml~(-1), respectively. Surprisingly, the relative bioavailability of formulation B was found to be only 59.8%±32.6% (P<0.01). The low bioavailability of the latter formulation was attributed to poor release of roxithromycin in the gastric site, which was proposed as a key factor to influence drug absorption. Other related factors were also discussed.

为比较不同剂型罗红霉素的生物利用度,用微生物管碟检定法(藤黄微球菌CMCC(B)28001)测定了10名男性健康受试者口服罗红霉素分散片(制剂A)和罗红霉素片(制剂B)后不同时间血浆中活性药物的浓度,绘制了血药浓度—时间曲线。结果表明,受试者交叉口服含罗红霉素150mg的制剂A和制剂B后,血浆Tmax分别为17±09和37±16h,Cmax分别为497±117和204±126μg·ml-1,AUC0→∞分别为622±119和350±169μg·h·ml-1。以制剂A为参比,制剂B中罗红霉素的相对生物利用度仅为598%±326%,两种制剂的药物吸收程度有显著差异(P<001)。初步分析提示,罗红霉素在胃中的迅速溶出是保证其片剂生物利用度的关键之一

 
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