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plaque forming cell
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  空斑形成细胞
    The suppressive effects of cyclosporin A ( CsA ) made in China on immune function were studied in mice. CsA ( 25 and 50 mg/kg ig for 4 d ) caused a significant decrease of spleen plaque forming cell ( PFC ) in mice.
    当剂量为25~100mg/kg·d~(-1),ig×4d时,国产环孢素A(CsA)显著抑制小鼠脾脏空斑形成细胞数和溶血素生成,并呈剂量依赖方式。
短句来源
    SPG_1 (1.25, 2.5 and 5.0mg/kg, ip for 1 day) and SPG_2 (2.5 and 5.0 mg/kg, ip for 1 day) promoted the plaque forming cell(PFC) response to sheep red blood cells (SRBC) in mice. The effects of SPG_1 and SPG_2 on immune function were studied in aged immunodeficient mice.
    小鼠ip SPG_1可显著增强羊红细胞(SRBC)诱导的小鼠脾脏空斑形成细胞(PFC)反应。
短句来源
    It was found that the spleen plaque forming cell(PFC)response to sheep red blood cells,delayed cuta- neous hypersensitivity(DCH)induced by dinitrochlorobenzene and the lymphocyte prolifer- ation stimulated by concanavalin A(Con A)were significantly decreased in stressed mice. In addition.
    结果指出,应激可使羊红细胞(SRBC)致敏小鼠脾脏的空斑形成细胞(PFC)减少,使二硝基氯苯(DNCB)所致迟发型皮肤过敏反应(DCH)和刀豆素A(Con A)诱导的脾淋巴细胞增殖反应减弱。
短句来源
    TAM 50mg/kg markedly increased ANAE(+) cell percentage of peripheral blood lymphocytes and the production of spleen plaque forming cell(PFC) in hydrocortisone treated mice.
    北豆根总碱50mg/kgip能显著增加模型鼠外周血淋巴细胞ANAE阳性百分率,增加脾脏空斑形成细胞溶血能力。
短句来源
    Objective:To observe the effects of extract of river clam(KAL) on delayed type hypersensitivity(DTH)response and hemolytic plaque forming cell(PEC) response in immunosuppression mice.
    目的 :观察河蚌提取物 (KAL)对免疫低下小鼠的迟发性过敏反应 (DTH)和溶血空斑形成细胞 (PFC)反应的影响。
短句来源
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  溶血空斑形成细胞
    Objective:To observe the effects of extract of river clam(KAL) on delayed type hypersensitivity(DTH)response and hemolytic plaque forming cell(PEC) response in immunosuppression mice.
    目的 :观察河蚌提取物 (KAL)对免疫低下小鼠的迟发性过敏反应 (DTH)和溶血空斑形成细胞 (PFC)反应的影响。
短句来源
  “plaque forming cell”译为未确定词的双语例句
    Results In 250mg/kg and 1 000mg/kg dose group,the thymus and spleen weight,the plaque forming cell count,the serum hemolysin volume,the toe thickness as well as the carbon clearance index were all significantly lower than those of control group(P<0 05,P<0 01).
    结果  2 5 0mg/kg、10 0 0mg/kg剂量组的胸腺和脾脏质量明显低于对照组 (P <0 0 1) ,PFC对数值、血清溶血素抗体积数、足跖肿胀度及碳廓清指数均低于对照组 (P <0 0 5 ,P <0 0 1)。
短句来源
    Isopinosine (ISO, 25·100 mg/kg·d-1ip for 4 or 5d) significantly increased the production of serum hemolysin-and spleen plaque forming cell ( PFC) in normal mice immunized with SRBC. The same result was observed in immunosuppressive mice induced by cy clophospha-mide.
    在正常小鼠和注射环磷酰胺所致的免疫功能抑制的小鼠,异丙肌苷)25,50,100mg/kg,ip)能显著促进溶血素生成;
短句来源
    Administration of ABP to ICR mice at the dose of 50 mg·kg-1 for sd not onlyraised serum total IgG and serum specific hem0lysiri content but also promoted:the plaque forming cell (PFC)-response to sheep red blood cells (SRBC).
    ABPip50mg·kg-1×5d能明显提高血清总IgG及特异性抗体溶血素的含量,并增加脾脏PFC数;
短句来源
    studied included leukocyte type of mouse,mouse body weight increasing and organ weight,plaque forming cell assay and macrophage phagocytosis function test. The results showed:After mouses were exposed to GEPOE(10mg/kg\,40mg/kg\,160mg/kg)by a single intraperitoneal injection,the percentage of lymphacyte in leukocyte was decreased,mouse body weight increasing slowed,spleen and thymus atrophied,plaque forming cell decreasingly secreted plaque,macrophage phagocytosis function was inhibited.
    结果表明:小鼠腹腔染毒尾气颗粒物有机提取物(10mg/kg 、40mg/kg 、160mg/kg) 均可引起外周血白细胞中淋巴细胞比例降低、小鼠体重增长缓慢、脾脏与胸腺萎缩、抗体生成细胞分泌抗体减少、巨噬细胞吞噬功能受到抑制,并且均具有剂量反应关系。
短句来源
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  plaque forming cell
Aged C57BL/10 and C57BL/10.BR mice demonstrated significantly reduced plaque forming cell (PFC) responses to both T-dependent and-independent antigens.
      
CMI was evaluated by measuring delayed type of hypersensitivity (DTH) response and humoral by plaque forming cell (PFC) assay.
      
Soybean inhibitor, aprotinin, α-antitrypsin and ovomucoid (1 mg) diminished significantly the direct plaque forming cell response per spleen 3 days after immunization with 108 sheep erythrocytes (SRBC), when given at the same time as the antigen.
      
The splenic plaque forming cell (PFC) response to red sheep cells were measured for treatment levels of 0.01 to 1,000 ppb (μg/kg).
      
Using a reverse plaque forming cell (PFC) assay the production of immunoglobulin (Ig) by peripheral blood mononuclear cells (MNCs) in vitro was studied in 12 patients with Wegener's granulomatosis (WG).
      
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Isopinosine (ISO, 25·100 mg/kg·d-1ip for 4 or 5d) significantly increased the production of serum hemolysin-and spleen plaque forming cell ( PFC) in normal mice immunized with SRBC. The same result was observed in immunosuppressive mice induced by cy clophospha-mide. In 16 month aged mice, ISO (ip for 5 d) showed potentiating effect on anti-SRBC PFC response at the dose of 2 .5 mg/kg, no significant effect at the dose of 5 .0 mg/kg, and inhibiting effect at the dose of 25 and 100 mg/kg respectively. 1SO(25,50...

Isopinosine (ISO, 25·100 mg/kg·d-1ip for 4 or 5d) significantly increased the production of serum hemolysin-and spleen plaque forming cell ( PFC) in normal mice immunized with SRBC. The same result was observed in immunosuppressive mice induced by cy clophospha-mide. In 16 month aged mice, ISO (ip for 5 d) showed potentiating effect on anti-SRBC PFC response at the dose of 2 .5 mg/kg, no significant effect at the dose of 5 .0 mg/kg, and inhibiting effect at the dose of 25 and 100 mg/kg respectively. 1SO(25,50 and 100 mg/kg·d-1 ip for 9 or 10 d ) remarkably enhanced delayed cutaneous hypersensiti-vity (DCH) to 2, 4 -dinitrochlorobenzene (DNCB) in normal mice as well as in immunosuppressive mice induced by cyclophospha-mide. ISO (5, 10 and 20 mg/L ) signficantly increased ConA-induced lymphocyte proliferation of spleen cells from C57BL/6J mice in vitro. There was also potentiating effect on lymphocyte proliferation induced by ConA in 16 month aged mice.

在正常小鼠和注射环磷酰胺所致的免疫功能抑制的小鼠,异丙肌苷)25,50,100mg/kg,ip)能显著促进溶血素生成;增加空斑形成细胞数;增强二硝基氯苯所致迟发型皮肤超敏反应。在16月龄老年小鼠,异丙肌苷(2.5mg/kg,ip)可使减少的空斑形成细胞数增加至接近3月龄小鼠的水平,加大剂量作用反减弱或使空斑形成细胞数显著减少。体外试验,异丙肌苷(5,10,20mg/L)可显著增强刀豆素A诱导的C57 BL/6J小鼠的淋巴细胞增殖反应,并使16月龄老年小鼠低下的刀豆素A诱导的淋巴细胞增殖反应明显恢复。

The suppressive effects of cyclosporin A ( CsA ) made in China on immune function were studied in mice. CsA ( 25 and 50 mg/kg ig for 4 d ) caused a significant decrease of spleen plaque forming cell ( PFC ) in mice. At the dose of 25, 50 and 100 mg/kg ig for 4 d, CsA inhibited the production of hemolysin in a dose-dependent manner in mice immunized with SRBC. CsA ( 25, 50 and 100 mg/kg ig for 10d ) also markedly inhibited the delayed cutaneous hypersensitivity ( DCH ) induced by DNCB in mice. CsA 50 mg/kg...

The suppressive effects of cyclosporin A ( CsA ) made in China on immune function were studied in mice. CsA ( 25 and 50 mg/kg ig for 4 d ) caused a significant decrease of spleen plaque forming cell ( PFC ) in mice. At the dose of 25, 50 and 100 mg/kg ig for 4 d, CsA inhibited the production of hemolysin in a dose-dependent manner in mice immunized with SRBC. CsA ( 25, 50 and 100 mg/kg ig for 10d ) also markedly inhibited the delayed cutaneous hypersensitivity ( DCH ) induced by DNCB in mice. CsA 50 mg/kg ig for 14d prolongated survival time of cardiac grafts. The treatment with CsA could not reduce the clearance rate of iv charcoal particles as well as bone marrow cells in mice. There was no significant difference of immu-nosuppressive effect on PFC response between China-made CsA and Sandoz-made CsA

当剂量为25~100mg/kg·d~(-1),ig×4d时,国产环孢素A(CsA)显著抑制小鼠脾脏空斑形成细胞数和溶血素生成,并呈剂量依赖方式。该剂量给药10d,可显著抑制2,4—二硝基氯苯所致小鼠迟发型皮肤超敏反应。CsA(50 mg/kg·d~(-1),ig×14d)能明显延长小鼠移植心脏的存活时间。CsA(50,100mg/kg·d~(-1),ig×4d)对小鼠iv碳粒廓清速率和骨髓细胞数均无明显影响。国产CsA和进口CsA对小鼠脾脏空斑形成细胞反应的抑制作用无显著差异。

SPG_1 and SPG_2 are polysaccharides extracted respectively from fermented cultural mycelium and fermentation fluid of Schizophyllum commune. This paper reports the effect of SPG_1 and SPG_2 on concanavalin A (Con A) induced proliferation of lymphocyte from C_(57)BL/6J mice in vitro. SPG_1 (10, 25, 50 and 100 μg/ml) and SPG_2 (10, 50 and 100μg/ml) was found to significantly increase lymphocyte proliferation. In addition, SPG_1 (10, 25, 50 and 75μg/ml) antagonized the suppressive effect of hydrocortisone on proliferation...

SPG_1 and SPG_2 are polysaccharides extracted respectively from fermented cultural mycelium and fermentation fluid of Schizophyllum commune. This paper reports the effect of SPG_1 and SPG_2 on concanavalin A (Con A) induced proliferation of lymphocyte from C_(57)BL/6J mice in vitro. SPG_1 (10, 25, 50 and 100 μg/ml) and SPG_2 (10, 50 and 100μg/ml) was found to significantly increase lymphocyte proliferation. In addition, SPG_1 (10, 25, 50 and 75μg/ml) antagonized the suppressive effect of hydrocortisone on proliferation of mouse spleen cells, while SPG_2 did not. In vivo, at the dose of 2.5 and 5.0 mg/kg ip for 9 days, SPG_1 and SPG_2 remarkably enhanced the delayed-type hypersensitivity to 2, 4-dinitrochlorobenzene (DNCB) in mice. SPG_1 (1.25, 2.5 and 5.0mg/kg, ip for 1 day) and SPG_2 (2.5 and 5.0 mg/kg, ip for 1 day) promoted the plaque forming cell(PFC) response to sheep red blood cells (SRBC) in mice. The effects of SPG_1 and SPG_2 on immune function were studied in aged immunodeficient mice. SPG_1 (10 and 25 μg/ml) and SPG_2 (25 μg/ml) was found to enhance the Con A induced lymphocyte proliferation in 14 months aged mice. At the dose of 2.5 mg/kg, SPG_1 and SPG_2 produced respectively 162.1 and 136.0% increase in PFC response in 14 months aged mice.

裂褶菌孢内多糖(SPG_1)和孢外多糖(SPG_2)是分别从发酵培养的裂褶菌菌丝体和发酵液中提取的多糖。SPG_1和SPG_2均能显著促进Con A诱导的小鼠脾淋巴细胞增殖反应,SPG_1还显著地对抗氢可的松对淋巴细胞增殖反应的抑制作用。SPG_1和SPG_2均可恢复14月龄老年小鼠低下的脾淋巴细胞增殖反应。给小鼠ip SPG_1和SPG_2均能显著增强二硝基氯苯(DNCB)所致小鼠迟发型皮肤过敏反应(DCH)。小鼠ip SPG_1可显著增强羊红细胞(SRBC)诱导的小鼠脾脏空斑形成细胞(PFC)反应。SPG_1和SPG_2还可使老年小鼠的PFC反应恢复至成年小鼠水平。

 
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