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oral
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  口服
    The Study of Oral Drug Delivery System with Insulin-Adsorbed Porous Microspheres
    胰岛素-多孔羟基磷灰石微球口服给药系统的研究
短句来源
    Study on Absorption of Hyaluronic Acid after Oral Administration and Its Mechanism
    透明质酸口服吸收及其机制的研究
短句来源
    EXPERIMENTAL THERAPY OF SCHISTOSOMIASIS JAPONICA,Ⅻ.EFFECTIVENESS OF 8-HYDROXYQUINOLINE-ANTIMONY COMPLEX IN THE ORAL TREATMENT OF EXPERIMENTAL SCHISTOSOMIASIS IN MICE
    口服8-羟喹啉锑实验治疗小白鼠血吸虫病的研究(血吸虫病实验治疗研究之十二)
短句来源
    STUDIES ON ORAL DIURETICS Ⅱ. THE PHYSIOLOGICAL DISPOSITION OF 5-CHLORO-2,4-DISULFO-NAMIDOANILINE(DSA) IN RATS
    口服利尿药的研究——Ⅱ.5-氯-2,4-双磺酰氨基-苯胺(DSA)的利尿作用和体內代謝
短句来源
    PHARMACOLOGICAL STUDIES OF A LONG-ACTING ORAL CONTRACEPTIVE——COMPOUND QUINESTROL Ⅱ. SUBACUTE AND CHRONIC TOXICITY TESTS
    口服长效避孕药复方炔雌醚的药理研究——Ⅱ.亚急性和慢性毒性试验
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  经口
    STUDIES ON TOXICOKINETICS OF ~3H-SULFOLANE IN RAT AFTER ORAL ADMINISTRATION
    ~3H-环丁砜经口染毒后在大鼠体内的毒代动力学
短句来源
    Drug delivery systems (DDS)Ⅲ Oral drug delivery systems
    药物传递系统(DDS)Ⅲ经口给药途经的DDS
短句来源
    Results:The oral LD(50) of hepatic peptide in both mice and rats was more than 20.0 g/kg·BW,so the hepatic peptide belonged to actual non-toxicity.
    结果:复肝肽对雌雄性小鼠和雌雄性大鼠经口LD50均大于20.0 g/kg体重,属无毒类。
短句来源
    Study on the oral LD_(50) prediction model of aromatic chemicals in rats
    芳香族化合物大鼠经口LD_(50)预测模型的研究
短句来源
    Effects of Oral Administration of Aluminum Potassium Sulfate on Liver and Kidney of Rabbits
    经口摄入硫酸铝钾对兔肝肾影响的实验研究
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  “oral”译为未确定词的双语例句
    STUDIES ON HEMEROCALLIS THUNBERGII BAKER Ⅱ.EFFECTIVENESS OF HEMEROCALLIS THUNBERGII IN ORAL TREATMENT OF EXPERIMENTAL SCHISTOSOMIASIS IN MICE
    萱草根的研究 Ⅱ.萱草根实验治疗小白鼠血吸虫病的研究
短句来源
    Ⅱ. PHARMACOKINETIC OF 3H-A-OT-FU BY ORAL ADMINISTRATION
    Ⅱ、~3H-A-OT-FU在小鼠体内的药物动力学
短句来源
    Anorexia corrected by oral mixture zinc gluconate in 83 children
    葡萄糖酸锌合剂治疗小儿厌食83例
短句来源
    Effect of Oral Contraceptives on Lipoprotein Metabolism
    女用复方甾体避孕药对血浆脂蛋白代谢影响的研究
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    Accumulation of the mycotoxin ~3H-alternariol monomethyl ether (AME)in mice after oral administration
    小鼠灌服~3H交链孢酚单甲醚的体内蓄积作用
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  oral
Pre-clinical studies were carried out (N=3) by oral, intramuscular and intravenous routes, while clinical studies (N=13) were performed intramuscularly.
      
5-FU-PT was given to rats by oral administration at a dosage of 22.5?mg kg-1.
      
Immure response induced by oral DNA vaccination against FMDV delivered by attenuated Salm onella choleraesuis C500
      
Specific immune response to this recombinant strain was evaluated by oral administration of the recombinant live bacteria pBO1/S.
      
The sequence of fetation might have appeared on the corolliform oral region of Punctatus emeiensis.
      
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Solutions of potassium antimony tartrate and sodium antimony gluconate were given per os to infected rabbits.Although their oral dosages were,respectively,9 and 4 times as much as their intravenous ones,the therapeutic results of the oral groups were far inferior to those of intrave- nous groups,while the animal mortalities of the former decidely higher than those of the later. In similar doses,one preparation (kindly supplied to us by Hsing Hwa)of the enteric tablets of potas- sium antimony tartrate...

Solutions of potassium antimony tartrate and sodium antimony gluconate were given per os to infected rabbits.Although their oral dosages were,respectively,9 and 4 times as much as their intravenous ones,the therapeutic results of the oral groups were far inferior to those of intrave- nous groups,while the animal mortalities of the former decidely higher than those of the later. In similar doses,one preparation (kindly supplied to us by Hsing Hwa)of the enteric tablets of potas- sium antimony tartrate was tried and found to be useless,in view of its great potentialities the oral route of administration for antimony com- pounds is worth further and more intensive inves- tigation.

应用酒石酸锑钾与葡萄精酸锑~(Ⅲ)钠溶液的经口给药法,试治家兎血吸虫病,确有相当疗效。口服剂量虽较注射剂量分别加至九倍与四倍,但其疗效仍远不如注射法给药各组,而动物死亡率反较高。延长治程而酌减每次口服剂量,经口给药与静脉给药适当结合,仍不能提高其安全性。所试的酒石酸锑钾肠溶片在相同剂量时完全无效。口服锑剂的进一步研究应在吸收控制与剂型改进两方面努力。

The toxicity and pharmacological properties of p:p'-diaminodiphenoxy heptane, a compoud with schistosomicidal activity.are described. The LD_(50) for mice was 1260 mg./kg. orally and 195 mg./kg.intravenously. Mice became less active and lost appetite after taking the drug orally.Intravenous injection of the compound caused the extremities of mice to paralize for a few seconds.This was followed by clonic convulsion and opisthotonus.Death was due to cardiac arrest. When mice and rats were given small doses of...

The toxicity and pharmacological properties of p:p'-diaminodiphenoxy heptane, a compoud with schistosomicidal activity.are described. The LD_(50) for mice was 1260 mg./kg. orally and 195 mg./kg.intravenously. Mice became less active and lost appetite after taking the drug orally.Intravenous injection of the compound caused the extremities of mice to paralize for a few seconds.This was followed by clonic convulsion and opisthotonus.Death was due to cardiac arrest. When mice and rats were given small doses of the drug once daily for 14 days,there was no change in blood picture,blood sugar and body temperature. However,the growth of the animals was arrested due to loss of appetite. Oral administation of p:p'-diaminodiphenoxy heptane at a does of 50-100 mg./kg.to dogs caused vomiting in about one and half hours. After abut 24 hours,the pupils of the animals were dilated;light reflex was absent.The dogs did not recover from these effects until after about a month.Intravenous injection of 30 mg./kg.of the drug causdd similar reactions. However,feeding a monkey with 60 mg./kg.through stomach tube did not cause any reaction.This was true even when the monkey was given 20mg./kg.daily for 5 days.The liver function (B.S.P.) and blood N.P.N.levels of the dogs and the monkey fed chronically with the drug were not changed. Intravenous injections of 0.5-2.5mg./kg to anesthetized dogs and cats caused a transient fall of blood pressure.The intestinal movement of the cat was inhibited. Respiration was not affected significantly in the dog.In anesthetized cats,the amplitude of respiration was decreased in most experiments. Addihon of p:p'-diaminodiphenoxy heptane to a bath containing a segment of guinea-pig ileum caused only a slight relaxation of the tissue.However,addition of the drug to a concentration of 1:5000,000-1:50,000 decreased or abolished the reaction of the tissue to acetylcholine,histamine and barium choride.Intravenous injection of 15-20mg./kg.of the drug to rabbits under anesthesia increased the tension of the uterus.

1.对氮苯氧庚烷对小鼠的半数致死量口服为1260毫克/公斤,静脉注射为195毫克/公斤。小白鼠每日口服50-200毫克/公斤,连续两周,因影响食欲致使体重的增加受到抑制,停药后即渐恢复。2.对氨苯氧庚烷对麻醉猫和狗的血压,在静脉注射时有显著而短暂的降低,剂最愈大或注射速度愈快,血压下降亦愈多。3.对于麻醉猫的迴肠及豚鼠离休迴肠,对氨苯氧庚烷均有明显抑制作用。对氨苯氧庚烷并能对抗组织胺、乙醯胆龄及氯化钡对离体豚鼠迴肠的作用。对在体家兔子宫有收缩作用,而对离体子宫则有抑制作用。

The analgesic, antiphlogistic, anti-anaphylactoid shock and anti-amebic effects of tetrandrine and demethyl-tetrandrine have been reported previously. Further studies on their cardiovascular effects were undertaken with the following results: (1) By intravenous and intramuscular injection as well as per oral administration, tetrandrine and demethyl-tetrandrine caused a profound hypotensive effect in urethan-anesthetized cats. The hypotensive effect of tetrandrine was found to be stronger and more sustained...

The analgesic, antiphlogistic, anti-anaphylactoid shock and anti-amebic effects of tetrandrine and demethyl-tetrandrine have been reported previously. Further studies on their cardiovascular effects were undertaken with the following results: (1) By intravenous and intramuscular injection as well as per oral administration, tetrandrine and demethyl-tetrandrine caused a profound hypotensive effect in urethan-anesthetized cats. The hypotensive effect of tetrandrine was found to be stronger and more sustained than that of demethyl-tetrandrine. The blood pressure was reduced by more than 50% in the case of tetrandrine and the effect lasted for several hours at a dose of 3 mg/kg regardless of its route of administration. (2) Large doses of the two alkaloids, when injected intravenously, but not intramuscularly, caused a decrease in the contractile force of the cat's heart, which returned to normal within 2-5 minutes. (3) During the fall of the blood pres ure induced by tetrandrine and demethyltetrandrine, the splenic volume of the animals was invariably increased, but it might be reduced in size when the fall of blood pressure was abrupt and severe. (4) These two alkaloids, 1.5-3.0 mg/kg given intravenously, did not cause any significant change in EKG except the reduction of the amplitude of the R wave. The P-R interval was unaltered but sometimes it became shortened under tetrandrine and lengthened under demethyl-tetrandrine; (5) In perfused isolated rabbit's ears, these two alkaloids showed direct vasodilating effects, the minimal effective concentrations of tetrandrine and demethyl-tetrandrine being 1:20,000 and 1:4,000 respectively. In equimolar concentrations, the vasodilating effect of tetrandrine was more prominent and lasted for a longer time in contrast with papaverine. (6) In perfused isolated rabbit's ears with the innervation intact, these two alkaloids and papaverine, at the dosage of 3 mg/kg intravenously, produced reflex vasodilatation. The effect of tetrandrine appeared to be the strongest and lasted the longest, papaverine being the weakest.

1.以汉防已甲素或乙素3毫克/公斤靜脉注射、肌肉注射或灌胃,均可使麻醉猫的血压明显下降,甲素之降压作用較乙素大而持久,甲素靜脉注射时,降压作用急驟而持久,可維持1—5小时;肌肉注射及灌胃时,降压作用較緩慢,但亦甚持久。 2.乙素之降压作用較甲素弱而短暫,靜脉給药之作用較肌肉注射为强,灌胃之降压作用又較肌肉注射为弱。 3.静脉注射甲素或乙素3毫克/公斤,在血压下降的同时,可見暫时性心收縮力減弱;但肌肉注射同样或更大剂量(5毫克/公斤),則不出現心力抑制現象,甲素对心率之影响較少,乙素則往往引起心率減慢,心动电流圖上仅見R波幅度之減小,对P-R間歇及T波等均無影响。 4.甲素及乙素可使脾容积增加,但在血压急剧下降时,則可使脾容积縮小。 5.甲素及乙素均可使离体兎耳血管扩張,直接对平滑肌之抑制作用及神經反射机制均参加在內.甲素之血管扩張作用較乙素及罂粟硷为大而持久。

 
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