During the design of Angang's primary material field,programmable controller S7-300 was used to make unloading facilities and mineral facilities realizing automatic control,it was used to realize the chain controlling of belt conveyer that take the tilting mechanism as the core machine at the same time,and it was used to realize the experience of PID regulation and automatical burden in blow tank.
Spiro 1,3 oxazole derivatives, 3,8 disubstituted 1 oxa 2.8 diazaspiro[4,5] 2 decene, were cleaved by hydrogenolysis to γ amino alcohols 4. Through condensation of γ amino alcohols 4 with aceton or benzaldehyde, tautomeride of 1,3 oxazines and open chain schiff bases were obtained.
The direct measurements of the residuary concentration of C2F4 show that in addition to the direct pyrolysis there are 10 times more consumption of C2F4 caused by a polymerization chain initiated by the released H atom in the system as a consequence of the reaction of CF2 with H2.
Substituents at the 4th and 5th positions of the target thiazoles were introduced by a Hantzsch reaction, and the chain at the second position was extended through a Sandmeyer reaction, formylation, and Wittig olefination.
The best ligand (9, sigma-1 Ki = 0.56 nM, selectivity ratio >amp;gt;1000) was obtained with an azepine side-chain.
We present the results in terms of structure-activity relationships, focusing on the lack of the methoxy group and the influence of the amide side chain.
Compounds 13-19 were evaluated for in vitro bronchodilatory activity using isolated guinea pig tracheal chain.
Compounds 5 and 8 with seven-member C ring were more active than etofylline and caused 100% relaxation of both the histamine and acetycholine pre-contracted guinea pig tracheal chain.