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affinity
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  亲和力
    Methods 125 I-rhK5 was prepared by small amount of iodogen with repeated labeling. Biological activity of 125 I-rhK5 was evaluated by cell proliferation assays and cell affinity assays.
    方法:采用基因工程方法制备重组人纤溶酶原Kringle 5(rhK 5),以小剂量Iodogen多次重复标记法标记rhK 5,细胞增殖抑制试验和亲和力试验检测125I-rhK 5活性,并研究其在大鼠体内的药代动力学。
短句来源
    CCR7 is the high affinity receptor of SLC. There is a close correlation between the expression of CCR7 and SLC and tumor lymphatic metastasis.
    CCR7是SLC的高亲和力受体,近年来研究发现,CCR7和SLC的表达与肿瘤的淋巴转移密切相关。
短句来源
    Change of ~(125)I-IudR-Insulin specific affinity in hepatocellular carcinogenesis
    ~(125)I-IudR-胰岛素在肝细胞癌变过程中特异性亲和力变化的免疫组化观察
短句来源
    Density and Affinity of IL-6 Receptors in Human Leukemic Cells
    IL-6受体在人白血病细胞膜上的表达及亲和力
短句来源
    Affinity maturation of a single-chain antibody for hepatocellular carcinoma by error-prone PCR and DNA shuffling
    错配PCR和DNA改组技术提高抗肝癌单链抗体亲和力
短句来源
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  亲和性
    6 of 16 phage clones were identified positive by competitive ELISA,which had comparatively strong binding activity to rhEndoglin. Five sequences were obtained,and the predominant sequence was AHKHVHHVPVRL. Competitive inhibition test showed that positive phage clones had good affinity to Endoglin,with the affinity constant as(1.431±0.293)×107 mol/L.
    结果:三轮生物筛选,噬菌体得到有效富集,竞争性ELISA显示6个阳性噬菌体克隆与rhEndoglin有较强的结合活性,测序获得5种多肽序列,优势序列为:AHKHVHHVPVRL,竞争抑制实验显示阳性噬菌体克隆与Endoglin有良好的亲和性,其亲和常数为:(1.431±0.293)×107mol/L。
短句来源
    PREPARATION OF N-SUCCINYL-CHITOSANS WITH DIFFERENT MOLECULAR WEIGHT AND THEIR AFFINITY FOR K562 LEUKEMIA CELLS
    不同分子量N-琥珀酰壳聚糖的制备及其与K562肿瘤细胞间亲和性的初步探讨
短句来源
    Estimation of the affinity of HLA-A*0201 restricted CTL epitope based on SCORE function
    基于SCORE函数估算HLA-A*0201限制性CTL表位亲和性
短句来源
    A clinical pathological study of affinity about the metastasis of gastric carcinoma to ovary
    胃癌卵巢转移亲和性的临床病理研究
短句来源
    Study on the affinity of peptides K237 with human prostate cancer cell line LNcap
    多肽K237与前列腺癌细胞系LNcap的亲和性
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  “affinity”译为未确定词的双语例句
    The Study of Lectin Affinity Histochemistry on Experimental Gastric Garcinomas in Rats
    大鼠实验性胃癌的凝集素亲合组织化学研究
短句来源
    ENZYMO-ROCKET ELECTROPHORETIC ASSAY AND CROSSED AFFINITY ENZYMOIMMUNOELECTROPHORESIS AND ITS APLICATION IN DIAGNOSIS OF PLIMARY LIVER CANCER
    ENZYMO-ROCKET ELECTROPHORETIC ASSAY AND CROSSED AFFINITY ENZYMOIMMUNOELECTROPHORESIS AND ITS APLICATION IN DIAGNOSIS OF PLIMA
短句来源
    The results demonstrate that 3H-IN has good affinity to the tumor tissue and the major part accumulated in tumor is not the IN prototype.
    结果提示,3H-IN有很好的瘤组织趋向性,其药物原形并非在肿瘤中蓄积的主要成分。
短句来源
    The gastric carcinoma BGC-823 cellular membrane affinity constant of LHRH-PE40 was Kd=37.82±1.42 nmol/L,the maximum specific binding amount was Bmax=475±17.86 pmol/mg.
    其中LHRH-PE40与Lovo细胞的Kd=10.6±2.33 nmol/L,Bmax=345±7.59 pmol/mg; 与BGC-823细胞的Kd=37.82±1.42nmol/L,Bmax=475±17.86 pmol/mg。
短句来源
    Purification and identification of p185 HER2/neu tumor antigen by affinity chromatography tecnique
    肿瘤抗原p185蛋白的纯化及其鉴定
短句来源
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  affinity
3D-QSAR STUDIES ON SUBSTITUTED DIHYDROPYRIDINES FOR THEIR α1A-ADRENERGIC RECEPTOR BINDING AFFINITY
      
Both these models predicted binding affinity of internal and external test set compounds including the enantiomers of compound no.
      
For example, N1-(4-aminobenzenesulfonyl)-5-azaskatole (18; Ki = 41 nM) displayed an affinity comparable to N1-(4-aminobenzenesulfonyl)skatole.
      
All compounds were characterized by binding affinity determination for 5-HT2A and 5-HT2C subtypes and antagonistic activity for 5-HT2B receptor in rat stomach fundus.
      
None of the new compounds showed affinity for 5-HT2A and 5-HT2C subtypes, but some of them displayed antagonistic activity in rat stomach fundus at micromolar concentrations.
      
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A new oncofetal antigen on the plasma membrane of human hepatoma cells hasbeen detected and partially purified.Human hepatoma tissues obtained from partialhepatectomy were used to prepare plasma membrane by sucrose density gradientcentrifugation.The antiserum to this plasma membrane was absorbed by normalliver powder prepared from the normal portion of the liver of the same patient.Thisabsorbed antiserum gave a positive reaction with the soluble products of the hepatomacell plasma membrane in double immunodiffusion...

A new oncofetal antigen on the plasma membrane of human hepatoma cells hasbeen detected and partially purified.Human hepatoma tissues obtained from partialhepatectomy were used to prepare plasma membrane by sucrose density gradientcentrifugation.The antiserum to this plasma membrane was absorbed by normalliver powder prepared from the normal portion of the liver of the same patient.Thisabsorbed antiserum gave a positive reaction with the soluble products of the hepatomacell plasma membrane in double immunodiffusion and counter-current immuno-electrophoresis,but a negative reaction with those of the normal liver cell plasmamembrane.With the immunofluoresccent method,it is demonstrated that thisabsorbed antiserum reacts specifically with hepatoma cells and the 7402 cell line(ahuman hepatoma cell culture line).It may be surmised therefore that there is anantigen on the plasma membrane of the hepatoma cells but absent from normal livercells.Further studies indicated this membranous antigen to be of the oncofetal type.The plasma membrane of human embryonic liver(3~4 months old)also possesses thisantigen.We tried to purify this antigen from embryonic liver by means ofimmunoaffinity chromatography.A protein eluated from the column with thesedimentation coefficient of 0.33~0.45 exhibits specific affinity for antihepatomaserum.

在人肝癌细胞膜中发现了一个新的癌胚抗原,并且进行了部分纯化。从部分肝切除术取人肝癌组织,用蔗糖密度梯度超离心法分离细胞膜,以此细胞膜制备的抗血清,经患者本人正常肝粉吸收,吸收后的抗血清与肝癌细胞膜溶解物作双向免疫扩散和对流免疫电泳均呈阳性反应,而与正常肝细胞膜则均呈阴性。用免疫萤光法鉴定,证明该血清能特异性地作用于肝癌细胞膜和7402人肝癌细胞培养株的细胞膜。因此,我们认为:人肝癌细胞膜具有不存在于正常肝细胞的抗原。进一步研究证明,这种抗原也存在于3~4个月人胚胎肝细胞膜中,显示这是一种癌胚抗原。我们取人胚胎肝组织,用免疫亲和层析法尝试了这种膜抗原的纯化工作,从亲和层析柱流下的蛋白质,其沉降系数为0.33~0.45,并对上述吸收后的抗血清显示特异性的亲和力。

In this paper,it was shown mainly by immunoestimation that the pyruvatekinase (PyK) isozyme pattern was significantly changed in Hop A ascites hepatoma(Hep A).The major type of PyK in normal mouse liver was type L,and the activityof type K only accounted for 20% of the total PyK activity.The activity of type LPyK was decreased after starvation for 24 hours,so that the activity of type K PyKwas increased to about 30% of the total PyK activity.In Hep A,whether the micewere fasted or not,the activity of type K...

In this paper,it was shown mainly by immunoestimation that the pyruvatekinase (PyK) isozyme pattern was significantly changed in Hop A ascites hepatoma(Hep A).The major type of PyK in normal mouse liver was type L,and the activityof type K only accounted for 20% of the total PyK activity.The activity of type LPyK was decreased after starvation for 24 hours,so that the activity of type K PyKwas increased to about 30% of the total PyK activity.In Hep A,whether the micewere fasted or not,the activity of type K PyK was increased to more than 20 timesthat of type K in normal mouse liver,and accounted for more than 90% of the totalactivity.Type L PyK in normal mouse liver showed Michaelis-Menten kinetics withrespect to ADP,K_m=3.02 mM,whereas the type K PyK in Hep A showed positivecooperative allosteric kinetics with respect to ADP,Hill's coefficient(η_H)=1.40,andS_(0.5_=0.741 mM,showing that the affinity of type K PyK for ADP was greater thanthat of type L.Furthermore,type K PyK was less sensitive to feedback inhibitionby its reaction product ATP than type L.In Hep A,therefore,competition of cytosolK PyK with mitochondria for ADP was increasd to a greater extent in comparisonwith normal mouse liver.Changes in PyK isozyme pattern and differences in kineticsbetween type L and type K PyK may be another important mechanism of theCrabtree effect in cancer.The total activity of 3-phosphoglycerate kinase (3PGAK) was higher than thatof PyK in both normal mouse liver and Hop A,suggesting that 3PFAK is not therate limiting enzyme of glycolysis.The activity of 3PGAK in Hep A was 1.7 timesas high as that in normal mouse liver.So far it is uncertain whether 3PGAKisozymes exist or not.Therefore,3PGAK does not play an important role in affectingthe Crabtree effect in cancer.

本文用免疫测定法发现,在Hep A 腹水肝癌(简称Hep A)中,丙酮酸激酶(PyK)同工酶谱发生明显改变。正常小鼠肝以L 型为主,K 型只占总活性的20%。饥饿24小时后,L 型活性降低,以致K 型相对增高至30%左右。在Hep A 中,不论饥饿与否,K 型PyK 要比正常小鼠肝的活性高出20余倍,占总活性的90%以上。L 型PyK 对ADP 表现为米孟氏动力学,S_(0.5)=2.865mM;而Hep A 的K 型PyK 对ADP 则呈正协同的别构动力学,Hill 氏系数=1.40,S_(0.5)=0.741mM。故K 型PyK 对ADP的亲和力大于L 型PyK。并且K 型PyK 较L 型PyK 不易受其产物ATP 的反馈抑制,因而大大地增强了Hep A 胞液中的K 型PyK 同线粒体争夺ADP 的能力。PyK 同工酶谱的改变和这两型PyK 动力学上的差别,很可能是癌瘤中出现克奈特瑞效应的又一重要机理。不论在正常小鼠肝还是Hep A 中,3-磷酸甘油酸激酶(3 PGAK)的总活性均高于PyK,3PGAK 不是酵解通路的限速酶。Hep A 中3PGAK 的活性仅比正常的高出0.7倍,未肯定有同工酶,所以它和...

本文用免疫测定法发现,在Hep A 腹水肝癌(简称Hep A)中,丙酮酸激酶(PyK)同工酶谱发生明显改变。正常小鼠肝以L 型为主,K 型只占总活性的20%。饥饿24小时后,L 型活性降低,以致K 型相对增高至30%左右。在Hep A 中,不论饥饿与否,K 型PyK 要比正常小鼠肝的活性高出20余倍,占总活性的90%以上。L 型PyK 对ADP 表现为米孟氏动力学,S_(0.5)=2.865mM;而Hep A 的K 型PyK 对ADP 则呈正协同的别构动力学,Hill 氏系数=1.40,S_(0.5)=0.741mM。故K 型PyK 对ADP的亲和力大于L 型PyK。并且K 型PyK 较L 型PyK 不易受其产物ATP 的反馈抑制,因而大大地增强了Hep A 胞液中的K 型PyK 同线粒体争夺ADP 的能力。PyK 同工酶谱的改变和这两型PyK 动力学上的差别,很可能是癌瘤中出现克奈特瑞效应的又一重要机理。不论在正常小鼠肝还是Hep A 中,3-磷酸甘油酸激酶(3 PGAK)的总活性均高于PyK,3PGAK 不是酵解通路的限速酶。Hep A 中3PGAK 的活性仅比正常的高出0.7倍,未肯定有同工酶,所以它和癌瘤中出现的克奈特瑞效应关系不大。

The dinitrosopiperazine (DNP) in its subthreshold dose was used as an initiator and Niso4 gel (Ni-gel) or Niso4 water solution (Ni-water) as a promotor in inducing NPC in rats. In the experiment four groups, namely, DNP + Ni-gel, DNP + Ni-water, Ni-gel and DNP, were designed. The results showed that five carcinomas were found in 22 rats of the DNP + Ni-gel experimental group and no carcinoma developed in the other three groups. This demonstrated that nickel sulfate may be recognised as a promotor in inducing...

The dinitrosopiperazine (DNP) in its subthreshold dose was used as an initiator and Niso4 gel (Ni-gel) or Niso4 water solution (Ni-water) as a promotor in inducing NPC in rats. In the experiment four groups, namely, DNP + Ni-gel, DNP + Ni-water, Ni-gel and DNP, were designed. The results showed that five carcinomas were found in 22 rats of the DNP + Ni-gel experimental group and no carcinoma developed in the other three groups. This demonstrated that nickel sulfate may be recognised as a promotor in inducing NPC which had been reported previously by the authers themselves.Among the five carcinomas 2 occured in the nasopharynx (carcinoma in situ and early squamous cell carcinoma), 2 in the nasal cavity (undifferentiated carcinoma and squamous cell carcinoma) and 1 on the hard palate (Squamous cell carcimoma). It is worthwhile to point out that the carcinomas induced by the application of subthreshold dinitrosopiperazine and nickel sulfate developed not only in the nasopharynx but in the nasal cavity as well as hard palate also. This finding reveals that though the dinitrosopiperazine has the affinity to the nasopharynx for carcinogenesis, the nasal cavity and hard palate may alco be the sites to be affected.

本文报导我们再次应用一次低剂量的二亚硝基哌嗪作为起动因子,用硫酸镍作为促动因子,进行诱发大鼠鼻咽癌的实验。将90只成年大鼠分为四组,即:二亚硝基哌嗪+镍胶组,二亚硝基哌嗪+镍水组,镍胶组和二亚硝基哌啼组。实验进行270天以后,将全部大鼠处死作病理检查。结果表明,在二亚硝基哌嗪+镍胶组的22只大鼠中,有5例发生恶性肿瘤(鼻咽原位鳞癌和早期鳞癌各1例,鼻腔未分化癌和鳞癌各1例,硬腭鳞癌1例),其它组则未见肿瘤发生。这再次表明,微量元素镍在诱发大鼠鼻咽癌中有促癌作用。 本实验还表明,肿瘤不仅发生在鼻咽,而且也发生在鼻腔和硬腭,因此,二亚硝基哌嗪不仅对鼻咽有亲合力,对鼻腔和硬腭也是有亲合力的。

 
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