Results: “In vitro” and “in vivo” opioid receptor binding studies showed very high affinity (Ki=4×10-4 μmol/L), 63% of 20minpostinjection specific binding and good imaging as a degradationresistant of this agent in mouse brain.
In this research, the NH_3/O_2 plasma and plasma grafting after Ar plasma treatment were used to modify its surface in order to improve its hydrophilicity, and discussed the affection on the amino density of material surface, the grafting density of PVP, the surface form before and after treatment, the change of contact-angle by different treatment conditions and make research on the cell affinity of modified materials.
Using monoclonal antibody M1 as a substitute of the platelet the binding affinity of FG M1 complex of a few polymer biomaterials was measured by ELISA. Compared the changs in binding affinity of M1 to one of the platelet binding domain of FG adsorbed to different materials so that evaluated the blood compatibility of those polymer biomaterials.
Using this model, the predictive sets are predicted for binding affinity of peptide-MHC complex molecule, and the result is satisfying.
In this paper, a binding affinity model of peptide-MHC complex molecule is studied by QSAR method based on partial least squares (PLS), and it results a satisfied formula between the binding affinity of peptide-MHC complex molecule and the sequence of peptide.