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Adriamycin thermotherapy through the hepatic artery using VX2 carcinoma in rabbit liver as a model
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How do transurethral needle ablation of the prostate and transurethral microwave thermotherapy compare with transurethral prosta
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This review compares high- and lowenergy transurethral microwave thermotherapy (TUMT) and transurethral needle ablation (TUNA) of the prostate with TURP in clinical efficacy and safety.
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Long-term treatment outcomes of coretherm microwave feedback thermotherapy
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This review article discusses microwave thermotherapy as such an option and reports the long-term experience with the CoreTherm (CoreTherm Operations AB, Sweden) device.
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| | Objectives To explore morphologic changes of lesion interstitial laser thermotherapy induced and modification of the blood-brain barrier ( BBB) in the periphery of the lesion. Methods The lesion was induced in the normal rat brains by ILTT, morphologic changes of ILTT-induced lesion were determined by light microscopic and electron microscopic methods, triphenyltetrazolium chloride(TTC) stain, and modification of the blood-brain barrier in the periphery of the lesion was surveyed through Evens blu... | | 目的 探讨激光间质内热疗诱导的效应灶的形态学变化和效应灶周围血脑屏障的改变。方法 利用正常鼠脑进行激光间质内热疗（ＩＬＴＴ），应用光学显微镜、电子显微镜等观察ＩＬＴＴ后效应灶形态学变化，伊文思蓝观察效应灶周围血脑屏障的改变。结果ＩＬＴＴ后效应灶急性期呈现显著的形态学变化：中央出血性假腔、凝固性坏死区、外周水肿；其后出现特征性的修复反应。效应灶周围血脑屏障暂时开放；细胞和亚细胞质膜的破坏在效应灶的形成过程中可能发挥重要作用。结论ＩＬＴＴ能够导致效应灶组织凝固性坏死和开放效应灶周围组织血脑屏障，这些结果有助于未来脑肿瘤激光间质内热疗的临床应用。 | | 文摘来源 | | Objective To explore the optimal heating power, heating time, effects and mechanisms of laser interstitial thermotherapy (LITT) for treatment of glioma. Methods The Walker glioma cells were subcutaneously transplanted into the rear legs of rats, the diameters of tumors reached 1.4 - 2. 0 cm 10 days after transplantation. The neodymium yttrium aluminium garnet ( Nd-YAG) laser was applied for interstitial thermotherapy under low power of 2 W, 5 W and 10 W respectively, and for heating time of 800 ... | | 目的 探讨激光间质热疗（LITT）治疗胶质瘤的最适热功率、照射时间、热效应及作用机制。方法 将Walker胶质瘤细胞接种于大鼠后肢皮下,接种10d后瘤体直径达1.4～2.0cm。分别用钕钇铝石榴石（Nd-YAG）激光在2W、5W、10W三种低功率下进行间质热疗,激光作用时间分别为800s、800s和600s,并设立对照组。观察肿瘤直径、肿瘤病理组织学及超微结构的改变。结果LITT后3d及6d各治疗组与对照组肿瘤直径无显著差异（P>0.05）;LITT后9d及12d各治疗组肿瘤直径明显小于对照组（P<0.01）。治疗组肿瘤中心炭化,外围变性、坏死。治疗组肿瘤细胞超微结构也发生明显变化。结论 低功率Nd-YAG激光LITT可明显抑制胶质瘤的生长,具有良好的应用前景。 | | 文摘来源 | | Objective To study the effects of local thermochemotherapy on apoptosis of C6gliomas cell in rats,and to explore the probability of developing a new method of treating gliomas.Methods C6gliomas cell were subcutaneously injected in rats,who were randomly divided into4groups,i.e.thermotherapy,chemotherapy,thermochemotherapy and control groups.The volume and weight the of subcutaneous tumors were measured.The expression of bax and bcl-2protein were detected by S-P immunohisto-chemical staining.The apopto... | | 目的研究局部热化疗对大鼠胶质瘤细胞凋亡的作用,探讨其作为胶质瘤辅助治疗的可行性。方法将传代培养的C6细胞接种于大鼠背部皮下熏肿瘤生长至1.5～2cm直径时,分组进行局部热疗、化疗和热化疗。继续观察皮下肿瘤生长情况,测量瘤体体积和重量;用免疫组化s-p法检测bax、bcl-2蛋白表达;用HE染色法、电镜、TUNEL法观察细胞凋亡;电镜观察肿瘤血管的变化。结果肿瘤接种32d后,热疗、化疗及热化疗组肿瘤的重量分别为(1.95±0.34)g,(1.86±0.40)g,(1.09±0.21)g,明显较对照组(2.95±0.36)g轻(P<0.001);各治疗组肿瘤体积也明显小于对照组;各治疗组bax蛋白表达亦明显强于对照组(P<0.001),且热化疗组也强于单纯热疗和化疗组(P<0.001);bcl-2蛋白表达改变不明显(P>0.05);热疗、化疗及热化疗组细胞凋亡指数分别为18.96±2.54、20.05±3.64、36.62±8.96,明显大于对照组的4.68±1.68(P<0.001)。各治疗组肿瘤微血管外径变小,血管壁变厚,血管减少,血管内皮细胞紧密连接增多,细胞连接间隙减小,有的血管甚至只能发现完整的基膜而缺... | | 文摘来源 | | |
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