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botulinus toxin
相关语句
  肉毒毒素
     Influential factors of the clinical function of botulinus toxin and the countermeasures
     肉毒毒素临床作用的影响因素及对策
短句来源
     Results The short-term effect of the botulinus toxin Type A injection treatment to blepharospasm and facial spasm was 92.7%,the half-year relapse rate was 58.3%,and there was no anaphylactic response or serious systemic adverse reaction.
     结果应用A型肉毒毒素治疗特发性眼睑、面肌痉挛的短期有效率为97.2%,半年的复发率为58.3%,未见过敏反应及严重全身不良反应。
短句来源
     Conclusion Botulinus toxin Type A is the first choice in treating blepharospasm and facial spasm,although its curative effect last for half a year,it is still a simple and effective treatment method.
     结论A型肉毒毒素为治疗特发性眼睑、面肌痉挛首选药物,尽管其疗效半年左右,但仍不失为一种简单有效的治疗方法。
短句来源
     Methods 72 patients of idiopathic blepharospasm and facial spasm were divided into different grades betweenⅡ-Ⅳaccording to Cohen and Albert,were treated with botulinus toxin Type A injection treatment on many-points including orbicularis oculi,orbicularis oris,and facial muscles,classify the state of illness before and after the treatment,and then analyze the treatment result.
     方法应用A型肉毒毒素对按Cohen、Albert等分级为Ⅱ~Ⅳ级特发性眼睑、面肌痉挛的患者72例进行眼轮匝肌、口轮匝肌及面部肌肉多点注射治疗,对治疗前后的病情分级进行对比。
短句来源
     Clinical Analysis of Botulinus Toxin A for Hemifacial Spasm
     A型肉毒毒素治疗半侧面肌痉挛的临床疗效评价
短句来源
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  “botulinus toxin”译为未确定词的双语例句
     Botulinus toxin from a clostridium botulin fermentation broth was separated and purified by membrane filtration technology. To remove the bacteria from the fermentation broth, we chose a 0.65 μm pore size microfiltration membrane, reaching a removal ratio of 100%.
     报道了把膜分离技术应用于肉毒发酵液的纯化.用孔径为0.65μm的微滤膜对发酵液进行除菌,除菌率达到100%;
短句来源
  相似匹配句对
     Influential factors of the clinical function of botulinus toxin and the countermeasures
     肉毒毒素临床作用的影响因素及对策
短句来源
     Clinical Analysis of Botulinus Toxin A for Hemifacial Spasm
     A型肉毒毒素治疗半侧面肌痉挛的临床疗效评价
短句来源
     2.toxin.
     2疫毒学说;
短句来源
     Phytopathogenic Toxin
     植物病原毒素
短句来源
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  botulinus toxin
Mechanisms of neurotrophic disturbances in skeletal muscles caused by botulinus toxin
      
Reinnervation of muscles after intramuscular injection of sublethal doses of botulinus toxin was investigated in rats.
      
Role of neurotrophic regulation in disturbances of striated muscle polarization by botulinus toxin
      
Injection of a sublethal dose of botulinus toxin into one masseter muscle leads to unilateral paralysis of that muscle, accompanied by the development of biting.
      
Mechanism of reinnervation of skeletal muscles injured by botulinus toxin
      
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The interaction between toosendanin (Toes) and botulinus toxin (BoTx) was examined with electron microscope. When Toes (9.0 mg/kg) was injected (sc) to mice and followed immediately or 1 h later by challenge of type A BoTx (1.7 LD 50 per mouse), the ultrastructural changes of NMJ were similar to those seen in the mice treated with Toes alone. The main changes included an obvious decrease in synaptic vesicle number and an increase in elongated vesicle number, In addition, myeloid body or phagosome-like...

The interaction between toosendanin (Toes) and botulinus toxin (BoTx) was examined with electron microscope. When Toes (9.0 mg/kg) was injected (sc) to mice and followed immediately or 1 h later by challenge of type A BoTx (1.7 LD 50 per mouse), the ultrastructural changes of NMJ were similar to those seen in the mice treated with Toes alone. The main changes included an obvious decrease in synaptic vesicle number and an increase in elongated vesicle number, In addition, myeloid body or phagosome-like structure can be seen more frequently. When Toes was administrated 5 or 24 h after the challenge of BoTx, however, the average density of synaptic vesicles in areas within 2500 from the presynaptic membrane of NMJ was approximately 90% higher as compared with the average density of synaptic vesicles of the mice treated with Toes alone. The results suggest that once BoTx has already acted on NMJ, it may prevent, in some manner, the vesicle-releasing process evolved by Toes subsequently administerted.

本实验用电子显微镜观察了小鼠在不同时间给以川楝素和肉毒毒素后,膈肌神经肌肉接头超微结构的改变。给川楝素后立即或1小时后给毒素,其改变与单给川楝素小鼠的相似。主要是突触小泡明显减少,长管形泡较多,髓膜样或自噬体样结构经常可见等变化。但是,如果先给毒素,5小时或24小时后再给川楝素,则突触小泡平均密度比单给川楝素小鼠的高约90%。表明预先作用于神经肌肉接头的肉毒毒素对川楝素引起的突触小泡减少有阻碍效应。其他改变与单给川楝素的相似。

Botulinus toxin from a clostridium botulin fermentation broth was separated and purified by membrane filtration technology. To remove the bacteria from the fermentation broth, we chose a 0.65 μm pore size microfiltration membrane, reaching a removal ratio of 100%. In the second experiment, we used ultrafiltration to concentrate the toxin solution by 10 times, resulting in 48 fold increase of toxin efficacy. In a middle scale installasion, we were able to process about 50 kg/h of botulin...

Botulinus toxin from a clostridium botulin fermentation broth was separated and purified by membrane filtration technology. To remove the bacteria from the fermentation broth, we chose a 0.65 μm pore size microfiltration membrane, reaching a removal ratio of 100%. In the second experiment, we used ultrafiltration to concentrate the toxin solution by 10 times, resulting in 48 fold increase of toxin efficacy. In a middle scale installasion, we were able to process about 50 kg/h of botulin solution.

报道了把膜分离技术应用于肉毒发酵液的纯化.用孔径为0.65μm的微滤膜对发酵液进行除菌,除菌率达到100%;再以超滤法对毒素溶液进行浓缩,当毒素液被浓缩10倍后,其毒力效价达到未浓缩毒素溶液毒力效价的48倍.并对分离过程的动力学进行了初步研究.把该技术进一步放大到中试规模的应用,获得了较好的结果,对发酵液的处理量可达50kg/h.

OBJECTIVE On the basis of the study of botulinum toxin type A BTX-A on the treatment of muscle spasticity after upper motor neuron syndrome patients and explore the influential factors of the clinical function of botulinus toxin and the countermeasures DATA SOURCES A computer-based online search of Medline database was undertaken to identify articles about BTX-A in the treatment of muscle spasticity after upper motor neuron syndrome published in English from January 1998 to May 2005 by using the keywords...

OBJECTIVE On the basis of the study of botulinum toxin type A BTX-A on the treatment of muscle spasticity after upper motor neuron syndrome patients and explore the influential factors of the clinical function of botulinus toxin and the countermeasures DATA SOURCES A computer-based online search of Medline database was undertaken to identify articles about BTX-A in the treatment of muscle spasticity after upper motor neuron syndrome published in English from January 1998 to May 2005 by using the keywords of "botulinum toxin spasticity/spastic". Meanwhile Chinese articles about BTX-A in the treatment of muscle spasticity after upper motor neuron syndrome published between January 2003 and May 2005 were searched in Wanfang database the keywords were "botulinum toxin spasticity/spastic"in Chinese. STUDY SELECTION The literatures of randomized controlled trials containing study group and control group were selected. Inclusive criteria ① randomized controlled trials about BTX-A in the treatment of muscle spasticity after upper motor neuron syndrome ②clinical trial containing parallel control group ③ the subjects in the study group were treated with local intramuscular injections of BTX-A. Reviews and literatures without control group or not for upper motor neuron syndrome were excluded. DATA EXTRACTION Ninety-eight randomized controlled trials about BTX-A in the treatment of muscle spasticity after upper motor neuron syndrome were collected and 49 trials met the inclusive criteria. The excluded 49 trials included 6 papers of overview and 43 papers without control group. DATA SYNTHESIS Forty-night trials including 2 679 patients respectively analyzed the data of upper motor neuron syndrome after BTX-A treatment. During the treatments the functional goal was clear individualized dosage was used apposition was made accurate by electric simulation to ensure BTX-A could combine with action site at the myoneural junction maximally and play its maximal biological effect. However electric simulation stretch and other rehabilitative treatment after injection can enhance the therapeutic effect. CONCLUSION The injection of BTX-A is effective for limb spasticity after upper motor neuron syndromes but the system of treatment still needs further improvement and specification.

目的:从国内外肉毒毒素对上运动神经元损伤后肢体痉挛的治疗及相关研究出发,探讨影响肉毒毒素临床作用的因素及对策。资料来源:应用计算机检索Medline1998-01/2005-05与上运动神经元损伤后肉毒毒素治疗肢体痉挛相关的文献,检索词“botulinumtoxin,spasticity/spastic”,并限定文献语种为英文。同时计算机检索万方数据库2003-01/2005-05与上运动神经元损伤后肉毒毒素治疗肢体痉挛相关的文献,检索词“肉毒毒素,痉挛”,并限定文献语种为中文。资料选择:从资料中选取包括治疗组和对照组的文献,然后选择随机临床试验的研究。纳入标准:①上运动神经元损伤后肉毒毒素治疗肢体肌肉痉挛的随机对照临床试验。②临床试验研究包括平行对照组。③治疗组采用了含肉毒毒素的治疗。排除标准:非上运动神经元损伤后的肌张力异常,综述类文献,没有对照组的文献。资料提炼:共收集98篇关于上运动神经元损伤后肉毒毒素治疗肢体肌肉痉挛的临床试验。49个试验纳入标准。排除的49篇中6篇是综述,43篇为无对照组。资料综合:49个试验包括2679例患者,分别对肉毒毒素治疗上运动神经元损伤后肢体痉挛进行评价。在治疗过程中明确...

目的:从国内外肉毒毒素对上运动神经元损伤后肢体痉挛的治疗及相关研究出发,探讨影响肉毒毒素临床作用的因素及对策。资料来源:应用计算机检索Medline1998-01/2005-05与上运动神经元损伤后肉毒毒素治疗肢体痉挛相关的文献,检索词“botulinumtoxin,spasticity/spastic”,并限定文献语种为英文。同时计算机检索万方数据库2003-01/2005-05与上运动神经元损伤后肉毒毒素治疗肢体痉挛相关的文献,检索词“肉毒毒素,痉挛”,并限定文献语种为中文。资料选择:从资料中选取包括治疗组和对照组的文献,然后选择随机临床试验的研究。纳入标准:①上运动神经元损伤后肉毒毒素治疗肢体肌肉痉挛的随机对照临床试验。②临床试验研究包括平行对照组。③治疗组采用了含肉毒毒素的治疗。排除标准:非上运动神经元损伤后的肌张力异常,综述类文献,没有对照组的文献。资料提炼:共收集98篇关于上运动神经元损伤后肉毒毒素治疗肢体肌肉痉挛的临床试验。49个试验纳入标准。排除的49篇中6篇是综述,43篇为无对照组。资料综合:49个试验包括2679例患者,分别对肉毒毒素治疗上运动神经元损伤后肢体痉挛进行评价。在治疗过程中明确功能目标,采用个体化剂量,应用电刺激准确定位,确保A型肉毒毒素最大限度地与神经肌肉接头处的作用位点相结合,发挥其最大的生物学效应。而注射后采用电刺激、牵张等相应的康复治疗可以增强治疗效果。结论:肉毒毒素对上运动神经元损伤后肢体肌肉痉挛的疗效是肯定的,但其应用方法需要进一步研究和规范。

 
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