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retinoblastoma protein     
相关语句
  rb蛋白
     Expression of Retinoblastoma Protein during Apoptosis of Glioma Cell
     Rb蛋白在胶质瘤细胞凋亡中的表达
短句来源
     to determine the content of the retinoblastoma protein and the phosphorylase Rb protein of cells by ELISA method;
     ELISA法检测细胞总视网膜母细胞瘤蛋白 (Rb)和磷酸化Rb蛋白的含量;
短句来源
     Effect of sodium selenite on phosphorylation of retinoblastoma protein of human promyelocytic leukemia cells (HL-60)
     亚硒酸钠对人早幼粒白血病细胞的RB蛋白磷酸化的影响
短句来源
     The Clinical Implication of Retinoblastoma Protein Expression in Multiple Myeloma
     Rb蛋白在多发性骨髓瘤细胞中的表达及临床意义
短句来源
     Methods A549 cell line was transfected with p16 INK4A and the stably transfected strain was identified with Northern blot and Southern blot. Cell cycle was analysied by flow cytometry. The phosphorylation state of retinoblastoma protein(Rb) and cell phenotype were determined by Western blot and SA-β-gal staining.
     方法 用pcDNA3 p16质粒转染 p16基因缺失的A5 4 9肺小细胞腺癌细胞系并通过Northernblot和Westernblot鉴定 p16基因的异位表达 ,通过流式细胞仪分析转染后细胞周期变化 ,利用Westernblot和SA β gal染色检测Rb蛋白磷酸化状态的改变和细胞表型变化。
短句来源
  视网膜母细胞瘤蛋白
     he research was aimed to detect the expression levels of retinoblastoma protein (pRb) in child acute leukemia cells, and to explore its possible association with leukemia cells cycle, the risk of disease, minimal residual disease (MRD) monitoring and prognosis of B-ALL.
     本研究检测视网膜母细胞瘤蛋白(retinoblastoma protein,pRb)在不同类型儿童急性白血病细胞中的表达,并探讨其表达水平与细胞周期、危险度、微小残留病(minimal residual disease,MRD)监测、预后等临床诊断治疗监测指标的关系。
短句来源
     Expression of p57~(k1P2), retinoblastoma protein and proliferating cell nuclear antigen in human pancreatic cancer and their relationship with clinicopathology.
     胰腺癌p57~(kip2)、视网膜母细胞瘤蛋白和增殖细胞核抗原的表达及与临床病理的关系
短句来源
     Expression of Retinoblastoma Protein in Child Acute Leukemia Cells and Its Clinical Significance
     儿童急性白血病细胞视网膜母细胞瘤蛋白的表达及临床意义
短句来源
     The expression of cyclin D and E and phosphorylation of retinoblastoma protein was examined using Western-blot.
     Western-blot检测atRA对细胞周期蛋白D和E表达的影响,并观察对视网膜母细胞瘤蛋白(Rb)磷酸化的影响。
短句来源
     to determine the content of the retinoblastoma protein and the phosphorylase Rb protein of cells by ELISA method;
     ELISA法检测细胞总视网膜母细胞瘤蛋白 (Rb)和磷酸化Rb蛋白的含量;
短句来源
更多       
  成视网膜细胞瘤蛋白
     A missense mutation outside the large pocket of the retinoblastoma protein
     发生在成视网膜细胞瘤蛋白大袋立体结构外的错义突变
短句来源
  视网膜母细胞瘤基因
     Rb, also called retinoblastoma protein, was the first discovered anti-oncogene. It presents as nonphosphorylationduring the period from GO to Gl, when it bind to E2F, it prohibits the transcription activation of E2F.
     Rb,即视网膜母细胞瘤基因蛋白,是最早发现的抑癌基因,在G0及G1期在细胞内以非磷酸化活性形式存在,当与E2F以异二聚体结合时,则抑制了E2F的转录激活作用。
短句来源
     Objective:To investigate the expression of p16 gene and retinoblastoma protein(pRb)in human hepatocellular carcinoma(HCC).
     目的 :分析p16基因和视网膜母细胞瘤基因(Rb)在人肝癌细胞中表达的改变。
短句来源

 

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      retinoblastoma protein
    Sequence comparisons suggest that the RNA-dependent RNA polymerase (NIb) of potyviruses and bymoviruses, as well as the viral polymerase of potexviruses may contain a putative retinoblastoma protein (pRb) binding motif.
          
    During HCMV infection, one of its proteins interacts with a cell growth regulatory protein, the retinoblastoma protein (Rb) and stimulates DNA synthesis which is associated with chromosomal damage and cellular mitotic arrest.
          
    p53, p16/INK4a, p14/ARF, p15/INK4b, retinoblastoma protein (Rb), and Phosphatase and tensin homologue deleted from chromosome 10 (PTEN)) also participate actively in the development of the transformed phenotype.
          
    We have analyzed the significance of tumor suppressor genes p53, p21, p16 and retinoblastoma protein (pRb) and proliferative activity for survival in 77 high grade astrocytic tumors.
          
    Hyperphosphorylation of retinoblastoma protein (pRb), a pocket protein, leads to release of E2F1, resulting in transition from G1 to S phase.
          
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    Purpose To study expression of the tumor suppressor gene retinoblastoma protein (Rb) before and after apoptosis of SHG?44 glioma cell. Methods Rb expression was detected in SHG?44 cells by Western blot using N terminal Rb monoclone antibody.And the change of Rb expression after apoptosis induced by VP16 was examined. Results A 70×10 3 with N terminal Rb was found in SHG?44 cell line.After cell apoptosis,Rb was cleaved into a 48×10 3 protein with N?terminal and the glioma cells were arrested...

    Purpose To study expression of the tumor suppressor gene retinoblastoma protein (Rb) before and after apoptosis of SHG?44 glioma cell. Methods Rb expression was detected in SHG?44 cells by Western blot using N terminal Rb monoclone antibody.And the change of Rb expression after apoptosis induced by VP16 was examined. Results A 70×10 3 with N terminal Rb was found in SHG?44 cell line.After cell apoptosis,Rb was cleaved into a 48×10 3 protein with N?terminal and the glioma cells were arrested at G 11 phase. Conclusions A mutant Rb protein was expressed in SHG?44 cells.There is close relationship between Rb cleavage and apoptosis in glioma.

    目的 研究抑癌基因Rb在人胶质瘤SHG 44细胞调亡前后的表达情况。方法 利用N端Rb蛋白单克隆抗体通过Western印迹法检测SHG 44胶质瘤细胞株Rb蛋白的表达情况 ,并观察用VP16诱导细胞凋亡后Rb蛋白表达的改变。结果 在SHG 44胶质瘤细胞株中存在一相对分子质量约 70× 10 3 、具有N端的Rb蛋白。细胞凋亡后 ,Rb蛋白有裂解现象 ,出现一具有N端的约 48× 10 3 的裂解蛋白 ,并使细胞停滞于G1期。结论 在胶质瘤SHG 44细胞中有Rb基因突变体的表达 ,Rb蛋白的裂解与细胞凋亡密切相关。

    Objective To determine whether ET and ANP regulate the production and function of cyclin-dependent protein kinase (CDKS) and cyclin-dependent kinase-inhibitor (CKI) from astrocytes. Methods Nothern analysis, [ 35 S] methionine labeline of astrocytes for determining protein (cyclin D1, D3 and P 27 ,P 57 ) production, [ 3H] thymidine incorporation were used, and CDK activities against PRb or histone were directed. Results ET-3 significantly augmented the production of cyclin D1 and D3, whereas...

    Objective To determine whether ET and ANP regulate the production and function of cyclin-dependent protein kinase (CDKS) and cyclin-dependent kinase-inhibitor (CKI) from astrocytes. Methods Nothern analysis, [ 35 S] methionine labeline of astrocytes for determining protein (cyclin D1, D3 and P 27 ,P 57 ) production, [ 3H] thymidine incorporation were used, and CDK activities against PRb or histone were directed. Results ET-3 significantly augmented the production of cyclin D1 and D3, whereas ANP inhibited these signficantly. ET also stimulated the activation of the cyclin-dependent kinases, directed against the retinoblastoma protein PRb, and this was inhibited by ANP as much as 81%. ANP stimulated the production of cyclin-dependent kinase inhibitory (CKI) proteins including P 27 ,P 57 . In turn, ET inhibited ANP-stimulated production of CKIS. Conclusion The G l-S progression and the proliferation of hypothalamic astrocytes are positively and negatively regulated, respectively by ET-3 and ANP.

    目的观察内皮素 (ET)和心钠素 (ANP)对下丘脑胶质细胞周期素依赖蛋白激酶 (CDK)和周期素依赖蛋白激酶抑制性蛋白 (CKI)的影响。 方法采用细胞内蛋白质合成试验 (周期素D1、D3和P2 7、P57)、Northern印迹及3 H -TdR掺入试验 ,以GST -PRb和组蛋白为底物测定CDK的活性。 结果ET可增加周期素D1、D3、DNA的合成和CDK的活性 ;ANP则可逆转ET的作用 ,并增加P2 7、P57蛋白质的合成及P2 7mRNA的量。 结论ET和ANP能分别促进与抑制下丘脑细胞从G1到S期 ,从而参与细胞的增殖。

    Objective:To investigate the expression of p16 gene and retinoblastoma protein(pRb)in human hepatocellular carcinoma(HCC).Methods:40 cases of HCC and their adjacent tissues were examined by immunohistochemistry method.Results:The expression of p16 and pRb in liver showed abnormal,i,e,94.44%(34/36)and 45.71%(16/35),respectively.The expression of p16 and pRb showed negative correlation.The abnormal expression of p16 and Rb had no relation with degree of malignancy.Conclusion:Our rcsults suggested that abnormal...

    Objective:To investigate the expression of p16 gene and retinoblastoma protein(pRb)in human hepatocellular carcinoma(HCC).Methods:40 cases of HCC and their adjacent tissues were examined by immunohistochemistry method.Results:The expression of p16 and pRb in liver showed abnormal,i,e,94.44%(34/36)and 45.71%(16/35),respectively.The expression of p16 and pRb showed negative correlation.The abnormal expression of p16 and Rb had no relation with degree of malignancy.Conclusion:Our rcsults suggested that abnormal expression of p16 and pRb maybe involved in the occurrence of HCC and the change of p16 is prominent.

    目的 :分析p16基因和视网膜母细胞瘤基因(Rb)在人肝癌细胞中表达的改变。方法 :用免疫组织化学方法对40例肝细胞癌和癌旁组织进行检测。结果 :肝组织中的 p16蛋白和Rb蛋白的异常表达分别为94.44 %(34/36)和45.71%(16/35)。p16蛋白阴性或弱阳性而Rb呈强阳性者13例(13/34,38.23 %) ,两者的表达呈负相关关系。p16和Rb蛋白均异常者15例(15/34,44.11 %) ,表明Rb蛋白表达的调节除 p16外 ,还有其他途径。二者的异常表达与肝癌的恶性程度无相关关系。结论 :细胞调节因子p16和Rb基因的异常表达 ,均参与肝细胞癌的发生。以 p16蛋白表达的改变为主

     
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