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chloral hydrate
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  水合氯醛
     In three drugs interactions study, 15 min after treatment of naloxone at fixed dose (0.5 mg·kg -1 and 0.2 mg·kg -1) the mixture of chloral hydrate and ethanol (at 1∶1 and 1∶3 ratio) was given to induce sleep.
     在 3药相互作用研究中 ,在给予纳洛酮固定剂量 (0 .5mg·kg- 1和 0 .2mg·kg- 1) 15min后 ,混合给予水合氯醛与乙醇 (按照 1∶1和 1∶3比例 )来诱导睡眠。
短句来源
     The animals were anesthetized with intramuscular 10% Chloral Hydrate ( 0.5?mg/kg) solution.
     每只SD大鼠肌注 10 %水合氯醛 5mg/kg麻醉。
短句来源
     INTERVENTIONS:After intraperitoneal injection of chloral hydrate (0.5 mL),the male SD rats were deeply anesthetized.
     干预:雄性SD大鼠,腹腔注射水合氯醛0.5mL,处于深度麻醉状态,脑电平稳后,将贝美格注射液稀释一倍,腹腔注射0.5mL。
短句来源
     In order to determine the effects of different anesthetics on the performance of the arterial baroreflex, characteristics of the carotid reflex were analyzed in 25 Wistar rats under anesthesia with a-chloralose (75mg/kg), urethane (1.4g/kg), chloral hydrate (350mg/kg) and pentobarbital sodium (50mg/kg).
     Wistar大鼠25只,随机分成四组,分别经腹腔注射α-氯醛糖(75mg/kg),乌拉坦(1.4g/kg),水合氯醛(350mg/kg)或戊巴比妥钠(50mg/kg)麻醉。
短句来源
     ① Administration: The rats in seizures group were given lithium (3 mmol/kg) and pilocarpine (50 mg/kg) to induce acute epilepsy models injected into abdominal cavity. After lasting tic for 30 minutes, atropine (1 mg/kg) was given injected into abdominal cavity and after 30 minutes or when the tic was dangerous diazepam (10 mg/kg) the rats was associated injected with chloral hydrate (5 mL/kg) through abdominal cavity;
     ①给药:致痫组采用锂(3mmol/kg)-匹鲁卡品(50mg/kg)腹腔注射以诱导大鼠急性癫痫模型,持续抽搐达30min后,给予阿托品(1mg/kg)腹腔注射,30min后或大鼠抽搐濒危时再给予地西泮(10mg/kg),水合氯醛(5mL/kg)联合腹腔注射;
短句来源
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  水合三氯乙醛
     m-Bromooximidoacetoaniline(Ⅱ)was synthesized from m-bromoaniline(Ⅰ) and chloral hydrate in 90.5% yield.
     以间溴苯胺(Ⅰ)为起始原料,与水合三氯乙醛反应合成了间溴肟基乙酰苯胺(Ⅱ),反应收率90.5%。
短句来源
     Objective The contact allergenic activity of trichloroethylene and its three metabolites trichloroacetic acid, trichloroethanol, chloral hydrate were studied.
     目的 探讨三氯乙烯及其代谢产物三氯乙酸、三氯乙醇及水合三氯乙醛对豚鼠的皮肤致敏作用。
短句来源
     Bromomethyl-3,4-dihydro-2-methyl-4-oxoquinazoline is the key intermediate for the synthesis of some anti-cancer drugs inhibiting thymidylate synthase. In this paper,2-amino-5-methylbenzoic acid was prepared through reacting p-toluidine with chloral hydrate and hydroxylamine hydrochloride,treated with concentrated sulfuric acid,followed by alkaline H 2O 2 oxidation of the resulted 5-methylisatin.
     用对甲基苯胺与水合三氯乙醛、盐酸羟胺反应制得对甲基 (N 肟基乙酰 )苯胺 ,再与浓硫酸反应生成 5 甲基靛红 ,后经碱性过氧化氢氧化 ,制得 2 氨基 5 甲基苯甲酸。
短句来源
     Choosing nitrobenzene and chloral hydrate as model compound,the role of adsorption in the heterogeneous catalytic ozonation process was discussed by continuous or semi-continuous flow test.
     采用连续流和半连续流的运行方式,通过考察在催化剂表面的吸附能力有差异的两种有机污染物———硝基苯与水合三氯乙醛的催化臭氧氧化降解效能,对多相催化臭氧氧化工艺中催化剂的吸附作用进行了讨论。
短句来源
  “chloral hydrate”译为未确定词的双语例句
     From day 2~15, rats were treated with Tau 80, 160 and 320 mg/(kg·d)ip, the NS control and Iso model group received saline injection. On day 16, animals were anesthesiaed by chloral hydrate monitored in terms of myocardial indexes (heart weight/body weight, HW /BW and left ventricular weight/body weight, LVW /BW);
     造模第2天起给大鼠腹腔注射Tau80、160和320mg/(kg·d),连续用药14d,测量大鼠心脏重量指数(heart weight/bodyweight,HW/BW)和左心室重量指数(left ventricular weight/body weight,LVW/BW);
短句来源
     Results The allergenic rates of trichloroethylene, trichloroacetic acid and 2,4 dinitrochloro benzene were shown to be 71.4%, 58.3% and 100% respectively, whereas that of both trichloroethanol and chloral hydrate were 0%.
     结果 三氯乙烯、三氯乙酸和二硝基氯苯的致敏率分别为 71 4%、5 8 3 %和10 0 % ,平均反应值分别为 2 3、1 1和 6 0。
短句来源
     4. Brain removal and homogenizing: Rats were anesthetized with 10% chloral hydrate (300mg/kg, ip).
     4.取脑及制备脑组织匀浆:以 10%水含氯醛瞩00mg/kg)对大鼠行腹腔麻醉。
短句来源
     . They are chloral hydrate (Fig. 2), hexanoic acid(Fig. 4)and octanoic acid (Fig. 3 ) and the IC50 are 577. 6 μl/L(Fig. 5 ), 128. 4 μl/L(Fig.6)and 87. 7 μl/L(Fig. 7),respechvely.
     己酸和辛酸3种发芽抑制物质,其半抑制浓度分别为577.6、128.4和87.7μl/L。
短句来源
     The preceding disposal of the method is using (2 + 1) petroleum benzine-diethyl ether to extract chloral hydrate. RSD is 4. 9% and recovery rates are 91. 2%-101. 1%. The detection limit is 4×10-2ng.
     该方法用(2+1)石油醚-乙醚萃取废水中的三氯乙醛,方法的相对标准偏差4.9%,回收率91.2%~101.1%,最低检出限4×10~(-2)ng。
短句来源
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  chloral hydrate
Purpose To compare the effect of rectally administered diazepam and chloral hydrate on serial seizures or status epilepticus.
      
After application of diazepam or chloral hydrate, additional intervention due to recurrent seizures was necessary in 14% and 22% respectively (p=0.53).
      
Chloral hydrate seems to be a useful alternative to diazepam in the treatment of serial seizures.
      
Ultrasonic absorption in chloral and chloral hydrate
      
Values of ultrasonic velocity, absorption coefficient and viscosity in chloral and chloral hydrate have bean measured over a range of temperature at 7 MHz.
      
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Seven central depressants,including chloral hydrate,potassium bromide,sodium bromide,cal- cium bromide,alcohol,amytal and chloretone, were studied for their effects on the intraperito- neal toxicity of tartar emetic and sodium stibo- gluconate in mice. When chloral hydrate & sodium stibogluco- nate were given in suitable doses,significant protection,especially against tartar emetic,was observed.The lethal effect of both antimony compounds was somewhat increased by amytal, alcohol and chloretone....

Seven central depressants,including chloral hydrate,potassium bromide,sodium bromide,cal- cium bromide,alcohol,amytal and chloretone, were studied for their effects on the intraperito- neal toxicity of tartar emetic and sodium stibo- gluconate in mice. When chloral hydrate & sodium stibogluco- nate were given in suitable doses,significant protection,especially against tartar emetic,was observed.The lethal effect of both antimony compounds was somewhat increased by amytal, alcohol and chloretone. In our experiments no definite influence was observed with the 2 central stimuiants,caffeine and strychinine,but as the number of animals used was rather small and the range of their dosage rather narrow no final conclusion can be drawn.

1.关于吐酒石与葡萄糖酸锑 V 钠对小白鼠的致死作用,我们探索了一些中枢抑制药与兴奋药的影响。所试的抑制药有水合氯醛,溴化钾,溴化钠,溴化钙,酒精,安眠妥与三氯叔丁醇七种。兴奋药有苯甲酸钠咖啡硷与士的宁二种,以及溴咖合剂。2.在所试的药物中,水合氯醛与溴化物在适当剂量时,对于二种锑剂尤其是吐酒石中毒呈现比较显著的保护作用。安眠妥,酒精与三氯叔丁醇的数种剂量,似能增加锑剂的毒性。咖啡硷与士的宁在我们的实验条件下,并不表现明显的影响,但因所用动物数较少,剂量范围较窄,难于作出结论。

Intravenous injection of the aqueous extract of Salsola collina produced marked and prolonged hypotensive effect in anaesthetized dogs. Repeated administrations showed no marked tachyphylaxis. The drug had no influence on the hypotensive action of acetylcholine and the depressor response induced by electric stimulation of the peripheral end of vagus nerve. Its hypotensive effect was not blocked by previous administration of atropine, but reduced to some extent in vagotomized animals. Hence it had no effect...

Intravenous injection of the aqueous extract of Salsola collina produced marked and prolonged hypotensive effect in anaesthetized dogs. Repeated administrations showed no marked tachyphylaxis. The drug had no influence on the hypotensive action of acetylcholine and the depressor response induced by electric stimulation of the peripheral end of vagus nerve. Its hypotensive effect was not blocked by previous administration of atropine, but reduced to some extent in vagotomized animals. Hence it had no effect on the M-cholinergic system. It did not reveal any adrenolytic and ganglion-blocking action. During the period of hypotension, the pressor responses induced by serial occlusions of common carotid arteries and electric stimulation of the central end of sciatic nerve were inhibited or eliminated. The hypotensive effect was not influenced by bilateral section of the sinus nerves. Besides, the drug gave a reflex vasodilating effect in perfused isolated rabbit's ear with the innervation intact. Therefore it is suggested that the hypotensive mechanism was mainly due to an inhibition of the vasomotor centre or the central sympathetic structure. The aquaeous extract of Salsola collina exhibited a pronounced sedative action. It reduced the spontaneous activity, prolonged the pentobarbital induced sleeping time and potentiated the effect of nonsleeping doses of chloral hydrate to induce sleeping, but had no effect on the convulsion and death caused by strychnine and metrazol. In mice, by the method of motor defense conditioned reflex, subcutaneous injection of Salsola collina 3g/kg had no marked influence on the conditioned reflexes. When the doses were raised to 5, 10g/kg, it prolonged the latency of conditioned reflexes, partly abolished the conditioned reflexes, but did not alter the differentiation. At the dosage of 20g/kg, this effect was more pronounced. In subcutaneous doses of 5, 10g/kg, it accelerated the disappearance of positive conditioned reactions. In mice the acute LD_(50) by the subcutaneous route was found to be 56g/kg.

猪毛菜浸膏对麻醉动物有明显持久降压作用,无明显快速耐受現象。猪毛菜对乙酰胆碱及刺激迷走神經离中端所致降压作用无影响,阿託品不阻断猪毛菜的降压作用。双側迷走神經切断后,猪毛菜降压作用略減弱。猪毛菜不阻断頸上交感神經传导,亦无明显抗腎上腺素作用。猪毛菜抑制因压迫頸总动脉及刺激坐骨神經向中端所致的升压反射,二側竇神經切除亦不影响其降压作用。在猪毛菜引起降压作用时,带神經离体兔耳血管反射性扩张,因此推测猪毛菜对血管运动中枢或交感中枢有抑制作用。猪毛菜5,10克/公斤皮下注射能显著减少小白鼠自由活动。20克/公斤延长戊巴比妥鈉(35毫克/公斤)催眠作用的时間,并使非催眠剂量的水合氯醛(200毫克/公斤)产生催眠作用。但不能对抗中枢惊厥药(戊四氮及士的宁)的惊厥及致死作用。在小白鼠防御运动条件反射实驗中,皮下注射猪毛菜3克/公斤,对条件反射活动无明显影响。5克/公斤,10克/公斤时能使条件反射时延长,強化次数增加,分化相无变化。20克/公斤时条件反射显著抑制。5,10克/公斤皮下注射均能加速阳性条件反射消褪过程。小白鼠皮下注射猪毛菜LD_(50)为56克/公斤,大白鼠腹腔注射8克/公斤卽死亡。家兔口服(灌胃)40克/公斤...

猪毛菜浸膏对麻醉动物有明显持久降压作用,无明显快速耐受現象。猪毛菜对乙酰胆碱及刺激迷走神經离中端所致降压作用无影响,阿託品不阻断猪毛菜的降压作用。双側迷走神經切断后,猪毛菜降压作用略減弱。猪毛菜不阻断頸上交感神經传导,亦无明显抗腎上腺素作用。猪毛菜抑制因压迫頸总动脉及刺激坐骨神經向中端所致的升压反射,二側竇神經切除亦不影响其降压作用。在猪毛菜引起降压作用时,带神經离体兔耳血管反射性扩张,因此推测猪毛菜对血管运动中枢或交感中枢有抑制作用。猪毛菜5,10克/公斤皮下注射能显著减少小白鼠自由活动。20克/公斤延长戊巴比妥鈉(35毫克/公斤)催眠作用的时間,并使非催眠剂量的水合氯醛(200毫克/公斤)产生催眠作用。但不能对抗中枢惊厥药(戊四氮及士的宁)的惊厥及致死作用。在小白鼠防御运动条件反射实驗中,皮下注射猪毛菜3克/公斤,对条件反射活动无明显影响。5克/公斤,10克/公斤时能使条件反射时延长,強化次数增加,分化相无变化。20克/公斤时条件反射显著抑制。5,10克/公斤皮下注射均能加速阳性条件反射消褪过程。小白鼠皮下注射猪毛菜LD_(50)为56克/公斤,大白鼠腹腔注射8克/公斤卽死亡。家兔口服(灌胃)40克/公斤未見毒性反应,80克/公斤时可見死亡。

(1) The analgesic potency of acepromazine in a dose of 0.5 mg/kg was somewhat inferior to that of morphine (2mg/kg). By combining these two drugs, the analgesic effect was summated and the duration of action was prolonged. (2) After intracerebral injection, acepromazine produced more prominent tranquilizing and hypothermic effects than those elicited by hypodermic administration. It could also potentiate the hypothermic action of chloral hydrate and antipyrin. (3) Acepromazine, applied locally or injected...

(1) The analgesic potency of acepromazine in a dose of 0.5 mg/kg was somewhat inferior to that of morphine (2mg/kg). By combining these two drugs, the analgesic effect was summated and the duration of action was prolonged. (2) After intracerebral injection, acepromazine produced more prominent tranquilizing and hypothermic effects than those elicited by hypodermic administration. It could also potentiate the hypothermic action of chloral hydrate and antipyrin. (3) Acepromazine, applied locally or injected subcutaneously, produced definite surface anaesthesia in rabbit's cornea and potentiated the anaesthetic action of procaine. (4) The vasopressor response to 5 γ/kg of adrenaline in the anaesthetized cats was reduced by 2.5 γ/kg of acepromazine and reversed by 5 γ/kg of the antagonist. The contraction of the nictitating membrane due to preganglionic sympathetic stimulation and injection of adrenaline was reduced by the larger dose. (5) When the periarterial nerves of Finkleman's preparation were stimulated, the motor activity of the isolated rabbit's ileum was decreased and the tone was reduced. This inhibitory response to the nerve stimulation was potentiated by acepromazine and chlorpromazine in the concentrations of 1:1,000,000-4:1,000,000. It is concluded that acepromazine and chlorpromazine do not interfere, with the release of noradrenaline from the post-ganglionic sympathetic nerve endings.

(1)采用热水刺激小白鼠尾巴法試驗鎮痛作用,乙酰普馬嗪0.5毫克/公斤可使“疼痛”反应出現时間延迟,較盐酸嗎啡(2毫克/公斤)为弱;二者均以半量合并应用,鎮痛作用强度虽未見加强,但鎮痛时間則延长。(2)脑室內注射乙酰普馬嗪,可立即引起小白鼠安靜,并使其体溫明显下降;皮下注射同剂量时,安靜及降溫作用均不显著,但可明显加强安替比林及水合氯醛的降溫作用。(3)乙酰普馬嗪局部滴药及皮下注射均可产生角膜麻醉,并可加强普魯卡因的表面麻醉作用,尤以皮下注射法为强。(4)乙酰普馬嗪2.5微克/公斤即可減弱腎上腺素的升压作用;5微克/公斤时,使后者作用翻轉,并使电刺激交感神經节前纤維及注射腎上腺素所引起的瞬膜收縮反应減弱。(5)在离体兔神經——迴腸标本,电刺激交感神經节后纤維引起腸张力下降,运动減弱,乙酰普馬嗪及氯丙嗪均可加强此交感反应。

 
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