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fibrinogen
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  纤维蛋白原
    Effect of PKC inhibitor Ro31-8220 on the production of interleukin-6 and fibrinogen in rat liver
    PKC抑制剂Ro31-8220对大鼠肝产生IL-6和纤维蛋白原的作用
短句来源
    Method of Removal of Solvent/Detergent Residual in Fibrinogen Product Following Virus Inactivation Treatment by Solvent/Detergent
    S/D处理纤维蛋白原制品灭活病毒后去除S/D的方法研究
短句来源
    MethodsAdd the cefoperazone sodium,chloromycetin,ciprofloxacin lactate and gentamycin sulfate at different concentrations into plasma and determine the coagulation time and content of fibrinogen.
    方法采用凝固法,以加入抗菌素后血浆中纤维蛋白原的凝固时间为指标,观察不同浓度的头孢哌酮钠、氯霉素、乳酸环丙沙星和硫酸庆大霉素对血浆纤维蛋白原的影响。
短句来源
    In 1L pig plasma,about 31.41g albumin and 13.86g immunoglobulin and 0.22g thrombin and 2.67g fibrinogen have been extracted. The specific activity of thrombin is 38.5U/mg.
    1L猪血浆可同时提得白蛋白31.41g、免疫球蛋白13.86g、凝血酶粗品0.22g(比活力为38.5U/mg)、纤维蛋白原2.67g.
短句来源
    The Progress of the Nonpeptide Fibrinogen Receptor Antagonists
    非肽类纤维蛋白原受体拮抗剂的研究进展
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  “fibrinogen”译为未确定词的双语例句
    Results: IL-6 (0~100 kU/L) dose-dependently enhanced fibrinogen production after cultured with hepatocytes(3×106/ml) for 24 h and Ro31-8220 (0.1~10 umol/L) markedly reduced IL-6 secretion.
    结果:大鼠肝细胞(3×1O6/ml)与rhIL-6(0~100kU/L)孵育24h,刺激肝细胞分泌Fgn增加; Ro31-8220(0.1~10μmol/L)显著抑制枯否细胞释放IL-6。
短句来源
    RESULTS: LDL_ch as well as LDL_ch/HDL_ch were remarkably reduced after treatment. Apo AI was increased significantly low_cut viscosity and high_cut viscosity were reduced significantly (P<0.01), fibrinogen was reduced significantly (P<0.05), but TC, TG, HDL_ch, Apo B, hematocrit and ESR were no significant difference (P>0.05).
    结果:LDL_ch,LDL_ch/HDL_ch较服药前显著下降,ApoAI明显增高,血粘度中之高切粘度、低切粘度及血浆凝血因子I明显降低(P<0.05~0.01),而TC,TG,HDL_ch,ApoB及血细胞比容、血沉等差别无显著意义(P>0.05)。
短句来源
    plasma viscosity, fibrinogen, platelet adhesion rate , and hematocrit were decreased ( P < 0.01 or P<0.05).
    另外血浆粘度、凝血因子I、血小板粘附率和血细胞比容较治疗前明显下降(P<0.01或P<0.05)。
短句来源
    2. In contrast to the control, IL - 6 raised the concentration of plasma fibrinogen at 24h after injection ( P < 0. 01).
    2.与对照组相比,IL-6在注人24h后使用血浆Fbg水平明显增高(P<0.01)。
短句来源
    Conclusion: IL - 6 can stimulate TXA2 and fibrinogen secretion, and induce TXA2/PGI2 imbalance and hyper - coagulation status. These actions may be associated with the deterioration of the prognosis by IL - 6.
    结论:IL-6能刺激TXA_2和Fbg的分泌以及引起TXA_2/PCI_2的失衡和高凝状态,这些作用可能与IL-6加重疾病、预后恶化有关。
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  fibrinogen
The Mechanism of Cross-Linking of Fibrinogen and Its Early Structural Homolog-XFragment
      
We studied the mechanism of the cross-linking of fibrinogen, as well as its closest structural homolog Xfragment, under the influence of a fibronectin-stabilizing factor (factor XIIIa).
      
We propose that enzymatic cross-linking proceeds only with the gradual accumulation of structurally imperfect molecules of fibrinogen and fragment Xthat are prone to intermolecular D-Dend-to-end contacts.
      
The Influence of the End Products of Plasmin-Mediated Hydrolysis of Fibrinogen and Fibrin (EF and Ef Fragments) on Fibrinogen Cr
      
We studied the influence of the end products of plasmin-mediated hydrolysis of fibrinogen and nonstabilized fibrin (EF and Ef fragments) on covalent cross-linking of fibrinogen molecules catalyzed by a fibrin-stabilizing factor (factor XIIIa).
      
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(1)The present communication is a continuation of previous study of drugs on the pathologico-physiological reactions of the infected rabbits.The following indices of the reactions were used,namely:(1) erythrocyte sedimentation rate (ESR),(2) plasma fibrinogen content,(3) plasma gamma globulin content,(4) prothrombin time and (5)body weight. (2)It was shown that a full course of potassium antimony tartrate (PAT) could depress the abnormal rise of ESR of the infected rabbit.The effect was more striking in...

(1)The present communication is a continuation of previous study of drugs on the pathologico-physiological reactions of the infected rabbits.The following indices of the reactions were used,namely:(1) erythrocyte sedimentation rate (ESR),(2) plasma fibrinogen content,(3) plasma gamma globulin content,(4) prothrombin time and (5)body weight. (2)It was shown that a full course of potassium antimony tartrate (PAT) could depress the abnormal rise of ESR of the infected rabbit.The effect was more striking in the early (i.e.7th day after inoculation) than the late treatment (i.e.33rd day after inoculation).This effect of PAT on the ESR was found to be in parallelism with its therapeutic effect.This method may be utilized for evaluation of drugs against schistosomiasis. (3)Neither PAT nor strychnine had any effect on the ESR of the normal rabbit.Strychnine was also found to have no significant effect on the ESR of the infected rabbit,but it could markedly modify the inhibitory effect of the PAT. (4)The therapeutic effect of half-course of PAT was found to be about 10—20% less marked than that of combined treatment with strychnine. Strychnine alone did not show any therapeutic effect.It was also found that the dose of strychnine used in our experiment did not increase the toxicity of PAT as shown by mice toxicity test. (5)The therapeutic dose of PAT showed no effect on the plasma fibrinogen content of the normal rabbit but it could bring the increased plasma fibrinogen content back to normal in the infected animal. (6)After a course of PAT in the infected animal,the double peak rise of the palsma gamma globulin content was distinctly suppressed as compared with the control group.On the contrary,the new drug,1:7-Bis (p-dimethylaminophenoxy) heptane (APH) did not show the same effect, probably indicating its weak action against schistosomiasis. (7)The body weight of the PAT treated group was found to be much higher than the non-treated group,However,the group treated with APH showed a continuous drop of body weight. (8)It has been found,as by others,that the APH showed high toxicity and low therapeutic effect in the experimental animals.From the fact that APH showed pronounced effect on ESR and plasma fibrinogen content of the infected animal,one could not yet decide,with the available data,whether these effects are due to its action on the schistosome or its eggs,or to its toxic action on the host.

(一)本文报告了药物对于血吸虫病病兔及正常家兔的红血球沉降率,血浆纤维蛋白,丙种球蛋白,凝血酶元时值及体重的影响。(二)酒石酸锑钾的治疗,无论在家兔患病的早期或后期,均可抑制其血沉的加速,而以早期治疗的抑制作用更为显著。同时这个抑制血沉的作用与治疗后的成虫发育率是符合的。因此利用这种方法,可以考虑作为研究一些治疗血吸虫病药物的疗效指标。(三)酒石酸锑钾及士的宁本身对正常家兔的血沉并不引起改变,士的宁对于病兔的血沉也无明显作用,但士的宁可以影响酒石酸锑钾对病兔血沉的抑制作用。 (四)半疗程剂量酒石酸锑钾并用士的宁之疗效较单独应用半疗程剂量酒石酸锑钾者为高(10—20%),而单独应用士的宁并无任何疗效,轻度激动量士的宁也不增加酒石酸锑钾的毒性。(五)酒石酸锑钾的治疗剂量对于正常家兔之血浆纤维蛋白元无明显影响,但能使病兔增高之血浆纤维蛋白元回复正常。(六)酒石酸锑钾的治疗可以使病兔的丙种球蛋白在一定时期内保持在接近正常值范围内,这一抑制作用与感染对照组相比,甚为明显,而氨苯氧烷却无此作用,这一点可能与疗效是有关系的。(七)酒石酸锑钾治疗后的病兔之体重较感染对照组病兔显著增高,而经氨苯氧烷治疗后之病兔,其体重仍日见减...

(一)本文报告了药物对于血吸虫病病兔及正常家兔的红血球沉降率,血浆纤维蛋白,丙种球蛋白,凝血酶元时值及体重的影响。(二)酒石酸锑钾的治疗,无论在家兔患病的早期或后期,均可抑制其血沉的加速,而以早期治疗的抑制作用更为显著。同时这个抑制血沉的作用与治疗后的成虫发育率是符合的。因此利用这种方法,可以考虑作为研究一些治疗血吸虫病药物的疗效指标。(三)酒石酸锑钾及士的宁本身对正常家兔的血沉并不引起改变,士的宁对于病兔的血沉也无明显作用,但士的宁可以影响酒石酸锑钾对病兔血沉的抑制作用。 (四)半疗程剂量酒石酸锑钾并用士的宁之疗效较单独应用半疗程剂量酒石酸锑钾者为高(10—20%),而单独应用士的宁并无任何疗效,轻度激动量士的宁也不增加酒石酸锑钾的毒性。(五)酒石酸锑钾的治疗剂量对于正常家兔之血浆纤维蛋白元无明显影响,但能使病兔增高之血浆纤维蛋白元回复正常。(六)酒石酸锑钾的治疗可以使病兔的丙种球蛋白在一定时期内保持在接近正常值范围内,这一抑制作用与感染对照组相比,甚为明显,而氨苯氧烷却无此作用,这一点可能与疗效是有关系的。(七)酒石酸锑钾治疗后的病兔之体重较感染对照组病兔显著增高,而经氨苯氧烷治疗后之病兔,其体重仍日见减轻。(八)氨苯氧烷有较高的毒性,但疗效甚低,它对病兔的血沉及纤维蛋白元所出现的抑制作用,究竟属于对血吸虫或其虫卵的作用,抑系对于病兔机体的毒性作用,目前还不能肯定。

Based on the fact that during coagulation and fibrinolysis plasma changes from a liquid state to a gel and again from gel to a liquid state with a marked alteration in optical density, a method designated as 'Fibrino-lysodynamicogram' has been developed with which the whole process of coagulation and fibrinolysis can be recorded automatically as a continuous curve by a spectrophotometer.From this fibrinolysodynamicogram three parameters can be determined simultaneously, namely: plasma coagulation time, fibrinolysis...

Based on the fact that during coagulation and fibrinolysis plasma changes from a liquid state to a gel and again from gel to a liquid state with a marked alteration in optical density, a method designated as 'Fibrino-lysodynamicogram' has been developed with which the whole process of coagulation and fibrinolysis can be recorded automatically as a continuous curve by a spectrophotometer.From this fibrinolysodynamicogram three parameters can be determined simultaneously, namely: plasma coagulation time, fibrinolysis time and plasma clottability. Besides,the plasma fibrinogen content can be estimated.This method is simple, fast, sensitive in reaction and is capable of giving results with good reproducibility. It was used for observing fibrinolytic activities in chronic hepatitis,uraemia and acute myocardial infarction(M.I.), and measurig the changes of fibrinolytic activities produced during the process of treatming patients of M.I. with Chinese Traditional Medicine.This method and equipment may be used in any process which has an optical change during the course of reaction.

作者根据血浆在凝固和溶解过程中由液态→胶体→液态时在光密度上产生显著变化的特性,用分光光度计和电子电位差计自动描绘此变化的过程,得到一曲线图,——纤维蛋白溶解活性动态图。该图可同时反应血浆凝固时间、程度及凝块溶解时间等三个参数,并能计算出纤维蛋白的含量。用它观察慢性肝炎、尿毒症和急性心肌梗塞等疾病以及急性心肌梗塞患者治疗过程中纤溶系统活性的变化,结果比较满意.作者认为本方法操作简便、重复性好、反应灵敏、节省时间,凡在反应过程中光密度产生变化者均可应用,有推广价值。

The anticoagulant and fibrinolytic effects of the total glucosides of Chi-Shao(Paeonia Iactifora)in rats were studied. When the drug was added in vitro in rat plasma at concentrations of 10.8 and 21.6 tag/ml, the plasma recalcium time was prolonged by 73 and 249% respectively ( P<0.01 ) while the blood platelet aggregation in platelet rich plasma induced by ADP (Bern's turbidimetric method)were reduced from 67.2% (mean aggregation of the control ) to 24.2 and 7.25% respectively. When the drug was admin-isterd...

The anticoagulant and fibrinolytic effects of the total glucosides of Chi-Shao(Paeonia Iactifora)in rats were studied. When the drug was added in vitro in rat plasma at concentrations of 10.8 and 21.6 tag/ml, the plasma recalcium time was prolonged by 73 and 249% respectively ( P<0.01 ) while the blood platelet aggregation in platelet rich plasma induced by ADP (Bern's turbidimetric method)were reduced from 67.2% (mean aggregation of the control ) to 24.2 and 7.25% respectively. When the drug was admin-isterd in vivo intravenously at a dosage of 324mg/kg, the plasma recalcium time was also prolonged and the platelet aggregation inhibited.The mean euglobulinolytic time of the group, to which total glucosides of Chi-Shao were administered intravenously, was 83 minutes and less than that of the control ( 110 minutes, P<0.01 ) , while the blood fibrinogen content remained unchanged.

本文报道赤芍总甙对大鼠的抗凝和纤维蛋白溶解作用。在试管内一定剂量可使血浆复钙时间延长73%~249%,静脉注射亦有类似作用。试验还证明赤芍总甙静注有抑制血小板聚集的作用,且可加快优球蛋白的溶解。

 
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