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anti angiogenesis     
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  抗血管生成
     Conclusion The studies shows an experimental basis for the clinical application of TIMP 2 gene on the anti angiogenesis treatment of malignant glioma.
     结论 TIMP 2基因是为胶质瘤的抗血管生成治疗的临床应用提供了实验依据
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     The aim of this study is to screen out the monoclonal antibody reactive to a kind of endothelial cell line (ECV304) from SZ 1, 2, 21, 22, 51, 65, 262 and explore its function of anti angiogenesis.
     本研究的目的是从SZ 1, 2 , 2 1, 2 2 , 5 1, 6 5及 2 6 2 (GPⅡb ⅢaMcAb)中筛选出与ECV30 4 (人脐静脉内皮细胞株 )起反应的单抗 ,研究其抗血管生成的能力。
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     Conclusion The results suggest that NDGA inhibits the expression of VEGF in glioma cells as well as that of VEGF receptor KDR in endothelial cells, which may be the important molecular mechanism of anti angiogenesis of NDGA.
     结论 NDGA对胶质瘤细胞VEGF的表达有抑制作用 ,NDGA也抑制了内皮细胞KDR的表达 ,此抑制作用可能是NDGA抗血管生成的重要分子基础
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     99 Tc m AS probably can be used in predicting the effects of anti angiogenesis therapy in tumor treatment.
     99Tcm AS有可能在肿瘤抗血管生成治疗疗效评价中发挥作用
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     So anti angiogenesis will be an efficient method in the inhibition of the growth and metastasis of tumor.
     所以抗血管生成将是一种很有希望的对抑制肿瘤生长和转移的有效方法 .
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  血管生成抑制因子
     MCF 7 and SMMC 7721 gfp derived tumor showed sensitive to single anti angiogenesis gene therapy, yet definite suppression of growth and metastasis of BTT gfp tumor was resulted from co tranfer of sFlk 1 and ExTek gene mediated by electroporation.
     MCF 7对血管生成抑制因子基因转移治疗较敏感 ,单独应用反义VEGF12 1、sFlk 1或ExTek即显示明确的治疗效果 . SMMC 772 1 gfp单独应用sFlk 1有效 .
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  “anti angiogenesis”译为未确定词的双语例句
     To research anti angiogenesis activity of, human AK(1 3)[angiostatin kringle(1 3)],rat serum albumin signal pipeptide was transfected into C6 cell utilizing lipofectamine.
     为研究人AngiostatinKringle( 1 3) [AK( 1 3) ]抑制血管内皮细胞生长的活性 ,利用脂质体法将带有大鼠血清白蛋白分泌信号的人AK( 1 3)基因导入大鼠C6胶质瘤细胞 ,并用G41 8筛选获得目的细胞株。
短句来源
     RESULTS The acquired AK (1 3) protein, which was 12 % of all bacteria protein, had anti angiogenesis activity. AK (1 3) at the dose of 5 mg·kg -1 ·d -1 or 10 mg·kg -1 ·d -1 inhibited the human glioma growth in nude mice. The tumor inhibition rate were 34 5% and 64 6% respectively.
     结果 获得抑制人脐带静脉血管内皮细胞生长活性的AK(1 3)原核表达蛋白 (Mr 为 35× 10 3) ,其蛋白总量占菌体总蛋白的 12 % ,该纯化表达蛋白 5mg·kg- 1 ·次 - 1 和 10mg·kg- 1 ·次- 1 组均可抑制裸鼠皮下人脑胶质瘤生长 ,抑瘤率分别为 34 5 %和 6 4 6 % .
短句来源
     Conclusions The anti angiogenesis of suramin is due to reducing the receptor expression and inhibiting the combination of VEGF and it's receptors.
     结论 苏拉明抑制食管癌血管生成的作用机制可能是通过抑制血管内皮细胞上的VEGF受体表达 ,减少VEGF与其受体结合所致。
短句来源
     Conclusion These results suggest that CAM inhibits the expression of MMP 9 in LCC which may be attributed to the important molecular mechanism of anti angiogenesis of CAM.
     结论 CAM对人小细胞肺癌细胞MMP 9的蛋白表达有明显的抑制作用 ,对VEGF的表达也有一定的抑制作用 ,这种抑制作用可能是CAM抗肿瘤血管生成的分子基础
短句来源
     Objective To investigate the anti angiogenesis effects of recombinant human kringle 5 (rhk5) eye drops on corneal neovascularization (CNV) in rabbits induced by alkali burn.
     目的 观察重组人kringle 5 (K 5蛋白 )滴眼液抑制碱烧伤诱导的兔角膜新生血管(neovascularization ,NV)的效果 ,探讨其作用机制。
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  anti angiogenesis
We believe these data represent the first evidence of maxi-K channel activity in the rosiglitazone-induced anti-angiogenesis in endothelial cells.
      
Whether these patients are more suitable candidates for anti-angiogenesis therapy is currently unknown.
      
The role of the new anti-angiogenesis therapy, either as a therapy or a potential cause resulting in fluid retention, is not known at present.
      
The potential for targeting anti-angiogenesis therapy through specific receptor complexes will also be discussed.
      
The present study defines CD148 as a valuable molecular target for anti-angiogenesis therapy.
      
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TNP-470,a semisynthetic analogue of fumagillin has a potent antiangiogenesis effects. In order to test its anti-tumor effect, Walker 256 carcinoma cells(2×107/rat)were inoculated to 50 Wistar rats which were randomized into 5 groups. From the 2nd day.S. C. administration of NS (control), THP-470 (30, 50, 100mg/kg),CTX(30mg/kg)were given to each group.On the 9th day,the mean weight of the subcutanuous tumors of each group was 3. 88±1. 24,2. 20±0. 58,1.64±0. 25,0. 86±0. 30,1.17±0. 33(g) respectively,an anti-tumor...

TNP-470,a semisynthetic analogue of fumagillin has a potent antiangiogenesis effects. In order to test its anti-tumor effect, Walker 256 carcinoma cells(2×107/rat)were inoculated to 50 Wistar rats which were randomized into 5 groups. From the 2nd day.S. C. administration of NS (control), THP-470 (30, 50, 100mg/kg),CTX(30mg/kg)were given to each group.On the 9th day,the mean weight of the subcutanuous tumors of each group was 3. 88±1. 24,2. 20±0. 58,1.64±0. 25,0. 86±0. 30,1.17±0. 33(g) respectively,an anti-tumor effect of TNP-470 was clearly demonstrated in a dose dependent manner when analysized by Stu-dent-Newman-keuls test. Pathological study of the tumors showed that compared with the other 2 groups the number of tumor blood vessels was significantly decreased in TNP-470 treated groups;The extent of tumor necrosis was more severe in the former than the latter. These results suggest that the anti-tumor effect of TNP-470 was mediated by its anti-angiogenesis function.

TNP-470是半合成的烟曲霉素类似物,具有较强的抗血管生成活性.为了验证其抗癌作用,本文将Walker256肉瘤细胞接种于Wistar大鼠皮下(2×10~7/鼠),将50只大鼠随机分成A、B、C、D E5组.第二天起分别给予生理盐水.TNP-470(30、50、100mg/kg)、CTX(30mg/kg)S.C.,q.o.d.第九天时,A、B、C、D、E各组皮下瘤重分别为3.88±1.24、2.20±0.58、1.64±0.25、0.86±0.30、1.17±0.33克.经统计学检验表明TNP-470能明显抑制Walker256肉瘤的生长,而且其抑制作用具有剂量相关性.对皮下肿瘤的病理研究发现:给TNP-470各组的肿瘤血管数目明显少于其他两组,而肿瘤坏死程度显著高于其他两组.该结果支持TNP-470通过抑制血管生成而抑制肿瘤生长

Objective To investigate the effect of C1027, an enediyne antitumor antibiotic, on angiogenesis and its anti metastatic activity. Methods Chick embryo chorioallantoic membrane assay was used for anti angiogenesis activity and bFGF receptor binding assay was used for the elucidation of the possible mechanism. Spontaneous pulmonary metastasis of Lewis carcinoma in mice was employed to evaluate the anti metastatic effect. Results C1027 was highly potent in suppressing angiogenesis...

Objective To investigate the effect of C1027, an enediyne antitumor antibiotic, on angiogenesis and its anti metastatic activity. Methods Chick embryo chorioallantoic membrane assay was used for anti angiogenesis activity and bFGF receptor binding assay was used for the elucidation of the possible mechanism. Spontaneous pulmonary metastasis of Lewis carcinoma in mice was employed to evaluate the anti metastatic effect. Results C1027 was highly potent in suppressing angiogenesis with a minimum effective dose of 0.01 μg/egg. Enediyne chromophore moiety of the C1027 molecule was essential to anti angiogenesis activity. Receptor binding assay showed that C1027 blocked bFGF binding to its receptor with an IC 50 value of 2.3×10 -6 μg/ml. C1027 markedly inhibited pulmonary metastasis of Lewis carcinoma in mice. Compared at equitoxic dosage level (1/4 LD 50 ), C1027 (0.01 mg/kg, iv, x 2) was more effective than mitomycin (1.25 mg/kg, iv, x 2) and the percent inhibition of metastatic foci in the lung was 98% and 78%, respectively. Conclusions C1027 is a new potent anti angiogenesis agent with markedly anti metastatic activity. The mechanism of C1027 suppressing angiogenesis may be related to its blocking effect on bFGF binding to its receptor.

寻找新的血管生成抑制剂,探讨其抗肿瘤转移作用及机理。方法利用鸡胚尿囊膜模型,观察抗肿瘤抗生素C1027对血管生成的抑制作用。经静脉途径给予C1027和丝裂霉素治疗,比较二者对小鼠Lewis癌自发性肺转移的影响;同时进行受体结合分析,观察碱性成纤维细胞生长因子(bFGF)受体是否为C1027作用的靶点。结果C1027有很强的抑制血管生成作用,在低剂量(0.01μg/鸡胚)即可抑制鸡胚尿囊膜的血管生成,并且可以阻断bFGF与受体蛋白结合,其半数有效抑制浓度(IC50)为2.3×10-6μg/ml。采用等毒性剂量进行比较:C1027(0.1mg/kg)和丝裂霉素(1.25mg/kg)对小鼠Lewis癌的肺转移抑制率分别为98%和78%,对皮下肿瘤的抑制率分别为86%和50%,前者明显高于后者。结论C1027是一种很强的血管生成抑制剂,可能以bFGF的受体为作用靶点,抑制血管生成,并阻断小鼠Lewis癌的自发性肺转移。

Objective To investigate the anti cancer effect of tissue inhibitor of metalloproteinase 3(TIMP 3) and its mechanism of action. Methods Recombinant TIMP 3(rTIMP 3) was prepared and used to study its effect on tumor growth and metastases in mice, and its effect on angiogenesis in chicken embryo allantoic membrane (CAM). Results rTIMP 3 was able to inhibit growth of subcutaneously implanted S180 sarcoma and hepatic carcinoma H22 in a dose dependent manner. When the rTIMP 3 was given ip at...

Objective To investigate the anti cancer effect of tissue inhibitor of metalloproteinase 3(TIMP 3) and its mechanism of action. Methods Recombinant TIMP 3(rTIMP 3) was prepared and used to study its effect on tumor growth and metastases in mice, and its effect on angiogenesis in chicken embryo allantoic membrane (CAM). Results rTIMP 3 was able to inhibit growth of subcutaneously implanted S180 sarcoma and hepatic carcinoma H22 in a dose dependent manner. When the rTIMP 3 was given ip at a daily dose of 20 mg/kg body weight for 10 days, the growth of S180 sarcoma and H22 carcinoma was inhibited by 63.2% and 73.4%, respectively. The metastases of iv injected Lewis lung carcinoma(3LLC) was also suppressed by rTIMP 3, with an inhibition rate of 59.8%. rTIMP 3 was found to significantly inhibit angiogenesis in CAM assay. Conclusion rTIMP 3 has anti cancer activity, and the mechanism of action might be associated with its inhibition on extracellular matrix degradation and anti angiogenesis.

目的观察组织金属蛋白酶抑制因子3(TIMP3)对实验性肿瘤的抑制作用,并探讨其作用机理。方法利用重组TIMP3(rTIMP3)进行抗实验性肿瘤生长、转移及抑制鸡胚绒毛尿囊膜(CAM)血管生成的研究。结果rTIMP3对小鼠实验性S180肉瘤、肝癌H22有显著的抑制作用,并呈明显的剂量依赖关系。当rTIMP3剂量为每只20mg/kg给药10天后,对S180肉瘤、肝癌H22的抑制率分别为63.2%和73.4%;同样上述剂量的rTIMP3对小鼠LLC实验性肺转移的抑制率为59.8%。CAM血管生成抑制实验表明,rTIMP3具有显著的抑制血管生成作用。结论rTIMP3可能通过抑制细胞外基质的降解及抑制血管的生成来发挥其抗肿瘤作用。

 
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