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corneal allograft
相关语句
  角膜移植
     Methods:Corneal allograft:30 SD rats and 30 Wistar rats,right eye.
     方法:异体角膜移植:30只SD大鼠与30只Wistar大鼠相互进行右眼角膜移植
短句来源
     Experimental Study on Effects and Mechanism of a Inhibitor (J2) of CD4/MHC-Ⅱ Molecule in Prevention of Mouse Corneal Allograft Rejection
     拮抗CD4/MHC-Ⅱ小分子化合物J2抗角膜移植排斥作用的实验研究
短句来源
     Research on the CD40-CD154 costimulatory signal in corneal allograft rejection
     CD40-CD154共刺激信号及其在角膜移植排斥中的研究进展
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     Corneal allograft and B7
     角膜移植与B7分子
短句来源
     Influence of donor storage time on corneal allograft survival
     供体角膜保存时间的长短对同种异体角膜移植存活的影响
短句来源
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  异体角膜移植
     Methods:Corneal allograft:30 SD rats and 30 Wistar rats,right eye.
     方法:异体角膜移植:30只SD大鼠与30只Wistar大鼠相互进行右眼角膜移植。
短句来源
     Influence of donor storage time on corneal allograft survival
     供体角膜保存时间的长短对同种异体角膜移植存活的影响
短句来源
     Transplantation of corneal allograft for corneal blindness and role of B7 molecule in tissue engineering
     组织工程中同种异体角膜移植治疗角膜盲与B7分子的作用
短句来源
     Corneal allograft is the most effective treatment for corneal blindness,but corneal graft rejective reaction is the main cause of corneal allograft.
     同种异体角膜移植是治疗角膜盲最为有效的方法,而角膜移植排斥反应仍然是移植失败的主要原因;
短句来源
     CONCLUSION:The immature syngeneic TGFβ2-DC captured with donor antigen can induce donor-specific immune tolerance in the recipients,in which the corneal allograft rejection is delayed and the allograft survival time is prolonged.
     结论:摄取供体抗原的不成熟自体DC可以诱导受体获得供体抗原的特异性免疫耐受,使小鼠同种异体角膜移植的免疫排斥反应延迟,植片存活时间明显延长。
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  同种异体角膜
     Influence of donor storage time on corneal allograft survival
     供体角膜保存时间的长短对同种异体角膜移植存活的影响
短句来源
     Suppression effects of TGFβ2-DC on corneal allograft rejection
     TGFβ2-DC对小鼠同种异体角膜移植排斥反应的抑制作用
短句来源
     2. Study on the expression of CD86 and OX-62 of the corneal allografts during the acute immune rejection in experiment penetrating keratoplasty in rats and to analysis the roles of CD86+ cells and OX-62+DCs in the corneal allograft rejection.
     建立同种异体角膜移植排斥反应的大鼠模型,检测急性排斥反应角膜上表达CD86的APC及表达OX一62的DC的分布,分析其与角膜移植免疫排斥反应之间的关系。
短句来源
     Transplantation of corneal allograft for corneal blindness and role of B7 molecule in tissue engineering
     组织工程中同种异体角膜移植治疗角膜盲与B7分子的作用
短句来源
     Corneal allograft is the most effective treatment for corneal blindness,but corneal graft rejective reaction is the main cause of corneal allograft.
     同种异体角膜移植是治疗角膜盲最为有效的方法,而角膜移植排斥反应仍然是移植失败的主要原因;
短句来源
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  “corneal allograft”译为未确定词的双语例句
     Study on Expression of IL-2 and IL-12 in Rat Corneal Allograft and Immunosupressant IL-1RA on Its Rejection
     IL-2、IL-12在大鼠角膜移植物的表达及IL-1RA的抗免疫排斥作用研究
短句来源
     The experimental effects of treatment with IL 2 PE40,CsA and triperygiumwilfordii hook on corneal allograft rejection
     IL-2-PE40、CsA、雷公藤治疗角膜移植排斥反应实验研究
短句来源
     RESULTS:After TGFβ2-DC injection,the corneal allograft rejection was delayed and the survival time of grafts was prolonged. The mean survival time of PBS injection group and TGFβ2-DC injection group was 17.8±3.01d and 37.6±1.65d,respectively (P< 0.001).
     结果:TGFβ2-DC注射后,植片发生移植排斥反应的时间延迟,植片存活时间明显延长,PBS组及TGFβ2-DC尾静脉组植片的存活时间分别为17.8±3.01d和37.6±1.65d(P<0.01)。
短句来源
     The group receiving anti- TNF-α mAb had a significant delay in corneal allograft rejection with mean survival time of 13.8±2.17 days vs 10.2±1.94 days for the control group (P<0.01).
     异基因移植大鼠植片存活时间为 10 .2± 1.94d ,而抗体治疗组 13.8± 2 .17d ,二者相比差异有显著性 (P <0 .0 1)。
短句来源
     CONCLUSION: 1,25(OH)2D3 can be effective in suppressing acute immunological rejection after high risk corneal transplantation and prolong the survival time of corneal allograft. The mechanism may include the inhibitive role in proinflammatory cytokines (IL 1α,TNF α) and have no remarkable relation with VEGF.
     结论:1,25(OH)2D能有效地抑制高危角移后急性期免疫排斥反应,延3长移植物存活时间,机制可能包括它对前炎症因子(IL-1α,TNF-α)生成的抑制,而与血管生长因子VEGF无明显关系。
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  corneal allograft
Early recognition of corneal graft rejection and prompt treatment are mandatory for the successful survival of the corneal allograft.
      
Early recognition of corneal allograft rejection and aggressive treatment may improve the survival of the corneal graft.
      
Recent advances in sutures, storage media, microsurgical instrumentation, and new pharmacological strategies have greatly improved the success of corneal transplantation and the prevention of corneal allograft rejection.
      
The unique structure of the cornea, with its absence of blood vessels and corneal lymphatic, allows the survival of corneal allograft.
      
Ability of intracamerally inoculated B- and T-cell enriched allogeneic lymphocytes to enhance corneal allograft survival
      
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16 eyes with corneal allograft rejection after penetrating keratoplasty were treated with 0.5% cyclosporin A (CsA) eyedrops, 9 eyes were completely cured, 6 eyes markedly improved, and one eye ineffective. Follow-up for 5~24 months found that 3 of the 9 cured eyes recurred, 2 eyes after suspension of CsA and one eye after removal sutures. The recurrence was cured with resumed or increased application of the drug. The study indicated that treatment with CsA eyedrops yielded good curative rerults, particularly...

16 eyes with corneal allograft rejection after penetrating keratoplasty were treated with 0.5% cyclosporin A (CsA) eyedrops, 9 eyes were completely cured, 6 eyes markedly improved, and one eye ineffective. Follow-up for 5~24 months found that 3 of the 9 cured eyes recurred, 2 eyes after suspension of CsA and one eye after removal sutures. The recurrence was cured with resumed or increased application of the drug. The study indicated that treatment with CsA eyedrops yielded good curative rerults, particularly in eyes of satisfactory preoperative transplantation bed. The authors suggested that CsA should be used and then tapered slowly over a long period of time, especially in the cases with corneal vascularization or other significant risk factors of rejection. In the cases with poor preoperative corneal transplantation beds, increased concentration of CsA or combination with other immunosuppressants should be considered. The efficacy of CsA and its mechanism of action on corneal graft rejection were discussed.

应用0.5%环孢霉素A(cyclosporin A,CsA)滴眼治疗穿透性角膜移植术后发生免疫排斥患者16例(16只眼),治愈9只眼,好转6只眼,无效1只眼。随访5~24个月,其中2只眼因停药复发,1只眼于拆线后复发,继续用药或增加给药次数后治愈。研究表明0.5%CsA滴眼剂治疗术前移植床条件较好,角膜移植术后发生免疫排斥的病例可得到良好疗效;而对术前移植床条件较差,角膜移植术后发生免疫排斥的病例有一定的疗效。作者对眼局部应用CsA治疗角膜移植排斥的疗效和作用机理进行了讨论。

We used a new immunosuppressive agent interleukin( IL )-2-Pseudomonas exotoxin 40(PE40 ) to treat corneal allograft rejection,using the Wistar rat model of heterograft-heterotopic graft rejection, 36 rats were divided randomly into the treatment and the control groups. On 2,5,7, 10 and 14 days after the transplantation,the transplanted corneas were removed for pathological examinations. The peripheral blood was collected for the analysis of T cell subgroups and T lymphocyte colony forming unit(T- CFU)...

We used a new immunosuppressive agent interleukin( IL )-2-Pseudomonas exotoxin 40(PE40 ) to treat corneal allograft rejection,using the Wistar rat model of heterograft-heterotopic graft rejection, 36 rats were divided randomly into the treatment and the control groups. On 2,5,7, 10 and 14 days after the transplantation,the transplanted corneas were removed for pathological examinations. The peripheral blood was collected for the analysis of T cell subgroups and T lymphocyte colony forming unit(T- CFU) assay,These results indicate that IL-2-PE40 can delay the development of corneal graft rejection and significantly reduce the percentage of T-helper cells. On the other hand,IL-2-PE40 can weaken the gathering capacity of the peripheral T- cells.

采用新型免疫抑制剂白细胞介素-2-绿脓杆茵外毒素(interleukin-2-Pseudomonasexotoxin40,IL-2-PE40)对角膜移植排斥反应进行实验性治疗。以Wistar大鼠异种角膜异位移植为模型,将36只鼠随机分为治疗组及对照组,并在术后第2、5、7、10、14天分别取出植片做病理切片,收集外周血进行T淋巴细胞亚群及T淋巴细胞集落形成数分析。结果显示:IL-2-PE40可推迟排斥反应的发生时间;有明显减少外周血中辅助T淋巴细胞百分率的作用;并能减弱大鼠外周血T淋巴细胞巢落形成能力。

Langerhans cells(LC)of ocular surface may play a central role in corneal allograft rejection. If LCs are depleted by something before or after cornea-grafting, grafted cornea may survive longer.In this paper, we treated mice's eyeballs with hydrocortisone.By means of ATPase histochemistry and image analysis,the effect on LCs in corneal and conjunctival epithelia of normal mice was investigated. The results showed that the number of LCs and ATPase reactive degree were decreased as the amount of hydrocortisone...

Langerhans cells(LC)of ocular surface may play a central role in corneal allograft rejection. If LCs are depleted by something before or after cornea-grafting, grafted cornea may survive longer.In this paper, we treated mice's eyeballs with hydrocortisone.By means of ATPase histochemistry and image analysis,the effect on LCs in corneal and conjunctival epithelia of normal mice was investigated. The results showed that the number of LCs and ATPase reactive degree were decreased as the amount of hydrocortisone increased.As the amount of hydrocortisone arrived at 1.7mg/ ml, none of ATPase-positive LCs was found in peripheral cornea and conjunctiva and it was only found in corneal border.When arrived at 2. 0mg/ ml there were few ATPase-positive LCs in corneal border.

郎格罕细胞(LC)在角膜排斥反应中起着重要的作用,若能在角膜移植前后选择性地抑制LC的功能活性,有可能延长移植角膜的存活期。本实验选用免疫抑制剂──氢化可的松处理小鼠眼球,利用酶组化──ATP酶法和图像分析仪,观察其对角膜、结膜上皮内LC密度以及酶活性的影响。结果显示,随着氢化可的松浓度的增大,LC内ATP酶反应程度、LC密度显示下降趋势。当氢化可的松浓度增加至1.7mg/ml时,除角巩缘外,周边角膜和结膜已无ATPase阳性的LC,当浓度达到2.0mg/ml时,角巩缘也很少见ATPase阳性的Lc。

 
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