The calculation with RHF/PM3 has been applied to study the gas-phase pyrolytic reaction mechanism of N-Ethyl, N-Isopropyl and N-t-butyl substituted 2-Aminopyrimidine.
Fluvastatin sodium, an antihypercholesterolemic HMG CoA reductase inhibitor, was synthesized from fluorobenzene by Friedel-Crafts acylation with chloroacetyl chloride, followed by condensation with N-isopropyl aniline and cyclization to give 3-(4-fluorophenyl)-1-isopropyl-1H-indole, which was subjected to Vilsmeier-Haack reaction, condensation with methyl acetoacetate, selective reduction, hydrolysis and salt formation with an overall yield of 26%.
In this paper,the preparation of N-isopropyl acrylamide(NIPA) and N,N-methylene bis acrylamide(Bis) hydrogel bead by inverse suspension polymerization and the separation properties of the hydrogel were studied.
The temperature-sensitive poly(N-isopropyl acrylamide) (PNIPA) hydrogel was synthesized and applied into the refolding of Hen egg white lysozyme(HEWL) and recombinant bovine prethrombin-2(pThr-2) inclusion bodies.
Iodination of N-isopropyl- and N-benzyl-2-(2-cyclohexenyl)anilines gave the corresponding 1-iodo-hexahydrocarbazoles which underwent quantitative isomerization into 3-iodo-2,4-propano-1,2,3,4-tetrahydro-quinolines.
Quantum-chemical predictions of the formation of H-bonds between the N-phenyl-N'-isopropyl-p-phenylenediamine and N,N'-diphenyl-
Molecular chain properties of poly (N-isopropyl acrylamide)
A series of poly(N-isopropyl acrylamide) (PNIPAM) samples with molecular weight ranging from 2.23 × 104 to 130 × 104 and molecular weight distributionMw/Mn ≤1.
The mechanism of protection from 5 (N-ethyl-N-isopropyl)amiloride differs from that of ischemic preconditioning in rabbit heart
Nitration of cis-β-(2-furyl) acrylic acid afforded the corresponding cis-β-(5-nitro-furyl), acrylic acid. It was readily converted to cis-β-(5-nitro-2-furyl)-N-isopropyl-acrylamide by amination with isopropylamine through the mixed anhydride method.The biological activity of this cis-isomer was examined in laboratory animals against experimental schistosomiasis and was shown to possess activity similar to that already reported for the trans-isomer.
This paper deals w(?) the synthetical routes and the tech(?) processof O-methyl-N-isopropyl-O-[(2-isopropoxycarbonyl)phenyl]thiophosphoramidate.The average yield of this compound is 65.3-66.3%.
Amiprophos-M, ethyl 2-nitro-4-methylphenyl N-isopropyl phosphoramidothionate, crystallizes in the triclinic space group P1 with two molecules in the unit cell. The crystallography parameters are: a=8.636 (1), b=10.483 (2),c=10.694(2) A; a=110.92(1)°, β=111.27(1)°, γ=98.97(1)°;V=796.2(3)A~3; D_c=1.33g/cm~3; F(000)=336;(MoK_α)=3.2cm~(-1). The crystal structure has been solved by the direct method and refined by the block-diagonal least-squares procedures to final R values of R_1=0.055 and R_2=0.047. The...
Amiprophos-M, ethyl 2-nitro-4-methylphenyl N-isopropyl phosphoramidothionate, crystallizes in the triclinic space group P1 with two molecules in the unit cell. The crystallography parameters are: a=8.636 (1), b=10.483 (2),c=10.694(2) A; a=110.92(1)°, β=111.27(1)°, γ=98.97(1)°;V=796.2(3)A~3; D_c=1.33g/cm~3; F(000)=336;(MoK_α)=3.2cm~(-1). The crystal structure has been solved by the direct method and refined by the block-diagonal least-squares procedures to final R values of R_1=0.055 and R_2=0.047. The phosphorus atom of the Amiprophos molecule forms four tetrahedral covalent bends, of which the P-S bond exhibits rather high double bond character. It implies that the empty 3d-orbital of the phosphorus atom should be involved in the chemical bond formation.